3,723 research outputs found
Reprocessing the Hipparcos data for evolved stars III Revised Hipparcos period-luminosity relationship for galactic long-period variable stars
We analyze the K band luminosities of a sample of galactic long-period
variables using parallaxes measured by the Hipparcos mission. The parallaxes
are in most cases re-computed from the Hipparcos Intermediate Astrometric Data
using improved astrometric fits and chromaticity corrections. The K band
magnitudes are taken from the literature and from measurements by COBE, and are
corrected for interstellar and circumstellar extinction. The sample contains
stars of several spectral types: M, S and C, and of several variability
classes: Mira, semiregular SRa, and SRb. We find that the distribution of stars
in the period-luminosity plane is independent of circumstellar chemistry, but
that the different variability types have different P-L distributions. Both the
Mira variables and the SRb variables have reasonably well-defined
period-luminosity relationships, but with very different slopes. The SRa
variables are distributed between the two classes, suggesting that they are a
mixture of Miras and SRb, rather than a separate class of stars. New
period-luminosity relationships are derived based on our revised Hipparcos
parallaxes. The Miras show a similar period-luminosity relationship to that
found for Large Magellanic Cloud Miras by Feast et al. (1989). The maximum
absolute K magnitude of the sample is about -8.2 for both Miras and
semi-regular stars, only a little fainter than the expected AGB limit. We show
that the stars with the longest periods (P>400d) have high mass loss rates and
are almost all Mira variables.Comment: Comments welcome. Submitted to A&A 11 pages, 7 figs, 3 table
Mechanical and Damping Properties of Resin Transfer Moulded Jute-Carbon Hybrid Composites
Hybrid composites with carbon and natural fibres offer high modulus and strength combined with low cost and the ability to damp vibration. This study investigates carbon (CFRP), jute (NFRP) and hybrid (HFRP) fibre reinforced polymers manufactured using the resin transfer moulding process.
Tensile strength reduced with increasing injection pressure for NFRP (72.7 MPa at 4 bar, 45.5 MPa at 8 bar) and HFRP (98.4 MPa at 4 bar, 92.4 MPa at 8 bar). The tensile modulus for HFRP (15.1 GPa) was almost double that for NFRP (8.2 GPa) and one third of CFRP (44.2 GPa).
Loss factor reduced at small strains (10−4) with increasing pressure for NFRP (0.0123 at 4 bar, 0.0112 at 8 bar) and HFRP (0.0048 at 4 bar, 0.0038 at 8 bar) but all were greater than CFRP (0.0024).
Increased injection pressure improved the surface properties and prevented read through of the weave pattern, NFRP (Ra = 2.15 μm at 4 bar, 1.51 μm at 8 bar) and HFRP (Ra = 1.80 μm at 4 bar, 1.42 μm at 8 bar). Hybridisation of low cost, sustainable jute with carbon fibre offers a more sustainable and economic alternative to CFRPs with excellent damping properties
Optimization and Validation of Methods for Mapping of the Radiofrequency Transmit Field at 3T
MRI techniques such as quantitative imaging and parallel transmit require precise knowledge of the radio-frequency transmit field (). Three published methods were optimized for robust mapping at 3T in the human brain: three-dimensional (3D) actual flip angle imaging (AFI), 3D echo-planar imaging (EPI), and two-dimensional (2D) stimulated echo acquisition mode (STEAM). We performed a comprehensive comparison of the methods, focusing on artifacts, reproducibility, and accuracy compared to a reference 2D double angle method. For the 3D AFI method, the addition of flow-compensated gradients for diffusion damping reduced the level of physiological artifacts and improved spoiling of transverse coherences. Correction of susceptibility-induced artifacts alleviated image distortions and improved the accuracy of the 3D EPI imaging method. For the 2D STEAM method, averaging over multiple acquisitions reduced the impact of physiological noise and a new calibration method enhanced the accuracy of the maps. After optimization, all methods yielded low noise maps (below 2 percentage units), of the nominal flip angle value (p.u.) with a systematic bias less than 5 p.u. units. Full brain coverage was obtained in less than 5 min. The 3D AFI method required minimal postprocessing and showed little sensitivity to off-resonance and physiological effects. The 3D EPI method showed the highest level of reproducibility. The 2D STEAM method was the most time-efficient technique. Magn Reson Med, 2010. © 2010 Wiley-Liss, Inc
Charge Delocalization in Self-Assembled Mixed-Valence Aromatic Cation Radicals
The spontaneous assembly of aromatic cation radicals (D+•) with their neutral counterpart (D) affords dimer cation radicals (D2+•). The intermolecular dimeric cation radicals are readily characterized by the appearance of an intervalence charge-resonance transition in the NIR region of their electronic spectra and by ESR spectroscopy. The X-ray crystal structure analysis and DFT calculations of a representative dimer cation radical (i.e., the octamethylbiphenylene dimer cation radical) have established that a hole (or single positive charge) is completely delocalized over both aromatic moieties. The energetics and the geometrical considerations for the formation of dimer cation radicals is deliberated with the aid of a series of cyclophane-like bichromophoric donors with drastically varied interplanar angles between the cofacially arranged aryl moieties. X-ray crystallography of a number of mixed-valence cation radicals derived from monochromophoric benzenoid donors established that they generally assemble in 1D stacks in the solid state. However, the use of polychromophoric intervalence cation radicals, where a single charge is effectively delocalized among all of the chromophores, can lead to higher-order assemblies with potential applications in long-range charge transport. As a proof of concept, we show that a single charge in the cation radical of a triptycene derivative is evenly distributed on all three benzenoid rings and this triptycene cation radical forms a 2D electronically coupled assembly, as established by X-ray crystallography
