HI observations of luminous infrared galaxy mergers

A total of 19 luminous infrared galaxy mergers, with L_IR~2 10^11 L_sun for H_0=75 km/s/Mpc, have been observed in the HI line at Nancay and four of them were observed at Arecibo as well. Of these 19, ten had not been observed before. Six were clearly detected, one of which for the first time. The objective was to statistically sample the \HI gas mass in luminous infrared mergers along a starburst merger sequence where the molecular CO gas content is already known.Comment: 11 pages, accepted for Astron. Astrophys., 22/12/200

Modeling the spectral energy distribution of ULIRGs I: the radio spectra

As a constraint for new starburst/AGN models of IRAS bright galaxies we determine the radio spectra of 31 luminous and ultraluminous IRAS galaxies (LIRGs/ULIRGs). We construct the radio spectra using both new and archival data. From our sample of radio spectra we find that very few have a straight power-law slope. Although some sources show a flattening of the radio spectral slope at high frequencies the average spectrum shows a steepening of the radio spectrum from 1.4 to 22.5 GHz. This is unexpected because in sources with high rates of star formation we expect flat spectrum, free-free emission to make a significant contribution to the radio flux at higher radio frequencies. Despite this trend the radio spectral indices between 8.4 and 22.5 GHz are flatter for sources with higher values of the FIR-radio flux density ratio q, when this is calculated at 8.4 GHz. Therefore, sources that are deficient in radio emission relative to FIR emission (presumably younger sources) have a larger thermal component to their radio emission. However, we find no correlation between the radio spectral index between 1.4 and 4.8 GHz and q at 8.4 GHz. Because the low frequency spectral index is affected by free-free absorption, and this is a function of source size for a given mass of ionized gas, this is evidence that the ionized gas in ULIRGs shows a range of densities. The youngest LIRGs and ULIRGs are characterized by a larger contribution to their high-frequency radio spectra from free-free emission. However, the youngest sources are not those that have the greatest free-free absorption at low radio frequencies. The sources in which the effects of free-free absorption are strongest are instead the most compact sources. Although these have the warmest FIR colours, they are not necessarily the youngest sources.Comment: 16 pages. Submitted to A&A Re-submitted, with aesthetic improvements to the text and figure

Modelling galaxy spectra in presence of interstellar dust. II. From the UV to the far infrared

In this paper, we present spectrophotometric models for galaxies of different morphological type whose spectral energy distributions (SEDs) take into account the effect of dust in absorbing UV-optical light and re-emitting it in the infrared (IR). The models contain three main components: (i) the diffuse interstellar medium (ISM) composed of gas and dust, (ii) the large complexes of molecular clouds (MCs) in which new stars are formed and (iii) the stars of any age and chemical composition. The galaxy models stand on a robust model of chemical evolution taylored in such a way to match the gross properties of galaxies of different morphological type. A simple geometrical model is adopted for each type of galaxy. The total gas and star mass provided by the chemical model are distributed over the whole volume by means of suitable density profiles, one for each component and depending on the galaxy type (spheroidal, disk and disk plus bulge). The galaxy is then split in suitable volume elements to each of which the appropriate amounts of stars, MCs and ISM are assigned. We derive the SEDs of galaxies of different morphological type. First the the basic relations driving the interaction between the physical components of the galaxy are presented. Second, the main parameters are examined and their effects on the SED of three prototype galaxies (a disk, an elliptical and a starburster) are highlighted. The final part of the paper is devoted to assess the ability of our galaxy models in reproducing the SEDs of a few real galaxies of the Local Universe.Comment: 28 pages, 23 figures and 1 table. Accepted by MNRA

Galaxy Properties from the Ultra-violet to the Far-Infrared: Lambda-CDM models confront observations

We combine a semi-analytic model of galaxy formation with simple analytic recipes describing the absorption and re-emission of starlight by dust in the interstellar medium of galaxies. We use the resulting models to predict galaxy counts and luminosity functions from the far-ultraviolet to the sub-mm, from redshift five to the present, and compare with an extensive compilation of observations. We find that in order to reproduce the rest-UV and optical luminosity functions at high redshift, we must assume an evolving normalization in the dust-to-metal ratio, implying that galaxies of a given bolometric luminosity (or metal column density) must be less extinguished than their local counterparts. In our best-fit model, we find remarkably good agreement with observations from rest-frame 1500 Angstroms to 250 microns. At longer wavelengths, most dramatically in the sub-mm, our models underpredict the number of bright galaxies by a large factor. The models reproduce the observed total IR luminosity function fairly well. We show the results of varying several ingredients of the models, including various aspects of the dust attenuation recipe, the dust emission templates, and the cosmology. We use our models to predict the integrated Extragalactic Background Light (EBL), and compare with an observationally-motivated EBL model and with other available observational constraints.Comment: 27 pages, 17 figures, 1 table, accepted to MNRAS, this version matches accepted manuscrip

