127 research outputs found
Imaging Synapse Formation during Thymocyte Selection Inability of CD3ζ to Form a Stable Central Accumulation during Negative Selection
- Publication venue
- Cell Press.
- Publication date
- Field of study
AbstractTCR signaling can result in cell fates ranging from activation to tolerance to apoptosis. Organization of molecules in an âimmunological synapseâ between mature T cells and APCs correlates with the strength of TCR signaling. To investigate synapse formation during thymic selection, we have established a reaggregate system in which molecular recruitment of GFP fusion proteins to thymocyte:stromal cell interfaces can be visualized in real time. We demonstrate that negative selection is associated with efficient conjugate formation and rapid recruitment of p56lck and CD3ζ to an immunological synapse. Interestingly, CD3ζ-GFP does not accumulate at the center of the synapse, as in mature T cells, but at the periphery across a wide range of ligand densities. This implicates differences in synapse geometry in initiation of alternate signals downstream of the TCR
The Earth: Plasma Sources, Losses, and Transport Processes
- Author
- A. Glocer
- a. Glocer
- A. Hasegawa
- A. Hasegawa
- A. Kullen
- A. Miura
- A. Opitz
- A. Otto
- A. Posner
- A. Teste
- A.W. Yau
- A.W. Yau
- A.W. Yau
- A.W. Yau
- A.W. Yau
- A.W. Yau
- Andrew Fazakerley
- Andrew Yau
- B. Hultqvist
- B. Lavraud
- B. Lavraud
- B. Ni
- B. Ni
- B.A. Whalen
- B.H. Mauk
- B.J. Anderson
- B.M. Walsh
- B.M.A. Cooling
- B.R. Sandel
- B.R. Sandel
- B.T. Tsurutani
- B.U.O. Sonnerup
- C. Chaston
- C. Foster
- C. Foullon
- C. Harvey
- C. Twitty
- C.-P. Wang
- C.-P. Wang
- C.-P. Wang
- C.-P. Wang
- C.-P. Wang
- C.-P. Wang
- C.-S. Huang
- C.E. McIlwain
- C.G. Park
- C.J. Owen
- C.J. Pollock
- C.M. Cully
- C.M. Cully
- C.P. Wang
- C.R. Chappell
- C.R. Chappell
- C.R. Chappell
- Chih-Ping Wang
- D. Nagata
- D.A. Hardy
- D.A. Hardy
- D.A. Hardy
- D.C. Delcourt
- D.C. Delcourt
- D.C. Delcourt
- D.C. Delcourt
- D.C. Hamilton
- D.G. Mitchell
- D.G. Sibeck
- D.H. Fairfield
- D.L. Carpenter
- D.M. Klumpar
- D.M. Klumpar
- D.T. Welling
- D.T. Welling
- D.T. Welling
- Daniel T. Welling
- Dominique Delcourt
- Dominique Fontaine
- E. Drakou
- E. Engwall
- E. Engwall
- E. Engwall
- E. Möbius
- E.A. Kronberg
- E.E. Antonova
- E.G. Shelley
- E.G. Thomas
- E.W. Hones
- F. Darrouzet
- F. Darrouzet
- F.M. Ipavich
- G. Gloeckler
- G. Haerendel
- G. Paschmann
- G. Paschmann
- G. Siscoe
- G.A. Kotova
- G.L. Siscoe
- G.L. Siscoe
- G.Q. Yan
- H. Hasegawa
- H. Hasegawa
- H. Hasegawa
- H. Liu
- H. Nilsson
- H. Nilsson
- H. Nilsson
- H. Nilsson
- H. Rosenbauer
- H. RĂšme
- H.C. Carlson
- H.E. Spence
- H.U. Frey
- I. Dandouras
- I. Dandouras
- I. Yoshikawa
- I.A. Daglis
- I.L. Ovchinnikov
- Iannis Dandouras
- J. Akinrimisi
- J. Borovsky
- J. Etcheto
- J. Goldstein
- J. Lemaire
- J. Lemaire
- J. Liao
- J. Liao
- J. Liao
- J. Tu
- J. Zhang
- J.-A. Sauvaud
- J.A. Sauvaud
- J.A. Slavin
- J.A. Slavin
- J.A. Slavin
- J.C. Foster
- J.C. Foster
- J.C. Foster
- J.C. Foster
- J.C. Foster
- J.E. Borovsky
- J.E. Borovsky
- J.E. Borovsky
- J.E. Borovsky
- J.E. Borovsky
- J.E. Ouellette
- J.F. Lemaire
- J.F. Lemaire
- J.F. Lemaire
- J.G. Luhmann
- J.G. Roederer
- J.G. Roederer
- J.G. Roederer
- J.H. Lee
- J.L. Horwitz
- J.M. Weygand
- J.P. Eastwood
- J.P. McFadden
- J.R. Johnson
- J.R. Johnson
- J.T. Gosling
- J.U. Kozyra
- J.U. Kozyra
- J.U. Kozyra
- J.U. Kozyra
- J.W. Dungey
- James A. Slavin
- John Foster
- Justin H. Lee
- K. Keika
- K. Keika
- K. Maezawa
- K. Nykyri
- K. Seki
- K. Seki
- K. Seki
- K. Seki
- K. Seki
- K. Seki
- K. Takagi
- K. Takahashi
- K. Torkar
- K.-J. Hwang
- K.-J. Hwang
- K.J. Trattner
- K.J. Trattner
- K.S. Garcia
- L. Chen
- L. Zhu
- L.A. Daglis
- L.C. Lee
- L.M. Kistler
- L.M. Kistler
- L.M. Kistler
- L.M. Kistler
- L.M. Kistler
- Lynn Kistler
- M. André
- M. André
- M. Bouhram
- M. Candidi
- M. Faganello
- M. Faganello
- M. Förster
- M. Hirahara
- M. Hirahara
- M. Hirahara
- M. Nosé
- M. Nosé
- M. Wiltberger
- M. Wiltberger
- M. Ăieroset
- M. Ăieroset
- M.-C. Fok
- M.-C. Fok
- M.B. Bavassano Cattaneo
- M.E. Greenspan
- M.G. Henderson
- M.G.G.T. Taylor
- M.G.G.T. Taylor
- M.W. Liemohn
- M.W. Liemohn
- M.W. Liemohn
- M.W. Liemohn
- M.W. Liemohn
- Mats André
- Michael W. Liemohn
- Michael Wiltberger
- N. André
- N. Sckopke
- N.A. Tsyganenko
- N.G.J. Gazey
- O.J. Brambles
- O.J. Brambles
- O.J. Brambles
- P. Song
- P.A. Cassak
- P.M. Banks
- P.M. Banks
- Q.-G. Zong
- R. Ilie
- R. Maggiolo
- R. Maggiolo
- R. Maggiolo
- R. Smets
- R. Strangeway
- R.A. Heelis
- R.B. Horne
- R.C. Elphic
- R.C. Fear
- R.D. Zwickl
- R.E. Lopez
- R.J. Pellinen
- R.L. Arnoldy
- R.L. McPherron
- R.M. Winglee
- R.M. Winglee
- R.M. Winglee
- R.S. Grew
- R.W. Schunk
- Raluca Ilie
- S. Haaland
- S. Haaland
- S. Orsini
- S. Taguchi
- S. Takahashi
- S. Wing
- S. Wing
- S. Zou
- S.-I. Akasofu
- S.A. Fuselier
- S.A. Fuselier
- S.A. Fuselier
- S.A. Fuselier
- S.A. Fuselier
- S.M. Imber
- S.M. Krimigis
- S.P. Christon
- S.W.H. Cowley
- S.W.H. Cowley
- S.W.Y. Tam
- T. Abe
- T. Abe
- T. Abe
- T. Abe
- T. Nagai
- T. Tanaka
- T. Terasawa
- T.A. Fritz
- T.E. Moore
- T.E. Moore
- T.E. Moore
- T.E. Moore
- T.G. Onsager
- T.K.M. Nakamura
- T.W. Speiser
- V. Angelopoulos
- V. Angelopoulos
- V. Pierrard
- V. Pierrard
- V. Pierrard
- V.K. Jordanova
- V.K. Jordanova
- V.K. Jordanova
- V.K. Jordanova
- V.K. Jordanova
- V.K. Jordanova
- W. Baumjohann
- W. Bristow
- W. Li
- W. Lotko
- W. Miyake
- W. Miyake
- W.D. Gonzalez
- W.G. Pilipp
- W.J. Heikkila
- W.K. Peterson
- W.K. Peterson
- W.T. Roberts
- X.-Z. Zhou
- Y. Ebihara
- Y. Harada
- Y. Lin
- Y. Lin
- Y. Obana
- Y. Ogawa
- Y. Ogawa
- Y. Ono
- Y. Saito
- Y. Yu
- Y. Zheng
- Y.-J. Su
- Y.-J. Su
- Y.I. Feldstein
- Z. Kaymaz
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
This paper reviews the state of knowledge concerning the source of magnetospheric plasma at Earth. Source of plasma, its acceleration and transport throughout the system, its consequences on system dynamics, and its loss are all discussed. Both observational and modeling advances since the last time this subject was covered in detail (Hultqvist et al., Magnetospheric Plasma Sources and Losses, 1999) are addressed
Novel genetic loci associated with hippocampal volume
- Author
- Abramovic L. (Lucija)
- Adams H.H.H. (Hieab)
- Agartz I. (Ingrid)
- Alhusaini S. (Saud)
- Almasy L. (Laura)
- Ames D.J. (David)
- Amin N. (Najaf)
- Amouyel P. (Philippe)
- Andersson M. (Micael)
- Andreassen O.A. (Ole)
- Arepalli S. (Sampath)
- Arfanakis K. (Konstantinos)
- Arias-VĂĄsquez A. (Alejandro)
- Aribisala B. (Benjamin)
- Armstrong N.J. (Nicola J.)
