What classicality? Decoherence and Bohr's classical concepts

Niels Bohr famously insisted on the indispensability of what he termed "classical concepts." In the context of the decoherence program, on the other hand, it has become fashionable to talk about the "dynamical emergence of classicality" from the quantum formalism alone. Does this mean that decoherence challenges Bohr's dictum -- for example, that classical concepts do not need to be assumed but can be derived? In this paper, we'll try to shed some light down the murky waters where formalism and philosophy mingle. To begin, we'll clarify the notion of classicality in the decoherence description. We'll then discuss Bohr's and Heisenberg's takes on the quantum-classical problem and reflect on the different meanings of the terms "classicality" and "classical concepts" in the writings of Bohr and his followers. This analysis will allow us to put forward some tentative suggestions for how we may better understand the relation between decoherence-induced classicality and Bohr's classical concepts.Comment: 6 page

Beyond the stigma of methadone maintenance treatment : neurocognitive recovery in individuals with opiate use disorders

Background: Studies of cognitive functioning in drug addiction have shown consistent impairments among substance dependent populations. Several attempts to highlight the neurocognitive recovery of former opioid dependent individuals who are stabilised on methadone, have resulted in contradictory conclusions. The aim of this study is to compare the cognitive function of recovering opioid dependent individuals on methadone maintenance treatment to those who are not on methadone treatment, relative to healthy controls. -- Methods: The Montreal Cognitive Assessment Tool was administered to three groups of participants: 22 former opioid dependents receiving methadone maintenance treatment, 21 former opioid dependents withdrawn from all opiates and 22 healthy controls without a history of illicit substance dependence. The specific cognitive domains tested include executive function, visuospatial skills, naming, attention, language, abstraction, delayed recall and orientation. -- Results: Visuospatial skills and executive function were significantly improved with methadone. The language domain appears to be significantly impaired in both opioid dependent groups with a strong negative correlation to the duration of dependency. Participants who had stopped methadone were significantly impaired in all other aspects of cognition tested apart from naming and orientation when compared to healthy controls. Participants on methadone did not significantly differ in the other areas of cognition when compared to controls. -- Conclusions: Methadone treatment appears to be associated with an improvement in cognitive function in opioid dependent individuals. Thus, methadone may facilitate public health by ensuring compliance of opioid dependent individuals to their treatment plan with fewer relapse rates and mitigation of risky behaviours.peer-reviewe

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.

Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain-gut interactions underlying IBS

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Funder: Kennedy Trust Rheumatology Research Prize StudentshipFunder: DFG Cluster of Excellence “Precision Medicine in Chronic In-flammation” (PMI; ID: EXC2167)Funder: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: “Ideas” Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013)); doi: https://doi.org/10.13039/100011199; Grant(s): 715772Funder: NWO-VIDI grant 016.178.056, the Netherlands Heart Foundation CVON grant 2018-27, and NWO Gravitation grant ExposomeNLFunder: Li Ka Shing Foundation (Li Ka Shing Foundation Limited); doi: https://doi.org/10.13039/100007421Abstract: Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain–gut interactions underlying IBS

Heisenberg and quantum mechanics : the evolution of a philosophy of nature

The ideas in Heisenberg's paper on quantum mechanics in 1925 mark the beginning not only of a new phase in modern physics, but also of Heisenberg's own philosophical journey. This thesis examines that journey between 1925 and the late 1950s by situating Heisenberg's philosophy of quantum mechanics in the context of his encounters with his contemporaries as well as the context of various strands of thought in the German-speaking world at the time. Heisenberg's early philosophical critique of the 'classical' viewpoint between 1925 and 1927 bears the decisive influence of Einstein's theory of relativity, more specifically, the positivism he saw as underpinning Einstein's emancipation from Newtonian physics. The positivist influence on Heisenberg's early attitude to quantum mechanics is evident in three ways: (a) his invocation of an observability principle in 1925 to justify the renunciation of the concept of the electron orbit, (b) an instrumentalist conception of understanding, which characterised Heisenberg's response to Schrodinger's demand for classical visualisation in space and time in 1926-7, and (c) the introduction of an operational definition of concepts such as position and velocity in 1927, in an attempt to replace the concepts of classical physics. But after discussions with Bohr and Einstein in 1926-7, Heisenberg soon recognised what we might term his `empiricist' viewpoint was problematic. In 1927 Heisenberg's thought undergoes a shift away from the `empiricist' viewpoint that had underpinned his early philosophy of quantum mechanics. The nature and scope of this transformation, which forms the central theme in this thesis, has, up until now, been poorly understood and often completely neglected. Through his discussions with Bohr, Heisenberg came to the realisation that despite their limitations, classical concepts were conditions for the possibility of the description of all experience. This marked the abandonment of his earlier attempt to replace classical concepts with quantum concepts. The recognition of the primacy of classical language forms the point of departure for much of Heisenberg's later thought, which brought him into contact with the attempts in the German-speaking world in the 1920s to reconstruct Kantian epistemology. By the mid-1930s, Heisenberg advocated a 'pragmatic transformation' of Kantian philosophy, in which classical concepts were held to be a priori in the sense that they remained the conditions for the possibility of experience, but were no longer held to be necessary or universal in a strict Kantian sense. After 1940 Heisenberg saw the paradoxes of quantum mechanics under the aegis of what can be termed a 'transcendental conception of language', according to which language is not a mere tool, but actively shapes, gives form, and objectifies, our 'reality'. The limits of a classical 'description' in quantum mechanics therefore came to signify for Heisenberg, the limits of 'objective reality'. While Bohr exerted perhaps the most important philosophical influence on Heisenberg, their intellectual relationship was characterised by disagreement and misunderstanding. This is most strikingly displayed in their respective views on wave-particle duality and complementarily. While after 1927 Heisenberg accepted Bohr's basic insight that our knowledge of the quantum world is mediated through classical language, he did not share Rohr's interpretation of complementarity. While Heisenberg certainly used terms such as 'complementarity' and wave-particle duality' in his writings, a close reading reveals that these terms had very different meanings for the two physicists. This is particularly evident in the contrast between Heisenberg's notion of wave-particle equivalence and Bohr's idea of complementarity. In bringing to light these divergences between Bohr and Heisenberg, this thesis lends further weight to the view - already advocated by scholars such as John Hendry and Mara Beller - that the so-called Copenhagen interpretation of quantum mechanics should not be thought of as a unified philosophical position, but actually comprises a number of different strands

Heisenberg and the wave-particle duality

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