Control interno y su relación con los estados financieros de las empresas constructoras del distrito de Lince, año 2018

El presente trabajo de investigación, tiene por objetivo “Determinar de qué manera el control interno se relaciona con los estados financieros de las empresas constructoras del distrito de Lince, año 2018. La importancia del estudio consiste en explicar la necesidad de la posibilidad de implementar un sistema de control interno en una organización y los beneficios que conlleva la implementación de uno, de manera que permita que las operaciones de las empresas cuenten con un grado de seguridad adecuado y el margen de error que exista sea mínimo y por ende el camino hacia el cumplimiento de los objetivos propuestos por la entidad, sea mucho más accesible. La investigación se realizó con el marco conceptual de La Contraloría General de la Republica, una de las principales entidades de nuestro medio que nos brindan información de lo que es el control interno, su importancia, características y sus componentes. El tipo de investigación es correlacional, el diseño de investigación es no experimental transversal correlacional, con una población universal de 45 personas que pertenecen al área de contabilidad y tesorería en 9 empresas. La técnica que se utilizo es la encuesta, y el instrumento de recolección de datos el cuestionario, que fue aplicado a las empresas seleccionadas. Para determinar la validez de los instrumentos se utilizó el criterio de juicios de expertos, además de estar respaldado por el uso de Alfa de Cronbach y la comprobación de las hipótesis se realizó con la prueba del Chi cuadrado. En la presente investigación se llegó a la conclusión que el control interno tiene relación con los estados financieros de las empresas constructoras del distrito de Lince, año 2018

Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia

Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage. The present study evaluated the pharmacological effects of the selective cyclooxygenase-2 inhibitor nimesulide on delayed neuronal death of hippocampal CA1 neurons following transient global cerebral ischemia in gerbils. Administration of therapeutically relevant doses of nimesulide (3, 6 and 12 mg/kg; i.p.) 30 min before ischemia and at 6, 12, 24, 48 and 72 h after ischemia significantly (P<0.01) reduced hippocampal neuronal damage. Treatment with a single dose of nimesulide given 30 min before ischemia also resulted in a significant increase in the number of healthy neurons in the hippocampal CA1 sector 7 days after ischemia. Of interest is the finding that nimesulide rescued CA1 pyramidal neurons from ischemic death even when treatment was delayed until 24 h after ischemia (34+/-9% protection). Neuroprotective effect of nimesulide is still evident 30 days after the ischemic episode, providing the first experimental evidence that cyclooxygenase-2 inhibitors confer a long-lasting neuroprotection. Oral administration of nimesulide was also able to significantly reduce brain damage, suggesting that protective effects are independent of the route of administration. The present study confirms the ability of cyclooxygenase-2 inhibitors to reduce brain damage induced by cerebral ischemia and indicates that nimesulide can provide protection when administered for up to 24 h post-ischemia

Fuzzy inference system for integrated VVC in isolated power systems

This paper presents a fuzzy inference system for integrated volt/var control (VVC) in distribution substations. The purpose is go forward to automation distribution applying conservation voltage reduction (CVR) in isolated power systems where control capabilities are limited. A fuzzy controller has been designed. Working as an on-line tool, it has been tested under real conditions and it has managed the operation during a whole day in a distribution substation. Within the limits of control capabilities of the system, the controller maintained successfully an acceptable voltage profile, power factor values over 0,98 and it has ostensibly improved the performance given by an optimal power flow based automation system. CVR savings during the test are evaluated and the aim to integrate it in the VVC is presented.Comment: arXiv admin note: substantial text overlap with arXiv:1401.163

La efectividad de los sistemas de salud para la protección del derecho de salud mental en la población de Paita, 2022

RESUMEN La presente tesis titulada “La efectividad de los sistemas de salud para la protección del derecho de salud mental en la población de Paita ,2022”, cuyo objetivo general Determinar la eficacia del sistema de salud en los tratamientos para proteger el derecho de salud mental, cuyo objetivo general Determinar la eficacia del sistema de salud en los tratamientos para proteger el derecho de salud mental; asimismo , Se aplicó un diseño no experimental con enfoque cuantitativo, nivel básico, descriptivo correlacional, a una muestra de 27 familiares de los pacientes y 24 trabajadores del centro de salud, instrumento un cuestionario, sometido al programa SPSS, para su confiabilidad y se obtuvo como resultado parte de los familiares el 55,6 % deficiente la financiación los centros de salud para una atención de calidad y de los trabajadores el 66,7% el sis y essalud brinda un servicio deficiente: el impacto actual es deficiente ya que solo existe un centro de tratamientos mentales, para atender la demanda de la población de Paita, ante ello se refleja que es insuficiente estos sistemas de salud, así mismo los sistemas no cuenta con los profesionales necesario para rehabilitar a los pacientes

Relación entre nivel de ansiedad y miedo dental en pacientes adultos atendidos en un centro odontológico-Lima 2022