MicroRNA: an Emerging Therapeutic Target and Intervention Tool

MicroRNAs (miRNAs) are a class of short non-coding RNAs with posttranscriptional regulatory functions. To date, more than 600 human miRNAs have been experimentally identified, and estimated to regulate more than one third of cellular messenger RNAs. Accumulating evidence has linked the dysregulated expression patterns of miRNAs to a variety of diseases, such as cancer, neurodegenerative diseases, cardiovascular diseases and viral infections. MiRNAs provide its particular layer of network for gene regulation, thus possessing the great potential both as a novel class of therapeutic targets and as a powerful intervention tool. In this regard, synthetic RNAs that contain the binding sites of miRNA have been shown to work as a “decoy” or “miRNA sponge” to inhibit the function of specific miRNAs. On the other hand, miRNA expression vectors have been used to restore or overexpress specific miRNAs to achieve a long-term effect. Further, double-stranded miRNA mimetics for transient replacement have been experimentally validated. Endogenous precursor miRNAs have also been used as scaffolds for the induction of RNA interference. This article reviews the recent progress on this emerging technology as a powerful tool for gene regulation studies and particularly as a rationale strategy for design of therapeutics

Current management of the gastrointestinal complications of systemic sclerosis.

Systemic sclerosis is a multisystem autoimmune disorder that involves the gastrointestinal tract in more than 90% of patients. This involvement can extend from the mouth to the anus, with the oesophagus and anorectum most frequently affected. Gut complications result in a plethora of presentations that impair oral intake and faecal continence and, consequently, have an adverse effect on patient quality of life, resulting in referral to gastroenterologists. The cornerstones of gastrointestinal symptom management are to optimize symptom relief and monitor for complications, in particular anaemia and malabsorption. Early intervention in patients who develop these complications is critical to minimize disease progression and improve prognosis. In the future, enhanced therapeutic strategies should be developed, based on an ever-improving understanding of the intestinal pathophysiology of systemic sclerosis. This Review describes the most commonly occurring clinical scenarios of gastrointestinal involvement in patients with systemic sclerosis as they present to the gastroenterologist, with recommendations for the suggested assessment protocol and therapy in each situation

Intestinal Leiomyositis: A Cause of Chronic Intestinal Pseudo‐Obstruction in 6 Dogs

BACKGROUND: Intestinal leiomyositis is a suspected autoimmune disorder affecting the muscularis propria layer of the gastrointestinal tract and is a cause of chronic intestinal pseudo‐obstruction in humans and animals. OBJECTIVE: To characterize the clinical presentation, histopathologic features, and outcome of dogs with intestinal leiomyositis in an effort to optimize treatment and prognosis. ANIMALS: Six client‐owned dogs. METHODS: Retrospective case series. Medical records were reviewed to describe signalment, clinicopathologic and imaging findings, histopathologic diagnoses, treatment, and outcome. All biopsy specimens were reviewed by a board‐certified pathologist. RESULTS: Median age of dogs was 5.4 years (range, 15 months–9 years). Consistent clinical signs included vomiting (6/6), regurgitation (2/6), and small bowel diarrhea (3/6). Median duration of clinical signs before presentation was 13 days (range, 5–150 days). Diagnostic imaging showed marked gastric distension with dilated small intestines in 4/6 dogs. Full‐thickness intestinal biopsies were obtained in all dogs by laparotomy. Histopathology of the stomach and intestines disclosed mononuclear inflammation, myofiber degeneration and necrosis, and fibrosis centered within the region of myofiber loss in the intestinal muscularis propria. All dogs received various combinations of immunomodulatory and prokinetic treatment, antimicrobial agents, antiemetics, and IV fluids, but none of the dogs showed a clinically relevant improvement with treatment. Median survival was 19 days after diagnosis (range, 3–270 days). CONCLUSIONS AND CLINICAL IMPORTANCE: Intestinal leiomyositis is a cause of intestinal pseudo‐obstruction and must be diagnosed by full‐thickness intestinal biopsy. This disease should be considered in dogs with acute and chronic vomiting, regurgitation, and small bowel diarrhea