Diagonal Form Factors and Heavy-Heavy-Light Three-Point Functions at Weak Coupling

In this paper we consider a special kind of three-point functions of HHL type at weak coupling in N=4 SYM theory and analyze its volume dependence. At strong coupling this kind of three-point functions were studied recently by Bajnok, Janik and Wereszczynski [1]. The authors considered some cases of HHL correlator in the su(2) sector and, relying on their explicit results, formulated a conjecture about the form of the volume dependence of the symmetric HHL structure constant to be valid at any coupling up to wrapping corrections. In order to test this hypothesis we considered the HHL correlator in su(2) sector at weak coupling and directly showed that, up to one loop, the finite volume dependence has exactly the form proposed in [1]. Another side of the conjecture suggests that computation of the symmetric structure constant is equivalent to computing the corresponding set of infinite volume form factors, which can be extracted as the coefficients of finite volume expansion. In this sense, extracting appropriate coefficients from our result gives a prediction for the corresponding infinite volume form factors.Comment: 37 pages, 9 figure

The complexity of the list homomorphism problem for graphs

We completely classify the computational complexity of the list H-colouring problem for graphs (with possible loops) in combinatorial and algebraic terms: for every graph H the problem is either NP-complete, NL-complete, L-complete or is first-order definable; descriptive complexity equivalents are given as well via Datalog and its fragments. Our algebraic characterisations match important conjectures in the study of constraint satisfaction problems.Comment: 12 pages, STACS 201

SR 2D micro-XRF imaging on entire rat thin sections in view of a pharmacokinetic study of a new bromine containing drug agains tuberculosis

Tuberculosis (TB) is a common and often deadly infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis in humans. Because of population growth, the absolute number of new cases is still increasing. Multi-drug-resistant tuberculosis (MDR-TB) is defined as resistance to the two most effective first-line TB drugs and is a public health issue in many developing countries, as treatment is longer and requires more expensive drugs. Recently, a new experimental diarylquinoline anti-tuberculosis drug was discovered at Janssen Pharmaceutica, referred to as TMC207 and shown in Fig. 1. Before TMC207 can be made commercially available, one of the necessary investigations is a thorough pharmacokinetic study to investigate its absorption, distribution, metabolism and excretion (ADME)

Elemental bio-imaging of uranium and plutonium in tissues from occupationally exposed former nuclear workers

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Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells

Neurocognitive deficits are serious sequelae that follow cranial irradiation used to treat patients with medulloblastoma and other brain neoplasms. Cranial irradiation causes apoptosis in the subgranular zone of the hippocampus leading to cognitive deficits. Valproic acid (VPA) treatment protected hippocampal neurons from radiation-induced damage in both cell culture and animal models. Radioprotection was observed in VPA-treated neuronal cells compared to cells treated with radiation alone. This protection is specific to normal neuronal cells and did not extend to cancer cells. In fact, VPA acted as a radiosensitizer in brain cancer cells. VPA treatment induced cell cycle arrest in cancer cells but not in normal neuronal cells. The level of anti-apoptotic protein Bcl-2 was increased and the pro-apoptotic protein Bax was reduced in VPA treated normal cells. VPA inhibited the activities of histone deacetylase (HDAC) and glycogen synthase kinase-3β (GSK3β), the latter of which is only inhibited in normal cells. The combination of VPA and radiation was most effective in inhibiting tumor growth in heterotopic brain tumor models. An intracranial orthotopic glioma tumor model was used to evaluate tumor growth by using dynamic contrast-enhanced magnetic resonance (DCE MRI) and mouse survival following treatment with VPA and radiation. VPA, in combination with radiation, significantly delayed tumor growth and improved mouse survival. Overall, VPA protects normal hippocampal neurons and not cancer cells from radiation-induced cytotoxicity both in vitro and in vivo. VPA treatment has the potential for attenuating neurocognitive deficits associated with cranial irradiation while enhancing the efficiency of glioma radiotherapy

Urinary N-Acetyl-Beta-D-Glucosaminidase Activity in Rat Experimental Ischemic and Toxic Models of Acute Kidney Injury

The identification of a suitable prevention method which facilitates limiting the deleterious effects of acute kidney injuries is highly required. In order to identify a proper treatment for acute kidney injuries, a suitable experimental model that replicates the structural, metabolic and inflammatory lesions that occur in the natural acute injured kidney is highly necessary. Intense urinary NAG activity can be found in a variety of renal disease such as toxic nephropathies, ischemic renal injury following cardiac surgery or renal transplantation but also in glomerular disease especially in diabetic nephropathy. Rises in urinary NAG enzyme activity strongly suggests tubular cell damage and support NAG enzyme as a biomarker of renal tubular injury. The aim of this paper is to obtain a stable in vivo acute kidney injury experimental model, in Wistar, rats and to evaluate the urinary activity of N-acetyl-β-D-glucosaminidase (NAG) enzyme, blood levels of urea and creatinine and microstructural renal alterations induced by ischemia/reperfusion injury respectively gentamicin nephrotoxicity. For this purpose we have used a rat experimental model. Adult male Wistar rats weighing 250-300 g were randomly divided into 3 groups with 8 rats in each group. Group 1 served as a model for the renal ischemia/reperfusion injury experiment, group 2 served for toxic kidney injury experimental model and group 3 served as control group. All individuals in both groups 1 and 2 presented marked elevations in blood urea and creatinine at the moment of euthanasia (day 3 for group 1 and day 9 for group 2) compared to the control group where biochemical values remained within normal limits. Urine analysis of both group 1 and 2 showed marked urinary NAG index activity which suggests acute tubular injury, suggestion confirmed by histological evaluation of the renal parenchyma sampled from this subject

New concepts for traffic, resource and mobility management in software-defined mobile networks

The evolution of mobile telecommunication networks is accompanied by new demands for the performance, portability, elasticity, and energy efficiency of network functions. Network Function Virtualization (NFV), Software Defined Networking (SDN), and cloud service technologies are claimed to be able to provide most of the capabilities. However, great leap forward will only be achieved if resource, traffic, and mobility management methods of mobile network services can efficiently utilize these technologies. This paper conceptualizes the future requirements of mobile networks and proposes new concepts and solutions in the form of Software-Defined Mobile Networks (SDMN) leveraging SDN, NFV and cloud technologies. We evaluate the proposed solutions through testbed implementations and simulations. The results reveal that our proposed SDMN enhancements supports heterogeneity in wireless networks with performance improvements through programmable interfaces and centralized control

The Oncogenic EWS-FLI1 Protein Binds In Vivo GGAA Microsatellite Sequences with Potential Transcriptional Activation Function

The fusion between EWS and ETS family members is a key oncogenic event in Ewing tumors and important EWS-FLI1 target genes have been identified. However, until now, the search for EWS-FLI1 targets has been limited to promoter regions and no genome-wide comprehensive analysis of in vivo EWS-FLI1 binding sites has been undertaken. Using a ChIP-Seq approach to investigate EWS-FLI1-bound DNA sequences in two Ewing cell lines, we show that this chimeric transcription factor preferentially binds two types of sequences including consensus ETS motifs and microsatellite sequences. Most bound sites are found outside promoter regions. Microsatellites containing more than 9 GGAA repeats are very significantly enriched in EWS-FLI1 immunoprecipitates. Moreover, in reporter gene experiments, the transcription activation is highly dependent upon the number of repeats that are included in the construct. Importantly, in vivo EWS-FLI1-bound microsatellites are significantly associated with EWS-FLI1-driven gene activation. Put together, these results point out the likely contribution of microsatellite elements to long-distance transcription regulation and to oncogenesis

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe