An exact solution for arbitrarily rotating gaseous polytropes with index unity

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society ©: 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.Many gaseous planets and stars are rapidly rotating and can be approximately described by a polytropic equation of state with index unity.We present the first exact analytic solution, under the assumption of the oblate spheroidal shape, for an arbitrarily rotating gaseous polytrope with index unity in hydrostatic equilibrium, giving rise to its internal structure and gravitational field. The new exact solution is derived by constructing the non-spherical Green’s function in terms of the oblate spheroidal wavefunction. We then apply the exact solution to a generic object whose parameter values are guided by the observations of the rapidly rotating star α Eridani with its eccentricity Eα = 0.7454, the most oblate star known. The internal structure and gravitational field of the object are computed from its assumed rotation rate and size. We also compare the exact solution to the three-dimensional numerical solution based on a finite-element method taking full account of rotation-induced shape change and find excellent agreement between the exact solution and the finite-element solution with about 0.001 per cent discrepancy.NSFCScience & Technology Facilities Council (STFC)HKRGCNational Science Foundatio

On fluid flows in precessing narrow annular channels: asymptotic analysis and numerical simulation

Copyright © 2010 Cambridge University PressWe consider a viscous, incompressible fluid confined in a narrow annular channel rotating rapidly about its axis of symmetry with angular velocity Ω that itself precesses slowly about an axis fixed in an inertial frame. The precessional problem is characterized by three parameters: the Ekman number E, the Poincaré number ε and the aspect ratio of the channel Γ. Dependent upon the size of Γ, precessionally driven flows can be either resonant or non-resonant with the Poincaré forcing. By assuming that it is the viscous effect, rather than the nonlinear effect, that plays an essential role at exact resonance, two asymptotic expressions for ε ≪ 1 and E ≪ 1 describing the single and double inertial-mode resonance are derived under the non-slip boundary condition. An asymptotic expression describing non-resonant precessing flows is also derived. Further studies based on numerical integrations, including two-dimensional linear analysis and direct three-dimensional nonlinear simulation, show a satisfactory quantitative agreement between the three asymptotic expressions and the fuller numerics for small and moderate Reynolds numbers at an asymptotically small E. The transition from two-dimensional precessing flow to three-dimensional small-scale turbulence for large Reynolds numbers is also investigated

Thermal-gravitational wind equation for the wind-induced gravitational signature of giant gaseous planets: mathematical derivation, numerical method, and illustrative solutions

© 2015. The American Astronomical Society. All rights reserved. Received 26 February 2015, accepted for publication 4 May 2015 Published 23 June 2015Please cite the published version available at DOI: 10.1088/0004-637X/806/2/270The standard thermal wind equation (TWE) relating the vertical shear of a flow to the horizontal density gradient in an atmosphere has been used to calculate the external gravitational signature produced by zonal winds in the interiors of giant gaseous planets. We show, however, that in this application the TWE needs to be generalized to account for an associated gravitational perturbation. We refer to the generalized equation as the thermalgravitational wind equation (TGWE). The generalized equation represents a two-dimensional kernel integral equation with the Green’s function in its integrand and is hence much more difficult to solve than the standard TWE. We develop an extended spectral method for solving the TGWE in spherical geometry. We then apply the method to a generic gaseous Jupiter-like object with idealized zonal winds. We demonstrate that solutions of the TGWE are substantially different from those of the standard TWE. We conclude that the TGWE must be used to estimate the gravitational signature of zonal winds in giant gaseous planets

Precessing cylinders at the second and third resonance: Turbulence controlled by geostrophic flow

Copyright © 2015 American Physical SocietyWe investigate, via both asymptotic analysis and direct numerical simulation, precessionally driven flow of a homogeneous fluid confined in fluid-filled circular cylinders that rotate rapidly about their symmetry axis and precess about a different axis and that are marked by radius-height aspect ratios Γ=1.045945 and Γ=1.611089 . At these radius-height aspect ratios, the Poincaré force resonates directly with the two special inertial modes that have the simplest vertical structure. An asymptotic analytical solution in closed form describing weakly precessing flow is derived in the mantle frame of reference for asymptotically small Ekman numbers, showing quantitative agreement with the result of direct nonlinear numerical simulation. Our numerical simulation makes use of a finite-element method with the three-dimensional tetrahedralization of a cylindrical cavity that allows the construction of dense nodes in the vicinity of the bounding surface of the cavity for resolving the thin viscous boundary layer. It is found that axisymmetric geostrophic flow in the alternating eastward and westward direction can be generated and maintained by nonlinear and viscous effects in the viscous boundary layer. It is also found that, when the precessing rate is moderate and, consequently, the geostrophic flow is weak, nonlinear interaction between the resonant inertial mode and the nonesonant inertial modes driven by the Poincaré force and the boundary-layer influx leads to strongly turbulent flow with irregular temporal-spatial fluctuation. When the cylinders are strongly precessing such that the geostrophic flow becomes predominant, however, the effect of the geostrophic flow controls/stabilizes its nonlinear dynamics, leading to weakly turbulent flow that can be largely described by a dominant quasisteady geostrophic component and a weak nonaxisymmetric component localized in the region where the geostrophic flow is weak.Leverhulme TrustMacau FDCTNSF

