29 research outputs found
Exploring the magnetized cosmic web through low frequency radio emission
- Author
- Ananthakrishnan
- Bagchi
- Balsara
- Beck
- Beck
- Blandford
- Bridle
- Bridle
- C. Pfrommer
- Carilli
- Cavaliere
- Cen
- Clarke
- Danforth
- Davé
- Dolag
- Dolag
- Drury
- Dubois
- Ellison
- Enßlin
- Enßlin
- Enßlin
- Enßlin
- Feretti
- Ferrari
- Fukugita
- Furlanetto
- Gardner
- Geller
- Giacintucci
- Govoni
- Grasso
- Guidetti
- Haardt
- Hellsten
- Hernquist
- J. L. Sievers
- J. R. Bond
- Jubelgas
- Kang
- Kassim
- Katz
- Katz
- Kempner
- Keshet
- Keshet
- Keshet
- Komatsu
- Kronberg
- Kulsrud
- Loeb
- Malkov
- Masson
- Miniati
- Miniati
- Miniati
- Miniati
- Morales
- Murgia
- N. Battaglia
- Pfrommer
- Pfrommer
- Pfrommer
- Pfrommer
- Pizzo
- Price
- Price
- Rees
- Ryu
- Röttgering
- Röttgering
- Röttgering
- Schekochihin
- Schlickeiser
- Schuecker
- Schuecker
- Sijacki
- Simard-Normandin
- Springel
- Springel
- Springel
- Subramanian
- T. A. Enßlin
- Taylor
- Tribble
- Vladimirov
- Vogt
- Vogt
- Widrow
- Wielebinski
- Yoshida
- Zaroubi
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2009
- Field of study
Recent improvements in the capabilities of low frequency radio telescopes
provide a unique opportunity to study thermal and non-thermal properties of the
cosmic web. We argue that the diffuse, polarized emission from giant radio
relics traces structure formation shock waves and illuminates the large-scale
magnetic field. To show this, we model the population of shock-accelerated
relativistic electrons in high-resolution cosmological simulations of galaxy
clusters and calculate the resulting radio synchrotron emission. We find that
individual shock waves correspond to localized peaks in the radio surface
brightness map which enables us to measure Mach numbers for these shocks. We
show that the luminosities and number counts of the relics strongly depend on
the magnetic field properties, the cluster mass and dynamical state. By
suitably combining different cluster data, including Faraday rotation measures,
we are able to constrain some macroscopic parameters of the plasma at the
structure formation shocks, such as models of turbulence. We also predict upper
limits for the properties of the warm-hot intergalactic medium, such as its
temperature and density. We predict that the current generation of radio
telescopes (LOFAR, GMRT, MWA, LWA) have the potential to discover a
substantially larger sample of radio relics, with multiple relics expected for
each violently merging cluster. Future experiments (SKA) should enable us to
further probe the macroscopic parameters of plasma physics in clusters.Comment: 18 pages, 13 figures, accepted to MNRAS Oct 23 2008, minor changes,
full resolution version available at
http://www.astro.utoronto.ca/~battaglia/Publications
Magnetic Field Amplification in Galaxy Clusters and its Simulation
- Author
- A. Bauer
- A. Beresnyak
- A. Beresnyak
- A. Bonafede
- A. Bonafede
- A. Bonafede
- A. Bonafede
- A. Brandenburg
- A. Brandenburg
- A. Dedner
- A. Finoguenov
- A. Kolmogorov
- A. Lazarian
- A. Lazarian
- A. Maier
- A. Marcowith
- A. Neronov
- A. Ruzmaikin
- A. Schekochihin
- A. Schekochihin
- A. Stroe
- A. Stroe
- A. Vikhlinin
- A. Vladimirov
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Schekochihin
- A.A. Vikhlinin
- A.D. Chernin
- A.E. Broderick
- A.E. Evrard
- A.G. Kritsuk
- A.M. Beck
- A.M. Beck
- A.M. Beck
- A.M. Beck
- A.M. Bykov
- A.M. Bykov
- A.M. Bykov
- A.N. Kolmogorov
- A.P. Kazantsev
- A.R. Bell
- B. Dennison
- B. Reville
- B. Reville
- B.E. Robertson
- B.M. Gaensler
- C. Caprini
- C. Federrath
- C. Federrath
- C. Federrath
- C. Federrath
- C. Ferrari
- C. Gheller
- C. Pfrommer
- C. Pfrommer
- C. Pfrommer
- C. Vogt
- C.L. Dobbs
- C.L. Sarazin
- C.L. Sarazin
- C.L. Sarazin
- D. Caprioli
- D. Caprioli
- D. Caprioli
- D. Lee
- D. Nagai
- D. Ryu
- D. Ryu
- D. Ryu
- D. Wittor
- D. Wittor
- D.H. Porter
- D.J. Price
- D.J. Price
- D.N. Hoang
- D.R.G. Schleicher
- D.R.G. Schleicher
- D.S. Balsara
- D.S. Young De
- E. Churazov
- E. Parizot
- E. Roediger
- E. Roediger
- E. Zinger
- E.R. Harrison
- E.T. Lau
- F. Aharonian
- F. Fraschetti
- F. Govoni
- F. Govoni
- F. Guo
- F. Guo
- F. Marinacci
- F. Marinacci
- F. Marinacci
- F. Miniati
- F. Miniati
- F. Miniati
- F. Miniati
- F. Miniati
- F. Mogavero
- F. Rincon
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Vazza
- F. Zandanel
- F.A. Stasyszyn
- F.J. Sánchez-Salcedo
- F.N. Owen
- G. Brunetti
- G. Brunetti
- G. Brunetti
- G. Brunetti
- G. Brunetti
- G. Brunetti
- G.K. Batchelor
- G.M. Voit
- G.R. Burbidge
- H. Alfvén
- H. Böhringer
- H. Chen
- H. Kang
- H. Xu
- H. Xu
- H.J. Völk
- I. Butsky
- I. Zhuravleva
- I.B. Zeldovich
- J. Binney
- J. Cho
- J. Donnert
- J. Donnert
- J. Donnert
- J. Donnert
- J. Giacalone
- J. Meinecke
- J. Roland
- J. Schober
- J. Wiener
- J. Wiener
- J. ZuHone
- J.A. Zuhone
- J.A. ZuHone
- J.A. ZuHone
- J.A. ZuHone
- J.A. ZuHone
- J.D. Barrow
- J.M. Burgers
- J.M.F. Donnert
- J.M.F. Donnert
- J.O. Burns
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Dolag
- K. Nakazawa
- K. Nelson
- K. Rajpurohit
- K. Roettiger
- K. Roettiger
- K. Roettiger
- K. Subramanian
- K. Subramanian
- K. Waagan
- L. Biermann
- L. Campanelli
- L. Iapichino
- L. Iapichino
- L. Iapichino
- L. Spitzer
- L.D. Landau
- L.D. Shaw
- L.J. Dursi
- L.J. Dursi
- L.M. Widrow
- L.O. Drury
- M. Ackermann
- M. Brüggen
- M. Brüggen
- M. Brüggen
- M. Brüggen
- M. Brüggen
- M. Gaspari
- M. Gendron-Marsolais
- M. Langer
- M. Lyutikov
- M. Markevitch
- M. Rieder
- M. Ruszkowski
- M. Ruszkowski
- M. Takizawa
- M.A. Latif
- M.A. Malkov
- M.A. Riquelme
- M.A. Riquelme
- M.A.G. Willson
- M.S. Turner
- M.W. Kunz
- M.W. Kunz
- N. Asai
- N. Asai
- N. Asai
- N. Battaglia
- N. Werner
- N.E.L. Haugen
- N.E.L. Haugen
- N.L. Mitchell
- O. Goldshmidt
- P. Goldreich
- P. Kuchar
- P. Mazzotta
- P. Schuecker
- P. Slane
- P. Trivedi
- P.A. Thomas
- P.A.R. Ade
- P.F. Hopkins
- P.F. Hopkins
- P.M. Ricker
- P.P. Kronberg
- R. Beck
- R. Durrer
- R. Khatri
- R. Pakmor
- R. Pakmor
- R. Santos-Lima
- R. Santos-Lima
- R. Schlickeiser
- R. Taylor
- R. Valdarnini
- R.A. Laing
- R.H. Kraichnan
- R.M. Kulsrud
- R.M. Kulsrud
- R.M. Kulsrud
- R.P. Kraft
- S. Bertone
- S. Borgani
- S. Giacintucci
- S. Giacintucci
- S. Giacintucci
- S. Jacob
- S. Jacob
- S. Ji
- S. Li
- S. Martin-Alvarez
- S. Melville
- S. Paul
- S. Planelles
- S. Planelles
- S. Schindler
- S. Sur
- S.A. Walker
- S.G. Lucek
- S.I. Vaĭnshteĭn
- S.P. Reynolds
- S.R. Furlanetto
- S.W. Skillman
- T. Enßlin
- T. Inoue
- T. Kahniashvili
- T. Kahniashvili
- T. Kahniashvili
- T. Naab
- T. Sano
- T.A. Enßlin
- T.A. Gardiner
- T.C. Arlen
- T.S. Tricco
- T.W. Jones
- T.W. Shimwell
- U. Keshet
- U. Klein
- V. Springel
- V. Vacca
- V. Vacca
- V. Yakhot
- V.B. Semikoz
- V.N. Zirakashvili
- W. Chen
- W. Dobler
- W. Jaffe
- W. Schmidt
- X. Shi
- X. Shi
- X. Shi
- X.N. Bai
- Y. Birnboim
- Y. Dubois
- Y. Dubois
- Y. Ichinohe
- Y. Su
- Y.B. Zel’dovich
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
We review the present theoretical and numerical understanding of magnetic
field amplification in cosmic large-scale structure, on length scales of galaxy
clusters and beyond. Structure formation drives compression and turbulence,
which amplify tiny magnetic seed fields to the microGauss values that are
observed in the intracluster medium. This process is intimately connected to
the properties of turbulence and the microphysics of the intra-cluster medium.
Additional roles are played by merger induced shocks that sweep through the
intra-cluster medium and motions induced by sloshing cool cores. The accurate
simulation of magnetic field amplification in clusters still poses a serious
challenge for simulations of cosmological structure formation. We review the
current literature on cosmological simulations that include magnetic fields and
outline theoretical as well as numerical challenges.Comment: 60 pages, 19 Figure
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Aguero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M. N.
- Akinkugbe O.
- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
- Albakri J. K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A. E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I. A. M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Z.
- Allen L.
- Allen M.
- Allen S.
- Allibone S.
- Allison K. S.
- Allos R.
- Ally S. M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A. M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi A.
- Amitrano S.
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson M.
- Anderson P.
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew A.
- Andrew B.
- Andrew G.
- Andrews E.
- Andrews S. J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe D.
- Antinori A.
- Antoni M. D.
- Anumakonda V.
- Apetri E.
- Aquino M.
- Arabi Y. M.
- Aravindan L.
- Arbane G.
- Archer K.
- Arden T.
- Arias S. S.
- Arif S.
- Armstrong J.
- Armstrong L.
- Armstrong R.
- Arning N.
- Arnold S.
- Arranz M. J.
- Arribas E.
- Artuso R.
- Arumugam P.
- Ascolillo S.
- Ashraf S.
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain R.
- Asvold B. O.
- Atkinson E. G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin K.
- Austin P.
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R. R.
- Baillie J. K.
- Baines B.
- Baines D.
- Baines K.
- Baird Y.
- Bakthavatsalam D.
- Balaconis M. K.
- Baldassarri M.
- Ball C. A.
- Baltzell A. H.
- Bamford A.
- Bamford P.
- Banach D.
- Bancroft H.
- Band G.
- Bandini M.
- Bandla N.
- Bano S.
- Baptista D.
- Barakeh D.
- Baras A.
- Baratti S.
- Barber R.
- Barberis L.
- Barbieri C.
- Barclay L.
- Bargagli E.
- Barhoush E.
- Barker J.
- Barnes K. C.
- Baroni S.
- Barrett F.
- Barron A.
- Barry P.
- Bartels M.
- Bartley S.
- Baruah R.
- Bashyal A.
- Basikolo C.
- Bassetti M.
- Bastion V.
- Bates H.
- Bates M.
- Batini C.
- Battle C.
- Bauchmuller K.
- Baxter N.
- Baya N.
- Bayo L. -A.
- Beadle J.
- Bean S.
- Beaumont K.
- Beavis S.
- Beck A.
- Beckmann N. D.
- Bedini J. L.
- Bee C. E.
- Beech E.
- Beech V.
- Beekes M.
- Beesley K.
- Begg C.
- Beguin Y.
- Behan T.
- Beith C. M.
- Belagodu Z.
- Belbin G. M.
- Belfield H.
- Belhaj Y.
- Beligni G.
- Belisle A.
- Bell D.
- Bell G.
- Bell M.
- Bell S.
- Bellamy M.
- Belli M. A.
- Bellini A.
- Bellwood R.
- Below J.
- Bemand T.
- Benetti E.
- Benham L.
- Bennett D.
- Bennett S.
- Bentley D.
- Bentley M.
- Benyon S.
- Beranova E.
- Bercades G.
- Bergantini L.
- Bergomi P.
- Berkowitz N.
- Bernardo D.
- Bevan E.
- Bewley J.
- Bhatia N.
- Bhatterjee R.
- Bhuie P.
- Bi R.
- Biagio A. D.
- Bianchi F.
- Bibert S.
- Bibi F.
- Biddle J.
- Biggs H.
- Birch J.
- Birch J.
- Birch S.
- Birchall K.
- Birchall K.
- Bird S.
- Birkinshaw I.
- Birt M.
- Biscarini F.
- Black E.
- Black K.
- Blackledge B.
- Blackman H.
- Blakemore H.
- Blay N.
- Blow S.
- Blunt M.
- Board S.
- Bochud P. -Y.
- Bociek A.
- Boezen M.
- Boillat N.
- Bokhari M.
- Bolton M.
- Bolton R.
- Bonner S.
- Booker L.
- Borislavova B.
- Borra C.
- Botello A.
- Botfield L.
- Botta G.
- Bouab M.
- Bough L.
- Boughton A. P.
- Bowes A.
- Bowles R.
- Boyle P.
- Boyle R.
- Boz C.
- Bradford Y.
- Bradley C.
- Bradley P.
- Bradley-Potts J.
- Bradshaw Z.
- Brady A.
- Brady M.
- Brady R.
- Brandwood C.
- Branney D.
- Brantwood C.
- Brassard N.
- Brayne A.
- Brealey D.
- Bremmer P.
- Brenner B.
- Bretherick A. D.
- Brett M.
- Brett S.
- Brickell K.
- Bridgett V.
- Brimfield L.
- Brinkworth E.
- Briton K.
- Britvan B.
- Bromley M.
- Brooke H.
- Brooks S.
- Brown A.
- Brown A.
- Brown C. W.
- Brown E.
- Brown J.
- Bruce M.
- Brumpton B. M.
- Bruno R.
- Brunton M.
- Bruttini M.
- Bryant J.
- Bryant S.
- Buckley C.
- Buckley S.
- Bunni L.
- Burda D.
- Buring J. E.
- Burn I.
- Burnett C.
- Burns K.
- Burt K.
- Burtenshaw A.
- Burton M.
- Busani S.
- Bussotti M.
- Butcher D.
- Butler A.
- Butler J.
- Butler S.
- Butler-Laporte G.
- Butterworth A. S.
- Butterworth-Cowin N.
- Button H.
- Buxbaum J. D.
- Cabrelli L.
- Cagova L.
- Caldarelli G. P.
- Callaghan M.
- Callier S.
- Cameli P.
- Campbell A.
- Campbell A.
- Campbell H.
- Campbell R.
- Campbell S.
- Campos S.
- Camsooksai J.
- Canaccini A.
- Cantarini L.
- Cantor M. N.
- Capasso M.
- Capitani K.
- Cappelli S.
- Capps N.
- Carbral-Ortega L.
- Carcel-Marquez J.
- Carella M.
- Carey D. J.
- Carmody M.
- Carmody S.
- Carnahan M.
- Carreras A.
- Carriero M. L.
- Carter A.
- Carter D.
- Carter E.
- Carter J.
- Carter S.
- Carungcong J.
- Casey M.
- Castano-Vinyals G.
- Castelli F.
- Castle K.
- Castori M.
- Caswell M.
- Catena E.
- Caterson J.
- Cathcart S.
- Catlow L.
- Caulfield M. J.
- Cavazza A.
- Cawley K.
- Cawthron K.
- Ceri S.
- Chablani M.
- Chadbourn I.
- Chamnanphon M.
- Chan G.
- Chan R.
- Chandler B.
- Chang X.
- Chapman S.
- Chariyavilaskul P.
- Charles B.
- Charlesworth R.
- Charney A. W.
- Charnock R.
- Chasman D. I.
- Chasse M.
- Chaudhary K.
- Chavan S.
- Cheema Y.
- Chen H. -H.
- Chen J.
- Cheng N.
- Cherian S.
- Chetam L.
- Chetruengchai W.
- Cheyne C.
- Childs D.
- Chittoor G.
- Cho J. H.
- Cho K.
- Choi S.
- Choudhury Y.
- Christine Almaden-Boyle
- Chukkambotla S.
- Churchhouse C.
- Chwialkowska K.
- Claassen S.
- Clamp S.
- Clapham M.
- Claringbould A.
- Clark A.
- Clark M.
- Clark M.
- Clark R.
- Clark S.
- Clark V.
- Clarke D.
- Clarke N.
- Clarkson M.
- Clayton S.
- Clement I.
- Clements S.
- Coates C.
- Cockrell M.
- Coetzee S.
- Coghlan P.
- Coignet M.
- Coiro G.
- Coker D.
- Cole J.
- Cole J.
- Cole S.
- Coleman D.
- Coles H.
- Colley J.
- Collier D.
- Collier D.
- Collins A.
- Collins B. L.
- Collins C.
- Collins E.
- Collins E.
- Collins K.
- Collins R.
- Collis M.
- Colobran R.
- Colombo R.
- Combes E.
- Connolly K.
- Conticini E.
- Convery K.
- Conyngham J. -A.
- Cooper J.
- Cooper L.
- Corcoran E.
- Cordioli M.
- Cornell S.
- Corral M. A.
- Corridi M.
- Cortes B.
- Cosgrove D.
- Cosier T.
- Cossarizza A.
- Cother N.
- Coto E.
- Coton Z.
- Coulding M.
- Coutts A.
- Coventry T.
- Coviello D. A.
- Cowley A.
- Cowley N.
- Cowton A.
- Cox A.
- Coyle J.
- Craig J.
- Crawley R.
- Creagh-Brown B.
- Crew A.
- Crickmore V.
- Crisp N.
- Criste K.
- Cristiano D.
- Croci L.
- Croci S.
- Croft M.
- Crook D. W.
- Crooks K.
- Crotti L.
- Crowe R.
- Crowley M.
- Cruz C.
- Cullell N.
- Cullum L.
- Cunningham A.
- Cunningham M.
- Cupitt J.
- Curgenven H.
- Cusack R.
- Cusick C.
- Cutler S.
- D'Alessandro M.
- D'Mellow K.
- D'Sylva S.
- Da Gloria E. F.
- Daga S.
- Daglish J.
- Dale K.
- Dale S.
- Dalmau D.
- Daly M. J.
- Daly Z.
- Dalziel J.
- Dance A.
- Danesh J.
- Daniel A.
- Daniel P.
- Daniels A.
- Darcis G.
- Dark P.
- Darlington K.
- Das M.
- Das S.
- Dasgin J.
- Daubney E.
- Davey M.
- David B.
- Davidson N.
- Davies C.
- Davies E.
- Davies F.
- Davies G.
- Davies K.
- Davies L.
- Davies M.
- Davies R.
- Davis C.
- Davison C.
- Dawson D.
- Dawson J.
- Day N.
- Daya M.
- de Almeida Martins L. G.
- de Cid R.
- de Geus E.
- de Gordoa L. O. -R.
- de la Cal-Sabater P.
- De Neef M.
- De Vivo O.
- Deacon B.
- Dearden J.
- Death Y.
- Debreceni G.
- DeDiego M. L.
- Deelen P.
- Deery J.
- Dei S.
- Delgado C. C.
- Demetriou C.
- Denmade C.
- Dennis C.
- Dent K.
- Dent M.
- Depante M.
- Desanctis E.
- Dexter C.
- Di Angelantonio E.
- Di Domenico P.
- Di Pietro M.
- Dietl B.
- Digby B.
- Digby S.
- Ding L.
- Djeugam B.
- Do R.
- Dobano C.
- Doble P.
- Dobson E.
- Doddato G.
- Dodds S.
- Domingo C.
- Dominguez-Mayoral A.
- Donaldson A.
- Donaldson D.
- Donati A.
- Donlon S.
- Donnachie J.
- Donne B.
- Donnelly K.
- Donnelly L.
- Donner K.
- Donnison P.
- Donovan S.
- Dooks E.
- Doonan R.
- Dore R.
- Dormand N.
- Douglas K.
- Downes C.
- Drummond A.
- Duberly S.
- Duffield J.
- Duffin D.
- Duffy K.
- Duffy S.
- Duncan E.
- Duncan E.
- Duncan T.
- Dunmore C.
- Durand M.
- Durga L.
- Durie A.
- Durrans L. J.
- Durrant G.
- Duskova M.
- Dykes J.
- Eapen B.
- Earle S. G.
- Eastgate-Jackson C.
- Easthope A.
- Easton J.
- Ebano P.
- Eckbad C.
- Edmond I.
- Edwards M.
- Efford G.
- Egan J.
- Eid M. A.
- El-Jawhari J. J.
- El-Lawaty W. A.
- El-shanshory M. R.
- El-Sherbiny Y. M.
- Elgar G.
- Elhadidy T. A.
- Elhassan M.
- Elliott K.
- Elliott K. S.
- Elliott P.
- Ellis H.
- Elnagdy M. H.
- Elsaadany M.
- Elston K.
- Eltayeb A.
- Eltoukhy M. M.
- Emiliozzi A.
- English K.
- Erard V.
- Esko T.
- Esparza-Gordillo J.
- Evitts J.
- Ezeobu O.
- Fabbiani M.
- Fagan A.
- Falcone M.
- Fallerini C.
- Farnell-Ward S.
- Farquhar F.
- Farre X.
- Farzad Z.
- Faulkner B.
- Faulkner M.
- Fava F.
- Fawkes A.
- Fawns-Ritchie C.
- Fawzy M. S.
- Fearby M.
- Felemban W. A.
- Felton T.
- Feng Y. -C. A.
- Ferguson S.
- Feri M.
- Fernandes K.
- Fernandes R.
- Fernandez Z.
- Fernandez-Cadenas I.
- Fernandez-Roman J.
- Ferreira M. A. R.
- Ferri C.
- Fidler K.
- Filipe H.
- Filshtein-Sonmez T.
- Finch C.
- Findlay L.
- Fine C.
- Finer S.
- Finernan P.
- Finn J.
- Finn S.
- Finney C.
- Finucane H.
- Fiorentino G.
- Fisher E.
- Fiz-Lopez A.
- Flanagan R.
- Fletcher J.
- Flint N.
- Fofano A.
- Folkes L.
- Foote D.
- Ford A.
- Forgetta V.
- Forsey M.
- Foster L.
- Fotiadis S.
- Fottrell-Gould D.
- Fourman M. H.
- Fowler S.
- Fowler T.
- Fowler T. A.
- Fox C.
- Fox H.
- Fox J.
- Franchi F.
- Francisci D.
- Franco G.
- Franke G.
- Franke L.
- Frankham J.
- Frater A.
- Frediani B.
- Free R. C.
- Frippiat F.
- Frise M.
- Frithiof R.
- Frost V.
- Frullanti E.
- Fuller B.
- Furini S.
- Furlong A.
- Furniss J.
- Gabbi C.
- Gabrieli A.
- Gaddis M.
- Gales A.
- Gallagher B.
- Galvan-Femenia I.
- Ganesan A.
- Ganna A.
- Garcia S. M.
- Garcia-Aymerich J.
- Garcia-Clemente M.
- Garcia-Madrona S.
- Gardner A.
- Garg A.
- Garland Z.
- Garner L.
- Garrioch S.
- Gascoyne R.
- Gass M. C.
- Gatti F.
- Gay B.
- Gaylard J.
- Gaziano J. M.
- Geary T.
- Gellamucho M.
- Gemmell L.
- Gendall E.
- Genetu R.
- George A.
- George L.
- Georges M.
- Gettler K.
- Gherman A.
- Ghosh A.
- Ghosh B.
- Giannattasio F.
- Gibson S.
- Gignoux C. R.
- Gilbert K.
- Gilchrist T.
- Giliberti A.
- Gill J.
- Gill M.
- Giorli A.
- Giot J. -B.
- Girach R.
- Girardis M.
- Girshick A.
- Glasgow S.
- Glass L.
- Gledhill L.
- Glessner J. R.
- Glessner J. T.
- Goddard P.
- Goddard W.
- Goff E.
- Gofflot S.
- Golden D.
- Golder K.
- Golding H.
- Goldstein J. I.
- Golightly A.
- Gomez J.
- Gomez R.
- Gondo P.
- Gonzalez-Villa E.
- Goodchild D.
- Goodsell J.
- Goodwin E.
- Gopal S.
- Gordon A.
- Gordon E.
- Gori M.
- Gorman C.
- Graham C.
- Grassi D.
- Gratrix A.
- Grau N.
- Grauslyte L.
- Green J.
- Green R. C.
- Greer S.
- Gregory J.
- Greig J.
- Griffin D.
- Griffiths C. J.
- Griffiths F.
- Grimmer L.
- Grip J.
- Guarnaccia A.
- Gude E. T.
- Guerin J.
- Guerrini S.
- Guidelli L.
- Guindo-Martinez M.
- Guiot J.
- Gulati A.
- Gumbrill B.
- Gummadi M.
- Guntz J.
- Gupta A.
- Gupta R.
- Gurasashvili J.
- Gurr L.
- Guturu H.
- Guyatt A. L.
- Guzman C.
- Hadebe B.
- Hafezi K.
- Hairsine B.
- Hakonarson H.
- Halawani R. T.
- Haldeos A.
- Hales D.
- Halkes M.
- Hall K.
- Halls R.
- Hambrook G.
- Hamilton D.
- Hamilton D. O.
- Hammerton K.
- Hanley S.
- Hanratty H.
- Hanson H.
- Hanson K.
- Hansson K.
- Haq R.
- Hard K.
- Harden L.
- Harding P.
- Hardy J.
- Harerimana N.
- Harford R.
- Hargreaves J.
- Harling R.
- Harper R.
- Harrington K.
- Harris C.
- Harris J.
- Harris J. R.
- Harris N.
- Harrison A.
- Harrison A.
- Harrison L.
- Harrison W.
- Harthi F. A.
- Hartley J.
- Hartridge P.
- Harvey A.
- Hasanato R.
- Hass I.
- Hatton J.
- Hawcutt D.
- Hawes J.
- Hay A.
- Hayes A.
- Hayes K.
- Hayman M.
- Hays C.
- Hayward C.
- Hazelton T.
- Headlam E.
- Heeney E.
- Hegazy M. A. F.
- Helgeland O.
- Hellen M.
- Helm D.
- Henderson S.
- Hendry R.
- Hendry S. C.
- Henry D.
- Hensen K.
- Herdman-Grant R.
- Heron A. E.
- Hesseldon L.
- Hewitt C.
- Hey S.
- Hibbert M.
- Hierons S.
- Hiester L. L.
- Higham A.
- Highgate J.
- Hijazi M.
- Hill H.
- Hill M.
- Hilldrith A.
- Hilltout P.
- Hilton M.
- Hindale J.
- Hinds C.
- Hirankarn N.
- Ho Y. -L.
- Hobden G.
- Hobrok M.
- Hodgkiss T.
- Hodgson L.
- Hoggart C.
- Holcombe H.
- Holding K.
- Holdroyd K.
- Holland M.
- Hollox E. J.
- Home M.
- Hong E. L.
- Hope D.
- Hope S.
- Hopkins B.
- Horby P.
- Hormis A.
- Horner D.
- Hornsby J.
- Horowitz J. E.
- Horsley E.
- Hosseini A.
- Hottenga J. J.
- Houlden H.
- Housley K.
- Houston G.
- Howard K.
- Howe G. S.
- Howie L.
- Howle R.
- Howlett A.
- Hruska M.
- Huang Q. Q.
- Huckins L. M.
- Hudig L.
- Hudson A.
- Huffman J. E.
- Hughes A.
- Hughes G.
- Hughes R. A.
- Hugill K.
- Hull R.
- Hulme J.
- Hultstrom M.
- Humphrey C.
- Humphreys S.
- Hunt J.
- Hunt J.
- Hunt K. A.
- Hurford F.
- Hurt W. J.
- Hussain M.
- Hussain S.
- Hussain Y.
- Hutter J.
- Hutton P.
- Huynen P.
- Hveem K.
- Iglesias L. L.
- Ikram M. A.
- Imeson-Wood J.
- Ingham J.
- Inweregbu K.
- Iolascon A.
- Ireland J.
- Irvine V.
- Ishaq T.
- Itan Y.
- Jackson M.
- Jackson P.
- Jackson Y.
- Jackson-Lawrence K.
- Jacob R.
- Jacques J.
- Jacques N.
- Jakkula S.
- Jantarabenjakul W.
- Jardine C.
- Jarmain J.
- Jarman C.
- Javaid A.
- Jeffrey H.
- Jenkins S.
- Jenkins S.
- Jennings C.
- Jerome E.
- Jetha C.
- Jha R.
- Jhanji S.
- Jim R.
- Jimenez-Xarrie E.
- Joe W.
- Joefield T.
- John C.
- Johnson E.
- Johnson L.
- Johnson R.
- Johnston B.
- Jones C.
- Jones D.
- Jones G. A. L.
- Jones J.
- Jones J.
- Jones M.
- Jones O.
- Jones R.
- Jones S.
- Jones T. O.
- Jordan D. M.
- Jose S.
- Joseph A.
- Joseph R.
- Joseph S.
- Josyula N. S.
- Joy R.
- Jude E.
- Jung J.
- Justice A.
- Kadiri S.
- Kaliappan A.
- Kallaste A.
- Kallon D.
- Kamdar D.
- Kamundi C.
- Kanai M.
- Kannan T.
- Kanu R.
- Kapoor R.
- Karczewski K. J.
- Karjalainen J.
- Karlson E. W.
- Karp A.
- Karthik K.
- Kasipandian V.
- Kassam J.
- Katary A.
- Kaufmann D. E.
- Kaul S.
- Kaunisto M.
- Kausar R.
- Kay A.
- Kayani A.
- Kaye C.
- Kaye D.
- Kazi A.
- Keating L.
- Keating S.
- Keenan N.
- Keenan S.
- Keith S.
- Keller K.
- Kelly D.
- Kelly F.
- Kelly S.
- Kelsall O.
- Kennard-Holden G.
- Kennedy-Hay S.
- Kenny E. E.
- Kent A.
- Kent H.
- Kent M.
- Kerr S. M.
- Keshet-Price J.
- Khade R.
- Khafaga W. T.
- Khaliq W.
- Khan M.
- Khattab A. K.
- Khera J.
- Kibutu F.
- Kimchi N.
- Kinch A.
- King B.
- King D.
- King K.
- King L.
- Kingsley C.
- Kirkby A.
- Kisand K.
- Kitson R.
- Kivinen K.
- Klaric L.
- Knight A.
- Knight J.
- Knight S.
- Knighton A.
- Knights E.
- Knowles K.
- Koelling N.
- Kogevinas M.
- Kolakaluri L.
- Kong T.
- Koskelainen S.
- Kosmicki J. A.
- Kousathanas A.
- Krishnamurthy V.
- Kristiansson K.
- Kubisz-Pudelko A.
- Kumar R.
- Kumar R.
- Kumar S.
- Kuravi A.
- Laane E.
- Labkowsky A.
- Laha S.
- Laisk T.
- Lake V.
- Lall K.
- Lamb T.
- Lambermont B.
- Lamond Z.
- Lancaster N.
- Lancoma-Malcolm I.
- Langley M.
- Langton H.
- Lankester L.
- Lanting P.
- Latham S.
- Lathrop G. M.
- Latif M.
- Laurent L.
- Law A.
- Law D.
- Law R.
- Law S.
- Lawton T.
- Lazo M.
- Leader J. B.
- Lean R.
- Leaver S.
- Ledgard C.
- Lee E.
- Lee P. H.
- Lee S.
- Lee Y.
- LeFaive J.
- Leggett S.
- Leigh M.
- Lena F.
- Lenagh B.
- Lennon L.
- Leonar P.
- Lepage P.
- Lepamets M.
- Levy T.
- Lewis A.
- Lewis J.
- Lewis T.
- Li B.
- Li K. W.
- Li R.
- Liao R. G.
- Liderth S.
- Lidstone-Scott R.
- Liew J.
- Liggett S.
- Lim L.
- Lim L.
- Lim R.
- Lin S. -K.
- Lindergard G.
- Ling L.
- Linnett V.
- Lipcsey M.
- Lisboa A.
- Lista M.
- Little J.
- Liyanage K.
- Llucia-Carol L.
- Loader D.
- Lomas D.
- London E.
- Long K.
- Loos R. J. F.
- Loosley R.
- Lopera E.
- Lorubbio M.
- Lorusso R.
- Love N.
- Loveridge A.
- Low E.
- Lozano F.
- Lu W.
- Lubimbi G.
- Lucas A.
- Lucas R.
- Luchi S.
- Ludovisi S.
- Lye A.
- Lyle A.
- Lynch C.
- Lyon A.
- Lyons C.
- Lyons M.
- Ma L.
- Mac A.
- Maccacari E.
- MacCallum N.
- Macgillivray L.
- MacGoey P.
- Macharia I.
- Mackay C.
- Mackintosh K.
- Maclean A.
- MacMahon M.
- Maggiolo F.
- Magi R.
- Magnus P.
- Maharajh A.
- Mahay K.
- Mahenthran M.
- Mahjoob P.
- Mahmoud E. S.
- Mal H.
- Malaise O.
- Male M.
- Maleady-Crowe F.
- Malinauskas T.
- Mallinson J.
- Mallon L.
- Mamlouk N.
- Mancarella S.
- Mandala M.
- Mangino M.
- Mangul S.
- Manna S.
- Manso K.
- Manson J. E.
- Mantovani S.
- Mapfunde I.
- Maqsood Z.
- Marani M.
- Marcantonio S.
- Marciano C.
- Margalef J.
- Margarson M.
- Mari F.
- Maricic T.
- Marotti M.
- Marquez L.
- Marriott C.
- Marriott S.
- Marsden T.
- Marsh C.
- Marsh S.
- Marshall L.
- Marshall R.
- Marti-Fabregas J.
- Martin A. R.
- Martin D.
- Martin H. C.
- Martin J.
- Martin T.
- Martin-Nalda A.
- Martindale T.
- Martinelli E.
- Martinez A. P.
- Martinez M. L.
- Martinson V.
- Martir G.
- Mascarenhas M.
- Masjuan J.
- Maslove D.
- Mason D.
- Massadeh S.
- Masucci L.
- Masuko S.
- Masunda B.
- Matapure L.
- Matharu M.
- Matheson J.
- Mathew B.
- Mathew J.
- Matt R.
- Matthews J.
- May P.
- Mayangao I.
- Mayer A.
- Maynard V.
- Mazzei M. A.
- McAlindon M.
- McAuley D.
- McCafferty S.
- McCormack L.
- McCormick J.
- McCormick J. B.
- McCormick W.
- McCreath G.
- McCulloch C.
- McCurdy A.
- McCurdy S.
- McFarland D.
- McGowan J.
- McGregor A.
- McGregor A.
- McGuigan P. J.
- McGuinness H.
- McHugh T.
- McIvor S.
- McKechnie S.
- McKenley I.
- McKenna E.
- McLaughlan D.
- McMaster E.
- McMorrow L.
- McNeela F.
- McParland C.
- McParland C.
- McPhail M.
- Meadows E.
- Meaney E.
- Medhora J.
- Medina-Gomez C.
- Meghari H.
- Meigs J. B.
- Meikle A.
- Meikle J.
- Melia D.
- Melling S.
- Mellor S.
- Meloni I.
- Melville J.
- Menatti E.
- Mencarelli M. A.
- Menendez-Valladares P.
- Menzies D.
- Mepham S.
- Mercader J.
- Mercader J. M.
- Mercer O.
- Mercer P.
- Meredith M.
- Merla G.
- Merwaha E.
- Metcalfe A.
- Metherell S.
- Metsalu K.
- Metspalu A.
- Meuris C.
- Mew L.
- Michael A.
- Michael H. T.
- Michalak-Glinska N.
- Middleton H.
- Milani L.
- Millar J.
- Millar J.
- Millen G.
- Milligan B.
- Mills G. H.
- Millward H.
- Milner L.
- Mimbrera A. F.
- Miraglia F. G.
- Mirshahi T.
- Misset B.
- Mitchard S.
- Mitchell A. M.
- Mitchelmore O.
- Mitra A.
- Moahmed H. S.
- Moghaddam S. B. M.
- Mohamed A. A. S.
- Moncur E.
- Mondelli M. U.
- Monforte A. D.
- Monica M. D.
- Monnery S.
- Montagnani F.
- Montaser R.
- Montgomery H.
- Moore F.
- Moore L. S. P.
- Moore S. C.
- Mooser V.
- Moreno V.
- Moreno-Cuesta J.
- Morgan A.
- Morgan J.
- Morino E.
- Morrice K.
- Morris A.
- Morris L.
- Morris M.
- Morris S.
- Morrison A.
- Morrison D. R.
- Moss S.
- Mostoles L.
- Motherwell N.
- Moultrie S.
- Moutschen M.
- Moutsianas L.
- Msiska M.
- Mtuwa S.
- Muchenje N.
- Muino E.
- Mulcahy M.
- Mulla S.
- Mullan D.
- Munt S.
- Mupudzi M.
- Murdoch E.
- Murdoch S.
- Murphy A.
- Murphy C.
- Murphy L.
- Murphy L.
- Murphy S.
- Murphy S. N.
- Mussini C.
- Mutairi A. A.
- Mutch R.
- Mwaura E.
- Mwaura L.
- Naaber P.
- Naderpour Z.
- Nadkarni G. N.
- Nagra I.
- Naisbitt J.
- Nakanishi T.
- Naranjo A.
- Nasir F.
- Nayak M.
- Nazari R.
- Neal A.
- Neale B. M.
- Nencioni C.
- Neofytos D.
- Netherton K.
- Newell H.
- Newey L.
- Newman J.
- Newman T.
- Newton M.
- Ng A.
- Nguyen H.
- Niavarani A.
- Niblo K.
- Nichol A.
- Nicholson A.
- Nicholson A.
- Nicol L.
- Niemi M. E. K.
- Nikitas N.
- Nilaratanakul V.
- Nilsson A.
- Nivard M.
- Nixon R.
- Nkambul L.
- Nkambul L.
- Noble H.
- Nolan C.
- Norman K.
- Norris J.
- Nortcliffe T.
- North J.
- North K.
- Noto K.
- Novis C.
- Nown A.
- Nune A.
- Nussle S. G.
- Nwafor L.
- O'Brien L.
- O'Brien P.
- O'Connell A. M.
- O'Connell S.
- O'Connor D.
- O'Connor G.
- O'Donnell C. J.
- O'Hara M.
- O'Leary R.
- O'Malley L.
- O'Neil P.
- O'Neill L.
- O'Reilly K.
- O'Reilly P.
- O'Sullivan S.
- Oakley N.
- Oblak M.
- Odam M.
- Odhams C. A.
- Oetjens M.
- Ogg B.
- Ognibene A.
- Okasha K.
- Okeefe L.
- Oliveira M.
- Olufuwa O.
- Omar Z.
- Oosthuyzen W.
- Openshaw P. J. M.
- Ori A. P. S.
- Ostermann M.
- Otahal I.
- Oxspring S.
- Paciosi F.
- Packer R. J.
- Packham S.
- Padden G.
- Page V. J.
- Pairo-Castineira E.
- Pakou G.
- Palmer D. S.
- Palmieri M.
- Palotie A.
- Pancrazzi A.
- Panese S.
- Pappa E.
- Paramsothy R.
- Parati G.
- Parisi S. G.
- Park D.
- Park L.
- Parker R.
- Parkin J.
- Parkinson N.
- Parkinson P.
- Parmar C.
- Parravicini P.
- Parris V.
- Parsons P.
- Partha R.
- Partridge R.
- Pasko D.
- Passmore H.
- Patch C.
- Patel A.
- Patel B.
- Patel B.
- Patel K.
- Patel M.
- Patel T.
- Paterson T.
- Pathak G. A.
- Pathan N.
- Pattison N.
- Paul P.
- Pavlovic M.
- Pawley C.
- Pearson H.
- Pearson S.
- Peasgood E.
- Peloso G.
- Penacerrada M.
- Pendlebury J.
- Penn R.
- Pereira A. C.
- Perez E. F.
- Perez J.
- Perez-Tur J.
- Perkins E.
- Perna R.
- Perola M.
- Perrella A.
- Perry J.
- Peruggia M.
- Pessina G.
- Pesukova J.
- Peters C.
- Peters M. J.
- Peterson P.
- Petitjean L.
- Petrocelli P.
- Petty L. E.
- Pheby J.
- Philbin J.
- Phillips C.
- Phillips P.
- Phipps J.
- Phokaew C.
- Phull M.
- Piacentini P.
- Picchiotti N.
- Pickard A.
- Piercy C.
- Pigazzini S.
- Pinnell J.
- Pinoli P.
- Pinto A. M.
- Pinzuti I.
- Pippard L.
- Pirinen M.
- Piscopo C.
- Pitts S.
- Planas A. M.
- Player B.
- Pogreban T.
- Pogson D.
- Polgar O.
- Polgarova P.
- Polikowski H.
- Polimanti R.
- Pollard R.
- Polymeropoulos C.
- Polymeropoulos M. H.
- Polymeropoulos V.
- Pongpanich M.
- Ponting C. P.
- Poole A.
- Popescu M.
- Porteous D. J.
- Poscente M.
- Pothecary C.
- Potla D.
- Potoczna D.
- Potts K.
- Poulaka M.
- Poultney U.
- Prady H.
- Prager K.
- Praman K.
- Pratley A.
- Prendergast C.
- Prentice L.
- Preston S.
- Preuss M.
- Price A.
- Price C.
- Price R.
- Prime Z.
- Pristopan V.
- Pritchard K.
- Proudfoot N.
- Prout R.
- Prysyazhna O.
- Przychodzen B. P.
- Pugh R.
- Purewal B.
- Purewal M.
- Purohit D.
- Purvis S.
- Putchareon O.
- Puthanakit T.
- Puusepp M.
- Puxty A.
- Puxty K.
- Pye K.
- Qiu X.
- Quaid S.
- Queiroz J.
- Quinn A.
- Quinn H.
- Quinodoz M.
- Quiros-Roldan E.
- Rad L.
- Rader D.
- Rader D. J.
- Radford E.
- Radhakrishnan J.
- Rafaels N.
- Raggi P.
- Ragoussis J.
- Rahmouni S.
- Rai S. G.
- Raimondi F.
- Raith E.
- Raithatha A.
- Raj M.
- Ramos L.
- Rancan I.
- Rand J.
- Rand K.
- Randell G.
- Ranga P.
- Rangarajan H.
- Rankin T.
- Ratnam V.
- Rattray A.
