World report on violence and health

This report examines the types of violence that are present worldwide, in the everyday lives of people, and that constitute the bulk of the health burden imposed by violence. Accordingly, the information has been arranged in nine chapters, covering the following topics: 1. Violence – a global public health problem 2. Youth violence 3. Child abuse and neglect by parents and other caregivers 4. Violence by intimate partners 5. Abuse of the elderly 6. Sexual violence 7. Self-directed violence 8. Collective violence 9. The way forward: recommendations for action; Because it is impossible to cover all types of violence fully and adequately in a single document, each chapter has a specific focus. For example, the chapter on youth violence examines interpersonal violence among adolescents and young adults in the community. The chapter on child abuse discusses physical, sexual and psychological abuse, as well as neglect by parents and other caregivers; other forms of maltreatment of children, such as child prostitution and the use of children as soldiers, are covered in other parts of the report. The chapter on abuse of the elderly focuses on abuse by caregivers in domestic and institutional settings, while that on collective violence discusses violent conflict. The chapters on intimate partner violence and sexual violence focus primarily on violence against women, though some discussion of violence directed at men and boys is included in the chapter on sexual violence. The chapter on self-directed violence focuses primarily on suicidal behaviour. The chapter is included in the report because suicidal behaviour is one of the external causes of injury and is often the product of many of the same underlying social, psychological and environmental factors as other types of violence. The chapters follow a similar structure. Each begins with a brief discussion of definitions for the specific type of violence covered in the chapter, followed by a summary of current knowledge about the extent of the problem in different regions of the world. Where possible, country-level data are presented, as well as findings from a range of research studies. The chapters then describe the causes and consequences of violence, provide summaries of the interventions and policy responses that have been tried, and make recommendations for future research and action. Tables, figures and boxes are included to highlight specific epidemiological patterns and findings, illustrate examples of prevention activities, and draw attention to specific issues. The report concludes with two additional sections: a statistical annex and a list of Internet resources. The statistical annex contains global, regional and country data derived from the WHO mortality and morbidity database and from Version 1 of the WHO Global Burden of Disease project for 2000. A description of data sources and methods is provided in the annex to explain how these data were collected and analysed. The list of Internet resources includes web site addresses for organizations involved in violence research, prevention and advocacy. The list includes metasites (each site offers access to hundreds of organizations involved in violence research, prevention and advocacy), web sites that focus on specific types of violence, web sites that address broader contextual issues related to violence, and web sites that offer surveillance tools for improving the understanding of violence

El informe mundial sobre la violencia y la salud.

In 1996, the World Health Assembly declared violence a major public health issue. To follow up on this resolution, on October 3 this year, WHO released the first World Report on Violence and Health. The report analyses different types of violence including child abuse and neglect, youth violence, intimate partner violence, sexual violence, elder abuse, self-directed violence, and collective violence. For all these types of violence, the report explores the magnitude of the health and social effects, the risk and protective factors, and the types of prevention efforts that have been initiated. The launch of the report will be followed by a 1-year Global Campaign on Violence Prevention, focusing on implementation of the recommendations. This article summarises some of the main points of the world report.En 1966, la Organización Mundial de la Salud declaró la violencia como uno de los principales problemas de salud pública. Para dar seguimiento a dicha resolución, el 3 de octubre de este año, la OMS publicó el primer Informe mundial sobre la violencia y la salud, el cual analiza los diferentes tipos de violencia, incluidos el maltrato y abandono de menores, la violencia entre los jóvenes, la violencia contra la pareja, la violencia sexual, el maltrato a ancianos, la violencia autoinfligida y la violencia colectiva. Para todos estos tipos de violencia, el informe explora la magnitud de sus efectos en la salud y en la sociedad, los factores de riesgo y protección y los esfuerzos de prevención que se han desplegado. El lanzamiento del informe dará inicio a una Campaña Global de Prevención de la Violencia que durante un año se centrará en la aplicación de sus recomendaciones. Este artículo resume algunos de los puntos más importantes del informe mundial

HIV and adolescents: focus on young key populations

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138345/1/jia20076.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138345/2/jia20076-sup-0001.pd

Global development and diffusion of outcome evaluation research for interpersonal and self-directed violence prevention from 2007 to 2013: A systematic review

© 2014 The Authors. Published by Elsevier Ltd. Through a global review, we identified gaps in the geographical distribution of violence prevention evidence outcome evaluation studies and the types of violence addressed. Systematic literature searches identified 355 articles published between 2007 and 2013 that evaluated programs to prevent interpersonal or self-directed violence; focused on universal or selected populations; and reported outcomes measuring violence or closely related risk factors. The number of studies identified increased annually from 2008 (n = 37), reaching 64 in 2013. Over half (n = 203) of all studies focused on youth violence yet only one on elder maltreatment. Study characteristics varied by year and violence type. Only 9.3% of all studies had been conducted in LMICs. These studies were less likely than those in high income countries (HICs) to have tested established interventions yet more likely to involve international collaboration. Evaluation studies successfully established in LMIC had often capitalized on other major regional priorities (e.g. HIV). Relationships between violence and social determinants, communicable and non-communicable diseases, and even economic prosperity should be explored as mechanisms to increase the global reach of violence prevention research. Results should inform future research strategies and provide a baseline for measuring progress in developing the violence prevention evidence-base, especially in LMICs

HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis

<p>Abstract</p> <p>Background</p> <p>Although the <it>high mobility group A1 </it>(<it>HMGA1</it>) gene is widely overexpressed in diverse cancers and portends a poor prognosis in some tumors, the molecular mechanisms that mediate its role in transformation have remained elusive. <it>HMGA1 </it>functions as a potent oncogene in cultured cells and induces aggressive lymphoid tumors in transgenic mice. Because HMGA1 chromatin remodeling proteins regulate transcription, <it>HMGA1 </it>is thought to drive malignant transformation by modulating expression of specific genes. Genome-wide studies to define HMGA1 transcriptional networks during tumorigenesis, however, are lacking. To define the HMGA1 transcriptome, we analyzed gene expression profiles in lymphoid cells from <it>HMGA1a </it>transgenic mice at different stages in tumorigenesis.</p> <p>Results</p> <p>RNA from lymphoid samples at 2 months (before tumors develop) and 12 months (after tumors are well-established) was screened for differential expression of > 20,000 unique genes by microarray analysis (Affymetrix) using a parametric and nonparametric approach. Differential expression was confirmed by quantitative RT-PCR in a subset of genes. Differentially expressed genes were analyzed for cellular pathways and functions using Ingenuity Pathway Analysis. Early in tumorigenesis, HMGA1 induced inflammatory pathways with NFkappaB identified as a major node. In established tumors, HMGA1 induced pathways involved in cell cycle progression, cell-mediated immune response, and cancer. At both stages in tumorigenesis, HMGA1 induced pathways involved in cellular development, hematopoiesis, and hematologic development. Gene set enrichment analysis showed that stem cell and immature T cell genes are enriched in the established tumors. To determine if these results are relevant to human tumors, we knocked-down HMGA1 in human T-cell leukemia cells and identified a subset of genes dysregulated in both the transgenic and human lymphoid tumors.</p> <p>Conclusions</p> <p>We found that <it>HMGA1 </it>induces inflammatory pathways early in lymphoid tumorigenesis and pathways involved in stem cells, cell cycle progression, and cancer in established tumors. <it>HMGA1 </it>also dyregulates genes and pathways involved in stem cells, cellular development and hematopoiesis at both early and late stages of tumorigenesis. These results provide insight into <it>HMGA1 </it>function during tumor development and point to cellular pathways that could serve as therapeutic targets in lymphoid and other human cancers with aberrant <it>HMGA1 </it>expression.</p

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

10Kin1day: A Bottom-Up Neuroimaging Initiative.

We organized 10Kin1day, a pop-up scientific event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000+ existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000+ MRI connectome maps of the human brain

Global status report on violence prevention 2014

© 2016 American Journal of Preventive Medicine. Introduction Interpersonal violence affects millions of people worldwide, often has lifelong consequences, and is gaining recognition as an important global public health problem. There has been no assessment of measures countries are taking to address it. This report aims to assess such measures and provide a baseline against which to track future progress. Methods In each country, with help from a government-appointed National Data Coordinator, representatives from six to ten sectors completed a questionnaire before convening in a consensus meeting to decide on final country data; 133 of 194 (69%) WHO Member States participated. The questionnaire covered data, plans, prevention measures, and victim services. Data were collected between November 2012 and June 2014, and analyzed between June and October 2014. Global and country-level homicides for 2000-2012 were also calculated for all 194 Members. Results Worldwide, 475,000 people were homicide victims in 2012 and homicide rates declined by 16% from 2000 to 2012. Data on fatal and, in particular, non-fatal forms of violence are lacking in many countries. Each of the 18 types of surveyed prevention programs was reported to be implemented in a third of the 133 participating countries; each law was reported to exist in 80% of countries, but fully enforced in just 57%; and each victim service was reported to be in place in just more than half of the countries. Conclusions Although many countries have begun to tackle violence, serious gaps remain, and public health researchers have a critical role to play in addressing them