Reconciling carbon-cycle concepts, terminology, and methods
Author Posting. © The Author(s), 2006. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Ecosystems 9 (2006): 1041-1050, doi:10.1007/s10021-005-0105-7.Recent patterns and projections of climatic change have focused increased scientific and public attention on patterns of carbon (C) cycling and its controls, particularly the factors that determine whether an ecosystem is a net source or sink of atmospheric CO2. Net ecosystem production (NEP), a central concept in C-cycling research, has been used to represent two different concepts by C-cycling scientists. We propose that NEP be restricted to just one of its two original definitions—the imbalance between gross primary production (GPP) and ecosystem respiration (ER), and that a new term—net ecosystem carbon balance (NECB)—be applied to the net rate of C accumulation in (or loss from; negative sign) ecosystems. NECB differs from NEP when C fluxes other than C fixation and respiration occur or when inorganic C enters or leaves in dissolved form. These fluxes include leaching loss or lateral transfer of C from the ecosystem; emission of volatile organic C, methane, and carbon monoxide; and soot and CO2 from fire. C fluxes in addition to NEP are particularly important determinants of NECB over long time scales. However, even over short time scales, they are important in ecosystems such as streams,
estuaries, wetlands, and cities. Recent technological advances have led to a diversity of approaches to measuring C fluxes at different temporal and spatial scales. These approaches frequently capture different components of NEP or NECB and can therefore be compared across scales only by carefully specifying the fluxes included in the measurements. By explicitly identifying the fluxes that comprise NECB and other components of the C cycle, such as net ecosystem exchange (NEE) and net biome production (NBP), we provide a less ambiguous framework for understanding and communicating recent changes in the global C cycle.
Key words: Net ecosystem production, net ecosystem carbon balance, gross primary production, ecosystem respiration, autotrophic respiration, heterotrophic respiration, net ecosystem exchange, net biome production, net primary production
Building a Social Mandate for Climate Action: Lessons from COVID-19
The COVID-19 imposed lockdown has led to a number of temporary environmental side effects (reduced global emissions, cleaner air, less noise), that the climate community has aspired to achieve over a number of decades. However, these benefits have been achieved at a massive cost to welfare and the economy. This commentary draws lessons from the COVID-19 crisis for climate change. It discusses whether there are more sustainable ways of achieving these benefits, as part of a more desirable, low carbon resilient future, in a more planned, inclusive and less disruptive way. In order to achieve this, we argue for a clearer social contract between citizens and the state. We discuss how COVID-19 has demonstrated that behaviours can change abruptly, that these changes come at a cost, that we need a ‘social mandate’ to ensure these changes remain in the long-term, and that science plays an important role in informing this process. We suggest that deliberative engagement mechanisms, such as citizens’ assemblies and juries, could be a powerful way to build a social mandate for climate action post-COVID-19. This would enable behaviour changes to become more accepted, embedded and bearable in the long-term and provide the basis for future climate action
Interannual and seasonal variabilities in air-sea CO2 fluxes along the US eastern continental shelf and their sensitivity to increasing air temperatures and variable winds
Uncertainty in continental shelf air-sea CO2 fluxes motivated us to investigate the impact of interannual and seasonal variabilities in atmospheric forcing on the capacity of three shelf regions along the U.S. eastern continental shelf to act as a sink or source of atmospheric CO2. Our study uses a coupled biogeochemical-circulation model to simulate scenarios of present-day and future-perturbed mesoscale forcing variability. Overall, the U.S. eastern continental shelf acts as a sink for atmospheric CO2. There is a clear gradient in air-sea CO2 flux along the shelf region, with estimates ranging from -0.6MtCyr(-1) in the South Atlantic Bight (SAB) to -1.0MtCyr(-1) in the Mid-Atlantic Bight (MAB) and -2.5MtCyr(-1) in the Gulf of Maine (GOM). These fluxes are associated with considerable interannual variability, with the largest interannual signal exhibited in the Gulf of Maine. Seasonal variability in the fluxes is also evident, with autumn and winter being the strongest CO2 sink periods and summer months exhibiting some outgassing. In our future-perturbed scenario spatial differences tend to cancel each other out when the fluxes are integrated over the MAB and GOM, resulting in only minor differences between future-perturbed and present-day air-sea CO2 fluxes. This is not the case in the SAB where the position of the along-shelf gradient shifts northward and the SAB becomes a source of CO2 to the atmosphere (0.7MtCyr(-1)) primarily in response to surface warming. Our results highlight the importance of temperature in regulating air-sea CO2 flux variability
The evolution of rotating stars
First, we review the main physical effects to be considered in the building
of evolutionary models of rotating stars on the Upper Main-Sequence (MS). The
internal rotation law evolves as a result of contraction and expansion,
meridional circulation, diffusion processes and mass loss. In turn,
differential rotation and mixing exert a feedback on circulation and diffusion,
so that a consistent treatment is necessary.
