The Superparticle and the Lorentz Group

We present a unified group-theoretical framework for superparticle theories. This explains the origin of the ``twistor-like'' variables that have been used in trading the superparticle's $\kappa$-symmetry for worldline supersymmetry. We show that these twistor-like variables naturally parametrise the coset space ${\cal G}/{\cal H}$, where $\cal G$ is the Lorentz group $SO^\uparrow(1,d-1)$ and $\cal H$ is its maximal subgroup. This space is a compact manifold, the sphere $S^{d-2}$. Our group-theoretical construction gives the proper covariantisation of a fixed light-cone frame and clarifies the relation between target-space and worldline supersymmetries.Comment: 33 page

A twistor-like D=10 superparticle action with manifest N=8 world-line supersymmetry

We propose a new formulation of the $D=10$ Brink-Schwarz superparticle which is manifestly invariant under both the target-space super-Poincar\'e group and the world-line local $N=8$ superconformal group. This twistor-like construction naturally involves the sphere $S^8$ as a coset space of the $D=10$ Lorentz group. The action contains only a finite set of auxiliary fields, but they appear in unusual trilinear combinations. The origin of the on-shell $D=10$ fermionic $\kappa$ symmetry of the standard Brink-Schwarz formulation is explained. The coupling to a $D=10$ super-Maxwell background requires a new mechanism, in which the electric charge appears only on shell as an integration constant.Comment: 22pages, standard LATEX fil

Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β–induced Serpine1

In tumors, extravascular fibrin forms provisional scaffolds for endothelial cell (EC) growth and motility during angiogenesis. We report that fibrin-mediated angiogenesis was inhibited and tumor growth delayed following postnatal deletion of Tgfbr2 in the endothelium of Cdh5-CreERT2 Tgfbr2fl/fl mice (Tgfbr2iECKOmice). ECs from Tgfbr2iECKO mice failed to upregulate the fibrinolysis inhibitor plasminogen activator inhibitor 1 (Serpine1, also known as PAI-1), due in part to uncoupled TGF-β–mediated suppression of miR-30c. Bypassing TGF-β signaling with vascular tropic nanoparticles that deliver miR-30c antagomiRs promoted PAI-1–dependent tumor growth and increased fibrin abundance, whereas miR-30c mimics inhibited tumor growth and promoted vascular-directed fibrinolysis in vivo. Using single-cell RNA-Seq and a NanoString miRNA array, we also found that subtypes of ECs in tumors showed spectrums of Serpine1 and miR-30c expression levels, suggesting functional diversity in ECs at the level of individual cells; indeed, fresh EC isolates from lung and mammary tumor models had differential abilities to degrade fibrin and launch new vessel sprouts, a finding that was linked to their inverse expression patterns of miR-30c and Serpine1 (i.e., miR-30chi Serpine1lo ECs were poorly angiogenic and miR-30clo Serpine1hi ECs were highly angiogenic). Thus, by balancing Serpine1 expression in ECs downstream of TGF-β, miR-30c functions as a tumor suppressor in the tumor microenvironment through its ability to promote fibrin degradation and inhibit blood vessel formation

Structure and composition of the incisor enamel of extant and fossil mammals with tooth pigmentation

The inclusion of iron compounds in teeth, which impart a red to orange colour to them, is a phenomenon shown by several groups of vertebrates in different periods of their evolution. Incisors from fossil and extant shrews and from extant rodents were sectioned and studied with the techniques of scanning electron microscopy (SEM), transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM) to compare their structure and the distribution of Fe. The enamel in white- and red-toothed soricids has three layers; two of them are divided into two zones in the red-toothed species. However, the most external layer varies among taxa; it is well defined in Sorex but difficult to identify in the Early Pleistocene genera Beremendia or Dolinasorex. In the arvicoline rodent Terricola, only two layers can be defined, the outer of which is divided into two zones depending on the presence or absence of Fe. The Fe proportions in the larger soricids reach up to 45%, but in rodents only up to 10% (weight % with respect to Fe + Ca + P). The STEM study shows that in a fossil soricid the Fe phases form clusters of nanometric particles of very poor crystalline oxides or hydroxides surrounding the apatite crystals that form the enamel

Supersymmetry and Branes in M-theory Plane-waves

We study brane embeddings in M-theory plane-waves and their supersymmetry. The relation with branes in AdS backgrounds via the Penrose limit is also explored. Longitudinal planar branes are originated from AdS branes while giant gravitons of AdS spaces become spherical branes which are realized as fuzzy spheres in the massive matrix theory.Comment: 17 pages, JHEP style, references added, typos correcte

T-Duality and Penrose limits of spatially homogeneous and inhomogeneous cosmologies

Penrose limits of inhomogeneous cosmologies admitting two abelian Killing vectors and their abelian T-duals are found in general. The wave profiles of the resulting plane waves are given for particular solutions. Abelian and non-abelian T-duality are used as solution generating techniques. Furthermore, it is found that unlike in the case of abelian T-duality, non-abelian T-duality and taking the Penrose limit are not commutative procedures.Comment: 16 pages, 4 figures. Discussion on non-abelian T-duality expande

Ultra-High Energy Neutrino Fluxes and Their Constraints

Applying our recently developed propagation code we review extragalactic neutrino fluxes above 10^{14} eV in various scenarios and how they are constrained by current data. We specifically identify scenarios in which the cosmogenic neutrino flux, produced by pion production of ultra high energy cosmic rays outside their sources, is considerably higher than the "Waxman-Bahcall bound". This is easy to achieve for sources with hard injection spectra and luminosities that were higher in the past. Such fluxes would significantly increase the chances to detect ultra-high energy neutrinos with experiments currently under construction or in the proposal stage.Comment: 11 pages, 15 figures, version published in Phys.Rev.

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio

Observation of a new chi_b state in radiative transitions to Upsilon(1S) and Upsilon(2S) at ATLAS

The chi_b(nP) quarkonium states are produced in proton-proton collisions at the Large Hadron Collider (LHC) at sqrt(s) = 7 TeV and recorded by the ATLAS detector. Using a data sample corresponding to an integrated luminosity of 4.4 fb^-1, these states are reconstructed through their radiative decays to Upsilon(1S,2S) with Upsilon->mu+mu-. In addition to the mass peaks corresponding to the decay modes chi_b(1P,2P)->Upsilon(1S)gamma, a new structure centered at a mass of 10.530+/-0.005 (stat.)+/-0.009 (syst.) GeV is also observed, in both the Upsilon(1S)gamma and Upsilon(2S)gamma decay modes. This is interpreted as the chi_b(3P) system.Comment: 5 pages plus author list (18 pages total), 2 figures, 1 table, corrected author list, matches final version in Physical Review Letter

Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS

We present the results of a search for new, heavy particles that decay at a significant distance from their production point into a final state containing charged hadrons in association with a high-momentum muon. The search is conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS detector operating at the Large Hadron Collider. Production of such particles is expected in various scenarios of physics beyond the standard model. We observe no signal and place limits on the production cross-section of supersymmetric particles in an R-parity-violating scenario as a function of the neutralino lifetime. Limits are presented for different squark and neutralino masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final version to appear in Physics Letters