Planeamiento estratégico aplicado a la satisfacción del cliente de una pastelería pyme en el distrito de San Miguel, año 2021

El presente trabajo de investigación tiene como objetivo conocer el nivel de satisfacción actual del cliente de una pastelería pyme en el distrito de San Miguel, para proponer mejoras a través de herramientas de la planeación estratégica. El tipo de investigación es aplicada, de nivel descriptivo, y enfoque cuantitativo. Para un completo análisis de la información se investiga el desempeño actual de la empresa, por un lado, a través de las dimensiones del modelo Servqual y, por otro, mediante un análisis interno y externo. Lo anterior, para formular estrategias que permitirían mejorar la satisfacción del cliente al momento de su implementación. Entre los resultados, se calcula el coeficiente de Cronbach para medir el nivel de confiabilidad de la información obtenida, recolectada a través de la aplicación de dos tipos de encuestas que demuestran el nivel de satisfacción del cliente mediante brechas entre expectativas y percepción del servicio. Por otro lado, se exponen los resultados de los análisis interno y externo que han permitido identificar las principales fortalezas, debilidades, oportunidades y amenazas existentes. Finalmente, se formularon un conjunto de acciones estratégicas a través de la matriz FODA que permitirían mejorar el nivel de satisfacción del cliente

Justify your alpha

Benjamin et al. proposed changing the conventional “statistical significance” threshold (i.e.,the alpha level) from p ≤ .05 to p ≤ .005 for all novel claims with relatively low prior odds. They provided two arguments for why lowering the significance threshold would “immediately improve the reproducibility of scientific research.” First, a p-value near .05provides weak evidence for the alternative hypothesis. Second, under certain assumptions, an alpha of .05 leads to high false positive report probabilities (FPRP2 ; the probability that a significant finding is a false positive

The structure and function of Alzheimer's gamma secretase enzyme complex

The production and accumulation of the beta amyloid protein (Aβ) is a key event in the cascade of oxidative and inflammatory processes that characterizes Alzheimer’s disease (AD). A multi-subunit enzyme complex, referred to as gamma (γ) secretase, plays a pivotal role in the generation of Aβ from its parent molecule, the amyloid precursor protein (APP). Four core components (presenilin, nicastrin, aph-1, and pen-2) interact in a high-molecular-weight complex to perform intramembrane proteolysis on a number of membrane-bound proteins, including APP and Notch. Inhibitors and modulators of this enzyme have been assessed for their therapeutic benefit in AD. However, although these agents reduce Aβ levels, the majority have been shown to have severe side effects in pre-clinical animal studies, most likely due to the enzymes role in processing other proteins involved in normal cellular function. Current research is directed at understanding this enzyme and, in particular, at elucidating the roles that each of the core proteins plays in its function. In addition, a number of interacting proteins that are not components of γ-secretase also appear to play important roles in modulating enzyme activity. This review will discuss the structural and functional complexity of the γ-secretase enzyme and the effects of inhibiting its activity

Global prevalence and genotype distribution of hepatitis C virus infection in 2015 : A modelling study

Publisher Copyright: © 2017 Elsevier LtdBackground The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral therapies. Reliable disease burden estimates are required for national strategies. This analysis estimates the global prevalence of viraemic HCV at the end of 2015, an update of—and expansion on—the 2014 analysis, which reported 80 million (95% CI 64–103) viraemic infections in 2013. Methods We developed country-level disease burden models following a systematic review of HCV prevalence (number of studies, n=6754) and genotype (n=11 342) studies published after 2013. A Delphi process was used to gain country expert consensus and validate inputs. Published estimates alone were used for countries where expert panel meetings could not be scheduled. Global prevalence was estimated using regional averages for countries without data. Findings Models were built for 100 countries, 59 of which were approved by country experts, with the remaining 41 estimated using published data alone. The remaining countries had insufficient data to create a model. The global prevalence of viraemic HCV is estimated to be 1·0% (95% uncertainty interval 0·8–1·1) in 2015, corresponding to 71·1 million (62·5–79·4) viraemic infections. Genotypes 1 and 3 were the most common cause of infections (44% and 25%, respectively). Interpretation The global estimate of viraemic infections is lower than previous estimates, largely due to more recent (lower) prevalence estimates in Africa. Additionally, increased mortality due to liver-related causes and an ageing population may have contributed to a reduction in infections. Funding John C Martin Foundation.publishersversionPeer reviewe

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Justify your alpha

In response to recommendations to redefine statistical significance to p ≤ .005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level

Workplace ergonomics: Perceptions on employees stress levels and safety

Studies have shown that ergonomics implementation is beneficial for the companies and its employees. Benefits include decrease in medical costs and stress levels, and increase in employee productivity, comfort, and safety. Even with these benefits in place, ergonomics implementation is still not prevalent in the Philippine corporate setting. Therefore, this study would like to examine the effects of workplace stress levels and safety. A quantitative and qualitative approach was done through conducting a survey to 150 participants and through an interview with the president for human factors of the Philippine Ergonomic Society. The results indicate that ergonomic s implementation negatively affect employees perceptions stress level and positively affects their perceptions on safety. Ergonomics implementation in terms of work area design reduces employees perceived stress levels. Moreover, safety in terms of musculoskeletal disorder has a positive relationship with ergonomics design in terms of adjustable chair and work area design. The ergonomics design in terms of adjustable chair increase safety, in terms of decreasing the number of accidents and injuries in the workplace. Given the results of this study, it is recommended that companies implement ergonomics

The influence of psychological ownership on negative organizational outcomes

Researchers have theorized that psychological ownership can produce negative organizational outcomes such as resistance to change, workplace deviance, employee ostracism and a weaker intention to whistle blow, however few literatures have empirical evidence to support this assertion. To test the aforementioned claim, the researchers surveyed a total of 200 employees from 2 large corporations in Metro Manila. Researchers them employed the ordinary least squares regression to test the correlation between job and organization-based psychological ownership and the aforementioned negative outcomes. Results showed that high levels of psychological ownership among employees of Johnson and Johnson correlate with workplace deviance and whistle blowing intentions. Between job and organization-based psychological ownership, it is job-based psychological ownership that leads to greater negative outcomes. Results from P.A Alvarez and Development Corporation on the other hand, reveal that the high presence of psychological ownership positively correlates with workplace deviance and employee ostracism, but negatively correlated with whistle blowing intentions. As with the case of Johnson and Johnson, it is job-based psychological ownership that leads to greater negative outcomes. It is then imperative that managers, while reaping the positive benefits of psychological ownership, also consider possible avenues to mitigate its negative consequences