Termite sensitivity to temperature affects global wood decay rates.

Deadwood is a large global carbon store with its store size partially determined by biotic decay. Microbial wood decay rates are known to respond to changing temperature and precipitation. Termites are also important decomposers in the tropics but are less well studied. An understanding of their climate sensitivities is needed to estimate climate change effects on wood carbon pools. Using data from 133 sites spanning six continents, we found that termite wood discovery and consumption were highly sensitive to temperature (with decay increasing >6.8 times per 10°C increase in temperature)-even more so than microbes. Termite decay effects were greatest in tropical seasonal forests, tropical savannas, and subtropical deserts. With tropicalization (i.e., warming shifts to tropical climates), termite wood decay will likely increase as termites access more of Earth's surface

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

Two decades of land cover mapping in the Rio de la Plata grassland region: The mapBiomas Pampa initiative

The Río de la Plata Grasslands (RPG) region is the largest area of the temperate humid and subhumid grasslands biome in South America and one of the largest in the world. The region is located on fertile soils, generally very suitable for agricultural development, so it is undergoing an intense land cover change process. Our knowledge of these changes remains incomplete. Most regional-scale studies have been conducted over specific periods, limited subsets of the RGP, coarse resolution and, in general, used land cover classes that are not readily compatible. In this work we described and analyzed the land cover changes in the entire RPG region for the first two decades of the 21st century, especially those related to grasslands loss. We generated annual land cover maps with 30-m resolution that discriminate between 8 categories: native woody forma tion, forest plantation, swampy areas and flooded grassland, grassland, farming, non-vegetated area, water and non-observed. The map series was evaluated for the years 2001 and 2018 using a completely independent dataset, selected by stratified randomized sampling. Overall accuracy was 73.5% and 77.8% for 2001 and 2018, respectively, with user and producer accuracies that varied between classes and years. In 20 years, RPG region lost, at least, 2.4 million ha of grassland (9% of the remaining grassland area in 2001). Most of these losses are concentrated in Brazil and Uruguay and are associated with new agricultural or forestry areas that increased by 5% and 100%, respectively. Our maps allow a comprehensive understanding of the transformation processes that RPG are undergoing and provide the context on which to explore a large set of hy potheses related to ecosystem structure and functioning. It will also contribute to improving deci sion-making at both the regional and national levels.Fil: Baeza, Santiago. Universidad de la Republica. Facultad de Agronomía. Departamento de Sistemas Ambientales; UruguayFil: Velez Martín, E. GeoKarten Consultoria em Tecnologia da Informação Ltda.; BrasilFil: Abelleyra, Diego. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; ArgentinaFil: Banchero, Santiago. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; ArgentinaFil: Gallego, Federico. Universidad de la República. Facultad de Ciencias; UruguayFil: Schirmbeck, J. GeoKarten Consultoria em Tecnologia da Informação Ltda.; BrasilFil: Verón, Santiago Ramón. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Métodos Cuantitativos y Sistemas de Información; ArgentinaFil: Vallejos, M. Instituto Nacional de Investigación Agropecuaria. Programa de Investigación en Producción y Sustentabilidad Ambiental. El Semillero; UruguayFil: Weber, M. Universidade Federal do Rio Grande do Sul. Departamento Interdisciplinar e Programa de Pós-Graduação em Sensoriamento Remoto; BrasilFil: Oyarzabal, Mariano. Universidad de Buenos Aires. Facultad de Agronomía. Departamento de Métodos Cuantitativos y Sistemas de Información; ArgentinaFil: Barbieri, A. Universidad Nacional de la República. Facultad de Ciencias. Departamento de Geografía; UruguayFil: Petek, Mariana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Clima y Agua; ArgentinaFil: Guerra Lara, M. Universidad Nacional de San Luis. Instituto de Matemática Aplicada de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Matemática Aplicada de San Luis; ArgentinaFil: Sarrailhe, Sofia S. Universidad de Buenos Aires. Facultad de Agronomía; ArgentinaFil: Baldi, Germán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Matemática Aplicada de San Luis. Grupo de Estudios Ambientales; Argentina. Universidad Nacional de San Luis; ArgentinaFil: Bagnato, C. Universidad Nacional de Río Negro. IRNAD; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. IRNAD; ArgentinaFil: Bruzzone, L. Universidad de la República. Facultad de Ciencias. Instituto de Ecología y Ciencias Ambientales; UruguayFil: Ramos, S. Universidad de la República. Facultad de Ciencias. Departamento de Geografía; UruguayFil: Hasenack, H. Universidade Federal do Rio Grande do Sul. Departamento de Ecologia. IB e Programa de Pós-Graduação em Agronegócios; Brasi

Where Brain, Body and World Collide

The production cross section of electrons from semileptonic decays of beauty hadrons was measured at mid-rapidity (|y| < 0.8) in the transverse momentum range 1 < pt < 8 Gev/c with the ALICE experiment at the CERN LHC in pp collisions at a center of mass energy sqrt{s} = 7 TeV using an integrated luminosity of 2.2 nb^{-1}. Electrons from beauty hadron decays were selected based on the displacement of the decay vertex from the collision vertex. A perturbative QCD calculation agrees with the measurement within uncertainties. The data were extrapolated to the full phase space to determine the total cross section for the production of beauty quark-antiquark pairs

Las disputas por lo público en América Latina y el Caribe

Este libro configura un aporte sustancial para entender, desde un prisma distante de las concepciones hegemónicas en la academia, las dinámicas de lucha y las disputas en torno a lo público que signan la realidad contemporánea de América Latina y el Caribe. Un continente éste que, desde la perspectiva de los pueblos y clases subalternas que lo han forjado y habitan, ha sido renombrado como Abya Yala, Patria Grande o Nuestra América, todos ellos significantes que cargan una historia en común y una identidad cultivada al calor de las resistencias contra el despojo, la violencia y la explotación de un capitalismo neocolonial asentado en un entronque de patriarcados, y cuya unidad en la diversidad fue moldeada borgeanamente más a partir del espanto que del amor. Los capítulos que integran esta compilación auscultan el subsuelo de nuestras sociedades, hurgando en sus recovecos y márgenes para identificar, tornar comprensibles y potenciar aquellos procesos de creación, fortalecimiento y/o recuperación de lo público que, difícilmente, salgan en las tapas de diarios o los programas de televisión, salvo que acontezcan en ellos actos delictivos o represiones monumentales. Del Posfacio de Hernán Oubiñ