Scaling Properties of the Giant Dipole Resonance Width in Hot Rotating nuclei

We study the systematics of the giant dipole resonance width $\Gamma$ in hot rotating nuclei as a function of temperature $T$, spin $J$ and mass $A$. We compare available experimental results with theoretical calculations that include thermal shape fluctuations in nuclei ranging from A=45 to A=208. Using the appropriate scaled variables, we find a simple phenomenological function $\Gamma(A,T,J)$ which approximates the global behavior of the giant dipole resonance width in the liquid drop model. We reanalyze recent experimental and theoretical results for the resonance width in Sn isotopes and $^{208}$Pb.Comment: LaTeX, 4 pages with 4 figures (to appear in Phys. Rev. Lett.

Calcium Ions Regulate K+ Uptake into Brain Mitochondria: The Evidence for a Novel Potassium Channel

The mitochondrial response to changes of cytosolic calcium concentration has a strong impact on neuronal cell metabolism and viability. We observed that Ca2+ additions to isolated rat brain mitochondria induced in potassium ion containing media a mitochondrial membrane potential depolarization and an accompanying increase of mitochondrial respiration. These Ca2+ effects can be blocked by iberiotoxin and charybdotoxin, well known inhibitors of large conductance potassium channel (BKCa channel). Furthermore, NS1619 – a BKCa channel opener – induced potassium ion–specific effects on brain mitochondria similar to those induced by Ca2+. These findings suggest the presence of a calcium-activated, large conductance potassium channel (sensitive to charybdotoxin and NS1619), which was confirmed by reconstitution of the mitochondrial inner membrane into planar lipid bilayers. The conductance of the reconstituted channel was 265 pS under gradient (50/450 mM KCl) conditions. Its reversal potential was equal to 50 mV, which proved that the examined channel was cation-selective. We also observed immunoreactivity of anti-β4 subunit (of the BKCa channel) antibodies with ~26 kDa proteins of rat brain mitochondria. Immunohistochemical analysis confirmed the predominant occurrence of β4 subunit in neuronal mitochondria. We hypothesize that the mitochondrial BKCa channel represents a calcium sensor, which can contribute to neuronal signal transduction and survival

The damping width of giant dipole resonances of cold and hot nuclei: a macroscopic model

A phenomenological macroscopic model of the Giant Dipole Resonance (GDR) damping width of cold- and hot-nuclei with ground-state spherical and near-spherical shapes is developed. The model is based on a generalized Fermi Liquid model which takes into account the nuclear surface dynamics. The temperature dependence of the GDR damping width is accounted for in terms of surface- and volume-components. Parameter-free expressions for the damping width and the effective deformation are obtained. The model is validated with GDR measurements of the following nuclides, $^{39,40}$K, $^{42}$Ca, $^{45}$Sc, $^{59,63}$Cu, $^{109-120}$Sn,$^{147}$Eu, $^{194}$Hg, and $^{208}$Pb, and is compared with the predictions of other models.Comment: 10 pages, 5 figure

Evidence for the Jacobi shape transition in hot 46Ti

The gamma-rays from the decay of the GDR in 46Ti compound nucleus formed in the 18O+28Si reaction at bombarding energy 105 MeV have been measured in an experiment using a setup consisting of the combined EUROBALL IV, HECTOR and EUCLIDES arrays. A comparison of the extracted GDR lineshape data with the predictions of the thermal shape fluctuation model shows evidence for the Jacobi shape transition in hot 46Ti. In addition to the previously found broad structure in the GDR lineshape region at 18-27 MeV caused by large deformations, the presence of a low energy component (around 10 MeV), due to the Coriolis splitting in prolate well deformed shape, has been identified for the first time.Comment: 8 pages, 4 figures, proceedings of the COMEX1 conference, June 2003, Paris; to be published in Nucl. Phys.

Reaction mechanisms in the 6Li+59Co system

The reactions induced by the weakly bound 6Li projectile interacting with the intermediate mass target 59Co were investigated. Light charged particles singles and $\alpha$-$d$ coincidence measurements were performed at the near barrier energies E_lab = 17.4, 21.5, 25.5 and 29.6 MeV. The main contributions of the different competing mechanisms are discussed. A statistical model analysis, Continuum-Discretized Coupled-Channels calculations and two-body kinematics were used as tools to provide information to disentangle the main components of these mechanisms. A significant contribution of the direct breakup was observed through the difference between the experimental sequential breakup cross section and the CDCC prediction for the non-capture breakup cross section.Comment: 30 pages, 8 figure