Objetivo: El objetivo del estudio fue determinar la relación entre el nivel de ansiedad y miedo dental en pacientes adultos atendidos en un centro odontológicoLima 2022. Metodología: La investigación que se realizó fue básica, descriptiva, no experimental, transversal y correlacional. La muestra estuvo conformada por 265 adultos, con muestreo no probabilístico por conveniencia, utilizando Escala de Ansiedad Dental de Corah Modificado y Cuestionario de Miedos Dentales (CMD- 20) de Pál-Hegedus y Lejarza, mediante formularios google, por whatsapp. Resultados: Los pacientes femeninos tuvieron ansiedad moderada y moderado miedo dental 19,1 %, sexo masculino presentó ansiedad moderada y moderado miedo dental 16,2 %, según edad los adultos jóvenes presentaron el 20,9 % de ansiedad moderada y moderado miedo dental, adultos maduros el 14,1 % y adultos mayores tuvieron ansiedad severa y moderado miedo dental en un 29,7 %. Pacientes con instrucción primaria el 37,5 % presentaron ansiedad severa y moderado miedo dental, instrucción secundaria presentaron ansiedad leve y sin miedo dental el 15,1 %, con instrucción superior ansiedad moderada y moderado miedo dental un 19,6 % y sin instrucción tuvieron ansiedad leve y moderado miedo dental el 50%. Conclusión: Existe relación entre el nivel de ansiedad y miedo dental en pacientes adulto

Footprint preparation with nanofractures in a supraspinatus repair cuts in half the retear rate at 1-year follow-up. A randomized controlled trial

Purpose: To evaluate if adding nanofractures to the footprint of a supraspinatus tear repair would have any effect in the outcomes at one-year follow-up. Methods: Multicentric, triple-blinded, randomized trial with 12-months follow-up. Subjects with isolated symptomatic reparable supraspinatus tears smaller than 3 cm and without grade 4 fatty infiltration were included. These were randomized to two groups: In the Control group an arthroscopic supraspinatus repair was performed; in the Nanofracture group the footprint was additionally prepared with nanofractures (1 mm wide, 9 mm deep microfractures). Clinical evaluation was done with Constant score, EQ-5D-3L, and Brief Pain Inventory. The primary outcome was the retear rate in MRI at 12-months follow-up. Secondary outcomes were: characteristics of the retear (at the footprint or at the musculotendinous junction) and clinical outcomes. Results: Seventy-one subjects were randomized. Two were lost to follow-up, leaving 69 participants available for assessment at 12-months follow-up (33 in the Control group and 36 in the Nanofracture Group). The Nanofracture group had lower retear rates than the Control group (7/36 [19.4%] vs 14/33 [42.4%], differences significant, p = 0.038). Retear rates at the musculotendinous junction were similar but the Nanofracture group had better tendon healing rates to the bone (34/36 [94.4%] vs. 24/33 [66.71%], p = 0.014). Clinically both groups had significant improvements, but no differences were found between groups. Conclusion: Adding nanofractures at the footprint during an isolated supraspinatus repair lowers in half the retear rate at 12-months follow-up. This is due to improved healing at the footprint

Pluripotency factors regulate the onset of Hox cluster activation in the early embryo

Pluripotent cells are a transient population of the mammalian embryo dependent on transcription factors, such as OCT4 and NANOG, which maintain pluripotency while suppressing lineage specification. However, these factors are also expressed during early phases of differentiation, and their role in the transition from pluripotency to lineage specification is largely unknown. We found that pluripotency factors play a dual role in regulating key lineage specifiers, initially repressing their expression and later being required for their proper activation. We show that Oct4 is necessary for activation of HoxB genes during differentiation of embryonic stem cells and in the embryo. In addition, we show that the HoxB cluster is coordinately regulated by OCT4 binding sites located at the 3′ end of the cluster. Our results show that core pluripotency factors are not limited to maintaining the precommitted epiblast but are also necessary for the proper deployment of subsequent developmental programs

Identification of regulatory variants associated with genetic susceptibility to meningococcal disease.

Non-coding genetic variants play an important role in driving susceptibility to complex diseases but their characterization remains challenging. Here, we employed a novel approach to interrogate the genetic risk of such polymorphisms in a more systematic way by targeting specific regulatory regions relevant for the phenotype studied. We applied this method to meningococcal disease susceptibility, using the DNA binding pattern of RELA - a NF-kB subunit, master regulator of the response to infection - under bacterial stimuli in nasopharyngeal epithelial cells. We designed a custom panel to cover these RELA binding sites and used it for targeted sequencing in cases and controls. Variant calling and association analysis were performed followed by validation of candidate polymorphisms by genotyping in three independent cohorts. We identified two new polymorphisms, rs4823231 and rs11913168, showing signs of association with meningococcal disease susceptibility. In addition, using our genomic data as well as publicly available resources, we found evidences for these SNPs to have potential regulatory effects on ATXN10 and LIF genes respectively. The variants and related candidate genes are relevant for infectious diseases and may have important contribution for meningococcal disease pathology. Finally, we described a novel genetic association approach that could be applied to other phenotypes

Monitoring the Morphology of M87* in 2009–2017 with the Event Horizon Telescope

The Event Horizon Telescope (EHT) has recently delivered the first resolved images of M87*, the supermassive black hole in the center of the M87 galaxy. These images were produced using 230 GHz observations performed in 2017 April. Additional observations are required to investigate the persistence of the primary image feature—a ring with azimuthal brightness asymmetry—and to quantify the image variability on event horizon scales. To address this need, we analyze M87* data collected with prototype EHT arrays in 2009, 2011, 2012, and 2013. While these observations do not contain enough information to produce images, they are sufficient to constrain simple geometric models. We develop a modeling approach based on the framework utilized for the 2017 EHT data analysis and validate our procedures using synthetic data. Applying the same approach to the observational data sets, we find the M87* morphology in 2009–2017 to be consistent with a persistent asymmetric ring of ~40 μas diameter. The position angle of the peak intensity varies in time. In particular, we find a significant difference between the position angle measured in 2013 and 2017. These variations are in broad agreement with predictions of a subset of general relativistic magnetohydrodynamic simulations. We show that quantifying the variability across multiple observational epochs has the potential to constrain the physical properties of the source, such as the accretion state or the black hole spin

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe