Current Star Formation in the Perseus Molecular Cloud: Constraints from Unbiased Submillimeter and Mid-Infrared Surveys

We present a census of the population of deeply embedded young stellar objects (YSOs) in the Perseus molecular cloud complex based on a combination of Spitzer Space Telescope mid-IR data from the c2d legacy team and JCMT/SCUBA submillimeter maps from the COMPLETE team. The mid-IR sources detected at 24 micron and having [3.6]-[4.5] > 1 are located close to the center of the SCUBA cores, typically within 15" of their peaks. The narrowness of the spatial distribution of mid-IR sources around the peaks of the SCUBA cores suggests that no significant dispersal of the newly formed YSOs has occurred. This argues against the suggestion that motions of protostars regulate the time scales over which significant (Bondi-Hoyle) accretion can occur. The most deeply embedded YSOs are found in regions with high extinction, AV > 5, similar to the extinction threshold observed for the SCUBA cores. All the SCUBA cores with high concentrations have embedded YSOs, but not all cores with low concentrations are starless. An unbiased sample of 49 deeply embedded YSOs is constructed. Embedded YSOs are found in 40 of the 72 SCUBA cores with only three cores harboring multiple embedded YSOs within 15". The equal number of SCUBA cores with and without embedded YSOs suggests that the time scale for the evolution through the dense prestellar stages, where the cores are recognized in the submillimeter maps and have central densities of 5e4-1e5 cm^{-3}, is similar to the time scale for the embedded protostellar stages. The current star formation efficiency of cores is estimated to be approximately 10-15%. In contrast, the star formation efficiency averaged over the cloud life time and compared to the total cloud mass is only a few percent, reflecting also the efficiency in assembling cloud material into the dense cores forming stars.Comment: Accepted for publication in ApJ (36 pages, 13 figures

The Volume Conjecture, Perturbative Knot Invariants, and Recursion Relations for Topological Strings

We study the relation between perturbative knot invariants and the free energies defined by topological string theory on the character variety of the knot. Such a correspondence between SL(2;C) Chern-Simons gauge theory and the topological open string theory was proposed earlier on the basis of the volume conjecture and AJ conjecture. In this paper we discuss this correspondence beyond the subleading order in the perturbative expansion on both sides. In the computation of the perturbative invariants for the hyperbolic 3-manifold, we adopt the state integral model for the hyperbolic knots, and the factorized AJ conjecture for the torus knots. On the other hand, we iteratively compute the free energies on the character variety using the Eynard-Orantin topological recursion relation. We check the correspondence for the figure eight knot complement and the once punctured torus bundle over S^1 with the holonomy L^2R up to the fourth order. For the torus knots, we find trivial the recursion relations on both sides.Comment: 48 pages, 7 figure

Developing Brain Vital Signs: Initial Framework for Monitoring Brain Function Changes over Time

Clinical assessment of brain function relies heavily on indirect behavior-based tests. Unfortunately, behavior-based assessments are subjective and therefore susceptible to several confounding factors. Event-related brain potentials (ERPs), derived from electroencephalography (EEG), are often used to provide objective, physiological measures of brain function. Historically, ERPs have been characterized extensively within research settings, with limited but growing clinical applications. Over the past 20 years, we have developed clinical ERP applications for the evaluation of functional status following serious injury and/or disease. This work has identified an important gap: the need for a clinically accessible framework to evaluate ERP measures. Crucially, this enables baseline measures before brain dysfunction occurs, and might enable the routine collection of brain function metrics in the future much like blood pressure measures today. Here, we propose such a framework for extracting specific ERPs as potential “brain vital signs.” This framework enabled the translation/transformation of complex ERP data into accessible metrics of brain function for wider clinical utilization. To formalize the framework, three essential ERPs were selected as initial indicators: (1) the auditory N100 (Auditory sensation); (2) the auditory oddball P300 (Basic attention); and (3) the auditory speech processing N400 (Cognitive processing). First step validation was conducted on healthy younger and older adults (age range: 22–82 years). Results confirmed specific ERPs at the individual level (86.81–98.96%), verified predictable age-related differences (P300 latency delays in older adults, p < 0.05), and demonstrated successful linear transformation into the proposed brain vital sign (BVS) framework (basic attention latency sub-component of BVS framework reflects delays in older adults, p < 0.05). The findings represent an initial critical step in developing, extracting, and characterizing ERPs as vital signs, critical for subsequent evaluation of dysfunction in conditions like concussion and/or dementia

Millimeter-scale genetic gradients and community-level molecular convergence in a hypersaline microbial mat

To investigate the extent of genetic stratification in structured microbial communities, we compared the metagenomes of 10 successive layers of a phylogenetically complex hypersaline mat from Guerrero Negro, Mexico. We found pronounced millimeter-scale genetic gradients that were consistent with the physicochemical profile of the mat. Despite these gradients, all layers displayed near-identical and acid-shifted isoelectric point profiles due to a molecular convergence of amino-acid usage, indicating that hypersalinity enforces an overriding selective pressure on the mat community

Treatment adherence with the easypod™ growth hormone electronic auto-injector and patient acceptance: survey results from 824 children and their parents

<p>Abstract</p> <p>Background</p> <p>Accurately monitoring adherence to treatment with recombinant human growth hormone (r-hGH) enables appropriate intervention in cases of poor adherence. The electronic r-hGH auto-injector, easypod™, automatically records the patient's adherence to treatment. This study evaluated adherence to treatment of children who started using the auto-injector and assessed opinions about the device.</p> <p>Methods</p> <p>A multicentre, multinational, observational 3-month survey in which children received r-hGH as part of their normal care. Physicians reviewed the recorded dose history and children (with or without parental assistance) completed a questionnaire-based survey. Children missing ≤2 injections per month (92% of injections given) were considered adherent to treatment. Adherence was compared between GH treatment-naïve and treatment-experienced children.</p> <p>Results</p> <p>Of 834 recruited participants, 824 were evaluated. The median (range) age was 11 (1-18) years. From the recorded dose history, 87.5% of children were adherent to treatment over the 3-month period. Recorded adherence was higher in treatment-naïve (89.7%, n = 445/496) than in treatment-experienced children (81.7%, n = 152/186) [Fisher's exact test FI(X) = 7.577; <it>p </it>= 0.0062]. According to self-reported data, 90.2% (607/673) of children were adherent over 3 months; 51.5% (421/817) missed ≥1 injection over this period (mainly due to forgetfulness). Concordance between reported and recorded adherence was 84.3%, with a trend towards self-reported adherence being higher than recorded adherence. Most children liked the auto-injector: over 80% gave the top two responses from five options for ease of use (720/779), speed (684/805) and comfort (716/804). Although 38.5% (300/780) of children reported pain on injection, over half of children (210/363) considered the pain to be less or much less than expected. Given the choice, 91.8% (732/797) of children/parents would continue using the device.</p> <p>Conclusions</p> <p>easypod™ provides an accurate method of monitoring adherence to treatment with r-hGH. In children who received treatment with r-hGH using easypod™, short-term adherence is good, and significantly higher in treatment-naïve children compared with experienced children. Children/parents rate the device highly. The high level of acceptability of the device is reflected by a desire to continue using it by over 90% of the children in the survey.</p

The Initial Conditions of Clustered Star Formation I: NH3 Observations of Dense Cores in Ophiuchus

We present combined interferometer and single dish telescope data of NH3 (J,K) = (1,1) and (2,2) emission towards the clustered star forming Ophiuchus B, C and F Cores at high spatial resolution (~1200 AU) using the Australia Telescope Compact Array, the Very Large Array, and the Green Bank Telescope. While the large scale features of the NH3 (1,1) integrated intensity appear similar to 850 micron continuum emission maps of the Cores, on 15" (1800 AU) scales we find significant discrepancies between the dense gas tracers in Oph B, but good correspondence in Oph C and F. Using the Clumpfind structure identifying algorithm, we identify 15 NH3 clumps in Oph B, and 3 each in Oph C and F. Only five of the Oph B NH3 clumps are coincident within 30" (3600 AU) of a submillimeter clump. We find v_LSR varies little across any of the Cores, and additionally varies by only ~1.5 km/s between them. The observed NH3 line widths within the Oph B and F Cores are generally large and often mildly supersonic, while Oph C is characterized by narrow line widths which decrease to nearly thermal values. We find several regions of localized narrow line emission (\Delta v < 0.4 km/s), some of which are associated with NH3 clumps. We derive the kinetic temperatures of the gas, and find they are remarkably constant across Oph B and F, with a warmer mean value (T_K = 15 K) than typically found in isolated regions and consistent with previous results in clustered regions. Oph C, however, has a mean T_K = 12 K, decreasing to a minimum T_K = 9.4 K towards the submillimeter continuum peak, similar to previous studies of isolated starless cores. There is no significant difference in temperature towards protostars embedded in the Cores. [Abridged]Comment: ApJ, accepte