- Ravaglia S.
- Rawlik K.
- Rawlins J.
- Ray S.
- Raynard D.
- Reddy A.
- Reece-Anthony R.
- Reed A.
- Rees A.
- Rees S.
- Rees T.
- Rehman H.
- Reid K.
- Reimann E.
- Rekha P.
- Rendon A.
- Renieri A.
- Reschreiter H.
- Reyes A.
- Reynolds J.
- Rezk N.
- Rhead B.
- Rhead K.
- Rhodes D.
- Rhodes J.
- Rice P.
- Richards J. B.
- Richards O.
- Richardson N.
- Riches J.
- Riches K.
- Richmond A.
- Rico V.
- Ridker P. M.
- Rikunenko R.
- Ringmets I.
- Ripamonti D.
- Ripatti S.
- Rishton C.
- Ritchie M. D.
- Ritzema J.
- Riva A.
- Rivers V.
- Rivolta C.
- Rizzi M.
- Rizzo C. L.
- Roberts B.
- Roberts G.
- Robinson M.
- Robinson P.
- Robles V.
- Roche L.
- Roche L.
- Roche S.
- Rodden N.
- Roe N.
- Rogers N.
- Rogers P.
- Rogerson K.
- Rogne T.
- Rojo R.
- Rojo S.
- Romani D.
- Rooney K.
- Rooney L.
- Rooyackers O.
- Rosa A. D.
- Rosaroso L.
- Rose A.
- Rose S.
- Rossetti B.
- Rostron A.
- Rothwell J.
- Rovere M. T. L.
- Rowan K.
- Rowland-Jones S.
- Roy A.
- Roynon-Reed A.
- Rudkin J. K.
- Ruiz L.
- Ruiz-Jaen F.
- Runciman N.
- Ruotsalainen S.
- Rusconi S.
- Russell C. D.
- Russo R.
- Ryan L.
- Ryan-Smith J.
- Saad S.
- Sabrina R.
- Saeedi M.
- Safieh L. A.
- Saha R.
- Saha R.
- Saha S.
- Sainsbury H.
- Salberg A.
- Salciute E.
- Saleem M.
- Salehi S.
- Salerni L.
- Salib I.
- Salmi S.
- Salmon K.
- Salutous D.
- Saluzzio R. P.
- Samakomva T.
- Samir A.
- Sampson J.
- Sanarico M.
- Sanderson A.
- Sandhu R.
- Sangombe M.
- Sanguinetti M.
- Sarathy V.
- Sargeant J.
- Sarma G.
- Sarno L. D.
- Sarzi-Braga S.
- Sathe S.
- Satterstrom F. K.
- Saunderson A.
- Saunderson P.
- Sauvage A. -S.
- Savill H.
- Sawaji M.
- Scaggiante R.
- Scala R.
- Scanlon J.
- Schadt E. E.
- Scherewode J.
- Schiaroli E.
- Scholefield B.
- Schon K.
- Schumacher N.
- Schurr E.
- Scolletta S.
- Scott R. H.
- Scott T.
- Scott Z.
- Scotton P. G.
- Scriven J.
- Sealfon S. C.
- Seaman R.
- Sebra R. P.
- Seed C.
- Segala F. V.
- Segura T.
- Sell C.
- Sellick K.
- Selvanayagam S.
- Semple G.
- Semple M. G.
- Senaratne D.
- Serra-Llovich A.
- Serrano-Heras G.
- Serrano-Ruiz A.
- Service J.
- Sesso H. D.
- Shah N.
- Shahin D.
- Shankar-Hari M.
- Shanmugasundaram P.
- Sharififard B.
- Shastri A. J.
- Shaw D.
- Shaw D. M.
- Shaw L.
- Shaw R.
- Shelley B.
- Shelton J. F.
- Shelton S.
- Shen X.
- Shepardson S.
- Shepherd A.
- Shiel J.
- Shokkar R.
- Short A.
- Shortt J.
- Shotelersuk V.
- Shovelton C.
- Shrine N.
- Shuker K.
- Siano M.
- Sicat C.
- Siddiq A.
- Silva P.
- Sim M.
- Simms R.
- Simpson K.
- Simpson K.
- Singh J.
- Singleton J.
- Skinner D.
- Slater V.
- Slaughter M.
- Slawson N.
- Slevin K.
- Sloan B.
- Sloane G.
- Sloofman L. G.
- Smedley C.
- Smieszek S. P.
- Smith A. V.
- Smith E.
- Smith J.
- Smith J.
- Smith J.
- Smith K.
- Smith L.
- Smith M.
- Smith O.
- Smith T.
- Smithson E.
- Smoller J. W.
- Smuts S.
- Smyth D.
- Smyth M.
- Sobh A.
- Sodsai P.
- Soler P.
- Sollesta K.
- Solligard E.
- Solomonson M.
- Soranzo N.
- Soriano A.
- Sowter J.
- Spargi G.
- Spector T. D.
- Spencer C. C. A.
- Spencer K.
- Spencer S.
- Spertilli C.
- Spivey M.
- Springle P.
- Squeo G. M.
- Sri-Chandana C.
- Srikaran S.
- Stacey A.
- Stammers K.
- Starkopf J.
- Stead R.
- Stella A.
- Stenhouse A.
- Stephens D.
- Stephenson E.
- Stephenson L.
- Stevens C.
- Stevenson L.
- Stewart R.
- Stickley J.
- Stoddard E.
- Stone S.
- Stones E.
- Stowe B.
- Strachan D.
- Stroud K.
- Stroud N.
- Stuart C.
- Stuckey A.
- Suardi C.
- Suarez J. C.
- Subramanian D.
- Subramanian G.
- Suchartlikitwong P.
- Suh N.
- Sukha A.
- Sukumaran A.
- Suliman B. A.
- Summers C.
- Summers J.
- Sumoy L.
- Sun Y. V.
- Sundar A.
- Sundaram R.
- Sutherland I.
- Sutherland S. -B.
- Suttichet T. B.
- Swain A.
- Sweeney L.
- Sweet K.
- Swets M.
- Symon L.
- Symons A.
- Szakmany T.
- Szoor-McElhinney H.
- Tabri J.
- Tacconi D.
- Tadi H. A.
- Tagliavini E.
- Tamm A.
- Tampsett R.
- Taneski F.
- Tanfoni M.
- Tang L.
- Tardif N.
- Tariq A.
- Tatham K. C.
- Tavares S.
- Tavecchia L.
- Taylor A.
- Taylor J.
- Taylor M.
- Taylor M.
- Tebbutt J.
- Templeton M.
- Tench H.
- Tenesa A.
- Tetla D.
- Texeira J.
- Thanasi M.
- Thankachen M.
- Thirlwall Y.
- Thirumaran M.
- Thomas A.
- Thomas A.
- Thomas B.
- Thomas E.
- Thomas H.
- Thomas J.
- Thomas M.
- Thomas R.
- Thomas V.
- Thomis L.
- Thompsom M.
- Thompson C.
- Thompson R.
- Thompson R. C.
- Thomson N.
- Thornton D.
- Thornton L.
- Thorpe C.
- Thrasyvoulou L.
- Thrush J.
- Thwaites V.
- Thys M.
- Tibke C.
- Tierney C.
- Tilbey S.
- Tilney E.
- Timlick E.
- Timmers P. H. J.
- Ting L.
- Tiseo G.
- Tita R.
- Tivenan H.
- Tobin M. D.
- Todd A.
- Todd L.
- Tolson M.
- Tomas A. L.
- Tommasi A.
- Tonks L.
- Torky M. S.
- Torrents D.
- Torvorapanit P.
- Tracy B.
- Trankiem A.
- Tranter H.
- Trembath R. C.
- Tridente A.
- Trim F.
- Trivedi B.
- Trodd D.
- Trogstad L. -I. S.
- Trotman S.
- Trotta T.
- Trower H.
- Truman N.
- Trumper E.
- Tsao P.
- Tselios C.
- Tsinaslanidis G.
- Tsuo K.
- Tucci A.
- Tuckey V.
- Tully R.
- Tumbarello M.
- Turki S.
- Turley P.
- Turnbull A.
- Turner K.
- Turner L.
- Turner P.
- Turner V.
- Turner-Bone I.
- Turney S.
- Turtle L.
- Tutton R.
- Twiss S.
- Tyl D.
- Tyler A.
- Uitterlinden A. G.
- Underwood S. J.
- Vaghi M.
- Vaida M.
- Valente S.
- Valentine J.
- Valentino F.
- van Blokland I.
- van Heel D. A.
- van Koutrik L.
- Varghese M.
- Vecchia M.
- Vedage D.
- Veerapen K.
- Venkatesh H.
- Venn L. D.
- Venturelli S.
- Vergori A.
- Verlander M.
- Verma A.
- Verma S. S.
- Vertue M.
- Verula J.
- Verzuri A.
- Vigurs C.
- Villalonga J. M.
- Vincent R.
- Vincenti A.
- Virgilio E.
- Vitart V.
- Vizcaychipi M. P.
- Vochin A.
- Voide C.
- von Frenckell C.
- von Hohenstaufen K. A.
- Vonk J. M.
- Vulesevic B.
- Vuylsteke A.
- Wackett T.
- Wadams B.
- Waddington N.
- Wagstaff V.
- Wain L. V.
- Waite A. A. C.
- Wakefield P.
- Wakinshaw F.
- Waldron J.
- Walker D.
- Walker R.
- Walker S.
- Walker S.
- Wall A.
- Walsh T.
- Walters R. K.
- Walton O.
- Wang B.
- Wang J.
- Wang X.
- Wanying Z.
- Ward G.
- Ward L.
- Ward M.
- Warden S.
- Warmerdam R.
- Warren D.
- Wassall H.
- Wasson C.
- Watkins C.
- Watson E.
- Watson G.
- Watson J.
- Watters M.
- Waugh V.
- Weaver J.
- Webster A.
- Webster D.
- Webster K.
- Wei S.
- Weiss S. T.
- Weldon C. H.
- Wells C.
- Welters I. D.
- Weston H.
- Whileman A.
- Whitbread J.
- White D.
- White I.
- White K.
- White M.
- White N.
- White N.
- Whiteley S.
- Whiteside J.
- Whittle H.
- Whitton C.
- Whyte C.
- Wicks S. J.
- Wilby E.
- Wilcox L.
- Wilcox R.
- Wild H.
- Wild L.
- Wiles M.
- Wilkins J.
- Wilkinson A.
- Wilkinson B.
- Willer C.
- Williams A.
- Williams A.
- Williams A.
- Williams A. T.
- Williams D.
- Williams E.
- Williams F.
- Williams G.
- Williams H.
- Williams K.
- Williams M.
- Williams P.
- Williams S.
- Williams T.
- Willis C.
- Willis H.
- Wills M.
- Willson J.
- Wilson A.
- Wilson D. J.
- Wilson J.
- Wilson J. F.
- Winnard S.
- Winter-Goodwin B.
- Wolf-Roberts R.
- Wolford B.
- Wong J.
- Wood D.
- Wood H. -L.
- Wood S.
- Wood T.
- Woodford C.
- Woodruff M.
- Woods L.
- Woodyatt W.
- Woolley A. E.
- Worner R.
- Worsley L.
- Wray G.
- Wren L.
- Wright D.
- Wright J.
- Wright M.
- Wrobel N.
- Wu Y.
- Wulandari R.
- Wyllie D. H.
- Wynter I.
- Xavier K.
- Xue X.
- Yadav A.
- Yang J.
- Yassen A. M.
- Yates B.
- Ye C.
- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
- Zamikula J.
- Zanella I.
- Zborowski A. C.
- Zeberg H.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J. H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zollner S.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
- C Ahmed
- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
- C Beith
- C Borra
- C Brandwood
- C Brantwood
- C Burnett
- C Castro Delgado
- C Clark
- C Clulow
- C Collins
- C Cruz
- C Davis
- C Demetriou
- C Dennis
- C Dexter
- C Downes
- C Dunmore
- C Eastgate
- C Eckbad
- C Finch
- C Gibson
- C Gorman
- C Hays
- C Hewitt
- C Holl
- C Howcroft
- C Humphrey
- C Jackson
- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
- C McParland
- C Murphy
- C Parmar
- C Pawley
- C Phillips
- C Phillips
- C Pothecary
- C Pothecary
- C Prendergast
- C Price
- C Rishton
- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
- C Thompson
- C Thorpe
- C Tibke
- C Tierney
- C Vigurs
- C Wells
- C Whitton
- C Whyte
- C Wrey Brown
- Cameron J Fairfield
- Carmelo Piscopo
- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
- D Banach
- D Baptista
- D Bell
- D Branney
- D Brealey
- D Brealey
- D Butcher
- D Butcher
- D Childs
- D Clarke
- D Collier
- D Collier
- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
- D Mullan
- D Pogson
- D Potla
- D Potoczna
- D Purohit
- D Raynard
- D Salutous
- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
- I Otahal
- I Otahal
- I Turner-Bone
- I Welters
- I White
- I Wynter
- Ilaria Meloni
- Immacolata Andolfo
- Isabella Zanella
- J Allan
- J Barker
- J Bewley
- J Biddle
- J Birch
- J Birch
- J Bradley-Potts
- J Brown
- J Bryant
- J Butler
- J Camsooksai
- J Carter
- J Caterson
- J Cebrian Suarez
- J Cockerill-Taylor
- J Cole
- J Colley
- J Cooper
- J Cupitt
- J Cuttler
- J Daglish
- J Dasgin
- J Dawson
- J Dearden
- J Deery
- J Donnachie
- J Dykes
- J Easton
- J Egan
- J Fernandez Roman
- J Finn
- J Fletcher
- J Frankham
- J Gaylard
- J Gill
- J Godden
- J Goodsell
- J Gregory
- J Greig
- J Gurasashvili
- J Hardy
- J Harris
- J Hatton
- J Hawes
- J Highgate
- J Hornsby
- J Hulme
- J Hunt
- J Hutter
- J Ingham
- J Jones
- J Jones
- J K Baillie
- J Kassam
- J Kenneth Baillie
- J Kenneth Baillie
- J Keshet-Price
- J Liew
- J Little
- J Mallinson
- J Martin
- J Matthews
- J McCormick
- J Medhora
- J Melville
- J Moreno Cuesta
- J Morgan
- J Naisbitt
- J Norris
- J North
- J Parkin
- J Pendlebury
- J Perez
- J Perry
- J Pheby
- J Philbin
- J Pinnell
- J Queiroz
- J Radhakrishnan
- J Reid
- J Rhodes
- J Riches
- J Ritzema
- J Ruddy
- J Ryan-Smith
- J Scriven
- J Scriven
- J Scriven
- J Shiel
- J Singh
- J Singleton
- J Smith
- J Sowter
- J Strickley
- J Summers
- J Taylor
- J Tebbutt
- J Texeira
- J Thomas
- J Thrush
- J Tomlinson
- J Valentine
- J Whiteside
- J Wilkins
- J Willson
- J Zamikula
- Jake Dunning
- Jane Weaver
- Janet Harrison
- Janet T Scott
- Janie F Shelton
- Jen Meikle
- Jo Dalton
- Johnny Millar
- Jorge Esparza-Gordillo
- Jose E Krieger
- Julian A Hiscox
- K Archer
- K Austin
- K Baines
- K Bauchmuller
- K Beaumont
- K Beesley
- K Black
- K Burns
- K Burt
- K Cawley
- K Cawthron
- K Connolly
- K Convery
- K Criste
- K Dale
- K Darlington
- K Davies
- K Dent
- K Douglas
- K Duffy
- K Elliott
- K Elston
- K English
- K Fernandes
- K Fletcher
- K Gilbert
- K Golder
- K Hammerton
- K Hanson
- K Hanson
- K Hard
- K Harrington
- K Hayes
- K Holding
- K Holdroyd
- K Howard
- K Hugill
- K Inweregbu
- K Jackson-Lawrence
- K Karthik
- K King
- K Knowles
- K Lang
- K Liyanage
- K Manso
- K Netherton
- K Postlethwaite
- K Potts
- K Prager
- K Praman
- K Priestley
- K Pritchard
- K Puxty
- K Reid
- K Riches
- K Rooney
- K Sellick
- K Shuker
- K Simpson
- K Simpson
- K Slevin
- K Smith
- K Sollesta
- K Stammers
- K Stroud
- K Sweet
- K Tatham
- K Turner
- K Webster
- K White
- K Williams
- K Xavier
- Katarzyna Hafezi
- Keating Sean
- Kenneth A Mclean
- Kirstie Morrice
- Klaric Lucija
- Klenerman Paul
- Knight Julian
- Kousathanas Athanasios
- L Abel
- L Akeroyd
- L Allen
- L Armstrong
- L Barclay
- L Benham
- L Botfield
- L Bough
- L Brimfield
- L Bunni
- L Cabrelli
- L Cagova
- L Catlow
- L Ding
- L Ferguson
- L Folkes
- L Foster
- L Garner
- L Gemmell
- L George
- L Glass
- L Glass
- L Gledhill
- L Grauslyte
- L Grimmer
- L Gurr
- L Harrison
- L Hodgson
- L Hudig
- L Keating
- L Kittridge
- L Lankester
- L Lennon
- L Lim
- L Ma
- L Marshall
- L Matupe
- L McMorrow
- L McQuillan
- L Mew
- L Mostoles
- L Mwaura
- L Newey
- L O'Brien
- L O'Malley
- L O'Neill
- L Ortiz-Ruiz de Gordoa
- L Ortiz-Ruiz de Gordoa
- L Park
- L Pippard
- L Prentice
- L Rad
- L Ramos
- L Riddles
- L Roche
- L Roche
- L Rooney
- L Rosaroso
- L Shaw
- L Smith
- L Stevenson
- L Symon
- L Thomis
- L Thornton
- L Thrasyvoulou
- L Ting
- L Tonks
- L Turner
- L van Koutrik
- L Wilcox
- L Wild
- L Wilding
- L Woods
- L Wren
- L Zitter
- Lance C W Turtle
- Laura Bergantini
- Laura Di Sarno
- Laura Marsh
- Laura Merson
- Law Andrew
- Leonardo Croci
- Lia Crotti
- Ling Lowell
- Lisa Norman
- Lorenzo Salerni
- Lorna Donnelly
- Louise Cullum
- Louise Macgillivray
- Louise Sigfrid
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Luisa Tavecchia
- M Abdelrazik
- M Al-Moasseb
- M Balasubramaniam
- M Bates
- M Bellamy
- M Birt
- M Blunt
- M Bokhari
- M Bolton
- M Brady
- M Breekes
- M Brett
- M Bromley
- M Bruce
- M Brunton
- M Burton
- M Callaghan
- M Carmody
- M Carnahan
- M Casey
- M Caswell
- M Chablani
- M Clapham
- M Clark
- M Clark
- M Coulding
- M Croft
- M Cunningham
- M Davey
- M Davies
- M Davies
- M Edward
- M Elhassan
- M Elsaadany
- M Faulkner
- M Forsey
- M Frise
- M Gellamucho
- M Gill
- M Gummadi
- M Halkes
- M Harkins
- M Hill
- M Hobrok
- M Holland
- M Home
- M Hussain
- M Jackson
- M K Phull
- M Kent
- M Khan
- M Latif
- M Leigh
- M Lopez Martinez
- M Lyons
- M MacMahon
- M Male
- M Marani
- M Margarson
- M Marotti
- M Matharu
- M McLaughlin
- M McPhail
- M Meredith
- M Mpelembue
- M Msiska
- M Mulcahy
- M Mupudzi
- M Nauman Akhtar
- M Newton
- M Oblak
- M Odam
- M Ostermann
- M Patel
- M Peiu
- M Penacerrada
- M Peters
- M Popescu
- M Poulaka
- M Purewal
- M Raj
- M Robinson
- M Sangombe
- M Shankar-Hari
- M Sim
- M Slaughter
- M Smith
- M Smith
- M Spivey
- M T Hijazi
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Templeton
- M Thankachen
- M Thirumaran
- M Thomas
- M Tolson
- M Usher
- M Varghese
- M Verlander
- M Vertue
- M Watters
- M White
- M Wiles
- M Williams
- M Wills
- M Woodruff
- M Young
- Maaike Swets
- Mahdad Noursadeghi
- Manu Shankar-Hari
- Marco Castori
- Marco Feri
- Marco Gori
- Marco Mandalà
- Marco Sita
- Margherita Baldassarri
- Mari E K Niemi
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Eugenia Quiros-Roldan
- Maria Palmieri
- Maria Zambon
- Marie Connor
- Mario Capasso
- Mario U Mondelli
- Marta Corridi
- Maslove David
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Girardis
- Massimo Palmarini
- Massimo Vaghi
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Mattia Cordioli
- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
- McAuley Danny
- Meera Chand
- Meynert Alison
- Michelle Girvan
- Millar Jonathan
- Mirella Bruttini
- Miriana D'Alessandro
- Montgomery Hugh
- Moore Shona C
- Moutsianas Loukas
- Murphy Lee
- Murray Wham
- N Ahmad
- N Bandla
- N Baxter
- N Boyle
- N Capps
- N Clarke
- N Crisp
- N Davidson
- N Dormand
- N Grau
- N Harris
- N Jacques
- N Keenan
- N Lancaster
- N Love
- N MacCallum
- N Michalak-Glinska
- N Motherwell
- N Muchenje
- N Nikitas
- N Pathan
- N Pattison
- N Proudfoot
- N Rea
- N Richardson
- N Rodden
- N Roe
- N Rogers
- N Runciman
- N Schumacher
- N Schunki
- N Slawson
- N Staines
- N Thomson
- N Truman
- N White
- Nichol Alistair
- Nicholas Parkinson
- Nicholas Price
- Nicky Day
- Nicola Picchiotti
- O Adanini
- O Akinkugbe
- O Ezeobu
- O Jones
- O Kelsall
- O Mercer
- O Mitchelmore
- O Olufuwa
- O Prysyazhna
- O Zongo
- Oosthuyzen Wilna
- Openshaw Peter J M
- P Alexander
- P Anderson
- P Bamford
- P Barry
- P Boyle
- P Clark
- P Coghlan
- P Doble
- P Donnison
- P Ebano
- P Gondo
- P Grant
- P Harding
- P Henderson
- P Hutton
- P Jackson
- P MacGoey
- P May
- P McConnell
- P Mercer
- P O'Brien
- P O'Neil
- P Parkinson
- P Parsons
- P Paul
- P Polgarova
- P Ranga
- P Rice
- P Rogers
- P Saunderson
- P Shanmugasundaram
- P Springle
- P Szedlak
- P Turner
- P Williams
- Pairo-Castineira Erola
- Pamela Raggi
- Paola Magro
- Paolo Cameli
- Paolo Piacentini
- Parkinson Nick
- Pasko Dorota
- Patrick Sulem
- Patrizia Zucchi
- Paul Finernan
- Paul Klenerman
- Pereira Alexandre C
- Peter W Horby
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pietro Pinoli
- Ponting Chris P
- Porteous David J
- R Astin-Chamberlain
- R Barber
- R Baruah
- R Bi
- R Bolton
- R Bowles
- R Boyle
- R Bradley
- R Campbell
- R Campbell
- R Chan
- R Charlesworth
- R Clark
- R Crawley
- R Crowe
- R Cusack
- R Davies
- R Doonan
- R Flanagan
- R Gascoyne
- R Girach
- R Gomez
- R Griffiths
- R Hall
- R Hamill
- R Haq
- R Harford
- R Harper
- R Herdman-Grant
- R Howle
- R Jacob
- R Jha
- R Johnson
- R Jones
- R Joy
- R Kanu
- R Kapoor
- R Kausar
- R Khade
- R Kitson
- R Kumar
- R Lean
- R Lim
- R Loosley
- R Lorusso
- R M Genetu
- R Marshall
- R O'Leary
- R Paramsothy
- R Parker
- R Partridge
- R Penn
- R Pepermans Saluzzio
- R Pollard
- R Price
- R Prout
- R Pugh
- R Raobaikady
- R Reece-Anthony
- R Rikunenko
- R Rojo
- R Saha
- R Sandhu
- R Shaw
- R Shokkar
- R Simms
- R Stead
- R Stewart
- R Sundaram
- R Tully
- R Tutton
- R Vincent
- R Walker
- R Wilcox
- R Wolf-Roberts
- R Worner
- R Wulandari
- Rachel Law
- Raffaele Scala
- Rawlik Konrad
- Renieri
- Renzo Scaggiante
- Richard Clark
- Richard S Tedder
- Richmond Anne
- Riinu Pius
- Rita Perna
- Roberta Russo
- Ross Hendry
- Rossella Tita
- Rowan Kathy
- Russell Clark D
- Ruth Armstrong
- Ruth Lyons
- Ryan S Thwaites
- S Agrawal
- S Allen
- S Allibone
- S Anderson
- S Archer
- S Bano
- S Bean
- S Beavis
- S Bell
- S Bennett
- S Benyon
- S Bird
- S Blowes
- S Board
- S Bonner
- S Brett
- S Buckley
- S Campos
- S Cathcart
- S Chapman
- S Charlton
- S Cherian
- S Chukkambotla
- S Clamp
- S Clark
- S Clements
- S Coetzee
- S Cole
- S Cornell
- S Cutler
- S Dale
- S Donlon
- S Farnell-Ward
- S Fowler
- S Garrioch
- S Gibson
- S Gopal
- S Greer
- S Gurung Rai
- S Henderson
- S Hierons
- S Hope
- S Humphreys
- S Hussain
- S Jenkins
- S Jhanji
- S Jones
- S Jose
- S Joseph
- S Kaul
- S Keenan
- S Keith
- S Kennedy-Hay
- S Kimber
- S Kumar
- S Laha
- S Latham
- S Leaver
- S Lee
- S Leggett
- S MacFadyen
- S Manna
- S Marriott
- S Masuko
- S McIvor
- S McKechnie
- S Melling
- S Mellor
- S Mepham
- S Metherell
- S Mitchard
- S Mohamed Ally
- S Monnery
- S Moore
- S Morrison
- S Moultrie
- S Mtuwa
- S Mulla
- S Munt
- S Murdoch
- S O'Sullivan
- S Packham
- S Patch
- S Pearson
- S Pitts
- S Preston
- S Purvis
- S Quaid
- S Ray
- S Roche
- S Rose
- S Rundell
- S Salmi
- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
- S Sousa Arias
- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- Seán Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 × 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
- A. Bowes
- A. Brady
- A. Brayne
- A. Brown
- A. Brown
- A. Butler
- A. Carter
- A. Collins
- A. Cowley
- A. Cowton
- A. Cowton
- A. Cox
- A. Crew
- A. Dance
- A. Daniel
- A. Daniels
- A. Dela Rosa
- A. Drummond
- A. Durie
- A. E. Heron
- A. Easthope
- A. Easthorpe
- A. Evans.
- A. Fofano
- A. Gales
- A. Ganesan
- A. Gardner
- A. Garg
- A. Gherman
- A. Gordon
- A. Gratrix
- A. Gulati
- A. Gupta
- A. Haigh
- A. Haldeos
- A. Harrison
- A. Harvey
- A. Hayes
- A. Higham
- A. Higham
- A. Hilldrith
- A. Holden
- A. Hormis
- A. Hutcheon
- A. Javaid
- A. Joseph
- A. Kaliappan
- A. Katary
- A. Kay
- A. Kayani
- A. Kent
- A. Kirkby
- A. Knight
- A. Kubisz-Pudelko
- A. Kuravi
- A. Lewis
- A. Loveridge
- A. Lyle
- A. Mayer
- A. McAlpine
- A. McCarthy
- A. McGregor
- A. McGregor
- A. Meikle
- A. Mitchell
- A. Mitra
- A. Morris
- A. Morrison
- A. Naranjo
- A. Nicholson
- A. Nicholson
- A. Noakes
- A. Patel
- A. Pickard
- A. Price
- A. Puxty
- A. Quinn
- A. Quinn
- A. Raithatha
- A. Rattray
- A. Reddy
- A. Reed
- A. Reyes
- A. Rose
- A. Rose
- A. Rostron
- A. Roy
- A. Roynon-Reed
- A. S. Raj
- A. Salberg
- A. Sanderson
- A. Serrano-Ruiz
- A. Solesbury
- A. Sukha
- A. Swain
- A. Tariq
- A. Thomas
- A. Thomas
- A. Todd
- A. Tomas
- A. Tridente
- A. Tucci
- A. Turnbull
- A. Uriel
- A. Ustianowski
- A. Vochin
- A. Vuylsteke
- A. Waite
- A. Walden
- A. Whileman
- A. Wilkinson
- A. Williams
- A. Williams
- A. Wilson
- A. Zak
- A. Zaki
- Achille Iolascon
- Adam Brown
- Adam Krętowski
- Adriana Roży
- Agnese Verzuri
- Agnieszka Adamek
- Agnieszka Bielska
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Albert Tenesa
- Aleksandra Berkan-Kawinska
- Aleksandra Jezela-Stanek
- Aleksandra Starosz
- Alessandra Guarnaccia
- Alessandra Renieri &
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alice Donati
- Alison Meynert
- Alistair Nichol
- Anders Larsson
- Andrea Antinori
- Andrea Cossarizza
- Andrea Gabbuti
- Andrea Tommasi
- Andrew D. Bretherick
- Andrew Law
- Andrew Stenhouse
- Andrzej Eljaszewicz
- Andrzej Horban
- Andy Law
- Angelica Pagliazzi
- Angie Fawkes
- Anke Hinney
- Anna Canaccini
- Anna Kruk
- Anna Maria Pinto
- Anna Moniuszko-Malinowska
- Anna Parfieniuk-Kowerda
- Anna Piekarska
- Anna Szałkowska
- Annarita Giliberti
- Anne Richmond
- Antonella D. ’Arminio Monforte
- Antonella Vincenti
- Antonia Ho
- Antonio Di Biagio
- Antonio Perrella
- Arianna Emiliozzi
- Arianna Gabrieli
- Arsalin Azzadin
- Asma Al Thani &
- Athanasios Kousathanas
- Audrey Coutts
- Axel Schmidt
- Axel Schmidt
- B. Anwar
- B. Attwood
- B. Baines
- B. Blackledge
- B. Borislavova
- B. Chandler
- B. Charles
- B. Creagh-Brown
- B. David
- B. Deacon
- B. Deacon
- B. Digby
- B. Faulkner
- B. Fuller
- B. Gumbrill
- B. Gurung
- B. Hadebe
- B. Hairsine
- B. Hopkins
- B. Johnson
- B. Lenagh
- B. Masunda
- B. Ogg
- B. Patel
- B. Player
- B. Purewal
- B. Scholefield
- B. Shelley
- B. Sloan
- B. Thomas
- B. Wadams
- B. Welsh
- B. Wilkinson
- B. Winter-Goodwin
- B. Yates
- Barbara Rossetti
- Barbara Shih
- Barbara Sobala-Szczygiel
- Beata Puzanowska
- Benedetta Romanin
- Björn Jensen
- Bo Wang
- Brent Richards
- Bruno Frediani
- C. Adams
- C. Ahmed
- C. Almaden-Boyle
- C. Ashbrook-Raby
- C. Basikolo
- C. Battle
- C. Beazley
- C. Beith
- C. Borra
- C. Brandwood
- C. Brantwood
- C. Burnett
- C. Castro Delgado
- C. Clark
- C. Clulow
- C. Collins
- C. Cruz
- C. Davis
- C. Demetriou
- C. Dennis
- C. Dexter
- C. Downes
- C. Eastgate
- C. Finch
- C. Gibson
- C. Gorman
- C. Hays
- C. Hewitt
- C. Holl
- C. Howcroft
- C. Humphrey
- C. Jackson
- C. Jardine
- C. Jennings
- C. Jones
- C. Kaye
- C. Lynch
- C. Lyons
- C. McCulloch
- C. McParland
- C. McParland
- C. Murphy
- C. Parmar
- C. Pawley
- C. Phillips
- C. Phillips
- C. Pothecary
- C. Pothecary
- C. Prendergast
- C. Price
- C. Rishton
- C. Shovelton
- C. Sicat
- C. Stuart
- C. Summers
- C. Swan
- C. Thompson
- C. Thorpe
- C. Tibke
- C. Tierney
- C. Vigurs
- C. Wells
- C. Whitton
- C. Whyte
- C. Wrey Brown
- Carlo Maj
- Carmelo Piscopo
- Caroline Abernathy
- Caterina Lo Rizzo
- Ce Dunmore
- Cecilia Costa
- Ceilia Boz
- Cesira Nencioni
- Chadi Saad
- Charles Hinds
- Charlotte Summers
- Chenqing Zheng
- Chiara Barbieri
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli Raffaelli
- Chris P. Ponting
- Chris Ponting
- Christian Herr
- Christof Winter
- Christoph D. Spinner
- Clark D. Russell
- Claudia Suardi
- Claudio Ferri
- Clemens M. Wendtner
- Cristina Mussini
- D. Antcliffe
- D. Bakthavatsalam
- D. Banach
- D. Baptista
- D. Bell
- D. Branney
- D. Brealey
- D. Brealey
- D. Butcher
- D. Butcher
- D. Childs
- D. Clarke
- D. Collier
- D. Collier
- D. Cristiano
- D. Dawson
- D. Donaldson
- D. Duffin
- D. Golden
- D. Griffin
- D. Hawcutt
- D. Hope
- D. Horner
- D. Kallon
- D. Kaye
- D. Kelly
- D. Loader
- D. Lomas
- D. Martin
- D. McGlynn
- D. McLaughlanv
- D. Melia
- D. Menzies
- D. Mullan
- D. Pogson
- D. Potla
- D. Potoczna
- D. Purohit
- D. Raynard
- D. Salutous
- D. Salutous
- D. Scaletta
- D. Shaw
- D. Skinner
- D. Smyth
- D. Strachan
- D. Tetla
- D. Thornton
- D. Trodd
- D. Vedage
- D. Walker
- D. Warren
- D. Williams
- D. Wood
- D. Wright
- Daniela Francisci
- Danilo Tacconi
- Danny McAuley
- David Bennett
- David Harrison
- David Maslove
- Davide Grassi
- Davide Romani
- Dawn Law
- Diana Alaverdian
- Diana Martonik
- Diego Ripamonti
- Domenico A. Coviello
- Dorota Pasko
- Dorota Zarębska-Michaluk
- E. Abaleke
- E. Allan
- E. Anastasescu
- E. Andrews
- E. Apetri
- E. Beech
- E. Beranova
- E. Bevan
- E. Black
- E. Brinkworth
- E. Collins
- E. Combes
- E. Davies
- E. Dobson
- E. Dooks
- E. Fisher
- E. Gendall
- E. Goff
- E. Goodwin
- E. Gordon
- E. Heeney
- E. Horsley
- E. Hughes
- E. Johnson
- E. Jude
- E. Knights
- E. Lee
- E. London
- E. Maccacari
- E. Massey
- E. McKenna
- E. Meadows
- E. Moncur
- E. Morino
- E. Mwaura
- E. Peasgood
- E. Perkins
- E. Radford
- E. Raith
- E. Salciute L. Grauslyte
- E. Smith
- E. Smithson
- E. Stoddard
- E. Stones
- E. Thomas
- E. Tilney
- E. Timlick
- E. Treus Gude
- E. Virgilio
- E. Watson
- E. Wilby
- E. Wraith
- Edoardo Conticini
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Elvina Gountouna
- Emanuele Catena
- Enrico Cabri
- Enrico Martinelli
- Erika Fiorentini
- Erola Pairo-Castineira
- Erola Pairo-Castineira
- Esther Duncan
- Eugenia Quiros-Roldan
- Eva C. Schulte
- Eva C. Schulte
- F. Anderson
- F. Auld
- F. Bibi
- F. Davies
- F. Farquhar
- F. Fisher
- F. Hurford
- F. Kibutu
- F. McNeela
- F. Moore
- F. Nasir
- F. Trim
- F. Wakinshaw
- F. Williams
- Fabian Brand
- Fabio Lena
- Faisal Almalki
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Fiona Griffiths
- Floriana Valentino
- Francesca Andretta
- Francesca Ariani
- Francesca Colombo
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Minnai
- Francesca Montagnani
- Francesca Vichi
- Francesco Bianchi
- Francesco Brancati
- Francesco Castelli
- Francesco Menichetti
- Francesco Paciosi
- Francesco Raimondi
- Francesco Vladimiro Segala
- Francis P. Crawley
- Franco Maggiolo
- Franco Marinangeli
- G. Andrew
- G. Arbane
- G. Bell
- G. Bercades
- G. Croston
- G. Debreceni
- G. Durrant
- G. Hambrook
- G. Hobden
- G. Houston
- G. Hughes
- G. Jones
- G. Lubimbi
- G. Maloney
- G. Martir
- G. Millen
- G. Mills
- G. O’Connor
- G. Randell
- G. Sadera
- G. Seddon
- G. Sera Howe
- G. Sloane
- G. Subramanian
- G. Tsinaslanidis
- G. Turner
- G. Watson
- G. Wray
- Gabriela Sokołowska
- Gabriella Coiro
- Gabriella Doddato
- Gabriella Maria Squeo
- GEN-COVID Multicenter Study
- Genni Spargi
- GenOMICC Consortium
- Giada Beligni
- Gian Piero Caldarelli
- Gianfranco Parati
- Giovanna Morelli
- Giulia Gori
- Giuseppe Fiorentino
- Giuseppe Merla
- Giusy Tiseo
- Graeme Grimes
- Guillaume Butler-Laporte
- Guillaume Butler-Laporte
- H. Bancroft
- H. Bates
- H. Belfield
- H. Blackman
- H. Blakemore
- H. Brooke
- H. Button
- H. Coles
- H. Curgenven
- H. Filipe
- H. Fox
- H. Golding
- H. Hill
- H. Holcombe
- H. Houlden
- H. Jeffrey
- H. Kent
- H. Langton
- H. McGuinness
- H. Meghari
- H. Millward
- H. Moore
- H. Parker
- H. Prady
- H. Quinn
- H. Rangarajan
- H. Rehman
- H. Reschreiter
- H. Riley
- H. Sainsbury
- H. Savill
- H. Sturgeon
- H. T-Michael
- H. Tench
- H. Tiveran
- H. Turner
- H. Whittle
- H. Willis
- H. Wood
- Hadeel AlBardis
- Hamdi Mbarek
- Hanning Mal
- Helen Szoor-McElhinney
- Hugh Montgomery
- Hugo Zeberg
- Hugo Zeberg
- I. Ali Mohamed Ali
- I. Balagosa
- I. Birkinshaw
- I. Burn
- I. Chadbourn
- I. D. Clement
- I. Edmond
- I. Frost
- I. Hass
- I. Hussain
- I. Lancoma-Malcolm
- I. Leadbitter
- I. Nagra
- I. Otaha
- I. Otahal
- I. Turner-Bone
- I. Welters
- I. White
- I. Wynter
- Ilaria Meloni
- Ilaria Rancan
- Immacolata Andolfo
- Isabella Zanella
- Iwona Mozer-Lisewska
- J. Allan
- J. Barker
- J. Bewley
- J. Biddle
- J. Birch
- J. Birch
- J. Bradley-Potts
- J. Brent Richards
- J. brown
- J. Bryant
- J. Butler
- J. Camsooksai
- J. Camsooksai
- J. Carter
- J. Caterson
- J. Cebrian Suarez
- J. Cockerill-Taylor
- J. Cole
- J. Colley
- J. Cooper
- J. Cupitt
- J. Cuttler
- J. Daglish
- J. Dawson
- J. Dearden
- J. Deery
- J. Donnachie
- J. Dykes
- J. Easton
- J. Fernandez Roman
- J. Finn
- J. Fletcher
- J. Frankham
- J. Gaylard
- J. Gill
- J. Godden
- J. Goodsell
- J. Gregory
- J. Greig
- J. Gurasashvili
- J. Hardy
- J. Harris
- J. Hatton
- J. Hawes
- J. Highgate
- J. Hornsby
- J. Hulme
- J. Hunt
- J. Hutter
- J. Ingham
- J. Jones
- J. Jones
- J. K. Baillie
- J. Kassam
- J. Kenneth Baillie
- J. Kenneth Baillie
- J. Kenneth Baillie
- J. Keshet-price
- J. Liew
- J. Little
- J. Mallinson
- J. Martin
- J. Matthews
- J. McCormick
- J. Medhora
- J. Melville
- J. Moreno Cuesta
- J. Morgan
- J. Naisbitt
- J. North
- J. Parkin
- J. Pendlebury
- J. Perez
- J. Perry
- J. Pheby
- J. Philbin
- J. Pinnell
- J. Queiroz
- J. Radhakrishnan
- J. Reid
- J. Rhodes
- J. Riches
- J. Ritzema
- J. Ruddy
- J. Ryan-Smith
- J. Scriven
- J. Scriven
- J. Scriven
- J. Shiel
- J. Singh
- J. Singleton
- J. Smith
- J. Sowter
- J. Strickley
- J. Summers
- J. Taylor
- J. Tebbutt
- J. Texeira
- J. Thomas
- J. Thrush
- J. Tomlinson
- J. Valentine
- J. Whiteside
- J. Wilkins
- J. Willson
- J. Zamikula
- Jacek Bogocz
- Jacob Rosén
- James F. Wilson
- James Furniss
- James Furniss
- Jane Weaver
- Jen Meikle
- Jerzy Jaroszewicz
- Jessica Nordlund
- Jian Yang
- Joanna Chorostowska-Wynimko
- Jochen Schneider
- Johanna Erber
- John Kenneth Baillie
- Johnny Millar
- Jonathan Millar
- Jörn Walter
- Julia Fazaal
- Julia Schröder
- Julian Knight
- Junghyun Jung
- Justyna Kowalska
- Justyna Raczkowska
- K. Archer
- K. Austin’
- K. Baines
- K. Bauchmuller
- K. Beaumont
- K. Beesley
- K. Black
- K. Burns
- K. Burt
- K. Cawley
- K. Cawthron
- K. Connolly
- K. Convery
- K. Criste
- K. Dale
- K. Darlington
- K. Davies
- K. Dent
- K. Douglas
- K. Duffy
- K. Elliott
- K. Elston
- K. English
- K. Fernandes
- K. Fletcher
- K. Gilbert
- K. Golder
- K. Hammerton
- K. Hanson
- K. Hard
- K. Harrington
- K. Hayes
- K. Holding
- K. Holdroyd
- K. Howard
- K. Hugill
- K. Inweregbu
- K. Jackson-Lawrence
- K. Karthik
- K. King
- K. Knowles
- K. Lang
- K. Liyanage
- K. Manso
- K. Netherton
- K. Postlethwaite
- K. Potts
- K. Prager
- K. Praman
- K. Priestley
- K. Pritchard
- K. Puxty
- K. Reid
- K. Riches
- K. Rooney
- K. Sellick
- K. Shuker S. Greer
- K. Simpson
- K. Simpson
- K. Slevin
- K. Smith
- K. Sollesta
- K. Stammers D. Fottrell-Gould
- K. Stroud
- K. Sweet
- K. Tatham
- K. Turner
- K. Webster
- K. White
- K. Williams
- K. Xavier
- Kamil Grubczak
- Karolina Chwialkowska
- Katarzyna Hafezi
- Kathy Rowan
- Kathy Rowan
- Katia Capitani
- Katja Hanslin Anna Gradin
- Kerstin U. Ludwig
- Kerstin U. Ludwig
- Kirstie Morrice
- Konrad Rawlik
- Kristina Zguro
- Krzysztof Simon
- Krzysztof Tomasiewicz Małgorzata Pawłowska
- L. Abel
- L. Akeroyd
- L. Allen
- L. Armstrong
- L. Barclay
- L. Benham
- L. Botfield
- L. Bough
- L. Brimfield
- L. Bunni
- L. Cabrelli
- L. Cagova
- L. Catlow
- L. Ding
- L. Ferguson
- L. Folkes
- L. Foster
- L. Garner
- L. Gemmell
- L. Georg
- L. Glass
- L. Glass
- L. Gledhill
- L. Grimmer
- L. Gurr
- L. Harrison
- L. Hodgson
- L. Hudig
- L. Keating
- L. Kittridge
- L. Lankester
- L. Lennon
- L. Lim
- L. Ma
- L. Marshall
- L. Matupe
- L. Mc Morrow
- L. McQuillan
- L. Mew
- L. Mostoles
- L. Mwaura
- L. Newey
- L. Ortiz-Ruiz de Gordoa
- L. Ortiz-Ruizdegordoa
- L. O’Brien
- L. O’Malley
- L. O’Neill
- L. Park
- L. Pippard
- L. Prentice
- L. Rad
- L. Ramos
- L. Riddles
- L. Roche
- L. Roche
- L. Rooney
- L. Rosaroso
- L. Shaw
- L. Smith
- L. Stevenson
- L. Symon
- L. Thomis
- L. Thornton
- L. Thrasyvoulou
- L. Ting
- L. Tonks
- L. Turner
- L. van Koutrik
- L. Wilcox
- L. Wild
- L. Wilding
- L. Woods
- L. Wren
- L. Zitter
- Laura Bergantini
- Laura Di Sarno
- Lee Murphy
- Leonardo Croci
- Leonardo Gianluca Lacerenza
- Letizia Attala
- Lia Crotti
- Lisa Knopp
- Lombardi Stefania
- Lorenzo Salerni
- Lorna Donnelly
- Louise Cullum
- Louise Macgillivray
- Loukas Moutsianas
- Lowell Ling
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Lucia Vietri
- Lucija Klaric
- Luisa Tavecchia
- M. Abdelrazik
- M. Al-Moasseb
- M. Balasubramaniam
- M. Bellamy
- M. Birt
- M. Blunt
- M. Bokhari
- M. Bolton
- M. Brady
- M. Breekes
- M. Brett
- M. Bromley
- M. Bruce
- M. Brunton
- M. Burton
- M. Callaghan
- M. Carmody
- M. Carnahan
- M. Casey
- M. Casey
- M. Caswell
- M. Chablani
- M. Clapham
- M. Clark
- M. Clark
- M. Coulding
- M. Croft
- M. Cunningham
- M. Davey
- M. Davies
- M. Davies
- M. Edward
- M. Elhassan
- M. Elsaadany
- M. Faulkner
- M. Forsey
- M. Frise
- M. Gellamucho
- M. Gill
- M. Gummadi
- M. Halkes
- M. Harkins
- M. Hill
- M. Hobrok
- M. Holland
- M. Home
- M. Hussain
- M. Jackson
- M. Jacqui
- M. K. Phull
- M. Kent
- M. Khan
- M. Latif
- M. Leigh
- M. Lopez Martinez
- M. Lyons
- M. Male
- M. Marani
- M. Margarson
- M. Marotti
- M. Matharu
- M. McDonald
- M. McLaughlin
- M. McMahon
- M. McPhail
- M. Meredith
- M. Mpelembue
- M. Msiska
- M. Mulcahy
- M. Nauman Akhtar
- M. Newton
- M. Oblak
- M. Odam
- M. Ostermann
- M. Patel
- M. Peiu
- M. Penacerrada
- M. Peters
- M. Popescu
- M. Poulaka
- M. Purewal
- M. Raj
- M. Robinson
- M. Sangombe
- M. Shankar-Hari
- M. Sim
- M. Slaughter
- M. Smith
- M. Spivey
- M. T. Hijazi
- M. Taylor
- M. Taylor
- M. Taylor
- M. Taylor
- M. Taylor
- M. Templeton
- M. Thankachen
- M. Thirumaran
- M. Thomas
- M. Tolson
- M. Usher
- M. Varghese
- M. Verlande
- M. Vertue
- M. Watters
- M. White
- M. Williams
- M. Wills
- M. Woodruff
- M. Young