- Assareh A.A.
- Athanasiu L. (Lavinia)
- Axelsson T. (Tomas)
- Barral S. (Sandra)
- Bastin M.E. (Mark)
- Becker D.M. (Diane M.)
- Becker J.T. (James)
- Beecham A.H. (Ashley)
- Beiser A. (Alexa)
- Bennett D.A. (David A.)
- Bernard M. (Manon)
- Bis J.C. (Joshua)
- Björnsson A. (Asgeir)
- Blangero J. (John)
- Blanton S.H. (Susan H.)
- Bohlken M.M. (Marc M.)
- Bokhoven H. (Hans) van
- Boks M.P.M. (Marco)
- Boomsma D.I. (Dorret)
- Braber A. (Anouk) den
- Bralten L.B.C. (Linda)
- Brickman A.M. (Adam M.)
- Brodaty H. (Henry)
- Brouwer R.M. (Rachel)
- Brug M.P. (Marcel) van der
- Brunner H.G.
- Buckner M.
- Buitelaar J.K. (Jan)
- Bulayeva K. (Kazima)
- Cahn W. (Wiepke)
- Calhoun V.D. (Vince)
- Cannon D.M. (Dara)
- Carmichael O. (Owen)
- Cavalleri G. (Gianpiero)
- Chakravarty M.M. (M. Mallar)
- Chauhan G. (Ganesh)
- Chen Q. (Qiang)
- Cheng C.-Y. (Ching-Yu)
- Ching C.R.K. (Christopher)
- Chouraki V. (Vincent)
- Cichon S. (Sven)
- Cookson M.R. (Mark)
- Corvin A. (Aiden)
- Craen A.J. (Anton) de
- Crespo-Facorro B. (Benedicto)
- Crivello F. (Fabrice)
- Cuellar-Partida G. (Gabriel)
- Curran J.E. (Joanne)
- Czisch M. (Michael)
- Dale A.M. (Anders)
- Davies G.E. (Gareth)
- Deary I.J. (Ian)
- Debette S. (Stéphanie)
- DeCarli C. (Charles)
- Delanty N.
- Depondt C. (Chantal)
- DesriviĂšres S. (Sylvane)
- DeStefano A.L. (Anita)
- Dillman A. (Allissa)
- Djurovic S. (Srdjan)
- Doan N.T. (Nhat Trung)
- Donohoe D.J. (Dennis)
- Drevets D.A. (Douglas)
- Duggirala R. (Ravi)
- Duijn C.M. (Cornelia) van
- Dyer M.D. (Matthew)
- Ehrlich S.M. (Stefan)
- Eijk K.R. (Kristel) van
- Ent D. (Dennis) van 't
- Enzinger C. (Christian)
- Erk S.
- Erp T.G.M. (Theo G.) van
- Espeseth T. (Thomas)
- Fedko I.O. (Iryna O.)
- Fernåndez G. (Guillén)
- Ferrucci L. (Luigi)
- Fisher S.E. (Simon)
- Fleischman D. (Debra)
- Ford I. (Ian)
- Fornage M. (Myriam)
- Foroud T. (Tatiana)
- Fox P.T. (Peter)
- Francks C. (Clyde)
- Franke B. (Barbara)
- Fukunaga M. (Masaki)
- Geus E.J.C. (Eco) de
- Gibbs J.R. (J. Raphael)
- Giddaluru S. (Sudheer)
- Glahn D.C. (David)
- Goldman A.L. (Aaron L.)
- Gollub R.L. (Randy)
- Gottesman R.F. (Rebecca)
- Grabe H.J. (Hans Jörgen)
- Green R.C. (Robert C.)
- Grimm O. (Oliver)
- Griswold M.D. (Michael)
- Gruber O. (Oliver)
- Guadalupe T. (Tulio)
- Gudnason V. (Vilmundur)
- Guelfi S. (Sebastian)
- Gutman B.A. (Boris A.)
- Göring H.H.H. (Harald H.)
- Hansell N.K. (Narelle)
- Hardy J. (John)
- Haren N.E.M. (Neeltje E.) van
- Hartman C.A. (C.)
