Interpellations : Three Essays on Kent Monkman = Trois essais sur Kent Monkman

"In Interpellations. Three Essays on Kent Monkman the art historians Jonathan D. Katz, Richard W. Hill and Todd Porterfield offer perspectives and analyses on Monkman's work that address history and genre painting, the queered Romantic landscape, the shifting and unfixed subject, race, sexuality conquest and soverignty, and modern versus discontinuous temporality." -- p. [4] of cover

CUSigns: A Dynamic Solution for Digital Signage

Cedarville University has computer monitors located throughout campus in order to show advertisements and important information to students, faculty, and staff. The slides shown on these displays are scheduled using Concerto: web-based software which manages digital signage. Though the Concerto software is currently used to manage digital signage, Cedarville University’s IT department desires features which Concerto does not provide, including the ability to play videos, a better slide randomization algorithm, emergency broadcasting features, and an intuitive user interface. We have created a new solution for digital signage called CUSigns with the goal of providing the existing functionality of Concerto while also providing the additional features. Numerous in-depth interviews with members of Cedarville’s faculty and staff who are currently using Concerto have led to cycles of design and redesign allowing CUSigns to meet the user requirements necessary to replace Concerto. CUSigns is currently in Beta testing on three displays in the Engineering and Science building to ensure system stability as it is prepared to be released for widespread use at the end of April

Beginning to track 1000 datasets from public repositories into the published literature

Data sharing provides many potential benefits, although the amount of actual data reused is unknown. Here we track the reuse of data from three data repositories (NCBI\u27s Gene Expression Omnibus, PANGAEA, and TreeBASE) by searching for dataset accession number or unique identifier in Google Scholar and using ISI Web of Science to find articles that cited the data collection article. We found that data reuse and data attribution patterns vary across repositories. Data reuse appears to correlate with the number of citations to the data collection article. This preliminary investigation has demonstrated the feasibility of this method for tracking data reuse

Mediciones de potencial zeta de microesferas de vidrio en glicol de etileno y en soluciones tampón de fosfato

Este artículo cubre el procedimiento y los resultados obtenidos midiendo potencial zeta (¿) de microesferas de vidrio en glicol de etileno y en soluciones tampón (soluciones buffer) de fosfato. El potencial zeta fue medido usando el dispositivo NICOMP ZLS 388 el cual emplea el principio de dispersión electroforética de la luz. El potencial zeta de las microesferas en soluciones de agua y glicol de etileno fue medido entre -63 y -68 mV y en las soluciones tampón de fosfato varia entre -60 y -110 mV. Los resultados que fueron obtenidos son comparados con resultados publicados para las soluciones mencionadas. Finalmente son discutidas las dificultades asociadas con la medición del potencial zeta.This report covers the procedure and results obtained by measuring zeta potential (¿) of glass microspheres in phosphate buffers and ethylene glycol. Zeta potential was measured using the NICOMP ZLS 388 which employs electrophoretic light scattering. Zeta potential in ethylene glycol-water solutions was measured between -63 and -68 mV. The measured zeta potential of glass microspheres in phosphate buffer solutions varied between -60 and -110 mV. The obtained results are compared with similar published results for ethylene glycol and buffer solutions. Also discussed are the difficulties associated with measuring the zeta potential

Dehorning the Darwinian Dilemma for Normative Realism

Normative realists tend to consider evolutionary debunking arguments as posing epistemological challenges to their view. By understanding Sharon Street's 'Darwinian dilemma' argument in this way, they have overlooked and left unanswered her unique scientific challenge to normative realism. This paper counters Street's scientific challenge and shows that normative realism is compatible with evolutionary views of human evaluative judgment. After presenting several problems that her Adaptive Link Account (ALA) of evaluative judgments faces, I outline and defend an evolutionary byproduct perspective on evaluative judgment. I then argue that a consideration of levels of analysis in biological-behavioral explanation suggests that the realist who adopts the byproduct perspective I outline is not at a prima facie disadvantage to the normative anti-realist on grounds of parsimony. This perspective, I suggest, can enable normative realists to answer evolutionary challenges to their view

Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia.

Funder: National Institute for Health Research (NIHR) Queen Square Dementia Biomedical Research UnitFunder: Alzheimer's Research UK, Brain Research Trust and The Wolfson FoundationFunder: Medical Research CouncilFunder: Alzheimer’s Society and Alzheimer’s Research UKFunder: NIHR UCL/H Biomedical Research Centre and the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research FacilityFunder: DRI LtdWhilst initial anatomical studies of frontotemporal dementia focussed on cortical involvement, the relevance of subcortical structures to the pathophysiology of frontotemporal dementia has been increasingly recognized over recent years. Key structures affected include the caudate, putamen, nucleus accumbens, and globus pallidus within the basal ganglia, the hippocampus and amygdala within the medial temporal lobe, the basal forebrain, and the diencephalon structures of the thalamus, hypothalamus and habenula. At the most posterior aspect of the brain, focal involvement of brainstem and cerebellum has recently also been shown in certain subtypes of frontotemporal dementia. Many of the neuroimaging studies on subcortical structures in frontotemporal dementia have been performed in clinically defined sporadic cases. However, investigations of genetically- and pathologically-confirmed forms of frontotemporal dementia are increasingly common and provide molecular specificity to the changes observed. Furthermore, detailed analyses of sub-nuclei and subregions within each subcortical structure are being added to the literature, allowing refinement of the patterns of subcortical involvement. This review focuses on the existing literature on structural imaging and neuropathological studies of subcortical anatomy across the spectrum of frontotemporal dementia, along with investigations of brain-behaviour correlates that examine the cognitive sequelae of specific subcortical involvement: it aims to 'look beneath the surface' and summarize the patterns of subcortical involvement have been described in frontotemporal dementia

LED excitation of an on-chip imaging flow cytometer for bead-based immunoassay

A green LED is demonstrated to generate a uniform square illumination pattern for an on-chip imaging flow cytometer system. The proposed system is used to perform the detection of a bead-based immunoassay for a sepsis biomarker, procalcitonin

Potential neural substrates underlying circadian and olfactory disruptions in preclinical Alzheimer’s disease

Alzheimer’s disease (AD) is the leading cause of dementia, with over 45 million patients worldwide, and poses significant economic and emotional burdens to both patients and caregivers, significantly raising the number of those affected. Unfortunately, much of the existing research on the disease only addresses a small subset of associated symptomologies and pathologies. In this review, we propose to target the earliest stages of the disease, when symptomology first arises. In these stages, before the onset of hallmark symptoms of AD such as cognitive impairments and memory loss, circadian and olfactory disruptions arise and are detectable. Functional similarities between circadian and olfactory systems provide a basis upon which to seek out common mechanisms in AD which may target them early on in the disease. Existing studies of interactions between these systems, while intriguing, leave open the question of the neural substrates underlying them. Potential substrates for such interactions are proposed in this review, such as indirect projections that may functionally connect the two systems and dopaminergic signaling. These substrates may have significant implications for mechanisms underlying disruptions to circadian and olfactory function in early stages of AD. In this review, we propose early detection of AD using a combination of circadian and olfactory deficits and subsequent early treatment of these deficits may provide profound benefits to both patients and caregivers. Additionally, we suggest that targeting research toward the intersection of these two systems in AD could uncover mechanisms underlying the broader set of symptoms and pathologies that currently elude researchers

Vibratory Stimulus Reduces In Vitro Biofilm Formation On Tracheoesophageal Voice Prostheses

Objectives/Hypothesis Demonstrate that biofilm formation will be reduced on tracheoesophageal prostheses when vibratory stimulus is applied, compared to controls receiving no vibratory stimulus, in a dynamic in vitro model of biofilm accumulation simulating the interface across the tracheoesophageal puncture site. Study Design Prospective, randomized, controlled, crossover in university laboratory. Methods Ex vivo tracheoesophageal prostheses were obtained from university-affiliated speech language pathologists at Indiana University School of Medicine, Indianapolis. Prostheses demonstrating physical integrity and an absence of gross biofilm accumulation were utilized. Sixteen prostheses were cleansed and sterilized prior to random placement by length in two modified Robbins devices arranged in parallel. Each device was seeded with a polymicrobial oral flora on day 1 and received basal artificial salivary flow continuously with three growth medium meals daily. One device was randomly selected for vibratory stimulus, and 2 minutes of vibration was applied to each prosthesis before and after meals for 5 days. The prostheses were explanted and sonicated, and the biofilm cultured for enumeration. This process was repeated after study arm crossover. Results Tracheoesophageal prostheses in the dynamic model receiving vibratory stimulus demonstrated reduced gross biofilm accumulation and a significant biofilm colony forming unit per milliliter reduction of 5.56-fold compared to nonvibratory controls (P < 0.001). Significant reductions were observed within length subgroups. Conclusion Application of vibratory stimulus around meal times significantly reduces biofilm accumulation on tracheoesophageal prostheses in a dynamic in vitro model. Further research using this vibratory stimulus method in vivo will be required to determine if reduced biofilm accumulation correlates with longer device lifespan