High Energy Gamma Rays from p+X, X=Cu, Ag, Au at 34 MeV

In this paper we present results from the measurement of the gamma ray yield in the reaction of 34-MeV protons on Cu, Ag and Au. The protons were produced by the University of Washington superconducting linac. The gamma rays were measured using a large NaI and two large BaF{sub 2} detectors. Angular distributions were obtained for each of the three targets. Data for the Cu and Ag target were taken at six lab angles between 35 and 135 degrees, while data were taken at eight lab angles between 35 and 135 degrees for the Au target. The data were compared to several models. These included Hauser-Feshbach and direct-semidirect (DSD) calculations. We also compared the measurements to proton-nucleus bremsstrahlung calculations. The bremsstrahlung calculations greatly underpredicted the cross section and produced an angular distribution which was too flat. The Hauser-Feshbach calculations reproduced the yield of the softer portion of the spectrum reasonably well for all three targets. The DSD calculations reproduced the yield and angular distributions quite well for energies above about 20 MeV. However, the yields were underpredicted in the 15-18 MeV region, which suggests that multistep mechanisms may be needed for this target

A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel

Opening of BK-type Ca2+ activated K+ channels protects the heart against ischemia-reperfusion (IR) injury. However, the location of BK channels responsible for cardioprotection is debated. Herein we confirmed that openers of the SLO1 BK channel, NS1619 and NS11021, were protective in a mouse perfused heart model of IR injury. As anticipated, deletion of the Slo1 gene blocked this protection. However, in an isolated cardiomyocyte model of IR injury, protection by NS1619 and NS11021 was insensitive to Slo1 deletion. These data suggest that protection in intact hearts occurs by a non-cardiomyocyte autonomous, SLO1-dependent, mechanism. In this regard, an in-situ assay of intrinsic cardiac neuronal function (tachycardic response to nicotine) revealed that NS1619 preserved cardiac neurons following IR injury. Furthermore, blockade of synaptic transmission by hexamethonium suppressed cardioprotection by NS1619 in intact hearts. These results suggest that opening SLO1 protects the heart during IR injury, via a mechanism that involves intrinsic cardiac neurons. Cardiac neuronal ion channels may be useful therapeutic targets for eliciting cardioprotection

Testing ab initio nuclear structure in neutron-rich nuclei: Lifetime measurements of second 2+ state in 16C and 20O

To test the predictive power of ab initio nuclear structure theory, the lifetime of the second 2+ state in neutron-rich 20O,τ(2+2)=150+80−30fs, and an estimate for the lifetime of the second 2+ state in 16C have been obtained for the first time. The results were achieved via a novel Monte Carlo technique that allowed us to measure nuclear state lifetimes in the tens-to-hundreds of femtoseconds range by analyzing the Doppler-shifted γ-transition line shapes of products of low-energy transfer and deep-inelastic processes in the reaction 18O(7.0MeV/u)+181Ta. The requested sensitivity could only be reached owing to the excellent performances of the Advanced γ-Tracking Array AGATA, coupled to the PARIS scintillator array and to the VAMOS++ magnetic spectrometer. The experimental lifetimes agree with predictions of ab initio calculations using two- and three-nucleon interactions, obtained with the valence-space in-medium similarity renormalization group for 20O and with the no-core shell model for 16C. The present measurement shows the power of electromagnetic observables, determined with high-precision γ spectroscopy, to assess the quality of first-principles nuclear structure calculations, complementing common benchmarks based on nuclear energies. The proposed experimental approach will be essential for short lifetime measurements in unexplored regions of the nuclear chart, including r-process nuclei, when intense beams, produced by Isotope Separation On-Line (ISOL) techniques, become available

Phylogenetic Analysis of Mitochondrial Outer Membrane β-Barrel Channels

Transport of molecules across mitochondrial outer membrane is pivotal for a proper function of mitochondria. The transport pathways across the membrane are formed by ion channels that participate in metabolite exchange between mitochondria and cytoplasm (voltage-dependent anion-selective channel, VDAC) as well as in import of proteins encoded by nuclear genes (Tom40 and Sam50/Tob55). VDAC, Tom40, and Sam50/Tob55 are present in all eukaryotic organisms, encoded in the nuclear genome, and have β-barrel topology. We have compiled data sets of these protein sequences and studied their phylogenetic relationships with a special focus on the position of Amoebozoa. Additionally, we identified these protein-coding genes in Acanthamoeba castellanii and Dictyostelium discoideum to complement our data set and verify the phylogenetic position of these model organisms. Our analysis show that mitochondrial β-barrel channels from Archaeplastida (plants) and Opisthokonta (animals and fungi) experienced many duplication events that resulted in multiple paralogous isoforms and form well-defined monophyletic clades that match the current model of eukaryotic evolution. However, in representatives of Amoebozoa, Chromalveolata, and Excavata (former Protista), they do not form clearly distinguishable clades, although they locate basally to the plant and algae branches. In most cases, they do not posses paralogs and their sequences appear to have evolved quickly or degenerated. Consequently, the obtained phylogenies of mitochondrial outer membrane β-channels do not entirely reflect the recent eukaryotic classification system involving the six supergroups: Chromalveolata, Excavata, Archaeplastida, Rhizaria, Amoebozoa, and Opisthokonta