Ecosystem biogeochemistry considered as a distributed metabolic network ordered by maximum entropy production

Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of The Royal Society for personal use, not for redistribution. The definitive version was published in Philosophical Transactions of the Royal Society B 365 (2010): 1417-1427, doi:10.1098/rstb.2009.0272.We examine the application of the maximum entropy production principle for describing ecosystem biogeochemistry. Since ecosystems can be functionally stable despite changes in species composition, we utilize a distributed metabolic network for describing biogeochemistry, which synthesizes generic biological structures that catalyze reaction pathways, but is otherwise organism independent. Allocation of biological structure and regulation of biogeochemical reactions is determined via solution of an optimal control problem in which entropy production is maximized. However, because synthesis of biological structures cannot occur if entropy production is maximized instantaneously, we propose that information stored within the metagenome allows biological systems to maximize entropy production when averaged over time. This differs from abiotic systems that maximize entropy production at a point in space-time, which we refer to as the steepest descent pathway. It is the spatiotemporal averaging that allows biological systems to outperform abiotic processes in entropy production, at least in many situations. A simulation of a methanotrophic system is used to demonstrate the approach. We conclude with a brief discussion on the implications of viewing ecosystems as self organizing molecular machines that function to maximize entropy production at the ecosystem level of organization.The work presented here was funded by the PIE-LTER program (NSF OCE-0423565), as well as from NSF CBET-0756562, NSF EF-0928742 and NASA Exobiology and Evolutionary Biology (NNG05GN61G)

The initial conditions of star formation VIII: an observational study of the Ophiuchus cloud L1688 and implications for the prestellar core mass function

We re-analyse all of the archive observations of the Ophiuchus dark cloud L1688 that were carried out with the submillimetre common-user bolometer array (SCUBA) at the James Clerk Maxwell Telescope (JCMT). For the first time we put together all of the data that were taken of this cloud at different times to make a deeper map at 850 microns than has ever previously been published. Using this new, deeper map we extract the pre-stellar cores from the data. We use updated values for the distance to the cloud complex, and also for the internal temperatures of the pre-stellar cores to generate an updated core mass function (CMF). This updated CMF is consistent with previous results in so far as they went, but our deeper map gives an improved completeness limit of 0.1 Mo (0.16 Jy), which enables us to show that a turnover exists in the low-mass regime of the CMF. The L1688 CMF shows the same form as the stellar IMF and can be mapped onto the stellar IMF, showing that the IMF is determined at the prestellar core stage. We compare L1688 with the Orion star-forming region and find that the turnover in the L1688 CMF occurs at a mass roughly a factor of two lower than the CMF turnover in Orion. This suggests that the position of the CMF turnover may be a function of environment.Comment: 11 Pages. Accepted by MNRA

Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb^-1. The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b-hadrons in jets are reconstructed using information from the tracking detectors, or a muon-based method where the presence of a muon is used to identify semileptonic decays of b-hadrons inside jets. The inclusive b-jet cross-section is measured as a function of transverse momentum in the range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet cross-section is measured as a function of the dijet invariant mass in the range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets and the angular variable chi in two dijet mass regions. The results are compared with next-to-leading-order QCD predictions. Good agreement is observed between the measured cross-sections and the predictions obtained using POWHEG + Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet cross-section. However, it does not reproduce the measured inclusive cross-section well, particularly for central b-jets with large transverse momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final version published in European Physical Journal

Measurement of the polarisation of W bosons produced with large transverse momentum in pp collisions at sqrt(s) = 7 TeV with the ATLAS experiment

This paper describes an analysis of the angular distribution of W->enu and W->munu decays, using data from pp collisions at sqrt(s) = 7 TeV recorded with the ATLAS detector at the LHC in 2010, corresponding to an integrated luminosity of about 35 pb^-1. Using the decay lepton transverse momentum and the missing transverse energy, the W decay angular distribution projected onto the transverse plane is obtained and analysed in terms of helicity fractions f0, fL and fR over two ranges of W transverse momentum (ptw): 35 < ptw < 50 GeV and ptw > 50 GeV. Good agreement is found with theoretical predictions. For ptw > 50 GeV, the values of f0 and fL-fR, averaged over charge and lepton flavour, are measured to be : f0 = 0.127 +/- 0.030 +/- 0.108 and fL-fR = 0.252 +/- 0.017 +/- 0.030, where the first uncertainties are statistical, and the second include all systematic effects.Comment: 19 pages plus author list (34 pages total), 9 figures, 11 tables, revised author list, matches European Journal of Physics C versio