145 research outputs found
Ring closure reactions of bicyclic prolinol and prolin ester enantiomers
Starting from the of bicyclic proline ester, ethyl
exo-2-azabicyclo[2.2.1]heptane-3-carboxylate (+)-5 several hydantoines
and thiohydantoines were prepared by acidic ring closure of the
corresponding urea or thiourea derivatives. Enantiomer (-)-5 was
reduced to 2-azanorbornylmethanol 12, which was transformed to
5,8-methanooxazolo- and thiazolo[3,4-a] pyridine derivatives. The
structures, stereochemistry and relative configurations of the
synthesized compounds were proved by NMR
Kasvatustieteellisen osaamisen merkitys ammatillisissa opettajaopinnoissa opiskelijan kokemana
TiivistelmĂ€. TĂ€ssĂ€ tutkimuksessa vertailen yliopiston ja ammatillisen opettajakorkeakoulun jĂ€rjestĂ€miĂ€ kasvatustieteen opintoja (10 opintopistettĂ€) keskenÀÀn Oulun ammatillisen opettajakorkeakoulun opiskelijoiden kokemuksien perusteella. Kokemukset on kerĂ€tty itsearviointilomakkeella, jonka opiskelijat tekevĂ€t opintojen alussa, opintojen keskivaiheessa ja opintojen lopussa. Tutkimukseni itsearviointilomake on opintojen lopussa tehty ja opiskelijat ovat vastanneet yhteen kysymykseen kasvatustieteen opintoja koskien. Itsearviointilomakkeen vastaukset ovat vuosilta 2013â2017, lomakkeeseen vastanneet opiskelijat ovat aloittaneet opintonsa vuosina 2000â2006 ja 2008â2016 ja opiskelijat ovat suorittaneet kasvatustieteen opinnot viimeistÀÀn vuonna 2016. Tutkimus on teorialĂ€htöinen sisĂ€llönanalyysi.
Tutkimuksen teemoja ovat osaamisen kehittyminen, opettajan ammatillinen osaaminen, oppiminen ja opettajan ammatillinen kehittyminen. Osaamisen kehittyminen nÀkyi osaamisen kÀsitteen ymmÀrryksenÀ ja oman osaamisen kehittymisenÀ. Opettajan ammatillisessa osaamisessa opiskelijat kokivat oman osaamisen lisÀÀntyneen kasvatustieteiden opintojen myötÀ. Oppiminen nÀkyi opiskelijoiden itsetutkiskeluna kasvattajan roolissa. Opettajan ammatillisessa kehittymisessÀ tietoja ja taitoja hyödynnettiin kasvatustieteen opintojen jÀlkeen.
Yliopiston ja ammatillisen opettajakorkeakoulun jĂ€rjestĂ€missĂ€ kasvatustieteen opinnoissa on eroavaisuuksia Oulun ammatillisen opettajakorkeakoulun opiskelijoiden kokemusten mukaan. Kasvatustieteen opinnot yliopistossa suorittaneet opiskelijat kokivat opintojen olleen teoreettisia, joista ei saa uusia työkaluja kĂ€ytĂ€ntöön. Kasvatustieteellinen osaaminen integroituu ammattipedagogiseen osaamiseen vastauksissa, joissa opiskelijat osaavat yhdistÀÀ kasvatustieteen osaksi opetustyötÀÀn hyvin ja se nĂ€kyy vastauksissa esimerkiksi opetuksen monipuolistumisena.The meaning of pedagogical competence in professional teacher education experienced by students. Abstract. In this study, I compare educational studies (10 credits) arranged by the university and the school of professional teacher education. The comparison is based on experiences of students of the school of professional teacher education in Oulu. Experiences have been collected by a self-evaluation form, that students filled in at the start, middle and end of studies. The self-evaluation form used in my study is from the end of studies and students have answered one question about educational studies. Answers are from years 2013â2017, students who have answered have started their studies between years 2000â2006 and 2008â2016 and students have completed their studies by 2016. This study is theory-based content analysis.
Themes of this study are progression of competence, teacherâs professional competence, learning and teachers professional progression. Progression of competence appeared as understanding the concept of competence and experienced competence development. Regarding teacherâs professional competence students experienced that their competences developed based on the engagement in educational studies. Learning appeared as studentâs self-reflection about the role of an educator. Utilization of knowledge and skills after educational studies was described as part of teacherâs professional development.