- Maaike Swets
- Maciej Bura
- Maddalena Fratelli
- Magdalena Niemira
- Magdalena Ochab
- Malak Abedalthagafi Manal Alaamery
- Malcolm G. Semple
- Manola Pisani
- Manu Shankar-Hari
- Marc M. Berger
- Marcello Maffezzoni
- Marcin Moniuszko
- Marco Castori
- Marco Falcone
- Marco Feri
- Marco Gori
- Marco Mandalà
- Marco Rizzi
- Marco Tanfoni
- Marco Vecchia
- Margherita Baldassarri
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Lorubbio
- Maria Palmieri
- Maria Teresa La Rovere
- Marie Zechner
- Marie Zechner
- Mario Capasso
- Mario Tumbarello
- Mario U. Mondelli
- Markus M. Nöthen
- Marta Colaneri
- Marta Corridi
- Mary Ann Belli
- Massimiliano Fabbiani
- Massimo Antonio Di Pietro
- Massimo Carella
- Massimo Girardis
- Massimo Vaghi
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Maurizio Bussotti
- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
- Max Head Fourman
- Max Head Fourman
- Melania Degli Antoni
- Menè Roberto
- Michael Hultström
- Michael Hultström
- Miklos Lipcsey
- Miklós Lipcsey
- Mirco Lenzi
- Mirella Bruttini
- Miriam Lucia Carriero
- Miriana D’Alessandro
- Mirjam Lista
- Miroslaw Czuczwar
- Mirosław Kwasniewski
- Mohamed Fawzy
- Moneera Alsuwailm
- Monika Pazgan-Simon
- N. Ahmad
- N. Bandla
- N. Baxter
- N. Bhatia
- N. Boyle
- N. Capps
- N. Clarke
- N. Crisp
- N. Davidson
- N. Dormand
- N. Grau
- N. Harris
- N. Jacques
- N. Keenan
- N. Lancaster
- N. Love
- N. MacCallum
- N. Michalak-Glinska
- N. Motherwell
- N. Muchenje
- N. Nikitas
- N. Pathan
- N. Pattison
- N. Proudfoot
- N. Rea
- N. Richardson
- N. Rodden
- N. Roe
- N. Rogers
- N. Runciman
- N. Schumacher
- N. Schunki
- N. Slawson
- N. Staines
- N. Thomson
- N. Truman
- N. White
- Nicholas Parkinson
- Nick Parkinson
- Nicky Day
- Nicola Picchiotti
- Nicolas Casadei
- Nicole Ludwig
- Nora Aljawini
- O. Adanini
- O. Akinkugbe
- O. Ezeobu
- O. Hamilton
- O. Jones
- O. Kelsall
- O. Mercer
- O. Mitchelmore
- O. Olufuwa
- O. Prysyazhna
- O. Zongo
- Olaf H. Riess
- Oliver Witzke
- Oreste De Vivo
- P. Alexander
- P. Anderson
- P. Austin
- P. Bamford
- P. Barry
- P. Boyle
- P. Clark
- P. Coghlan
- P. Doble
- P. Donnison
- P. Ebano
- P. Gondo
- P. Grant
- P. Harding
- P. Henderson
- P. Hutton
- P. Jackson
- P. MacGoey
- P. May
- P. McConnell
- P. Mercer
- P. O’Brien
- P. O’Neil
- P. Parkinson
- P. Parsons
- P. Paul
- P. Polgarova
- P. Ranga
- P. Rice
- P. Rogers
- P. Saunderson
- P. Shanmugasundaram
- P. Springle
- P. Szedlak
- P. Turner
- P. Williams
- Pamela Raggi
- Paola Bergomi
- Paola Petrocelli
- Paolo Cameli
- Paolo Piacentini
- Patrizia Casprini
- Patrizia Zucchi
- Paul Finernan
- Paweł Olszewski
- Peter J. M. Openshaw
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pietro Pinoli
- Piotr Wasilewski
- R. Astin-Chamberlain
- R. Barber
- R. Baruah
- R. Bi
- R. Bolton
- R. Bowles
- R. Boyle
- R. Bradley
- R. Campbell
- R. Campbell
- R. Chan
- R. Charlesworth
- R. Clark
- R. Crawley
- R. Crowe
- R. Cusack
- R. Davies
- R. Doonan
- R. Flanagan
- R. Gascoyne
- R. Girach
- R. Gomez
- R. Griffiths
- R. Hall
- R. Hamill
- R. Haque
- R. Harford
- R. Harper
- R. Herdman-Grant
- R. Howle
- R. Jacob
- R. Jha
- R. Johnson
- R. Jones
- R. Joy
- R. Kanu
- R. Kapoor
- R. Kausar
- R. Khade
- R. Kitson
- R. Kumar
- R. Lean
- R. Lim
- R. Loosley
- R. M. Genetu
- R. Marshall
- R. O’Leary
- R. Parasomthy
- R. Parker
- R. Partridge
- R. Penn
- R. Pepermans Saluzzio
- R. Pollard
- R. Price
- R. Prout
- R. Pugh
- R. Raobaikady
- R. Reece-Anthony
- R. Rikunenko
- R. Rojo
- R. Saha
- R. Sandu
- R. Shaw
- R. Shokkar
- R. Simms
- R. Stead
- R. Stewart
- R. Sundaram
- R. Tully
- R. Tutton
- R. Vincent
- R. Walker
- R. Wilcox
- R. Wolf-Roberts
- R. Worner
- R. Wulandari
- Rachel Law
- Radja Badji
- Raffaele Bruno
- Raffaele Scala
- Ranran Zhai
- Regina Podlasin
- Renzo Scaggiante
- Riccardo Colombo
- Richard Clark
- Rita Perna
- Robert Bals
- Robert Flisiak
- Robert Frithiof
- Robert Frithiof
- Roberta Russo
- Rosangela Artuso
- Ross Hendry
- Rossella Tita
- Ruth Armstrong
- S. Agrawal
- S. Allen
- S. Allibone
- S. Anderson
- S. Archer
- S. Bano
- S. Bean
- S. Beavis
- S. Bell
- S. Bennett
- S. Benyon
- S. Bird
- S. Blowes
- S. Board
- S. Bonner
- S. Buckley
- S. Campos
- S. Cathcart
- S. Chapman
- S. Charlton
- S. Cherian
- S. Chukkambotla
- S. Clamp
- S. Clark
- S. Clements
- S. Coetzee
- S. Cole
- S. Cornell
- S. Cutler
- S. Dale
- S. Donlon
- S. Farnell-Ward
- S. Fowler
- S. Garrioch
- S. Gibson
- S. Gopal
- S. Gurung Rai
- S. Henderson
- S. Hierons
- S. Hope
- S. Humphreys
- S. Hussain
- S. Jenkins
- S. Jhanji
- S. Jones
- S. Jose
- S. Joseph
- S. Kaul
- S. Keenan
- S. Keith
- S. Kennedy-Hay
- S. Kimber
- S. Kumar
- S. Latham
- S. Leaver
- S. Lee
- S. Leggett
- S. MacFadyen
- S. Manna
- S. Marriott
- S. Masuko
- S. McIvor
- S. McKechnie
- S. Mellor
- S. Mepham
- S. Metherell
- S. Mitchard
- S. Mohamed Ally
- S. Monnery
- S. Moore
- S. Morrison
- S. Moultrie
- S. Mtuwa
- S. Mulla
- S. Munt
- S. Murdoch
- S. O’Sullivan
- S. Packham
- S. Patch
- S. Pearson
- S. Pitts
- S. Preston
- S. Purvis
- S. Quaid
- S. Ray
- S. Roche
- S. Rose
- S. Rundell
- S. Salmi
- S. Sathe
- S. Selvanayagam
- S. Shelton
- S. Shepardson
- S. Siddiqui
- S. Sousa Arias
- S. Spencer
- S. Srikaran
- S. Stone
- S. Swann
- S. Tilbey
- S. Turki
- S. Turney
- S. Twiss
- S. Wadd
- S. Whiteley
- S. Williams
- S. Wood
- S. Yussuf
- Sabino Scolletta
- Sabrina Ravaglia
- Said I. Ismail
- Salam Massadeh
- Sandra Uszok
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara Bulow Anderberg
- Sara Clohisey
- Sara Clohisey
- Sara Clohisey Peter Horby
- Sara Modica
- Sarah Galien
- Sarah Iacopini
- Sarah Law
- Sarah McCafferty
- Sauro Luchi
- Saverio Giuseppe Parisi
- Selina Rolker
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Silvia Baroni
- Silvia Cappelli
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slawomir Czaban
- SMelling
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Sten Rubertsson
- Stephan Ossowski
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Sławomir Pancewicz
- T. Anderson
- T. Arden
- T. Baird
- T. Behan
- T. Bemand
- T. Cosier
- T. Coventry
- T. Duncan
- T. Felton
- T. Geary
- T. Hazleton
- T. Joefield
- T. Kannan
- T. Marsden
- T. Martin
- T. McHugh
- T. Newman
- T. Nortcliffe
- T. O. Jones
- T. Pogreban
- T. Rees
- T. Samakomva
- T. Smith
- T. Smith
- T. Szakmany
- T. Varghes
- T. Williams
- T. Wood
- Tammy Gilchrist
- Thorsten Brenner
- Tim Walsh
- Tiziana Bachetti
- Tomas Luther
- Tommaso Matucci
- Tony Wackett
- Torsten Feldt
- Trevor Paterson
- Tullio Trotta
- U. Poultney
- Ulrike Protzer
- Umberto Zuccon
- Urszula Korotko
- Urszula Lechowicz
- Urszula Polowianiuk
- V. Amin
- V. Anumakonda
- V. Bastion
- V. Cannons
- V. Crickmore
- V. Gopal
- V. Irvine
- V. Kasipandian
- V. Krishnamurthy
- V. Lake
- V. Linnett
- V. Martinson
- V. Nagarajan
- V. Page
- V. Parris
- V. Parris
- V. Pristopan
- V. Ratnam
- V. Rivers’
- V. Sarathy
- V. Thomas
- V. Thwaites
- V. Tuckey
- V. Turner
- V. Wagstaff
- V. Waugh
- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Changes in correlation between promoter methylation and gene expression in cancer
- Author
- A Acharjee
- A Ben-Hur
- A Efrat
- A Meissner
- A Mortazavi
- AE Hoerl
- AK Maunakea
- BE Stranger
- C Nestor
- CN Henrichsen
- D Sproul
- D Sproul
- D Sproul
- DR Cox
- E Li
- EA Houseman
- EJ Keogh
- EL Kaplan
- Fabien Reyal
- G Yu
- HM Zhang
- I Keshet
- IJH van Vlodrop
- J Newell-Price
- Jean-Philippe Vert
- JM Vaquerizas
- JP Reddington
- K Struhl
- KD Hansen
- KE Varley
- L Laurent
- L Rabiner
- LAE Hughes
- M Bibikova
- M Ehrlich
- M Esteller
- M Haffner
- M Kulis
- M Kulis
- M Lauss
- M Reich
- M Toyota
- Matahi Moarii
- ND Vanderkraats
- PM Das
- PW Laird
- R Lister
- R Tibshirani
- RA Irizarry
- S Jin
- S Kriaucionis
- T Pollex
- TD Wu
- Valentina Boeva
- W Timp
- Y Qu
- Y Zhang
- ZD Smith
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial
- Author
- Abano N
- Abbott L
- Abbott W
- Abdul-Hamid A
- Abdul-Saheb M
- Abousleiman Y
- Abubakar S
- Adedoyin T
- Adie K
- Affley B
- Ahlquist K
- Ahmad N
- Ahmed A
- Ahmed S
- Ahmed Z
- Al Hussayni S
- Al-Samarrai N
- Alam I
- Alam S
- Ali A
- Ali K
- Allen C
- Allen J
- Allison J
- Allsop H
- Allsop L
- Almadenboyle C
- Alvares W
- Alwis L
- Alwis L
- Amero J
- Amis E
- Amlani S
- Amor K
- Anazodo C
- Anderson R
- Andrews J
- Anjum T
- Annamalai A
- Annison F
- Anthony A
- Appiatse G
- Archer J
- Argandona L
- Arif S
- Armer C
- Armstrong L
- Aruldoss P
- Arundell L-L
- Ashcroft P
- Asokanathan A
- Aubrey B
- Augustin M
- Auld G
- Austin D
- Awolesi J
- Ayer J
- Azim A
- Badiani B
- Bahk A
- Bailey D
- Bailey L
- Bakawala R
- Baker J
- Baker P
- Balami J
- Balasubramanian V
- Balian L
- Ball J
- Ball L
- Balogun I
- Bamford E
- Bamford J
- Banaras A
- Barber M
- Barbon E
- Barcroft H
- Barker J
- Barron C
- Barron L
- Barry A
- Barugh A
- Bate J
- Bateman G
- Bates M
- Bathula R
- Beadle H
- Beadling T
- Beard R
- Beardmore C
- Bedford C
- Bedford E
- Begum Y
- Bell A
- Bell J
- Bell J
- Bell S
- Bell S
- Bellfield R
- Benford A
- Bent C
- Benton L
- Beranova E
- Beranova E
- Besley S
- Bhalla A
- Bhandari M
- Bharaj K
- Bhargava M
- Bhattad M
- Bhome G
- Billingham S
- Birns J
- Black T
- Blackburn J
- Blackburn R
- Blair G
- Blane S
- Blight A
- Blight A
- Bloom S
- Board J
- Board S
- Bohannan E
- Bokhari M
- Bolton M
- Bond K
- Booth C
- Booth L
- Borley J
- Borley J
- Boulton A
- Boulton R
- Bower R
- Bowers R
- Bowie E
- Bowler H
- Bowring A
- Box C
- Bradfield S
- Bradshaw E
- Brady M
- Brammer S
- Bray H
- Breeds J
- Brewer C
- Brezitski M
- Bridger H
- Brighouse-Johnson C
- Brodie C
- Brodie F
- Brookes L
- Brotheridge S
- Brotherton L
- Broughton D
- Brown C
- Brown E
- Brown L
- Brown P
- Brown R
- Brown S
- Bruce D
- Buchan R
- Buchanan D
- Buckley C
- Bunworth K
- Burgess D
- Burgess L
- Burgess S
- Burgoyne J-R
- Burn I
- Burn M
- Burnip R
- Burns A
- Burns E
- Burova M
- Burton H
- Burton K
- Butler A
- Butler D
- Butler F
- Butler R
- Butler S
- Butt G
- Bwalya A
- Byrne A
- Cageao J
- Cain R
- Caine S
- Cairns F
- Cannon E
- Cape A
- Carpenter M
- Carpio R
- Carr L
- Carson S
- Carter T
- Cartwright B
- Cassidy T
- Cattermole E
- Causley C
- Ceccarelli D
- Chadbourn I
- Chadha D
- Chakrabarti A
- Chamberlain A
- Chan K
- Chandler S
- Chandrasena D
- Chaplin S
- Chapman N
- Chapman R
- Chapter T
- Charles B
- Chatterjee K
- Chattha N
- Chauhan M
- Chembala J
- Cheripelli B
- Chesser D
- Chin Y-M
- Chinery E
- Chohan O
- Chopra N
- Choy L
- Christie D
- Christie M
- Christmas N
- Chun Y
- Clark Brown P
- Clarke B
- Clarke C
- Clarke N
- Clarke R
- Clarke S
- Clarkson E
- Claydon F
- Clayton S
- Clements C
- Cloud G
- Cluckie G
- Coburn I
- Cohen D
- Collas D
- Collins K
- Collins S
- Colwill D
- Connell L
- Constantin C
- Cook A
- Cook P
- Cook S
- Cooke D
- Cooper L
- Cooper M
- Cooper P
- Copeland C
- Corbett T
- Corrigan P
- Cotterill D
- Cottrell P
- Cottrell P
- Courtauld G
- Couser M
- Cowan R
- Cowie L
- Cox C
- Cox C
- Cox P
- Coyle J
- Crabtree K
- Crause J
- Crawford P
- Creeden R
- Crisp S
- Crofts M
- Cron N
- Croome V
- Crothers S
- Crowther H
- Cuddy S
- Cuenoud L
- Culbert A
- Cullen C
- Culmsee C
- Cunningham J
- Cunningham J
- Curtis J
- Curwen R
- Cusack E
- Cvoro V
- Dabbagh S
- Dainty A
- Dakin K
- Dangri P
- Daniel D
- Darnbrook G
- Das S
- Datta P
- Davenport S
- Davey R
- David A
- David O
- David O
- Davies Y
- Davis F
- Davy M
- Day D
- Day N
- Dayal S
- De Bruijn S
- De Michele Hock L
- Dealing S
- Deary A
- Dellafera D
- Denham L
- Denic H
- Dennett K
- Dennis M
- Denny L
- Deveciana A
- Devine J
- Devitt N
- Dhakal M
- Dhar S
- Dickinson C
- Dickson C
- Dima S
- Dimartino V
- Dinsmore L
- Dixon L
- Dodd E
- Dodsworth K
- Donaldson D
- Donaldson D
- Donaldson F
- Donaldson S
- Donne C
- Donninson M
- Doughty L
- Douglas E
- Douris G
- Dow L
- Dowling T
- Doyle C
- Doyle D
- Drake M
- Drever J
- Drew J
- Driver E
- Drummond G
- Dsouza M
- Dube J
- Duberley S
- Duckett T
- Duffy J
- Duffy M
- Duggan C
- Dunn G
- Dunn S
- Dunne A
- Durairaj R
- Duran B
- Durman H
- Dutta D
- Duty S
- Dyer N
- Dyer S
- Dymond H
- Dynan K
- Earnshaw P
- Eastwood MJ
- Edmunds T
- Edwards A
- Edwards B
- Edwards C
- Edwards M
- Egerton S
- Eglinton C
- Eglinton C
- El Nour A
- El Tawil S
- Eldridge L
- Elitova S
- Ellam J
- Elliott E
- Elliott K
- Elliott M
- Ellis S
- Emms C
- Emsley H
- Endean K
- England T
- Epie N
- Epstein E
- Erande R
- Erumere E
- Esisi B
- Espanol A
- Esson D
- Evans N
- Evans R
- Evans R
- Evans S
- Ewing J
- Fairweather M
- Farquhar F
- Farron C
- Fazal A
- Featherstone J
- Fennelly R
- Ferdinand P
- Fergey L
- Fields A
- Finlay S
- Finney K
- Fitzsimmons P
- Fleming A
- Fletcher G
- Fletcher J
- Fluskey T
- Fong R
- Foot J
- Foote L
- Forbes J
- Ford G
- Fotherby K
- France E
- Francis J
- Francis L
- Fraser G
- Fraser R
- French R
- Frith A
- Frudd J
- Fung Lo S
- Funnell S
- Furnace J
- Furness R
- Gaba W
- Gadi N
- Gainsborough N
- Gallen B
- Gallifent R
- Gamble GE
- Gamble P
- Garcia T
- Garcia-Alen L
- Gartrell I
- Gautam N
- Gaylard J
- Ghani U
- Ghatala R
- Ghouri I
- Ghulam R
- Giallombardo E
- Gibbs C
- Gibson E
- Gillian A
- Gillian A
- Glover R
- Goff A
- Gohil S
- Goldenberg L
- Golding W
- Goldsworthy M
- Gompertz P
- Gonzalez C
- Goorah MN
- Gordon L
- Goshawk S
- Goulding A
- Gow H
- Graham C
- Graham J
- Graham L
- Graham S
- Green C
- Greenhalgh L
- Greenwood R
- Gregary B
- Greig J
- Griffiths K
- Griffiths K
- Grimmer C
- Grocott J
- Gulli G
- Gunathilagan G
- Guo F
- Gupwell K
- Guthrie LB
- Guyler P
- Hackett M
- Hagan S
- Hague A
- Haider S
- Haigh S
- Hairsine B
- Hakkak J
- Haley M
- Hall F
- Hamid U
- Hamill D
- Hamilton A
- Hamilton H
- Hammond T
- Hancevic M
- Handley D
- Hankey GJ
- Hankin V
- Hann G
- Hannon N
- Haque K
- Haque M
- Haque N
- Hardwick A
- Hare C
- Hargreaves M
- Hargroves D
- Haritakis M
- Haritakis M
- Harkness K
- Harlekar P
- Harman P
- Harper M
- Harrington F
- Harris K
- Harrison L
- Harrison M
- Harvey M
- Hasan A
- Hashmi A
- Hassan A
- Hassan H
- Hassan M
- Hawkes-Blackburn M
- Hayden D
- Hayes A
- Hayes K
- Hayes N
- Hayhoe H
- Hayman R
- Hazell L
- Healey GL
- Hedges A
- Hedstrom A
- Hemsley A
- Hervey S
- Hewitt C
- Hewitt E
- Hiden J
- Hill A
- Hill L
- Hilton D
- Hindle J
- Hlaing T
- Hmu C
- Hoeritzauer I
- Hogan A
- Hogan C
- Holden M
- Holland M
- Holland S
- Hollinshead P
- Holloway A
- Holmes C
- Homan JE
- Honour S
- Hooley M
- Horton J
- Hough L
- Hough M
- House A
- Howaniec L
- Howaniec L
- Howard G
- Howard J
- Howard-Brown J
- Howe J
- Howell G
- Huang X
- Hughes C
- Hughes C
- Hughes C
- Hughes M
- Hull G
- Humphrey S
- Hungwe R
- Hunt L
- Hunt N
- Hunter N
- Hunter N
- Hurdowar S
- Hurford F
- Hurley L
- Hussain M
- Hynes A
- Idrovo L
- Imam J
- Innes K
- Irvine J
- Ispoglou S
- Iveson E
- Jackson J
- Jackson L
- Jackson S
- Jackson T
- Jacob P
- Jagger J
- James A
- James C
- James M
- James T
- Janbieh J
- Jarrett D
- Jeffs C
- Jenkins C
- Jenkinson D
- Jennings G
- Jennings-Preece K
- Johnson A
- Johnson L
- Johnson M
- Johnson VV
- Johnston S
- Jones A
- Jones K
- Jones P
- Jones P
- Jones R
- Jones R
- Jones S
- Jones S
- Jones S
- Jones S
- Jones S
- Jones T
- Jones V
- Jones V
- Joyson A
- Justin F
- Kabash H
- Kalathil L
- Kalita M
- Kalladka D
- Kamara C
- Kambafwile M
- Kamuriwo L
- Kane I
- Kauldhar K
- Kavanagh K
- Kawafi K
- Keeling A
- Keeling E
- Keeling M
- Keenan S
- Kelavkar S
- Kelly C
- Kelly D
- Kelly S
- Keltos M
- Kemp LJ
- Kennedy J
- Kennedy K
- Kent A
- Kerwood L
- Keshet-Price J
- Keskeys R
- Ketley-O'donel J
- Khaira J
- Khan A
- Khan A
- Khan M
- Khan MF
- Khan N
- Khan S
- Khan T
- Khan U
- Kidd M
- Kidd S
- Kingwell H
- Kirthivasan R
- Krasinska-Chavez M
- Krishnamurthy R
- Krishnan M
- Kullane S
- Kumar P
- Kumar S
- Kundu A
- Kunhunny S
- Kyu M
- Ladner R
- Lambert C
- Lampard R
- Landicho M
- Lane C
- Lane L
- Lang M
- Langley M
- Lashley D
- Latter L
- Laurence J
- Lawrence K
- Lawrence T
- Le V
- Leach S
- Leason S
- Lee Carbon L
- Leonard C
- Leonard D
- Leonard D
- Leonard J
- Lepore M
- Levett T
- Levy S
- Lewis S
- Lijko S
- Lindert R
- Lindley C
- Little C
- Littleton E
- Littlewood K
- Livingstone G
- Lock S
- Loganathan S
- Loganathan T
- Lohan C
- Longland B
- Loosley R
- Lopez P
- Lowe J
- Lowthorpe V
- Lucas L
- Luder R
- Lumsdale G
- Lundström E
- Lush A
- Lyle A
- Lynda C
- Lynne D
- Lyon H
- Maatouk A
- Macdonald J
- Mackenzie N
- Macleod F
- Macleod M
- Macleod M
- Macleod MJ
- Macraild A
- Maguire H
- Maguire S
- Mahalingam S
- Mahawish K
- Maiden S
- Majid A
- Makanju E
- Makanju E
- Makawa L
- Man A
- Maney A
- Mangion D
- Mankin G
- Mannava N
- Manoj A
- Margalef J
- Margerum E
- Marigold JR
- Markova S
- Marks K
- Markus H
- Marner M
- Marshall S
- Maschauer E
- Mason C
- Mason G
- Massyn M
- Masters L
- Mate A
- Mathew M
- Mathieson P
- Maund B
- Mavinamane S
- Mawer S
- Mcauley S
- Mccann P
- Mcclelland B
- Mccormick K
- Mccormick K
- Mcdonald C
- Mcdonald S
- Mcgee J
- Mcghee C
- Mcgill C
- Mcgoldrick C
- Mcgowan D
- Mcgowan D
- Mcgrath A
- Mcilmoyle J
- Mcinnes C
- Mckenna A-M
- Mckenna S
- Mckenzie G
- Mclaughlin J
- Mclean B
- Mcleish K
- Mcloughlin A
- Mcneela F
- Mcredmond C
- Mead D
- Mead G
- Mears K
- Mears K
- Medcalf C
- Meegada M
- Meenakshisundaram S
- Mehta H
- Meir J
- Melander S
- Melikyan E
- Mellor Z
- Meneses C
- Mercer L
- Merritt C
- Metcalf AK
- Metiu M
- Mikhail S
- Miller K
- Miller L
- Miller R
- Mintias S
- Mir R
- Misra A
- Mitchell J
- Mitchelson K
- Mohammed N
- Mohd Nor A
- Mokoena L
- Montgomery K
- Moore K
- Morales D
- Moreton F
- Morgan D
- Morgan G
- Morrison S
- Morse D
- Moseley L
- Motherwell N
- Moynihan B
- Mpelembue M
- Mucha A
- Mudd P
- Muddegowda G
- Mukherjee I
- Mumani S
- Munuswamy Vaiyapuri E
- Murali E
- Murphy P
- Murphy R
- Murray A
- Murray V
- Mutton S
- Myint M
- Nadarajan V
- Naeem M
- Nagaratnam K
- Nair A
- Nair P
- Nallasivan A
- Namushi R
- Naqvi A
- Naqvi SN
- Nardone L
- Narh C
- Nari R
- Nasar AM
- Natarajan I
- Needle A
- Needle R
- Nelson S
- Nendick R
- Netherton K
- Nevajda B
- Neves-Silva Y
- Nevinson J
- Newman J
- Ng KX
- Ngeh J
- Nicholas P
- Nicolson A
- Nishiyama T
- Noor S
- Norton K
- Nurse E
- Nyo K
- O Neill M
- Oakley S
- Obaid M
- Ocallaghan A
- Oconnell J
- Oconnell S
- Ofori K
- Oji N
- Omahony P
- Omer S
- Omodunbi O
- Orath Prabakaran R
- Orefo C
- Orr S
- Orrell L
- Orugun E
- Osborn M
- Osborne E
- Oshodi A
- Osikominu E
- Osman K
- Otter L
- Ovington C
- Owoyele E
- Oza D
- Pace A
- Pagan J
- Pai Y
- Pak D
- Pallikona U
- Palmer H
- Palmones J
- Parakramawansha R
- Parkinson S
- Parry A
- Partridge R
- Passeron N
- Patel B
- Patel F
- Patel K
- Patel R
- Patel R
- Patel S
- Paterson J
- Patterson C
- Pattni R
- Paulton R
- Pawley C
- Peacocke A
- Peixoto C
- Penney H
- Penwarden I
- Pereira R
- Perkins C
- Perry D
- Perry J
- Persad N
- Peters G
- Peters J
- Petrides K
- Pitcher E
- Pitt Ford A
- Pitt M
- Porteous A-M
- Potter A
- Potter I
- Pound S
- Power M
- Power S
- Prasad S
- Pressly V
- Preston K
- Price F
- Price J
- Proeschel H
- Proudfoot F
- Pryor J
- Punekar S
- Punnoose S
- Purcell J
- Purohit K
- Pusalkar A
- Putteril J
- Qamar S
- Quinn O
- Ragab S
- Raj S
- Rajapakse A
- Ramachandra S
- Ramadan H
- Rana A
- Rana P
- Randall M
- Ranga L
- Rangasamy R
- Ransom B
- Rashed K
- Rashmi S
- Ravenhill G
- Rayessa R
- Raza SA
- Razak S
- Razik FZ
- Reckless I
- Redjep O
- Rees A
- Reid F
- Reid J
- Reidy P
- Remegoso A
- Rhian H
- Richards E
- Ritchie D
- Ritchie J
- Ritchings A
- Roberts J
- Robinson M
- Robinson R
- Robson D
- Rodriguez R
- Roffe C
- Rogers E
- Rogers G
- Ropun A
- Ross F
- Ross S
- Rotchell K
- Roughan C
- Rowe J
- Rudd A
- Rudenko H
- Rushworth P
- Rusk D
- Rutherford W
- Sahota G
- Said R
- Saksena R
- Salehin M
- Sami E
- Sandell T
- Sandercock P
- Sangaralingham S
- Sanyal R
- Saravanan N
- Sargent T
- Sargent T
- Sattar N
- Saunders G
- Schmit J
- Schofield C
- Schulz U
- Schumacher N
- Scott J
- Scott M
- Scott R
- Seagrave S
- Sein M
- Sekaran L
- Self CM
- Selvarajah J
- Sengupta N
- Sesay J
- Sethuraman S
- Shackcloth D
- Shah A
- Shah R
- Shah R
- Shah S
- Shah S
- Shahzad S
- Shakhon A
- Shanu S
- Sharma J
- Sharobeem K
- Sharon S
- Sharpe S
- Shaw A
- Sheppard M
- Shields N
- Short K
- Siddiqui A
- Siddiqui A
- Sigsworth A
- Simmons D
- Simpson J
- Simpson M
- Sims D
- Singh A
- Singh D
- Sinha D
- Sivakumar R
- Skewes J
- Skotnicka A
- Skwarski J
- Smalley P
- Smart A
- Smith A
- Smith F
- Smith J
- Smith M
- Smith S
- Smith T
- Smith W
- Smolen S
- Smyth N
- Soe T
- Soliman M
- Song A
- Southworth L
- Speirs O
- Spencer R
- Sproates D
- Spurway J
- Srinivasan M
- Stagg K
- Stanners A
- Steele A
- Stephen C
- Stephenson J
- Stephenson L
- Stephenson L
- Stevens A
- Stevens S
- Stevenson S
- Stewart J
- Stirling M
- Stocks K
- Stone H
- Strain D
- Subramanian K
- Sudkeo V
- Sukhdeep N
- Sukys U
- Sullivan F
- Sultan S
- Sundayi S
- Sunderland C
- Suttling A
- Sutton C
- Sutton D
- Sutton P
- Sutton V
- Sword J
- Sykes L
- Sykes L
- Tachtatzis A
- Tam C-K
- Tam CK
- Tam P-L
- Tandy J
- Tangney R
- Tarkas T
- Tate M
- Tauro S
- Taylor C
- Taylor P
- Taylor V
- Teal R
- Temlett E
- Tenbruck E
- Tench H
- Thavanesan K
- Thirugnana-Chandran T
- Thomas AL
- Thomas C
- Thomas E
- Thomas L
- Thompson Jones H
- Thompson A
- Thompson J
- Thompson P
- Thomson A
- Thornthwaite S
- Thorpe K
- Tilbey S
- Tinsley S
- Tiwari D
- Todd S
- Tongue R
- Tonks L
- Topia B
- Topliffe J
- Trainor L
- Tribbeck M
- Trippier S
- Trugeon-Smith T
- Tryambake D
- Tsang S-M
- Tucker S
- Turfrey J
- Turner L
- Tysoe S
- Uitenbosch G
- Ullah K
- Umasankar U
- Upton N
- Vahidassr D
- Valentine S
- Van Wijck F
- Varquez R
- Vasileiadis E
- Vassallo J
- Veraque E
- Verrion A
- Vickers C
- Villaruel M
- Vowden R
- Wadams B
- Wade L
- Wahishi I
- Walford J
- Walker E
- Walker P
- Walker R
- Walker S
- Walmsley B
- Walstow D
- Walters A
- Waltho K
- Walton E
- Wands M
- Wanklyn P
- Warburton E
- Ward D
- Ward J
- Ward M
- Wardale A
- Wareing W
- Warinton R
- Watchurst C
- Watkins C
- Watkinson C
- Watson E
- Watson F
- Waugh D
- Waugh D
- Weatherby S
- Webb T
- Webster T
- Weinling M
- Weir N
- Welch A
- Wells B
- Westcott J
- Westmoreland J
- Westmoreland J
- Whitcher A
- White J
- Whitehead L
- Whitehouse S
- Whiting R
- Whitmore P
- Whitworth S
- Wiggam I
- Wightman J
- Wijewardane A
- Wilkinson M
- Wilkinson P
- Willberry A
- Willcoxson P
- Williams C
- Williams M
- Williams R
- Williams R
- Williams R
- Williams S
- Williams S
- Williams-Yesson B
- Williamson J
- Williamson S
- Willmot M
- Wills R
- Willson J
- Wilmshurst N
- Wilson D
- Wilson H
- Wilson J
- Wilson J
- Wilson J
- Wilson L
- Wiltshire A
- Withers V
- Wong J
- Wong S
- Wood D
- Wood D
- Wood E
- Wood L
- Wood P
- Wood P
- Woodford E
- Wright A
- Wright L
- Wroath B
- Wynn-Williams R
- Wynter I
- Yeomans A
- Yip K
- Young E
- Young R
- Young S
- Zachariah G
- Zhang L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background
Results of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.
Methods
FOCUS was a pragmatic, multicentre, parallel group, double-blind, randomised, placebo-controlled trial done at 103 hospitals in the UK. Patients were eligible if they were aged 18 years or older, had a clinical stroke diagnosis, were enrolled and randomly assigned between 2 days and 15 days after onset, and had focal neurological deficits. Patients were randomly allocated fluoxetine 20 mg or matching placebo orally once daily for 6 months via a web-based system by use of a minimisation algorithm. The primary outcome was functional status, measured with the modified Rankin Scale (mRS), at 6 months. Patients, carers, health-care staff, and the trial team were masked to treatment allocation. Functional status was assessed at 6 months and 12 months after randomisation. Patients were analysed according to their treatment allocation. This trial is registered with the ISRCTN registry, number ISRCTN83290762.
Findings
Between Sept 10, 2012, and March 31, 2017, 3127 patients were recruited. 1564 patients were allocated fluoxetine and 1563 allocated placebo. mRS data at 6 months were available for 1553 (99·3%) patients in each treatment group. The distribution across mRS categories at 6 months was similar in the fluoxetine and placebo groups (common odds ratio adjusted for minimisation variables 0·951 [95% CI 0·839–1·079]; p=0·439). Patients allocated fluoxetine were less likely than those allocated placebo to develop new depression by 6 months (210 [13·43%] patients vs 269 [17·21%]; difference 3·78% [95% CI 1·26–6·30]; p=0·0033), but they had more bone fractures (45 [2·88%] vs 23 [1·47%]; difference 1·41% [95% CI 0·38–2·43]; p=0·0070). There were no significant differences in any other event at 6 or 12 months.
Interpretation
Fluoxetine 20 mg given daily for 6 months after acute stroke does not seem to improve functional outcomes. Although the treatment reduced the occurrence of depression, it increased the frequency of bone fractures. These results do not support the routine use of fluoxetine either for the prevention of post-stroke depression or to promote recovery of function.
Funding
UK Stroke Association and NIHR Health Technology Assessment Programme
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
- Adams C.
- Adams E.L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Agüero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich A.
- Al Harthi F.
- Al Mutairi A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A.E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I.A.M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Z.
- Allen L.
- Allen M.
- Allen S.
- Allibone S.
- Allison K.S.
- Allos R.
- Almaden-Boyle C.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi A.
- Amitrano S.
- Anastasescu E.
- Anderson F.
- Anderson J.
- Anderson M.
- Anderson P.
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew A.
- Andrew B.
- Andrew G.
- Andrews E.
- Andrews S.J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe D.
- Antinori A.
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino M.
- Arabi Y.M.
- Aravindan L.
- Arbane G.
- Archer K.
- Arden T.
- Arias S.S.
- Arif S.
- Armstrong J.
- Armstrong L.
- Armstrong R.
- Arning N.
- Arnold S.
- Arranz M.J.
- Arribas E.
- Artuso R.
- Arumugam P.
- Arumugam P.
- Ascolillo S.
- Ashraf S.
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain R.
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin K.
- Austin P.
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R.R.
- Baillie J.K.
- Baillie J.K.
- Baillie J.K.
- Baines B.
- Baines D.
- Baines K.
- Baird Y.
- Bakthavatsalam D.
- Balaconis M.K.
- Baldassarri M.
- Ball C.A.
- Baltzell A.H.
- Bamford A.
- Bamford P.
- Banach D.
- Bancroft H.
- Band G.
- Bandini M.
- Bandla N.
- Bano S.
- Baptista D.
- Barakeh D.
- Baras A.
- Baras A.
- Baratti S.
- Barber R.
- Barberis L.
- Barberis L.
- Barbieri C.
- Barclay L.
- Bargagli E.
- Barhoush E.
- Barker J.
- Barnes K.C.
- Baroni S.
- Barrett F.
- Barron A.
- Barry P.
- Bartels M.
- Bartley S.
- Baruah R.
- Bashyal A.
- Basikolo C.
- Bassetti M.
- Bastion V.
- Bates H.
- Bates M.
- Batini C.
- Battle C.
- Bauchmuller K.
- Baxter N.
- Baya N.
- Bayo L.-A.
- Beadle J.
- Bean S.
- Beaumont K.
- Beavis S.
- Beck A.
- Beckmann N.D.
- Bedini J.L.
- Bee C.E.
- Beech E.
- Beech V.
- Beekes M.
- Beesley K.
- Begg C.
- Beguin Y.
- Behan T.
- Beith C.M.
- Belagodu Z.
- Belbin G.M.
- Belfield H.
- Belhaj Y.
- Beligni G.
- Belisle A.
- Bell D.
- Bell G.
- Bell M.
- Bell S.
- Bellamy M.
- Belli M.A.
- Bellini A.
- Bellwood R.
- Below J.
- Bemand T.
- Benetti E.
- Benham L.
- Bennett D.
- Bennett S.
- Bentley D.
- Bentley M.
- Benyon S.
- Beranova E.
- Bercades G.
- Bergantini L.
- Bergomi P.
- Berkowitz N.
- Bernardo D.
- Bevan E.
- Bewley J.
- Bhatia N.
- Bhatterjee R.
- Bhuie P.
- Bi R.
- Bianchi F.
- Bibert S.
- Bibi F.
- Biddle J.
- Biggs H.
- Birch J.
- Birch J.
- Birch S.
- Birchall K.
- Birchall K.
- Bird S.
- Birkinshaw I.
- Birt M.
- Biscarini F.
- Black E.
- Black K.
- Blackledge B.
- Blackledge B.
- Blackman H.
- Blakemore H.
- Blay N.
- Blow S.
- Blunt M.
- Board S.
- Bochud P.-Y.
- Bociek A.
- Boezen M.
- Boillat N.
- Bokhari M.
- Bolton M.
- Bolton R.
- Bonner S.
- Booker L.
- Borislavova B.