- Hashimoto R. (Ryota)
- Hass J. (Johanna)
- Haukvik U.K. (Unn)
- Hegenscheid K. (Katrin)
- Heinz J. (Judith)
- Hernandez D.G. (Dena)
- Hernåndez M.C.V. (Maria C. Valdés)
- Heslenfeld D.J. (Dirk)
- Hibar D.P. (Derrek)
- Ho B.-C. (Beng-Choon)
- Hoehn D. (David)
- Hoekstra P.J. (Pieter)
- Hofer E. (Edith)
- Hoffmann W. (Wolfgang)
- Hofman A. (Albert)
- Holmes A.J. (Avram)
- Holsboer F. (Florian)
- Homuth G. (Georg)
- Hoogman M. (Martine)
- Hosten N. (Norbert)
- Hottenga J.J. (Jouke Jan)
- Huentelman M.J. (Matthew)
- HĂ„berg A.K. (Asta K.)
- Ikeda M. (Masashi)
- Ikram M.K. (Kamran)
- Ikram M.K. (M. Kamran)
- Jack C.R. (Clifford R.)
- Jager P.L. (Philip) de
- Jahanshad N. (Neda)
- Janowitz D. (Deborah)
- Jenkinson S. (Sarah)
- Jia T. (Tianye)
- Johnson R. (Robert)
- Jukema J.W.
- Jönsson E.G. (Erik G.)
- JĂžrgensen K.N. (Kjetil N.)
- Kahn R. (René)
- Kanai R. (Ryota)
- Karbalai N. (Nazanin)
- Kasperaviciute D. (Dalia)
- Kim S. (Shinseog)
- Klein M. (Marieke)
- Kloszewska I. (Iwona)
- Knopman D.S. (David S.)
- Kochunov P. (Peter)
- Kraemer B. (Bernd)
- Kwok J.B. (John B.)
- Launer L.J. (Lenore)
- Lawrie S. (Stephen)
- Le Hellard S. (Stephanie)
- Lee P.H. (Phil)
- Lee S.J. (Sven) van der
- LemaĂźtre H. (Herve)
- Liewald D.C.M. (David)
- Liu X. (Xinmin)
- Longo D.L. (Dan L.)
- Longstreth Jr W.T.
- Loohuis L.M.O. (Loes M. Olde)
- Lopez L.M. (Lorna)
- Lopez O.L. (Oscar L.)
- Lovestone S. (Simon)
- Luciano M. (Michelle)
- Lugt A. (Aad) van der
- MacAre C. (Christine)
- Marquand A.F. (Andre F.)
- Martin N.G. (Nicholas)
- Martinez O. (Oliver)
- Martinot J.-L. (Jean-Luc)
- Matarin M. (Mar)
- Mather R.
- Mattay V.S. (Venkata S.)
- Mattheisen M. (Manuel)
- McDonald C. (Colm)
- McIntosh A.M. (Andrew)
- McKay D.R. (David R.)
- McMahon F.J. (Francis J.)
- McMahon K.L. (Katie L.)
- Mecocci P. (Patrizia)
- Medland S.E. (Sarah)
- Melle I. (Ingrid)
- Meyer-Lindenberg A. (Andreas)
- Milaneschi Y. (Yuri)
- Mohnke S. (Sebastian)
- Montgomery G.W. (Grant W.)
- Morris D.W. (Derek W)
- Mosley T.H. (Thomas H.)
- Muñoz Maniega S. (Susana)
- MĂŒhleisen T.W. (Thomas)
- MĂŒller-Myhsok B. (B.)
- Nalls M.A. (Michael)
- Nauck M. (Matthias)
- Nho K. (Kwangsik)
- Nichols T.E. (Thomas)
- Niessen W.J. (Wiro)
- Nugent A.C. (Allison)
- Nyberg L. (Lars)
- Nyquist P. (Paul)
- Nöthen M.M. (Markus)
- Ohi K. (Kazutaka)
- Olvera R.L. (Rene)
- Oosterlaan J. (Jaap)
- Ophoff R.A. (Roel)
- Pandolfo M. (Massimo)
- Papmeyer M. (Martina)
- Paus T. (Tomas)
- Pausova Z. (Zdenka)
- Penninx B.W.J.H. (Brenda)
- Pike G.B. (G. Bruce)
- Pirpamer L. (Lukas)
- Pol H.H.
- Potkin S.G. (Steven)
- Psaty B.M. (Bruce)
- PĂŒtz B. (Benno)
- Ramasamy A. (Adaikalavan)
- RenterĂa M.E. (Miguel)
- Reppermund S.
- Richards J.S. (Jennifer S.)
- Rietschel M. (Marcella)
- Risacher S.L. (Shannon)
- Roffman J.L. (Joshua)
- Roiz-Santiañez R. (Roberto)
- Rommelse N. (Nanda)
- Ropele S. (Stefan)
- Rose E.J. (Emma)
- Rotter J.I. (Jerome I.)
- Royle N.A. (Natalie)
- Rundek T. (Tatjana)
- Ryten M. (Mina)
- Sacco R.L. (Ralph L.)