Educational studies arranged by University and school of professional teacher education seem to differ according to experiences of students of the school of professional teacher education in Oulu. Students who completed educational studies in University thought the studies were too theoretical and hard to implement in practice. Competence in educational science was integrated in professional pedagogical competence in responses where students described that they could combine educational science as part of their teaching. This appeared in the responses for example as diversification of teaching
Recyclizations of 2-aminobenzylimines and thioaroylhydrazones of N-substituted N-hydroxy-3-oxobutanamides
A universal scheme is proposed for the molecular design of heterocyclic recyclizations by replacing the exocyclic hydroxyl groups in exo-trig- ring-chain tautomeric molecules with substituted amines or hydrazines. The practical applicability of this approach is demonstrated by the condensations of 5-hydroxy-5-methyl-3-isoxazolidinones with thioaroyl-hydrazines and 2-aminomethylaniline. The condensation products were studied by modern 1H, 13C and 15N NMR spectroscopic methods using three solvents: CDCl3, DMSO[D6] and CD3CN. The solvent was found to have a strong effect to the relative amounts of the tautomers
Monoacylglycerol lipase inhibitor JZL184 reduces neuroinflammatory response in APdE9 mice and in adult mouse glial cells
Conclusions: JZL184 decreased the proinflammatory reactions of microglia and reduced the total A beta burden and its precursors in the APdE9 mouse model. It also reduced the proinflammatory responses of microglia and astrocytes isolated from adult mice.</p
Swift follow-up observations of candidate gravitational-wave transient events
We present the first multi-wavelength follow-up observations of two candidate
gravitational-wave (GW) transient events recorded by LIGO and Virgo in their
2009-2010 science run. The events were selected with low latency by the network
of GW detectors and their candidate sky locations were observed by the Swift
observatory. Image transient detection was used to analyze the collected
electromagnetic data, which were found to be consistent with background.
Off-line analysis of the GW data alone has also established that the selected
GW events show no evidence of an astrophysical origin; one of them is
consistent with background and the other one was a test, part of a "blind
injection challenge". With this work we demonstrate the feasibility of rapid
follow-ups of GW transients and establish the sensitivity improvement joint
electromagnetic and GW observations could bring. This is a first step toward an
electromagnetic follow-up program in the regime of routine detections with the
advanced GW instruments expected within this decade. In that regime
multi-wavelength observations will play a significant role in completing the
astrophysical identification of GW sources. We present the methods and results
from this first combined analysis and discuss its implications in terms of
sensitivity for the present and future instruments.Comment: Submitted for publication 2012 May 25, accepted 2012 October 25,
published 2012 November 21, in ApJS, 203, 28 (
http://stacks.iop.org/0067-0049/203/28 ); 14 pages, 3 figures, 6 tables;
LIGO-P1100038; Science summary at
http://www.ligo.org/science/Publication-S6LVSwift/index.php ; Public access
area to figures, tables at
https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p110003
Search for gravitational waves associated with the InterPlanetary Network short gamma ray bursts
We outline the scientific motivation behind a search for gravitational waves
associated with short gamma ray bursts detected by the InterPlanetary Network
(IPN) during LIGO's fifth science run and Virgo's first science run. The IPN
localisation of short gamma ray bursts is limited to extended error boxes of
different shapes and sizes and a search on these error boxes poses a series of
challenges for data analysis. We will discuss these challenges and outline the
methods to optimise the search over these error boxes.Comment: Methods paper; Proceedings for Eduardo Amaldi 9 Conference on
Gravitational Waves, July 2011, Cardiff, U
A First Search for coincident Gravitational Waves and High Energy Neutrinos using LIGO, Virgo and ANTARES data from 2007
We present the results of the first search for gravitational wave bursts
associated with high energy neutrinos. Together, these messengers could reveal
new, hidden sources that are not observed by conventional photon astronomy,
particularly at high energy. Our search uses neutrinos detected by the
underwater neutrino telescope ANTARES in its 5 line configuration during the
period January - September 2007, which coincided with the fifth and first
science runs of LIGO and Virgo, respectively. The LIGO-Virgo data were analysed
for candidate gravitational-wave signals coincident in time and direction with
the neutrino events. No significant coincident events were observed. We place
limits on the density of joint high energy neutrino - gravitational wave
emission events in the local universe, and compare them with densities of
merger and core-collapse events.Comment: 19 pages, 8 figures, science summary page at
http://www.ligo.org/science/Publication-S5LV_ANTARES/index.php. Public access
area to figures, tables at
https://dcc.ligo.org/cgi-bin/DocDB/ShowDocument?docid=p120000
Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions
A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrumâs acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50â75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed
Stereospecific fragmentations in the mass spectra of stereoisomeric isoindoloquinazolines
Maternal Antibody Transmission in Relation to Mother Fluctuating Asymmetry in a Long-Lived Colonial Seabird: The Yellow-Legged Gull Larus michahellis
Female birds transfer antibodies to their offspring via the egg yolk, thus possibly providing passive immunity against infectious diseases to which hatchlings may be exposed, thereby affecting their fitness. It is nonetheless unclear whether the amount of maternal antibodies transmitted into egg yolks varies with female quality and egg laying order. In this paper, we investigated the transfer of maternal antibodies against type A influenza viruses (anti-AIV antibodies) by a long-lived colonial seabird, the yellow-legged gull (Larus michahellis), in relation to fluctuating asymmetry in females, i.e. the random deviation from perfect symmetry in bilaterally symmetric morphological and anatomical traits. In particular, we tested whether females with greater asymmetry transmitted fewer antibodies to their eggs, and whether within-clutch variation in yolk antibodies varied according to the maternal level of fluctuating asymmetry. We found that asymmetric females were in worse physical condition, produced fewer antibodies, and transmitted lower amounts of antibodies to their eggs. We also found that, within a given clutch, yolk antibody level decreased with egg laying order, but this laying order effect was more pronounced in clutches laid by the more asymmetric females. Overall, our results support the hypothesis that maternal quality interacts with egg laying order in determining the amount of maternal antibodies transmitted to the yolks. They also highlight the usefulness of fluctuating asymmetry as a sensitive indicator of female quality and immunocompetence in birds
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