We review recent results on the evolution of internal rotation and the
surface rotational velocities for stars on the Upper MS, for red giants,
supergiants and W-R stars. A fast rotation is enhancing the mass loss by
stellar winds and reciprocally high mass loss is removing a lot of angular
momentum. The problem of the ``break-up'' or -limit is critically
examined in connection with the origin of Be and LBV stars. The effects of
rotation on the tracks in the HR diagram, the lifetimes, the isochrones, the
blue to red supergiant ratios, the formation of W-R stars, the chemical
abundances in massive stars as well as in red giants and AGB stars, are
reviewed in relation to recent observations for stars in the Galaxy and
Magellanic Clouds. The effects of rotation on the final stages and on the
chemical yields are examined, as well as the constraints placed by the periods
of pulsars. On the whole, this review points out that stellar evolution is not
only a function of mass M and metallicity Z, but of angular velocity
as well.Comment: 78 pages, 7 figures, review for Annual Review of Astronomy and
Astrophysics, vol. 38 (2000
Association of Circulating Tumor DNA Testing Before Tissue Diagnosis With Time to Treatment Among Patients With Suspected Advanced Lung Cancer: The ACCELERATE Nonrandomized Clinical Trial.
IMPORTANCE
Liquid biopsy has emerged as a complement to tumor tissue profiling for advanced non-small cell lung cancer (NSCLC). The optimal way to integrate liquid biopsy into the diagnostic algorithm for patients with newly diagnosed advanced NSCLC remains unclear.
OBJECTIVE
To evaluate the use of circulating tumor DNA (ctDNA) genotyping before tissue diagnosis among patients with suspected advanced NSCLC and its association with time to treatment.
DESIGN, SETTING, AND PARTICIPANTS
This single-group nonrandomized clinical trial was conducted among 150 patients at the Princess Margaret Cancer Centre-University Health Network (Toronto, Ontario, Canada) between July 1, 2021, and November 30, 2022. Patients referred for investigation and diagnosis of lung cancer were eligible if they had radiologic evidence of advanced lung cancer prior to a tissue diagnosis.
INTERVENTIONS
Patients underwent plasma ctDNA testing with a next-generation sequencing (NGS) assay before lung cancer diagnosis. Diagnostic biopsy and tissue NGS were performed per standard of care.
MAIN OUTCOME AND MEASURES
The primary end point was time from referral to treatment initiation among patients with advanced nonsquamous NSCLC using ctDNA testing before diagnosis (ACCELERATE [Accelerating Lung Cancer Diagnosis Through Liquid Biopsy] cohort). This cohort was compared with a reference cohort using standard tissue genotyping after tissue diagnosis.
RESULTS
Of the 150 patients (median age at diagnosis, 68 years [range, 33-91 years]; 80 men [53%]) enrolled, 90 (60%) had advanced nonsquamous NSCLC. The median time to treatment was 39 days (IQR, 27-52 days) for the ACCELERATE cohort vs 62 days (IQR, 44-82 days) for the reference cohort (P < .001). Among the ACCELERATE cohort, the median turnaround time from sample collection to genotyping results was 7 days (IQR, 6-9 days) for plasma and 23 days (IQR, 18-28 days) for tissue NGS (P < .001). Of the 90 patients with advanced nonsquamous NSCLC, 21 (23%) started targeted therapy before tissue NGS results were available, and 11 (12%) had actionable alterations identified only through plasma testing.
CONCLUSIONS AND RELEVANCE
This nonrandomized clinical trial found that the use of plasma ctDNA genotyping before tissue diagnosis among patients with suspected advanced NSCLC was associated with accelerated time to treatment compared with a reference cohort undergoing standard tissue testing.
TRIAL REGISTRATION
ClinicalTrials.gov Identifier: NCT04863924
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