Inertial convection in a rotating narrow annulus: Asymptotic theory and numerical simulation

The following article appeared in Physics of Fluids, 2015, Volume 27, and may be found at http://scitation.aip.org/content/aip/journal/pof2/27/10/10.1063/1.4934527.An important way of breaking the rotational constraint in rotating convection is to invoke fast oscillation through strong inertial effects which, referring to as inertial convection, is physically realizable when the Prandtl number Pr of rotating fluids is sufficiently small.We investigate, via both analytical and numerical methods, inertial convection in a Boussinesq fluid contained in a narrow annulus rotating rapidly about a vertical symmetry axis and uniformly heated from below, which can be approximately realizable in laboratory experiments [R. P. Davies-Jones and P. A. Gilman, “Convection in a rotating annulus uniformly heated from below,” J. Fluid Mech. 46, 65-81 (1971)]. On the basis of an assumption that inertial convection at leading order is represented by a thermal inertial wave propagating in either prograde or retrograde direction and that buoyancy forces appear at the next order to maintain the wave against the effect of viscous damping, we derive an analytical solution that describes the onset of inertial convection with the non-slip velocity boundary condition. It is found that there always exist two oppositely traveling thermal inertial waves, sustained by convection, that have the same azimuthal wavenumber, the same size of the frequency, and the same critical Rayleigh number but different spatial structure. Linear numerical analysis using a Galerkin spectral method is also carried out, showing a quantitative agreement between the analytical and numerical solutions when the Ekman number is sufficiently small. Nonlinear properties of inertial convection are investigated through direct three-dimensional numerical simulation using a finite-difference method with the Chorin-type projection scheme, concentrating on the liquid metal gallium with the Prandtl number Pr = 0.023. It is found that the interaction of the two counter-traveling thermal inertial waves leads to a timedependent, spatially complicated, oscillatory convection even in the vicinity of the onset of inertial convection. The nonlinear properties are analyzed via making use of the mathematical completeness of inertial wave modes in a rotating narrow annulus, suggesting that the laminar to weakly turbulent transition is mainly caused by the nonlinear interaction of several inertial wave modes that are excited and maintained by thermal convection at moderately supercritical Rayleigh numbers.Leverhulme TrustMacau FDCTChinese Academy of Science

Identification of dissociation factors in pancreatic Cancer using a mass spectrometry-based proteomic approach

Backgroud Pancreatic cancer is a highly malignant tumor of the digestive system. This secretome of pancreatic cancer is key to its progression and metastasis. But different methods of protein extraction affect the final results. In other words, the real secretion of proteins in cancer cells has been changed. Based on mass spectrometry, we analyze the secretome from the serum-containing and serum-free medium, using different protein pretreatment methods. This study aims to identify dissociation factors in pancreatic cancer. Methods In this study, pancreatic cancer cells were cultured in serum-containing or serum-free medium, and the corresponding supernatants were extracted as samples. Subsequently, the above samples were separated by size exclusion chromatography (SEC), and peptide segments were identified by LC-MS/MS. The final results were identified via the hamster secreted protein database and a public database. Results Although the number of identified proteins in the serum-free medium group was high, the real secretion of proteins in pancreatic cancer cells was changed. There were six significant secreted proteins in the serum-containing medium group. Survival analysis via the TCGA database suggested that patients with higher expression levels of YWHAG showed a worse overall survival rate than those with lower YWHAG expression. Conclusions Our study demonstrated the results in the serum-containing medium group were more similar to the real secretome of pancreatic cancer cells. YWHAG could be used as a prognostic indicator for pancreatic cancer

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

Global economic burden of unmet surgical need for appendicitis

Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially