An Approach to the Multivectorial Apparent Power in Terms of a Generalized Poynting Multivector

The purpose of this paper is to explain an exact derivation of apparent power in n-sinusoidal operation founded on electromagnetic theory, until now unexplained by simple mathematical models. The aim is to explore a new tool for a rigorous mathematical and physical analysis of the power equation from the Poynting Vector (PV) concept. A powerful mathematical structure is necessary and Geometric Algebra offers such a characteristic. In this sense, PV has been reformulated from a new Multivectorial Euclidean Vector Space structure (CGn-R3) to obtain a Generalized Poynting Multivector ( ~ S). Consequently, from ~ S, a suitable multivectorial form ( ~ P and ~D) of the Poynting Vector corresponds to each component of apparent power. In particular, this framework is essential for the clari¯cation of the connection between a Complementary Poynting Multivector (~D) and the power contribution due to cross-frequency products. A simple application example is presented as an illustration of the proposed power multivector analysis

Considerations on the non-active power using geometric algebra

Several approaches have been developed to define the non-active power concept under nonsinusoidal situations in electrical systems. Nevertheless, these contributions do not provide a complete and satisfactory solution to the non-active power reversibility between frequency domain and time domain. This paper presents a non-active power multivector concept, based on an original vector space frequency-domain approach that bridges the gap between both domains. The suggested correspondence can provide a convenient descriptive language to reconcile Fryze’s instantaneous non-active power with Budeanu´s deactive-power

Peer tutoring: Wiki as a tool for learning in the pedagogues training

Esta comunicación presenta los resultados de un trabajo de investigación desarrollado en la Facultad de Ciencias de la Educación (US) por un equipo de profesores y alumnos adscritos al departamento de Didáctica y Organización Educativa, dentro de las asignatura Prácticum I y II de la Licenciatura de Pedagogía. Bajo el objetivo principal de detectar las necesidades formativas de los/as alumnos/as de Pedagogía sobre las condiciones académicas requeridas en las asignaturas Practicum I y II, se elaboró en cursos anteriores, un Programa de Acción Tutorial entre Iguales (PATI) en el que quedaron plasmadas las principales carencias formativas que los alumnos encontraron en sus prácticas externas. Para ello se administró un Cuestionario sobre detección de necesidades formativas del alumnado del prácticum de Pedagogía a una muestra de 104 estudiantes. Una vez recogidos los datos y analizados los resultados, se construyó de manera colaborativa un wiki (http://proyectopati.wikispaces.com). Durante el curso académico 2010-2011, continuando con la segunda fase del proyecto, los alumnos de quinto de Pedagogía han elaborado el wiki, bajo la supervisión de sus tutores, y se ha establecido un sistema de tutoría entre iguales con los alumnos de tercero de Pedagogía. Nuestro espacio wiki puede ser considerado como una biblioteca dónde compartir información, recoger, añadir notas o responder a preguntas de sus compañeros.This paper presents the results of a research work developed at the Faculty of Educational Sciences (U.S.) developed by a team of teachers and students assigned to the Department of Didactics and Educational Organization, within the subject Practicum I and II of the Degree of Education. Under the main objective to identify the training needs of the pupil of Pedagogy on the academic conditions required subjects Practicum I and II, was developed in previous courses, a Program of Action Tutorial Peer (PATI ), which were embodied the main training gaps were students when developing their placement. This questionnaire was administered on identification of training needs of students of pedagogy practicum in a sample of 104 students. Once data are collected and analyzed the results, the program was developed and built a wiki to collaboratively (http://proyectopati.wikispaces.com). During the 2010-2011 academic year, continuing the second phase of the project, students in grades 5 of Education have developed the wiki, under the supervision of their tutors, and has established a system of peer tutoring with students in 3 of pedagogy. Our wiki space has been like a library where we have shared information and consequently the students of 3 rd have used it to obtain information and gather ideas and students in grades 5 have been able to add notes or answer questions from their peers

Los mármoles comerciales “Marrón Imperial” y “Marrón Emperador” (S.E. España). Caracterización petrológica y criterios de exploración

Los mármoles comerciales "Marrón Imperial" y "Marrón Emperador" son dolomías brechoides que de acuerdo con la clasificación del MIA pertenece al Grupo C de mármoles comerciales. Se determinan sus parámetros petrofísicos según la norma UNE. Sus rasgos petrológicos se estudian mediante microscopio petrográfico de luz transmitida y microscopio electrónico de barrido (MEB) (en modo de electrones secundarios y electrones retrodispersados). Estas rocas son básicamente dolomías mesocristalinas con abundantes vénulas calcíticas politexturales relacionadas con procesos de brechificación y de dolomitización. Rasgos kársticos aumentan la complejidad petrológica de estas rocas ornamentales cuyo litosoma son las dolomías masivas del Cretácico Superior (¿Turoniense?) del dominio Prebético Externo. El material explotado pertenece a una alineación morfoestructural que va desde Jumilla hasta el NE de Caudete y está relacionado con la falla Jumilla-Yecla-Caudete-Font de la Figuera. La relación entre esta falla y las dolomías turonienses son el principal criterio de exploración de estas rocas ornamentales.The "Marrón Imperial" and the "Marrón Emperador" commercial marble are brecciated dolomite rocks that, in agree with the soundness classification of MIA, belongs to the Group C of the commercial marbles. Petrophysical parameters of stones has been obtained using de UNE NORM (Spanish normalised test). The petrologic features have been defined from light microscopy and SEM data (secondary electrons and back scattered electrons modes). "Marrón Imperial" and "Marrón Emperador" are mesocrystalline dolostones with a reticulate of calcite veins, which are polytextural and are related to both brecciation and dedolomitization processes. Karstic features increase the petrologic complexity of this dimensional stone. The host lithosomes of "Marrón Imperial" and "Marrón Emperador" marbles are the massive dolostones of Upper Cretaceous (Turonian?) age of Outer Prebetic Domain. The quarried material outcrops from Jumilla to NE Caudete; Villena-La Encina, Jumilla (Fuente and Cingla Mountains) Yecla (Magdalena Mountains). Caudete and Yecla are the most important areas for extraction at the moment. The tectofacies that are the main responsible of the aesthetic properties of the Marrón Imperial and Marrón Emperador commercial marbles which main outcrops are probably related to the Jumilla-Yecla-Caudete-Font de la Figuera near strike-slip fault and associated events. The main exploration criteria from this type of commercial marble are the fault line distribution, and their influence over Turonian dolostones.Este trabajo forma parte del Proyecto AMB 93-0019 subvencionado por la CICYT

A novel ABCA12 pathologic variant identified in an Ecuadorian harlequin ichthyosis patient: A step forward in genotype‐phenotype correlations

Autosomal recessive congenital ichthyoses (ARCI) have been associated with different phenotypes including: harlequin ichthyosis (HI), congenital ichthyosiform erythroderma (CIE), and lamellar ichthyosis (LI). While pathogenic variants in all ARCI genes are associated with LI and CIE phenotypes, the unique gene associated with HI is ABCA12. In HI, the most severe ARCI form, pathogenic variants in both ABCA12 gene alleles usually have a severe impact on protein function. The presence of at least one non-truncating variant frequently causes a less severe congenital ichthyosis phenotype (LI and CIE). METHODS: We report the case of a 4-year-old Ecuadorian boy with a severe skin disease. Genetic diagnosis was performed by NGS. In silico predictions were performed using Alamut software v2.11. A review of the literature was carried out to identify all patients carrying ABCA12 splice-site and missense variants, and to explore their genotype-phenotype correlations. RESULTS: Genetic testing revealed a nonsense substitution, p.(Arg2204*), and a new missense variant, p.(Val1927Leu), in the ABCA12 gene. After performing in silico analysis and a comprehensive review of the literature, we conclude that p.(Val1927Leu) affects a well conserved residue which could either disturb the protein function or alter the splicing process, both alternatives could explain the severe phenotype of our patient. CONCLUSION: This case expands the spectrum of ABCA12 reported disease-causing variants which is important to unravel genotype-phenotype correlations and highlights the importance of missense variants in the development of HI. © 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.Fundación Ramón ArecesInstituto de Salud Carlos IIIXunta de GaliciaUniversidad Espíritu Santo-Ecuado

Validation Study Of Genetic Biomarkers Of Response To Tnf Inhibitors In Rheumatoid Arthritis

Genetic biomarkers are sought to personalize treatment of patients with rheumatoid arthritis (RA), given their variable response to TNF inhibitors (TNFi). However, no genetic biomaker is yet sufficiently validated. Here, we report a validation study of 18 previously reported genetic biomarkers, including 11 from GWAS of response to TNFi. The validation was attempted in 581 patients with RA that had not been treated with biologic antirheumatic drugs previously. Their response to TNFi was evaluated at 3, 6 and 12 months in two ways: change in the DAS28 measure of disease activity, and according to the EULAR criteria for response to antirheumatic drugs. Association of these parameters with the genotypes, obtained by PCR amplification followed by single-base extension, was tested with regression analysis. These analyses were adjusted for baseline DAS28, sex, and the specific TNFi. However, none of the proposed biomarkers was validated, as none showed association with response to TNFi in our study, even at the time of assessment and with the outcome that showed the most significant result in previous studies. These negative results are notable because this was the first independent validation study for 12 of the biomarkers, and because they indicate that prudence is needed in the interpretation of the proposed biomarkers of response to TNFi even when they are supported by very low p values. The results also emphasize the requirement of independent replication for validation, and the need to search protocols that could increase reproducibility of the biomarkers of response to TNFi

Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis

Introduction: In this study, our aim was to elucidate the role of four polymorphisms identified in a prior large genome-wide association study (GWAS) in which the investigators analyzed the responses of patients with rheumatoid arthritis (RA) to treatment with tumor necrosis factor inhibitors (TNFi). The authors of that study reported that the four genetic variants were significantly associated. However, none of the associations reached GWAS significance, and two subsequent studies failed to replicate these associations. Methods: The four polymorphisms (rs12081765, rs1532269, rs17301249 and rs7305646) were genotyped in a total of 634 TNFi-treated RA patients of Spanish Caucasian origin. Four outcomes were evaluated: changes in the Disease Activity Score in 28 joints (DAS28) after 6 and 12 months of treatment and classification according to the European League Against Rheumatism (EULAR) response criteria at the same time points. Association with DAS28 changes was assessed by linear regression using an additive genetic model. Contingency tables of genotype and allele frequencies between EULAR responder and nonresponder patients were compared. In addition, we combined our data with those of previously reported studies in a meta-analysis including 2,998 RA patients. Results: None of the four genetic variants showed an association with response to TNFi in any of the four outcomes analyzed in our Spanish patients. In addition, only rs1532269 yielded a suggestive association (P = 0.0033) with the response to TNFi when available data from previous studies were combined in the meta-analysis. Conclusion: Our data suggest that the rs12081765, rs1532269, rs17301249 and rs7305646 genetic variants do not have a role as genetic predictors of TNFi treatment outcomes

Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study.

INTRODUCTION: We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA). METHODS: The G1m genotypes were analyzed in three collections of patients with RA totaling 1037 subjects. The first, used for discovery, comprised 215 Spanish patients. The second and third were successively used for replication. They included 429 British and Greek patients and 393 Spanish and British patients, respectively. Two outcomes were considered: change in the Disease Activity Score in 28 joint (ΔDAS28) and the European League Against Rheumatism (EULAR) response criteria. RESULTS: An association between less response to INX and incompatibility of the G1m1,17 allotype was found in the discovery collection at 6 months of treatment (P = 0.03). This association was confirmed in the replications (P = 0.02 and 0.08, respectively) leading to a global association (P = 0.001) that involved a mean difference in ΔDAS28 of 0.4 units between compatible and incompatible patients (2.3 ± 1.5 in compatible patients vs. 1.9 ± 1.5 in incompatible patients) and an increase in responders and decrease in non-responders according to the EULAR criteria (P = 0.03). A similar association was suggested for patients treated with ADM in the discovery collection, but it was not supported by replication. CONCLUSIONS: Our results suggest that G1m1,17 allotypes are associated with response to INX and could aid improved therapeutic targeting in RA

Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus

5to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

El V Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2019, realizado del 6 al 8 de febrero de 2019 y organizado por la Universidad Politécnica Salesiana, ofreció a la comunidad académica nacional e internacional una plataforma de comunicación unificada, dirigida a cubrir los problemas teóricos y prácticos de mayor impacto en la sociedad moderna desde la ingeniería. En esta edición, dedicada a los 25 años de vida de la UPS, los ejes temáticos estuvieron relacionados con la aplicación de la ciencia, el desarrollo tecnológico y la innovación en cinco pilares fundamentales de nuestra sociedad: la industria, la movilidad, la sostenibilidad ambiental, la información y las telecomunicaciones. El comité científico estuvo conformado formado por 48 investigadores procedentes de diez países: España, Reino Unido, Italia, Bélgica, México, Venezuela, Colombia, Brasil, Estados Unidos y Ecuador. Fueron recibidas un centenar de contribuciones, de las cuales 39 fueron aprobadas en forma de ponencias y 15 en formato poster. Estas contribuciones fueron presentadas de forma oral ante toda la comunidad académica que se dio cita en el Congreso, quienes desde el aula magna, el auditorio y la sala de usos múltiples de la Universidad Politécnica Salesiana, cumplieron respetuosamente la responsabilidad de representar a toda la sociedad en la revisión, aceptación y validación del conocimiento nuevo que fue presentado en cada exposición por los investigadores. Paralelo a las sesiones técnicas, el Congreso contó con espacios de presentación de posters científicos y cinco workshops en temáticas de vanguardia que cautivaron la atención de nuestros docentes y estudiantes. También en el marco del evento se impartieron un total de ocho conferencias magistrales en temas tan actuales como la gestión del conocimiento en la universidad-ecosistema, los retos y oportunidades de la industria 4.0, los avances de la investigación básica y aplicada en mecatrónica para el estudio de robots de nueva generación, la optimización en ingeniería con técnicas multi-objetivo, el desarrollo de las redes avanzadas en Latinoamérica y los mundos, la contaminación del aire debido al tránsito vehicular, el radón y los riesgos que representa este gas radiactivo para la salud humana, entre otros