- Sachdev P.S. (Perminder)
- Saremi A. (Arvin)
- Satizabal C.L. (Claudia)
- Saykin A.J. (Andrew)
- Schmaal L. (Lianne)
- Schmidt H. (Helena)
- Schmidt R. (Reinhold)
- Schofield C.J. (Christopher)
- Schork N.J. (Nicholas)
- Schumann G. (Gunter)
- Seiferth N. (Nina)
- Seshadri S. (Sudha)
- Shen L. (Li)
- Shin J. (Jean)
- Shumskaya E. (Elena)
- Sigursson S. (Sigurdur)
- Simmons A. (Andrew)
- Singleton A. (Andrew)
- Sisodiya S.M. (Sanjay)
- Smith A.V. (Albert Vernon)
- Smith C. (Colin)
- Smoller J.W.
- Soininen H. (H.)
- Sprooten R. (Roy)
- Steen V.M. (Vidar)
- Stein J.L.
- Stott D.J. (David J.)
- Strike L.T. (Lachlan)
- Sussmann J. (Jessika)
- SĂ€mann P.G. (Philipp)
- Teumer A. (Alexander)
- Thalamuthu A. (Anbupalam)
- Thompson P.M. (Paul)
- Toga A.W. (Arthur W.)
- Tol M.J.D. (Marie-José) van
- Tordesillas-Gutierrez D. (Diana)
- Toro R. (Roberto)
- Trabzuni D. (Danyah)
- Traynor B. (Bryan)
- Trompet S. (Stella)
- Troncoso J.C. (Juan)
- Tsolaki M. (Magda)
- Tzourio C. (Christophe)
- Uitterlinden A.G. (André)
- Vaidya D. (Dhananjay)
- van der Grond J. (Jeroen)
- Van Der Meer D. (Dennis)
- Van Donkelaar M.M.J. (Marjolein M. J.)
- Van Rooij D. (Daan)
- Vardarajan B.N. (Badri)
- Vellas B. (Bruno)
- Veltman D.J. (Dick)
- Vernooij M.W. (Meike)
- Völzke H. (Henry)
- Walter H.J. (Henrik)
- Walton E. (Esther)
- Wardlaw J. (Joanna)
- Wassink A.M.J. (Annemarie)
- Weale M.E. (Michael)
- Wee N.J. (Nic) van der
- Weinberger D.R. (Daniel R.)
- Weiner M.W. (Michael W.)
- Wen W. (Wei)
- Westlye L.T. (Lars)
- Westman E. (Eric)
- Whelan C.D. (Christopher)
- White T.J.H. (Tonya)
- Windham B.G. (Gwen)
- Winkler A.M. (Anderson)
- Wittfeld K. (Katharina)
- Woldehawariat G. (Girma)
- Wolfers T. (Thomas)
- Wong T.Y. (Tien Y.)
- Wright C.B. (Clinton B.)
- Wright M.J. (Margaret)
- Yanek L.R. (Lisa)
- Yang J. (Jingyun)
- Zielke R.H. (Ronald H.)
- Zijdenbos A.P.
- Zonderman A.B.
- Zubicaray G.I. (Greig) de
- Zwiers M.P. (Marcel)
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/01/2017
- Field of study
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness
Age at first birth in women is genetically associated with increased risk of schizophrenia
- Author
- Adolfsson R.
- Agartz I. (Ingrid)
- Agerbo E. (Esben)
- Albus M. (Margot)
- Alexander M. (Madeline)
- Amin F. (Farooq)
- Andreassen O.A. (Ole)
- Bacanu S.A. (Silviu)
- Begemann M. (Martin)
- Belliveau R.A. (Richard A.)
- Bene J. (Judit)
- Bergen S.E. (Sarah)
- Bevilacqua E. (Elizabeth)
- Bigdeli T.B. (Tim B.)
- Black D.W. (Donald)
- Blackwood D.H.R. (Douglas)
- Borglum A.D. (Anders)
- Bramon E. (Elvira)
- Bruggeman R. (Richard)
- Buccola N.G. (Nancy G)
- Buckner M.
- Bulik-Sullivan B.K. (Brendan)
- Buxbaum J.D. (Joseph D.)
- Byerley W.F. (William F)
- Cahn W. (Wiepke)
- Cai G. (Guiqing)
- Campion D. (Dominique)
- Cantor R.M.
- Carr V.J. (Vaughan J.)
- Carrera N. (Noa)
- Catts S.V. (Stanley)
- Chambert K. (Kimberly)
- Chan R.C.K. (Raymond C. K.)
- Chen E.Y.H. (Eric Y. H.)
- Chen R.Y.L. (Ronald Y.)
- Cheng W. (Wei)
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- Zheng X. (Xuebin)
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- Publication venue
- Publication date
- 01/01/2018
- Field of study
Prof. Paunio on PGC:n jÀsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe
New insights into the genetic etiology of Alzheimer's disease and related dementias
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- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
Multiancestry analysis of the HLA locus in Alzheimerâs and Parkinsonâs diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-GĂłmez A.D.
- Adarmes-GĂłmez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- AlarcĂłn-MartĂn E.
- AlarcĂłn-MartĂn Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- AntĂșnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez CĂ©line
- Bellenguez CĂ©line
- Bellenguez CĂ©line
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse CĂ©line
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada MercĂš
- Boada MercĂš
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- BossĂč Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- BrÄthen Geir
- BrÄthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido MarĂa J.
- Bullido MarĂa J.
- Burguera J.A.
- Burholt Vanessa
- BĂrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ăngel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- CarriĂłn-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene GeneviĂšve
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- ClarimĂłn J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- CorbatĂłn-Anchuelo A.
- Cores Valeria
- Corma-GĂłmez AnaĂŻs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
- Daniele Antonio
- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
- David Smith A.
- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert JĂŒrgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen MĂłnica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso MarĂa
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
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- Duron Emmanuelle
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- Liu Jianjun
- Livingston Gill
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- LleĂł Alberto
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- Lord Jenny
- Love Seth
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- Lovestone Simon
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- Luis Royo Jose
- Luo Guo
- Lupton Michelle
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- MacĂas Juan
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- Mangialasche Francesca
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- Manzanares S.
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- Marco Spallazzi
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- Mayo Kevin
- McGuinness Bernadette
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- McQuillin Andrew
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- Mecocci Patrizia
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- Meggy Alun
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- Menéndez-Gonzålez Manuel
- Mignot Emmanuel
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- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
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- Molina-Porcel Laura
- Montrreal L.
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- Morgan Kevin
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- Toda Tatsushi
- Todd Stephen
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- Traykov Latchezar
- Tremolizzo Lucio
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- Tsolaki Magda
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- Uitterlinden Andre
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- Ulstein Ingun
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- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
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- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-SĂ©bastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Ălvarez I.
- Ălvarez V.
- Ălvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinsonâs disease (PD) and Alzheimerâs disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased AÎČ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes
- Author
- Aanensen David M.
- Abudahab Khalil
- Adams Alexander
- Adams Helen
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY.
- Aigrain Louise
- Alcolea-Medina Adela
- Alikhan Nabil-Fareed
- Allara Elias
- Amato Roberto
- Angyal Adrienn
- Annett Tara
- Aplin Stephen
- Ariani Cristina V.
- Asad Hibo
- Ash Amy
- Ashfield Paula
- Ashford Fiona
- Atkinson Laura
- Attwood Stephen W.
- Auckland Cressida
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barrett Jeffrey C.
- Barrow Magdalena
- Barton Edward
- Bashton Matthew
- Bassett Andrew R.
- Batra Rahul
- Baxter Chris
- Bayzid Nadua
- Beaver Charlotte
- Beckett Angela H.
- Beckwith Shaun M.
- Bedford Luke
- Beer Robert
- Beggs Andrew
- Bellis Katherine L.
- Berry Louise
- Bertolusso Beatrice
- Best Angus
- Betteridge Emma
- Bibby David
- Bicknell Kelly
- Binns Debbie
- Birchley Alec
- Bird Paul W.
- Bishop Chloe
- Blacow Rachel
- Blakey Victoria
- Blane Beth
- Bolt Frances
- Bonfield James
- Bonner Stephen
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Bradley Declan T.
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgett Stephen
- Bronner Iraad F.
- Brooks Ellena
- Broos Alice
- Brown Julianne R.
- Bucca Giselda
- Buchan Sarah L.
- Buck David
- Bull Matthew
- Burns Phillipa J.
- Burton-Fanning Shirelle
- Byaruhanga Timothy
- Byott Matthew
- Campbell Sharon
- Carabelli Alessandro M.
- Cargill James S.
- Carlile Matthew
- Carvalho SĂlvia F.
- Casey Anna
- Castigador Anibolina
- Catalan Jana
- Chalker Vicki
- Chaloner Nicola J.
- Chand Meera
- Chappell Joseph G.
- Charalampous Themoula
- Chatterton Wendy
- Chaudhry Yasmin
- Churcher Carol M.
- Clark Gemma
- Clarke Phillip
- Cogger Benjamin J.
- Cole Kevin
- Collins Jennifer
- Colquhoun Rachel
- Connor Thomas R.
- Cook Kate F.
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cotic Marius
- Cotton S.
- Cotton Seb
- Cottrell Simon
- Coupland Lindsay
- Cox Alison
- Cox MacGregor
- Craine Noel
- Crawford Liam
- Cross Aidan
- Crown Matthew R.
- Crudgington Dorian
- Cumley Nicola
- Curran Martin D.
- Curran Tanya
- Cutino-Moguel Teresa
- da Silva Filipe Ana
- Dabrer Gavin
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davies Robert M.
- Davis Thomas
- de Angelis Daniela
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Delgado Callico Laia
- Denton-Smith Rebecca
- Dervisevic Samir
- Dewar R.
- Dewar Rebecca
- Dey Jayasree
- Dias Joana
- Dobie Donald
- Dorman Matthew J.
- Downing Fatima
- Driscoll Megan
- du Plessis Louis
- Duckworth Nichola
- Durham Jillian
- Eastick Kirstine
- Easton Lisa J.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- El Bouzidi Kate
- Eldirdiri Sahar
- Ellaby Nicholas
- Elliott Scott
- Eltringham Gary
- Ensell Leah
- Erkiert Michelle J.
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Everson William
- Fairley Derek J.
- Fallon Karlie
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- Fearn Christopher
- Feltwell Theresa
- Ferguson Lynne
- Fina Laia
- Flaviani Flavia
- Fleming Vicki M.
- Forrest Sally
- Foster-Nyarko Ebenezer
- Foulkes Benjamin H.
- Foulser Luke
- Fragakis Mireille
- Frampton Dan
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Fryer Helen
- Fuchs Marc
- Fuller William
- Gajee Kavitha
- Galai Katerina
- Gallagher Abbie
- Gallagher Eileen
- Gallagher Michael D.
- Gallis Marta
- Gaskin Amy
- Gatica-Wilcox Bree
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Girgis Sophia T.
- Glaysher Sharon
- Goldstein Emily J.
- Golubchik Tanya
- Gomes Andrea N.
- Gonçalves Sónia
- Goodwin Scott
- Goudarzi Salman
- Gourtovaia Marina
- Graham Clive
- Graham Lee
- Grant Paul R.
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Guest Martyn
- Gunson Rory N.
- Gupta Ravi K.
- Gutierrez Bernardo
- Haas J.G.
- Haldenby Sam T.
- Hamilton William L.
- Hansford Samantha E.
- Haque Tanzina
- Harris Kathryn A.
- Harrison Ewan M.
- Harrison Ian
- Hart Jennifer
- Hartley John A.
- Harvey Matthew
- Harvey William T.
- Hassan-Ibrahim Mohammed O.
- Heaney Judith
- Helmer Thomas
- Henderson John H.
- Hesketh Andrew R.
- Hey Jessica
- Heyburn David
- Higginson Ellen E.
- Hill Jack D.
- Hill Verity
- Hilson Rachel A.
- Hilvers Ember
- Holden Matthew TG.
- Hollis Amy
- Holmes Alison H.
- Holmes Christopher W.
- Holmes Nadine
- Hopes Richard
- Hornsby Hailey R.
- Hosmillo Myra
- Houlihan Catherine
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- Weldon Danni
- Westwick Elaine
- Whalley Thomas
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- Whiteley Max
- Whitwham Andrew
- Wierzbicki Claudia
- Willford Nicholas J.
- Williams Catryn
- Williams Charlotte A.
- Williams Cheryl
- Williams Chris
- Williams Lesley-Anne
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
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- Wilson-Davies Eleri
- Witele Eric
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- Witney Adam A.
- Wolverson Paige
- Wong Nick
- Workma Trudy
- Wright Derek W.
- Wright Victoria
- Wyatt Tim
- Wyllie Sarah
- Xu-McCrae Li
- Yavus Mehmet
- Yaze Geraldine
- Yeats Corin A.
- Yebra Gonzalo
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Zarebski Alex E.
- Zhang Peijun
- Publication venue
- 'Elsevier BV'
- Publication date
- 09/03/2023
- Field of study
Background
The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes.
Aim
To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave.
Methods
A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records.
Findings
In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home.
Conclusion
The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine
Study of the lineshape of the chi(c1) (3872) state
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- Whitehead M.
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- Wilkinson M.
- Williams I.
- Williams Mark Richard James
- Williams Mike
- Wilson F.F.
- Wislicki W.
- Witek M.
- Witola L.
- Wormser G.
- Wotton S.A.
- Wu H.
- Wyllie K.
- Xiang Z.
- Xiao D.
- Xie Y.
- Xing H.
- Xu A.
- Xu J.
- Xu L.
- Xu M.
- Xu Q.
- Xu Z.
- Yang D.
- Yang Y.
- Yang Zhenwei
- Yang Zishuo
- Yao Y.
- Yeomans L.E.
- Yin H.
- Yu J.
- Yuan X.
- Yushchenko O.
- Zarebski K.A.
- Zavertyaev M.
- Zdybal M.
- Zenaiev O.
- Zeng M.
- Zhang D.
- Zhang L.
- Zhang S.
- Zhang Y.
- Zhelezov A.
- Zheng Y.
- Zhou X.
- Zhou Y.
- Zhu X.
- Zhukov V.
- Zonneveld J.B.
- Zucchelli S.
- Zuliani D.
- Zunica G.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2020
- Field of study
A study of the lineshape of the chi(c1) (3872) state is made using a data sample corresponding to an integrated luminosity of 3 fb(-1) collected in pp collisions at center-of-mass energies of 7 and 8 TeV with the LHCb detector. Candidate chi(c1)(3872) and psi(2S) mesons from b-hadron decays are selected in the J/psi pi(+)pi(-) decay mode. Describing the lineshape with a Breit-Wigner function, the mass splitting between the chi(c1 )(3872) and psi(2S) states, Delta m, and the width of the chi(c1 )(3872) state, Gamma(Bw), are determined to be (Delta m=185.598 +/- 0.067 +/- 0.068 Mev,)(Gamma BW=1.39 +/- 0.24 +/- 0.10 Mev,) where the first uncertainty is statistical and the second systematic. Using a Flatte-inspired model, the mode and full width at half maximum of the lineshape are determined to be (mode=3871.69+0.00+0.05 MeV.)(FWHM=0.22-0.04+0.13+0.07+0.11-0.06-0.13 MeV, ) An investigation of the analytic structure of the Flatte amplitude reveals a pole structure, which is compatible with a quasibound D-0(D) over bar*(0) state but a quasivirtual state is still allowed at the level of 2 standard deviations
Measurement of the CKM angle Îł in B±âDK± and B±âDϱ decays with DâKS0âh+hâ
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- Westhenry B.D.C.
- White D.J.
- Whitehead M.
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- Wilkinson G.
- Wilkinson M.
- Williams I.
- Williams Mark Richard James
- Williams Mike
- Wilson F.F.
- Wislicki W.
- Witek M.
- Witola L.
- Wormser G.
- Wotton S.A.
- Wu H.
- Wyllie K.
- Xiang Z.
- Xiao D.
- Xie Y.
- Xing H.
- Xu A.
- Xu J.
- Xu L.
- Xu M.
- Xu Q.
- Xu Zehua
- Xu Zhihao
- Yang D.
- Yang Y.
- Yang Zhenwei
- Yang Zishuo
- Yao Y.
- Yeomans L.E.
- Yin H.
- Yu J.
- Yuan X.
- Yushchenko O.
- Zarebski K.A.
- Zavertyaev M.
- Zdybal M.
- Zenaiev O.
- Zeng M.
- Zhang D.
- Zhang L.
- Zhang S.
- Zhang Yanxi
- Zhang Yu
- Zhelezov A.
- Zheng Y.
- Zhou X.
- Zhou Y.
- Zhu X.
- Zhukov V.
- Zonneveld J.B.
- Zucchelli S.
- Zuliani D.
- Zunica G.
- Publication venue
- J. High Energ. Phys.
- Publication date
- 01/01/2020
- Field of study
A measurement of CP-violating observables is performed using the decays
B±âDK± and B±âDϱ, where the D meson is
reconstructed in one of the self-conjugate three-body final states KSâÏ+Ïâ and KSâK+Kâ (commonly denoted KSâh+hâ). The decays are analysed in bins of the D-decay phase space, leading
to a measurement that is independent of the modelling of the D-decay
amplitude. The observables are interpreted in terms of the CKM angle Îł.
Using a data sample corresponding to an integrated luminosity of
9fbâ1 collected in proton-proton collisions at centre-of-mass
energies of 7, 8, and 13TeV with the LHCb experiment, Îł
is measured to be (68.7â5.1+5.2â)â. The hadronic
parameters rBDKâ, rBDÏâ, ÎŽBDKâ, and ÎŽBDÏâ,
which are the ratios and strong-phase differences of the suppressed and
favoured B± decays, are also reported
The LHCb upgrade I
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- Publication venue
- IOP Publishing
- Publication date
- 01/05/2024
- Field of study
The LHCb upgrade represents a major change of the experiment. The detectors have been almost completely renewed to allow running at an instantaneous luminosity five times larger than that of the previous running periods. Readout of all detectors into an all-software trigger is central to the new design, facilitating the reconstruction of events at the maximum LHC interaction rate, and their selection in real time. The experiment's tracking system has been completely upgraded with a new pixel vertex detector, a silicon tracker upstream of the dipole magnet and three scintillating fibre tracking stations downstream of the magnet. The whole photon detection system of the RICH detectors has been renewed and the readout electronics of the calorimeter and muon systems have been fully overhauled. The first stage of the all-software trigger is implemented on a GPU farm. The output of the trigger provides a combination of totally reconstructed physics objects, such as tracks and vertices, ready for final analysis, and of entire events which need further offline reprocessing. This scheme required a complete revision of the computing model and rewriting of the experiment's software
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