Benais – La Boire de Rigaudet

Date de l'opération : 1988 (SD) Inventeur(s) : Lecompte Jean-Paul 'inscrivant dans la continuité de la recherche pluridisciplinaire entreprise depuis plusieurs années sur le « terroir de Bourgueil », deux voies ont été mises au jour par le recalibrage du cours d'eau la « Boire du Rigaudet » en 1988 (Lecompte, 1987 et 1990). La première voie est construite sur un radier de bois, surmonté d'un lit de pierres dures (perrons), posées sur chant et dans lesquelles sont encastrés des pieux de chêne,..

Saint-Nicolas-de-Bourgueuil – La grand Prée et les Prés Daveau

Date de l'opération : 1990 (SU) Inventeur(s) : Lecompte Jean-Paul En raison de l'édification d'un pont, des travaux de recalibrage d'une partie du ruisseau « le Lane » en 1990 ont permis la mise au jour de structures archéologiques. L'ensemble des observations archéologiques révèlent la présence d'un gué aménagé avec des pieux, enfoncés verticalement dans le substrat sableux et alignés dans un même axe. Dans cet alignement, orienté nord-ouest, un lit de roulement est constitué d'un niveau de ..

Arrondissement de Saumur

Les prospections aériennes En 1991 et 1992, les prospections aériennes ont été poursuivies dans l’arrondissement de Saumur. Deux enclos protohistoriques ont été découverts dans la vallée alluviale de la Loire : l’un aux « Annières » à Allonnes, l’autre à « La Grande chênaie » à Longué. À Distré, sur une cinquantaine d’hectares, on a observé des traces d’alignements très serrés et entrecroisés, en discordance totale avec le parcellaire actuel et celui du cadastre napoléonien. Ceux-ci correspon..

Saint Nicolas-de-Bourgueuil – Les caves de la Gardière

Date de l'opération : 1984 (SD) Inventeur(s) : Lecompte Jean-Paul ; Boucher M A la suite du déblaiement d'une cave, un grand nombre de fragments de céramique furent récupérés par le propriétaire. En 1984, un relevé stratigraphique fut réalisé dans une petite partie du remblai qui paraît dater du XVe et du XVIe s

High Energy Physics Forum for Computational Excellence: Working Group Reports (I. Applications Software II. Software Libraries and Tools III. Systems)

Computing plays an essential role in all aspects of high energy physics. As computational technology evolves rapidly in new directions, and data throughput and volume continue to follow a steep trend-line, it is important for the HEP community to develop an effective response to a series of expected challenges. In order to help shape the desired response, the HEP Forum for Computational Excellence (HEP-FCE) initiated a roadmap planning activity with two key overlapping drivers -- 1) software effectiveness, and 2) infrastructure and expertise advancement. The HEP-FCE formed three working groups, 1) Applications Software, 2) Software Libraries and Tools, and 3) Systems (including systems software), to provide an overview of the current status of HEP computing and to present findings and opportunities for the desired HEP computational roadmap. The final versions of the reports are combined in this document, and are presented along with introductory material.Comment: 72 page

First pilot trial of the STAR-Liege protocol for tight glycemic control in critically ill patients

peer reviewe

Toward community standards in the quest for orthologs

The identification of orthologs—genes pairs descended from a common ancestor through speciation, rather than duplication—has emerged as an essential component of many bioinformatics applications, ranging from the annotation of new genomes to experimental target prioritization. Yet, the development and application of orthology inference methods is hampered by the lack of consensus on source proteomes, file formats and benchmarks. The second ‘Quest for Orthologs' meeting brought together stakeholders from various communities to address these challenges. We report on achievements and outcomes of this meeting, focusing on topics of particular relevance to the research community at large. The Quest for Orthologs consortium is an open community that welcomes contributions from all researchers interested in orthology research and applications. Contact: [email protected]

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant

Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratificatio