Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Measurement of single top-quark production in association with a W boson in the single-lepton channel at \sqrt{s} = 8\,\text {TeV} with the ATLAS detector

The production cross-section of a top quark in association with a W boson is measured using proton–proton collisions at \sqrt{s} = 8\,\text {TeV}. The dataset corresponds to an integrated luminosity of 20.2\,\text {fb}^{-1}, and was collected in 2012 by the ATLAS detector at the Large Hadron Collider at CERN. The analysis is performed in the single-lepton channel. Events are selected by requiring one isolated lepton (electron or muon) and at least three jets. A neural network is trained to separate the tW signal from the dominant t{\bar{t}} background. The cross-section is extracted from a binned profile maximum-likelihood fit to a two-dimensional discriminant built from the neural-network output and the invariant mass of the hadronically decaying W boson. The measured cross-section is \sigma _{tW} = 26 \pm 7\,\text {pb}, in good agreement with the Standard Model expectation

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Performance of electron and photon triggers in ATLAS during LHC Run 2

Abstract: Electron and photon triggers covering transverse energies from 5 GeV to several TeV are essential for the ATLAS experiment to record signals for a wide variety of physics: from Standard Model processes to searches for new phenomena in both proton–proton and heavy-ion collisions. To cope with a fourfold increase of peak LHC luminosity from 2015 to 2018 (Run 2), to 2.1×1034cm-2s-1, and a similar increase in the number of interactions per beam-crossing to about 60, trigger algorithms and selections were optimised to control the rates while retaining a high efficiency for physics analyses. For proton–proton collisions, the single-electron trigger efficiency relative to a single-electron offline selection is at least 75% for an offline electron of 31 GeV, and rises to 96% at 60 GeV; the trigger efficiency of a 25 GeV leg of the primary diphoton trigger relative to a tight offline photon selection is more than 96% for an offline photon of 30 GeV. For heavy-ion collisions, the primary electron and photon trigger efficiencies relative to the corresponding standard offline selections are at least 84% and 95%, respectively, at 5 GeV above the corresponding trigger threshold

Measurement of the t t ¯ production cross-section and lepton differential distributions in e μ dilepton events from pp collisions at s = 13 TeV with the ATLAS detector

Abstract: The inclusive top quark pair (tt¯) production cross-section σtt¯ has been measured in proton–proton collisions at s=13TeV, using 36.1 fb-1 of data collected in 2015–2016 by the ATLAS experiment at the LHC. Using events with an opposite-charge eμ pair and b-tagged jets, the cross-section is measured to be: σtt¯=826.4±3.6(stat)±11.5(syst)±15.7(lumi)±1.9(beam)pb, where the uncertainties reflect the limited size of the data sample, experimental and theoretical systematic effects, the integrated luminosity, and the LHC beam energy, giving a total uncertainty of 2.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. It is used to determine the top quark pole mass via the dependence of the predicted cross-section on mtpole, giving mtpole=173.1-2.1+2.0GeV. It is also combined with measurements at s=7TeV and s=8TeV to derive ratios and double ratios of tt¯ and Z cross-sections at different energies. The same event sample is used to measure absolute and normalised differential cross-sections as functions of single-lepton and dilepton kinematic variables, and the results are compared with predictions from various Monte Carlo event generators

Search for the HH → b b ¯ b b ¯ process via vector-boson fusion production using proton-proton collisions at s = 13 TeV with the ATLAS detector

Abstract: A search for Higgs boson pair production via vector-boson fusion (VBF) in the bb¯bb¯ final state is carried out with the ATLAS experiment using 126 fb−1 of proton- proton collision data delivered at s = 13 TeV by the Large Hadron Collider. This search is sensitive to VBF production of additional heavy bosons that may decay into Higgs boson pairs, and in a non-resonant topology it can constrain the quartic coupling between the Higgs bosons and vector bosons. No significant excess relative to the Standard Model expectation is observed, and limits on the production cross-section are set at the 95% confidence level for a heavy scalar resonance in the context of an extended Higgs sector, and for non-resonant Higgs boson pair production. Interpretation in terms of the coupling between a Higgs boson pair and two vector bosons is also provided: coupling values normalised to the Standard Model expectation of κ2V 2.90 are excluded at the 95% confidence level in data

Measurement of the t t ¯ production cross-section and lepton differential distributions in e μ dilepton events from pp collisions at s = 13 TeV with the ATLAS detector

Abstract: The inclusive top quark pair (tt¯) production cross-section σtt¯ has been measured in proton–proton collisions at s=13TeV, using 36.1 fb-1 of data collected in 2015–2016 by the ATLAS experiment at the LHC. Using events with an opposite-charge eμ pair and b-tagged jets, the cross-section is measured to be: σtt¯=826.4±3.6(stat)±11.5(syst)±15.7(lumi)±1.9(beam)pb, where the uncertainties reflect the limited size of the data sample, experimental and theoretical systematic effects, the integrated luminosity, and the LHC beam energy, giving a total uncertainty of 2.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. It is used to determine the top quark pole mass via the dependence of the predicted cross-section on mtpole, giving mtpole=173.1-2.1+2.0GeV. It is also combined with measurements at s=7TeV and s=8TeV to derive ratios and double ratios of tt¯ and Z cross-sections at different energies. The same event sample is used to measure absolute and normalised differential cross-sections as functions of single-lepton and dilepton kinematic variables, and the results are compared with predictions from various Monte Carlo event generators

Erratum to: Search for the HH → b b ¯ b b ¯ process via vector-boson fusion production using proton-proton collisions at s = 13 TeV with the ATLAS detector

One correction is noted for the paper

Search for the HH → b b ¯ b b ¯ process via vector-boson fusion production using proton-proton collisions at s = 13 TeV with the ATLAS detector

Abstract: A search for Higgs boson pair production via vector-boson fusion (VBF) in the bb¯bb¯ final state is carried out with the ATLAS experiment using 126 fb−1 of proton- proton collision data delivered at s = 13 TeV by the Large Hadron Collider. This search is sensitive to VBF production of additional heavy bosons that may decay into Higgs boson pairs, and in a non-resonant topology it can constrain the quartic coupling between the Higgs bosons and vector bosons. No significant excess relative to the Standard Model expectation is observed, and limits on the production cross-section are set at the 95% confidence level for a heavy scalar resonance in the context of an extended Higgs sector, and for non-resonant Higgs boson pair production. Interpretation in terms of the coupling between a Higgs boson pair and two vector bosons is also provided: coupling values normalised to the Standard Model expectation of κ2V 2.90 are excluded at the 95% confidence level in data