- Borra C.
- Botello A.
- Botfield L.
- Bottà G.
- Bouab M.
- Bough L.
- Boughton A.P.
- Bowes A.
- Bowles R.
- Boyle P.
- Boyle R.
- Boz C.
- Bradford Y.
- Bradley C.
- Bradley P.
- Bradley-Potts J.
- Bradshaw Z.
- Brady A.
- Brady M.
- Brady R.
- Brandwood C.
- Branney D.
- Brantwood C.
- Brassard N.
- Brayne A.
- Brealey D.
- Brealey D.
- Bremmer P.
- Brenner B.
- Bretherick A.D.
- Brett M.
- Brett S.
- Brickell K.
- Bridgett V.
- Brimfield L.
- Brinkworth E.
- Briton K.
- Britvan B.
- Bromley M.
- Brooke H.
- Brooks S.
- Brown A.
- Brown A.
- Brown A.
- Brown E.
- Brown J.
- Bruce M.
- Brumpton B.M.
- Bruno R.
- Brunton M.
- Bruttini M.
- Bryant J.
- Bryant S.
- Buckley C.
- Buckley S.
- Bunni L.
- Burda D.
- Buring J.E.
- Burn I.
- Burnett C.
- Burns K.
- Burt K.
- Burtenshaw A.
- Burton M.
- Busani S.
- Bussotti M.
- Butcher D.
- Butler A.
- Butler J.
- Butler S.
- Butler-Laporte G.
- Butterworth A.S.
- Butterworth-Cowin N.
- Button H.
- Buxbaum J.D.
- Cabrelli L.
- Cagova L.
- Caldarelli G.P.
- Callaghan M.
- Callier S.
- Cameli P.
- Campbell A.
- Campbell A.
- Campbell H.
- Campbell R.
- Campbell R.
- Campbell S.
- Campos S.
- Camsooksai J.
- Canaccini A.
- Cantarini L.
- Cantor M.N.
- Capasso M.
- Capitani K.
- Cappelli S.
- Capps N.
- Carbral-Ortega L.
- Carella M.
- Carey D.J.
- Carmody M.
- Carmody S.
- Carnahan M.
- Carreras A.
- Carriero M.L.
- Carter A.
- Carter D.
- Carter E.
- Carter J.
- Carter S.
- Carungcong J.
- Casey M.
- Castaño-Vinyals G.
- Castelli F.
- Castle K.
- Castori M.
- Caswell M.
- Catena E.
- Caterson J.
- Cathcart S.
- Catlow L.
- Caulfield M.J.
- Caulfield M.J.
- Cavazza A.
- Cawley K.
- Cawthron K.
- Ceri S.
- Chablani M.
- Chadbourn I.
- Chamnanphon M.
- Chan G.
- Chan G.
- Chan R.
- Chandler B.
- Chang X.
- Chapman S.
- Chariyavilaskul P.
- Charles B.
- Charlesworth R.
- Charney A.W.
- Charnock R.
- Chasman D.I.
- Chassé M.
- Chaudhary K.
- Chavan S.
- Cheema Y.
- Chen H.-H.
- Chen J.
- Cheng N.
- Cherian S.
- Chetam L.
- Chetruengchai W.
- Cheyne C.
- Childs D.
- Chittoor G.
- Cho J.H.
- Cho K.
- Choi S.
- Choudhury Y.
- Chukkambotla S.
- Churchhouse C.
- Chwialkowska K.
- Claassen S.
- Clamp S.
- Clapham M.
- Claringbould A.
- Clark A.
- Clark M.
- Clark M.
- Clark R.
- Clark R.
- Clark S.
- Clark V.
- Clarke D.
- Clarke N.
- Clarkson M.
- Clayton S.
- Clement I.
- Clements S.
- Clohisey Hendry S.
- Coates C.
- Cockrell M.
- Coetzee S.
- Coghlan P.
- Coignet M.
- Coiro G.
- Coker D.
- Cole J.
- Cole J.
- Cole S.
- Coleman D.
- Coles H.
- Colley J.
- Collier D.
- Collier D.
- Collins A.
- Collins B.L.
- Collins C.
- Collins E.
- Collins E.
- Collins K.
- Collins R.
- Collis M.
- Colobrán R.
- Colombo R.
- Combes E.
- Connolly K.
- Conticini E.
- Convery K.
- Conyngham J.-A.
- Cooper J.
- Cooper L.
- Corcoran E.
- Cordioli M.
- Cornell S.
- Corral M.A.
- Corridi M.
- Cortés B.
- Cosgrove D.
- Cosier T.
- Cossarizza A.
- Cother N.
- Coto E.
- Coton Z.
- Coulding M.
- Coutts A.
- Coventry T.
- Coviello D.A.
- Cowley A.
- Cowley N.
- Cowton A.
- Cox A.
- Coyle J.
- Craig J.
- Crawley R.
- Creagh-Brown B.
- Crew A.
- Crickmore V.
- Crisp N.
- Criste K.
- Cristiano D.
- Croci L.
- Croci S.
- Croft M.
- Crook D.W.
- Crooks K.
- Crotti L.
- Crowe R.
- Crowley M.
- Cruz C.
- Cullell N.
- Cullum L.
- Cunningham A.
- Cunningham M.
- Cupitt J.
- Curgenven H.
- Cusack R.
- Cusick C.
- Cutler S.
- Cárcel-Márquez J.
- Da Gloria E.F.
- Daga S.
- Daglish J.
- Dale K.
- Dale S.
- Dalmau D.
- Daly M.J.
- Daly Z.
- Dalziel J.
- Dance A.
- Danesh J.
- Daniel A.
- Daniel P.
- Daniels A.
- Darcis G.
- Dark P.
- Darlington K.
- Das M.
- Das S.
- Dasgin J.
- Daubney E.
- Davey M.
- David B.
- Davidson N.
- Davies C.
- Davies E.
- Davies F.
- Davies G.
- Davies K.
- Davies L.
- Davies M.
- Davies M.
- Davies R.
- Davis C.
- Davison C.
- Dawson D.
- Dawson J.
- Day N.
- Daya M.
- de Almeida Martins L.G.
- de Cid R.
- de Felipe Mimbrera A.
- de Geus E.
- de Gordoa L.O.-R.
- de la Cal-Sabater P.
- De Neef M.
- De Vivo O.
- Deacon B.
- Deacon B.
- Dearden J.
- Death Y.
- Debreceni G.
- DeDiego M.L.
- Deelen P.
- Deery J.
- Dei S.
- Dela Rosa A.
- Delgado C.C.
- Della Monica M.
- Demetriou C.
- Denmade C.
- Dennis C.
- Dent K.
- Dent M.
- Depante M.
- Desanctis E.
- Dexter C.
- Di Angelantonio E.
- Di Biagio A.
- Di Domenico P.
- Di Pietro M.
- Di Sarno L.
- Dietl B.
- Digby B.
- Digby S.
- Ding L.
- Djeugam B.
- Do R.
- Dobaño C.
- Doble P.
- Dobson E.
- Doddato G.
- Dodds S.
- Domingo C.
- Domínguez-Mayoral A.
- Donaldson A.
- Donaldson D.
- Donati A.
- Donlon S.
- Donnachie J.
- Donne B.
- Donnelly K.
- Donnelly L.
- Donner K.
- Donnison P.
- Donovan S.
- Dooks E.
- Doonan R.
- Dore R.
- Dormand N.
- Douglas K.
- Downes C.
- Drummond A.
- Duberly S.
- Duffield J.
- Duffin D.
- Duffy K.
- Duffy S.
- Duncan E.
- Duncan E.
- Duncan T.
- Dunmore C.
- Durand M.
- Durga L.
- Durie A.
- Durrans L.J.
- Durrant G.
- Duskova M.
- Dykes J.
- D’Alessandro M.
- D’Arminio Monforte A.
- D’Mellow K.
- D’Sylva S.
- Eapen B.
- Earle S.G.
- Eastgate-Jackson C.
- Easthope A.
- Easthope A.
- Easthope A.
- Easton J.
- Ebano P.
- Eckbad C.
- Edmond I.
- Edwards M.
- Efford G.
- Egan J.
- Eid M.A.
- El-Jawhari J.J.
- El-Lawaty W.M.
- El-shanshory M.R.
- El-Sherbiny Y.M.
- Elgar G.
- Elhadidy T.A.
- Elhassan M.
- Elliott K.
- Elliott K.S.
- Elliott P.
- Ellis H.
- Elnagdy M.H.
- Elsaadany M.
- Elston K.
- Eltayeb A.
- Eltoukhy M.M.
- Emiliozzi A.
- English K.
- Erard V.
- Esko T.
- Esparza-Gordillo J.
- Evitts J.
- Ezeobu O.
- Fabbiani M.
- Fagan A.
- Falcone M.
- Fallerini C.
- Farnell-Ward S.
- Farquhar F.
- Farré X.
- Farzad Z.
- Faulkner B.
- Faulkner M.
- Fava F.
- Fawkes A.
- Fawkes A.
- Fawns-Ritchie C.
- Fawzy M.S.
- Fearby M.
- Felemban W.A.
- Felton T.
- Feng Y.-C.A.
- Ferguson S.
- Feri M.
- Fernandes K.
- Fernandes R.
- Fernandez Z.
- Fernandez-Cadenas I.
- Fernandez-Roman J.
- Ferreira M.A.R.
- Ferreira M.A.R.
- Ferri C.
- Fidler K.
- Filipe H.
- Filshtein-Sonmez T.
- Finch C.
- Findlay L.
- Fine C.
- Finer S.
- Finernan P.
- Finn J.
- Finn S.
- Finney C.
- Finucane H.
- Fiorentino G.
- Fisher E.
- Fiz-López A.
- Flanagan R.
- Fletcher J.
- Flint N.
- Fofano A.
- Folkes L.
- Foote D.
- Ford A.
- Forgetta V.
- Forsey M.
- Foster L.
- Fotiadis S.
- Fottrell-Gould D.
- Fourman M.H.
- Fowler S.
- Fowler T.
- Fowler T.A.
- Fox C.
- Fox H.
- Fox J.
- Franchi F.
- Francisci D.
- Franco G.
- Franke G.
- Franke L.
- Frankham J.
- Frater A.
- Frediani B.
- Free R.C.
- Frippiat F.
- Frise M.
- Frithiof R.
- Frost V.
- Frullanti E.
- Fuller B.
- Furini S.
- Furlong A.
- Furniss J.
- Gabbi C.
- Gabrieli A.
- Gaddis M.
- Gales A.
- Gallagher B.
- Galván-Femenía I.
- Ganesan A.
- Ganna A.
- Garcia S.M.
- Garcia-Aymerich J.
- García-Clemente M.
- García-Madrona S.
- Gardner A.
- Garg A.
- Garland Z.
- Garner L.
- Garrioch S.
- Gascoyne R.
- Gass M.C.
- Gatti F.
- Gay B.
- Gaylard J.
- Gaziano J.M.
- Geary T.
- Gellamucho M.
- Gemmell L.
- Gendall E.
- Genetu R.
- George A.
- George L.
- Georges M.
- Gettler K.
- Gherman A.
- Ghosh A.
- Ghosh B.
- Giannattasio F.
- Gibson S.
- Gignoux C.R.
- Gilbert K.
- Gilchrist T.
- Giliberti A.
- Gill J.
- Gill M.
- Giorli A.
- Giot J.-B.
- Girach R.
- Girardis M.
- Girshick A.
- Glasgow S.
- Glass L.
- Gledhill L.
- Glessner J.R.
- Glessner J.T.
- Goddard P.
- Goddard W.
- Goff E.
- Gofflot S.
- Golden D.
- Golder K.
- Golding H.
- Goldstein J.I.
- Golightly A.
- Gomez J.
- Gomez R.
- Gondo P.
- González-Villa E.
- Goodchild D.
- Goodsell J.
- Goodwin E.
- Gopal S.
- Gordon A.
- Gordon E.
- Gori M.
- Gorman C.
- Graham C.
- Grassi D.
- Gratrix A.
- Grau N.
- Grauslyte L.
- Green J.
- Green R.C.
- Greer S.
- Gregory J.
- Greig J.
- Griffin D.
- Griffiths C.J.
- Griffiths F.
- Griffiths F.
- Grimmer L.
- Grip J.
- Guarnaccia A.
- Gude E.T.
- Guerin J.
- Guerrini S.
- Guidelli L.
- Guindo-Martinez M.
- Guiot J.
- Gulati A.
- Gumbrill B.
- Gummadi M.
- Guntz J.
- Gupta A.
- Gupta R.
- Gurasashvili J.
- Gurr L.
- Guturu H.
- Guyatt A.L.
- Guzman C.
- Hadebe B.
- Hafezi K.
- Hairsine B.
- Hakonarson H.
- Hakonarson H.
- Halawani R.T.
- Haldeos A.
- Hales D.
- Halkes M.
- Hall K.
- Halls R.
- Hambrook G.
- Hamilton D.
- Hamilton D.O.
- Hammerton K.
- Hanley S.
- Hanratty H.
- Hanson H.
- Hanson K.
- Hansson K.
- Haq R.
- Hard K.
- Harden L.
- Harding P.
- Hardy J.
- Harerimana N.
- Harford R.
- Hargreaves J.
- Harling R.
- Harper R.
- Harrington K.
- Harris C.
- Harris J.
- Harris J.
- Harris J.R.
- Harris N.
- Harrison A.
- Harrison A.
- Harrison L.
- Harrison W.
- Hartley J.
- Hartridge P.
- Harvey A.
- Hasanato R.
- Hass I.
- Hatton J.
- Hawcutt D.
- Hawes J.
- Hay A.
- Hayes A.
- Hayes K.
- Hayman M.
- Hays C.
- Hayward C.
- Hazelton T.
- Headlam E.
- Heeney E.
- Hegazy M.A.F.
- Helgeland Ø
- Hellen M.
- Helm D.
- Henderson S.
- Hendry R.
- Hendry S.C.
- Henry D.
- Hensen K.
- Herdman-Grant R.
- Heron A.E.
- Hesseldon L.
- Hewitt C.
- Hey S.
- Hibbert M.
- Hierons S.
- Hiester L.L.
- Higham A.
- Higham A.
- Highgate J.
- Hijazi M.
- Hill H.
- Hill M.
- Hilldrith A.
- Hilltout P.
- Hilton M.
- Hindale J.
- Hinds C.
- Hinds C.
- Hirankarn N.
- Ho Y.-L.
- Hobden G.
- Hobrok M.
- Hodgkiss T.
- Hodgson L.
- Hoggart C.
- Holcombe H.
- Holding K.
- Holdroyd K.
- Holland M.
- Hollox E.J.
- Home M.
- Hong E.L.
- Hope D.
- Hope S.
- Hopkins B.
- Horby P.
- Horby P.
- Hormis A.
- Horner D.
- Hornsby J.
- Horowitz J.E.
- Horowitz J.E.
- Horsley E.
- Hosseini A.
- Houlden H.
- Housley K.
- Houston G.
- Howard K.
- Howe G.S.
- Howie L.
- Howle R.
- Howlett A.
- Hruska M.
- Huang Q.Q.
- Huckins L.M.
- Hudig L.
- Hudson A.
- Huffman J.E.
- Hughes A.
- Hughes G.
- Hughes R.A.
- Hugill K.
- Hull R.
- Hulme J.
- Hultström M.
- Humphrey C.
- Humphreys S.
- Hunt J.
- Hunt J.
- Hunt K.A.
- Hurford F.
- Hurt W.J.
- Hussain M.
- Hussain S.
- Hussain Y.
- Hutter J.
- Hutton P.
- Huynen P.
- Hveem K.
- Iglesias L.L.
- Ikram M.A.
- Imeson-Wood J.
- Ingham J.
- Inweregbu K.
- Iolascon A.
- Ireland J.
- Irvine V.
- Ishaq T.
- Itan Y.
- Jackson M.
- Jackson P.
- Jackson Y.
- Jackson-Lawrence K.
- Jacob R.
- Jacques J.
- Jacques N.
- Jakkula S.
- Jan Hottenga J.
- Jantarabenjakul W.
- Jardine C.
- Jarmain J.
- Jarman C.
- Javaid A.
- Jeffrey H.
- Jenkins S.
- Jenkins S.
- Jennings C.
- Jerome E.
- Jetha C.
- Jha R.
- Jhanji S.
- Jim R.
- Jiménez-Xarrié E.
- Joe W.
- Joefield T.
- John C.
- Johnson E.
- Johnson L.
- Johnson R.
- Johnston B.
- Jones C.
- Jones D.
- Jones G.A.L.
- Jones J.
- Jones J.
- Jones M.
- Jones O.
- Jones R.
- Jones S.
- Jones T.O.
- Jordan D.M.
- Jose S.
- Joseph A.
- Joseph R.
- Joseph S.
- Josyula N.S.
- Joy R.
- Jude E.
- Jung J.
- Justice A.
- Justice A.E.
- Kadiri S.
- Kaliappan A.
- Kallaste A.
- Kallon D.
- Kamdar D.
- Kamundi C.
- Kanai M.
- Kannan T.
- Kanu R.
- Kapoor R.
- Karczewski K.J.
- Karjalainen J.
- Karlson E.W.
- Karp A.
- Karthik K.
- Kasipandian V.
- Kassam J.
- Katary A.
- Kaufmann D.E.
- Kaul S.
- Kaunisto M.
- Kausar R.
- Kay A.
- Kayani A.
- Kaye C.
- Kaye D.
- Kazi A.
- Keating L.
- Keating S.
- Keenan N.
- Keenan S.
- Keith S.
- Keller K.
- Kelly D.
- Kelly F.
- Kelly S.
- Kelsall O.
- Kennard-Holden G.
- Kennedy-Hay S.
- Kenny E.E.
- Kent A.
- Kent H.
- Kent M.
- Kerr S.M.
- Keshet-Price J.
- Khade R.
- Khafaga W.T.
- Khaliq W.
- Khaliq W.
- Khan M.
- Khattab A.K.
- Khera J.
- Kibutu F.
- Kimchi N.
- Kinch A.
- King B.
- King D.
- King K.
- King L.
- Kingsley C.
- Kirkby A.
- Kisand K.
- Kitson R.
- Kivinen K.
- Klaric L.
- Knight A.
- Knight J.
- Knight J.
- Knight S.
- Knighton A.
- Knights E.
- Knowles K.
- Koelling N.
- Kogevinas M.
- Kolakaluri L.
- Kong T.
- Koskelainen S.
- Kosmicki J.A.
- Kosmicki J.A.
- Kousathanas A.
- Kousathanas A.
- Krishnamurthy V.
- Kristiansson K.
- Kubisz-Pudelko A.
- Kumar R.
- Kumar R.
- Kumar S.
- Kuravi A.
- La Rovere M.T.
- Laane E.
- Labkowsky A.
- Laha S.
- Laisk T.
- Lake V.
- Lamb T.
- Lambermont B.
- Lamond Z.
- Lancaster N.
- Lancoma-Malcolm I.
- Langley M.
- Langton H.
- Lankester L.
- Lanting P.
- Latham S.
- Lathrop G.M.
- Latif M.
- Laurent L.
- Law A.
- Law A.
- Law D.
- Law R.
- Law S.
- Lawton T.
- Lazo M.
- Leader J.B.
- Lean R.
- Leaver S.
- Ledgard C.
- Lee E.
- Lee P.H.
- Lee S.
- Lee Y.
- LeFaive J.
- Leggett S.
- Leigh M.
- Lena F.
- Lenagh B.
- Lennon L.
- Lepage P.
- Lepamets M.
- Levy T.
- Lewis A.
- Lewis J.
- Lewis T.
- Li B.
- Li K.W.
- Li R.
- Liao R.G.
- Liderth S.
- Lidstone-Scott R.
- Liew J.
- Liggett S.
- Lim L.
- Lim L.
- Lim R.
- Lin S.-K.
- Lindergard G.
- Ling L.
- Ling L.
- Linnett V.
- Lipcsey M.
- Lisboa A.
- Lista M.
- Little J.
- Liyanage K.
- Llucià-Carol L.
- Loader D.
- Lomas D.
- London E.
- Long K.
- Loos R.J.F.
- Loosley R.
- Lopera E.
- Lorubbio M.
- Lorusso R.
- Love N.
- Loveridge A.
- Low E.
- Lozano F.
- Lu W.
- Lubimbi G.
- Lucas A.
- Lucas R.
- Luchi S.
- Ludovisi S.
- Lye A.
- Lyle A.
- Lynch C.
- Lyon A.
- Lyons C.
- Lyons M.
- Läll K.
- Léonard P.
- Ma L.
- Mac A.
- Maccacari E.
- MacCallum N.
- Macgillivray L.
- MacGoey P.
- Macharia I.
- Mackay C.
- Mackintosh K.
- Maclean A.
- MacMahon M.
- Maggiolo F.
- Magnus P.
- Maharajh A.
- Mahay K.
- Mahenthran M.
- Mahjoob P.
- Mahmoud E.S.
- Mal H.
- Malaise O.
- Male M.
- Maleady-Crowe F.
- Malinauskas T.
- Mallinson J.
- Mallon L.
- Mamlouk N.
- Mancarella S.
- Mandalà M.
- Mangino M.
- Mangul S.
- Manna S.
- Manso K.
- Manson J.E.
- Mantovani S.
- Mapfunde I.
- Maqsood Z.
- Marani M.
- Marcantonio S.
- Marciano C.
- Margalef J.
- Margarson M.
- Mari F.
- Maricic T.
- Marotti M.
- Marriott C.
- Marriott S.
- Marsden T.
- Marsh C.
- Marsh S.
- Marshall L.
- Marshall R.
- Martin A.R.
- Martin D.
- Martin H.C.
- Martin J.
- Martin T.
- Martindale T.
- Martinelli E.
- Martinez M.L.
- Martinson V.
- Martir G.
- Martí-Fàbregas J.
- Martín-Nalda A.
- Martínez A.P.
- Mascarenhas M.
- Masjuan J.
- Maslove D.
- Maslove D.
- Mason D.
- Massadeh S.
- Masucci L.
- Masuko S.
- Masunda B.
- Matapure L.
- Matharu M.
- Matheson J.
- Mathew B.
- Mathew J.
- Matt R.
- Matthews J.
- May P.
- Mayangao I.
- Mayer A.
- Maynard V.
- Mazzei M.A.
- McAlindon M.
- McAuley D.
- McAuley D.
- McCafferty S.
- McCormack L.
- McCormick J.
- McCormick J.B.
- McCormick W.
- McCreath G.
- McCulloch C.
- McCurdy A.
- McCurdy S.
- McFarland D.
- McGowan J.
- McGregor A.
- McGregor A.
- McGuigan P.J.
- McGuinness H.
- McHugh T.
- McIvor S.
- McKechnie S.
- McKenley I.
- McKenna E.
- McLaughlan D.
- Mcmaster E.
- McMorrow L.
- McNeela F.
- McParland C.
- McParland C.
- McPhail M.
- Meadows E.
- Meaney E.
- Medhora J.
- Medina-Gomez C.
- Meghari H.
- Meigs J.B.
- Meikle A.
- Meikle J.
- Melia D.
- Melling S.
- Mellor S.
- Meloni I.
- Melville J.
- Menatti E.
- Mencarelli M.A.
- Menzies D.
- Menéndez-Valladares P.
- Mepham S.
- Mercader J.
- Mercader J.M.
- Mercer O.
- Mercer P.
- Meredith M.
- Merla G.
- Merwaha E.
- Metcalfe A.
- Metherell S.
- Metsalu K.
- Metspalu A.
- Meuris C.
- Mew L.
- Michael A.
- Michael H.T.
- Michalak-Glinska N.
- Middleton H.
- Milani L.
- Millar J.
- Millar J.
- Millen G.
- Milligan B.
- Mills G.H.
- Millward H.
- Milner L.
- Miraglia F.G.
- Mirshahi T.
- Mirshahi T.
- Misset B.
- Mitchard S.
- Mitchell A.M.
- Mitchelmore O.
- Mitra A.
- Moahmed H.S.
- Moghaddam S.B.M.
- Mohamed Ally S.
- Mohamed A.A.S.
- Moncur E.
- Mondelli M.U.
- Monnery S.
- Montagnani F.
- Montaser R.
- Montgomery H.
- Montgomery H.
- Moore F.
- Moore L.S.P.
- Moore S.C.
- Mooser V.
- Moreno V.
- Moreno-Cuesta J.
- Morgan A.
- Morgan J.
- Morino E.
- Morrice K.
- Morrice K.
- Morris A.
- Morris L.
- Morris M.
- Morris S.
- Morrison A.
- Morrison D.R.
- Moss S.
- Mostoles L.
- Motherwell N.
- Moultrie S.
- Moutschen M.
- Moutsianas L.
- Moutsianas L.
- Msiska M.
- Mtuwa S.
- Muchenje N.
- Muiño E.
- Mulcahy M.
- Mulla S.
- Mullan D.
- Munt S.
- Mupudzi M.
- Murdoch E.
- Murdoch S.
- Murphy A.
- Murphy C.
- Murphy L.
- Murphy L.
- Murphy L.
- Murphy S.
- Murphy S.N.
- Mussini C.
- Mutch R.
- Mwaura E.
- Mwaura L.
- Márquez L.
- Mägi R.
- Naaber P.
- Naderpour Z.
- Nadkarni G.N.
- Nagra I.
- Naisbitt J.
- Nakanishi T.
- Naranjo A.
- Nasir F.
- Nayak M.
- Nazari R.
- Neal A.
- Neale B.M.
- Nencioni C.
- Neofytos D.
- Netherton K.
- Newell H.
- Newey L.
- Newman J.
- Newman T.
- Newton M.
- Ng A.
- Nguyen H.
- Niavarani A.
- Niblo K.
- Nichol A.
- Nichol A.
- Nichol A.
- Nicholson A.
- Nicholson A.
- Nicol L.
- Niemi M.E.K.
- Nikitas N.
- Nilaratanakul V.
- Nilsson A.
- Nivard M.
- Nixon R.
- Nkambul L.
- Nkambul L.
- Nkambule L.
- Noble H.
- Nolan C.
- Norman K.
- Norris J.
- Nortcliffe T.
- North J.
- North K.
- Noto K.
- Novis C.
- Nown A.
- Nune A.
- Nussle S.G.
- Nwafor L.
- Oakley N.
- Oblak M.
- Odam M.
- Odhams C.A.
- Odhams C.A.
- Oetjens M.
- Ogg B.
- Ognibene A.
- Okasha K.
- Okeefe L.
- Oliveira M.
- Olufuwa O.
- Omar Z.
- Oosthuyzen W.
- Oosthuyzen W.
- Openshaw P.J.M.
- Openshaw P.J.M.
- Ori A.P.S.
- Ostermann M.
- Otahal I.
- Otahal I.
- Oxspring S.
- O’Brien L.
- O’Brien P.
- O’Connell A.M.
- O’Connell S.
- O’Connor D.
- O’Connor G.
- O’Donnell C.J.
- O’Hara M.
- O’Leary R.
- O’Malley L.
- O’Neil P.
- O’Neill L.
- O’Reilly K.
- O’Reilly P.
- O’Sullivan S.
- Paciosi F.
- Packer R.J.
- Packham S.
- Padden G.
- Page V.J.
- Pairo-Castineira E.
- Pakou G.
- Palmer D.S.
- Palmieri M.
- Palotie A.
- Pancrazzi A.
- Panese S.
- Pappa E.
- Paramsothy R.
- Parati G.
- Parisi S.G.
- Park D.
- Park L.
- Parker R.
- Parkin J.
- Parkinson N.
- Parkinson N.
- Parkinson P.
- Parmar C.
- Parravicini P.
- Parris V.
- Parris V.
- Parsons P.
- Partha R.
- Partridge R.
- Pasko D.
- Passmore H.
- Patch C.
- Patel A.
- Patel B.
- Patel B.
- Patel K.
- Patel M.
- Patel T.
- Paterson T.
- Pathak G.A.
- Pathan N.
- Pattison N.
- Paul P.
- Pavlovic M.
- Pawley C.
- Pearson H.
- Pearson S.
- Peasgood E.
- Peloso G.
- Penacerrada M.
- Pendlebury J.
- Penn R.
- Pereira A.C.
- Perez E.F.
- Perez J.
- Perez-Tur J.
- Perkins E.
- Perna R.
- Perola M.
- Perrella A.
- Perry J.
- Peruggia M.
- Pessina G.
- Pesukova J.
- Peters C.
- Peters M.J.
- Peterson P.
- Petitjean L.
- Petrocelli P.
- Petty L.E.
- Pheby J.
- Philbin J.
- Phillips C.
- Phillips P.
- Phipps J.
- Phokaew C.
- Phull M.
- Piacentini P.
- Picchiotti N.
- Pickard A.
- Piercy C.
- Pigazzini S.
- Pinnell J.
- Pinoli P.
- Pinto A.M.
- Pinzuti I.
- Pippard L.
- Pirinen M.
- Piscopo C.
- Pitts S.
- Planas A.M.
- Player B.
- Pogreban T.
- Pogson D.
- Polgar O.
- Polgarova P.
- Polikowski H.
- Polimanti R.
- Pollard R.
- Polymeropoulos C.
- Polymeropoulos M.H.
- Polymeropoulos V.
- Pongpanich M.
- Ponting C.P.
- Ponting C.P.
- Poole A.
- Popescu M.
- Porteous D.J.
- Poscente M.
- Pothecary C.
- Pothecary C.
- Potla D.
- Potoczna D.
- Potts K.
- Poulaka M.
- Poultney U.
- Prady H.
- Prager K.
- Praman K.
- Pratley A.
- Prendergast C.
- Prentice L.
- Preston S.
- Preuss M.
- Price A.
- Price C.
- Price R.
- Prime Z.
- Pristopan V.
- Pritchard K.
- Proudfoot N.
- Prout R.
- Prysyazhna O.
- Przychodzen B.P.
- Pugh R.
- Purewal B.
- Purewal M.
- Purohit D.
- Purvis S.
- Putchareon O.
- Puthanakit T.
- Puusepp M.
- Puxty A.
- Puxty K.
- Pye K.
- Qiu X.
- Quaid S.
- Queiroz J.
- Quinn A.
- Quinn H.
- Quinodoz M.
- Quiros-Roldan E.
- Rad L.
- Rader D.
- Rader D.J.
- Radford E.
- Radhakrishnan J.
- Rafaels N.
- Raggi P.
- Ragoussis J.
- Rahmouni S.
- Rai S.G.
- Raimondi F.
- Raith E.
- Raith E.
- Raithatha A.
- Raj M.
- Ramos L.
- Rancan I.
- Rand J.
- Rand K.
- Randell G.
- Ranga P.
- Rangarajan H.
- Rankin T.
- Ratnam V.
- Rattray A.
- Ravaglia S.
- Rawlik K.
- Rawlins J.
- Ray S.
- Raynard D.
- Reddy A.
- Reece-Anthony R.
- Reed A.
- Rees A.
- Rees S.
- Rees T.
- Rehman H.
- Reid K.
- Reimann E.
- Rekha P.
- Rendon A.
- Rendon A.
- Renieri A.
- Reschreiter H.
- Reyes A.
- Reynolds J.
- Rezk N.
- Rhead B.
- Rhead K.
- Rhodes D.
- Rhodes D.
- Rhodes J.
- Rice P.
- Richards J.B.
- Richards O.
- Richardson N.
- Riches J.
- Riches K.
- Richmond A.
- Rico V.
- Ridker P.M.
- Rikunenko R.
- Ringmets I.
- Ripamonti D.
- Ripatti S.
- Rishton C.
- Ritchie M.D.
- Ritchie M.D.
- Ritzema J.
- Riva A.
- Rivers V.
- Rivolta C.
- Rizzi M.
- Rizzo C.L.
- Roberts B.
- Roberts G.
- Robinson M.
- Robinson P.
- Robles V.
- Roche L.
- Roche L.
- Roche S.
- Rodden N.
- Roe N.
- Rogers N.
- Rogers P.
- Rogerson K.
- Rogne T.
- Rojo R.
- Rojo S.
- Romani D.
- Rooney K.
- Rooney L.
- Rooyackers O.
- Rosaroso L.
- Rose A.
- Rose S.
- Rossetti B.
- Rostron A.
- Rothwell J.
- Rowan K.
- Rowan K.
- Rowland-Jones S.
- Roy A.
- Roynon-Reed A.
- Rudkin J.K.
- Ruiz L.
- Ruiz-Jaén F.
- Runciman N.
- Ruotsalainen S.
- Rusconi S.
- Russell C.D.
- Russo R.
- Ryan L.
- Ryan-Smith J.
- Saad S.
- Sabrina R.
- Saeedi M.
- Safieh L.A.
- Saha R.
- Saha R.
- Saha S.
- Sainsbury H.
- Salberg A.
- Salciute E.
- Saleem M.
- Salehi S.
- Salerni L.
- Salib I.
- Salmi S.
- Salmon K.
- Salutous D.
- Saluzzio R.P.
- Samakomva T.
- Samir A.
- Sampson J.
- Sanarico M.
- Sanderson A.
- Sandhu R.
- Sangombe M.
- Sanguinetti M.
- Sarathy V.
- Sargeant J.
- Sarma G.
- Sarzi-Braga S.
- Sathe S.
- Satterstrom F.K.
- Saunderson A.
- Saunderson P.
- Sauvage A.-S.
- Savill H.
- Sawaji M.
- Scaggiante R.
- Scala R.
- Scanlon J.
- Schadt E.E.
- Scherewode J.
- Schiaroli E.
- Scholefield B.
- Schon K.
- Schumacher N.
- Schurr E.
- Scolletta S.
- Scott R.H.
- Scott R.H.
- Scott T.
- Scott Z.
- Scotton P.G.
- Scriven J.
- Scriven J.
- Scriven J.
- Sealfon S.C.
- Seaman R.
- Sebra R.P.
- Seed C.
- Segala F.V.
- Segura T.
- Sell C.
- Sellick K.
- Selvanayagam S.
- Semple G.
- Semple M.G.
- Semple M.G.
- Senaratne D.
- Serra-Llovich A.
- Serrano-Heras G.
- Serrano-Ruiz A.
- Service J.
- Sesso H.D.
- Shah N.
- Shahin D.
- Shankar-Hari M.
- Shankar-Hari M.
- Shankar-Hari M.
- Shanmugasundaram P.
- Sharififard B.
- Shastri A.J.
- Shaw D.
- Shaw D.M.
- Shaw L.
- Shaw R.
- Shelley B.
- Shelton J.F.
- Shelton S.
- Shen X.
- Shepardson S.
- Shepherd A.
- Shiel J.
- Shokkar R.
- Short A.
- Shortt J.
- Shotelersuk V.
- Shovelton C.
- Shrine N.
- Shuker K.
- Siano M.
- Sicat C.
- Siddiq A.
- Silva P.
- Sim M.
- Simms R.
- Simpson K.
- Simpson K.
- Singh J.
- Singleton J.
- Skinner D.
- Slater V.
- Slaughter M.
- Slawson N.
- Slevin K.
- Sloan B.
- Sloane G.
- Sloofman L.G.
- Smedley C.
- Smieszek S.P.
- Smith A.V.
- Smith E.
- Smith J.
- Smith J.
- Smith J.
- Smith K.
- Smith L.
- Smith M.
- Smith O.
- Smith T.
- Smith T.
- Smithson E.
- Smoller J.W.
- Smuts S.
- Smyth D.
- Smyth M.
- Sobh A.
- Sodsai P.
- Soler P.
- Sollesta K.
- Solligard E.
- Solomonson M.
- Soranzo N.
- Soriano A.
- Sowter J.
- Spargi G.
- Spector T.D.
- Spencer C.C.A.
- Spencer K.
- Spencer S.
- Spertilli C.
- Spivey M.
- Springle P.
- Squeo G.M.
- Sri-Chandana C.
- Srikaran S.
- Stacey A.
- Stammers K.
- Starkopf J.
- Stead R.
- Stella A.
- Stenhouse A.
- Stephens D.
- Stephenson E.
- Stephenson L.
- Stevens C.
- Stevenson L.
- Stewart R.
- Stickley J.
- Stoddard E.
- Stone S.
- Stones E.
- Stowe B.
- Strachan D.
- Stroud K.
- Stroud N.
- Stuart C.
- Stuckey A.
- Stuckey A.
- Suardi C.
- Suarez J.C.
- Subramanian D.
- Subramanian G.
- Suchartlikitwong P.
- Suh N.
- Sukha A.
- Sukumaran A.
- Suliman B.A.
- Summers C.
- Summers C.
- Summers C.
- Summers J.
- Sumoy L.
- Sun Y.V.
- Sundar A.
- Sundaram R.
- Sutherland I.
- Sutherland S.-B.
- Suttichet T.B.
- Swain A.
- Sweeney L.
- Sweet K.
- Swets M.
- Symon L.
- Symons A.
- Szakmany T.
- Szoor-McElhinney H.
- Tabri J.
- Tacconi D.
- Tadi H.A.
- Tagliavini E.
- Tamm A.
- Tampsett R.
- Taneski F.
- Tanfoni M.
- Tang L.
- Tardif N.
- Tariq A.
- Tatham K.C.
- Tavares S.
- Tavecchia L.
- Taylor A.
- Taylor J.
- Taylor M.
- Taylor M.
- Taylor M.
- Tebbutt J.
- Templeton M.
- Tench H.
- Tenesa A.
- Tenesa A.
- Tetla D.
- Texeira J.
- Thanasi M.
- Thankachen M.
- Thirlwall Y.
- Thirumaran M.
- Thomas A.
- Thomas A.
- Thomas B.
- Thomas E.
- Thomas H.
- Thomas J.
- Thomas M.
- Thomas R.
- Thomas V.
- Thomis L.
- Thompsom M.
- Thompson C.
- Thompson R.
- Thompson R.C.
- Thomson N.
- Thornton D.
- Thornton L.
- Thorpe C.
- Thrasyvoulou L.
- Thrush J.
- Thwaites V.
- Thwaites V.
- Thys M.
- Tibke C.
- Tierney C.
- Tilbey S.
- Tilney E.
- Timlick E.
- Timmers P.R.H.J.
- Ting L.
- Tiseo G.
- Tita R.
- Tivenan H.
- Tobin M.D.
- Todd A.
- Todd L.
- Tolson M.
- Tomas A.L.
- Tommasi A.
- Tonks L.
- Torky M.S.
- Torrents D.
- Torvorapanit P.
- Tracy B.
- Trankiem A.
- Tranter H.
- Trembath R.C.
- Tridente A.
- Trim F.
- Trivedi B.
- Trodd D.
- Trogstad L.-I.S.
- Trotman S.
- Trotta T.
- Trower H.
- Truman N.
- Trumper E.
- Tsao P.
- Tselios C.
- Tsinaslanidis G.
- Tsuo K.
- Tucci A.
- Tuckey V.
- Tully R.
- Tumbarello M.
- Turki S.
- Turley P.
- Turnbull A.
- Turner K.
- Turner L.
- Turner P.
- Turner V.
- Turner-Bone I.
- Turney S.
- Turtle L.
- Tutton R.
- Twiss S.
- Tyl D.
- Tyler A.
- Uitterlinden A.G.
- Underwood S.J.
- Vaghi M.
- Vaida M.
- Valente S.
- Valentine J.
- Valentino F.
- van Blokland I.
- van Heel D.A.
- van Koutrik L.
- Varghese M.
- Vecchia M.
- Vedage D.
- Veerapen K.
- Venkatesh H.
- Venn L.D.
- Venturelli S.
- Vergori A.
- Verlander M.
- Verma A.
- Verma A.
- Verma S.S.
- Vertue M.
- Verula J.
- Verzuri A.
- Vigurs C.
- Villalonga J.M.
- Vincent R.
- Vincenti A.
- Virgilio E.
- Vitart V.
- Vizcaychipi M.P.
- Vochin A.
- Voide C.
- von Frenckell C.
- von Hohenstaufen K.A.
- Vonk J.M.
- Vulesevic B.
- Vuylsteke A.
- Wackett T.
- Wadams B.
- Waddington N.
- Wagstaff V.
- Wain L.V.
- Waite A.A.C.
- Wakefield P.
- Wakinshaw F.
- Waldron J.
- Walker D.
- Walker R.
- Walker S.
- Walker S.
- Walker S.
- Wall A.
- Walsh T.
- Walsh T.
- Walters R.K.
- Walton O.
- Wang B.
- Wang J.
- Wang X.
- Wanying Z.
- Ward G.
- Ward L.
- Ward M.
- Warden S.
- Warmerdam R.
- Warren D.
- Wassall H.
- Wasson C.
- Watkins C.
- Watson E.
- Watson G.
- Watson J.
- Watters M.
- Waugh V.
- Weaver J.
- Webster A.
- Webster D.
- Webster K.
- Wei S.
- Weiss S.T.
- Weldon C.H.
- Wells C.
- Welters I.D.
- Weston H.
- Whileman A.
- Whitbread J.
- White D.
- White I.
- White K.
- White M.
- White N.
- White N.
- Whiteley S.
- Whiteside J.
- Whittle H.
- Whitton C.
- Whyte C.
- Wicks S.J.
- Wilby E.
- Wilcox L.
- Wilcox R.
- Wild H.
- Wild L.
- Wild L.
- Wilding L.
- Wiles M.
- Wilkins J.
- Wilkinson A.
- Wilkinson B.
- Willer C.
- Williams A.
- Williams A.
- Williams A.
- Williams A.T.
- Williams D.
- Williams E.
- Williams F.
- Williams G.
- Williams H.
- Williams K.
- Williams M.
- Williams P.
- Williams S.
- Williams T.
- Willis C.
- Willis H.
- Wills M.
- Willson J.
- Wilson A.
- Wilson D.J.
- Wilson J.
- Wilson J.F.
- Wilson J.F.
- Winnard S.
- Winter-Goodwin B.
- Wolf-Roberts R.
- Wolford B.
- Wong J.
- Wood D.
- Wood H.-L.
- Wood S.
- Wood T.
- Woodford C.
- Woodruff M.
- Woods L.
- Woodyatt W.
- Woolley A.E.
- Worner R.
- Worsley L.
- Wray G.
- Wren L.
- Wrey Brown C.
- Wright D.
- Wright J.
- Wright M.
- Wrobel N.
- Wu Y.
- Wulandari R.
- Wyllie D.H.
- Wynter I.
- Xavier K.
- Xue X.
- Yadav A.
- Yang J.
- Yassen A.M.
- Yates B.
- Ye C.
- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
- Zamikula J.
- Zanella I.
- Zborowski A.C.
- Zeberg H.
- Zechner M.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J.H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Zöllner S.
- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Evolutionary stability under the replicator and the gradient dynamics
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A Simple Model of Circadian Rhythms Based on Dimerization and Proteolysis of PER and TIM
- Author
- Allada
- Bae
- Bela Novak
- Bliss
- C. Dennis Thron
- Christian I. Hong
- Cote
- Darlington
- Doedel
- Edelstein-Keshet
- Gekakis
- Goldbeter
- Goodwin
- Griffith
- Hardin
- Huang
- Hunter-Ensor
- John J. Tyson
- Kalmus
- Kloss
- Konopka
- Kronauer
- Lee
- Leloup
- Myers
- Myers
- Pavlidis
- Pittendrigh
- Price
- Ruoff
- Ruoff
- Ruoff
- Rutila
- Scheper
- Sehgal
- Sehgal
- Smith
- Suri
- Thron
- Tyson
- Tyson
- Vosshall
- Wever
- Wilsbacher
- Winfree
- Zeng
- Zeng
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study