Ivermectin, ‘Wonder drug’ from Japan: the human use perspective

Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals. It was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases which have plagued the world’s poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug

Gaia Data Release 2 Mapping the Milky Way disc kinematics

Context. The second Gaia data release (Gaia DR2) contains high-precision positions, parallaxes, and proper motions for 1.3 billion sources as well as line-of-sight velocities for 7.2 million stars brighter than G(RVS) = 12 mag. Both samples provide a full sky coverage. Aims. To illustrate the potential of Gaia DR2, we provide a first look at the kinematics of the Milky Way disc, within a radius of several kiloparsecs around the Sun. Methods. We benefit for the first time from a sample of 6.4 million F-G-K stars with full 6D phase-space coordinates, precise parallaxes (sigma((omega) over bar)/(omega) over bar Results. Gaia DR2 allows us to draw 3D maps of the Galactocentric median velocities and velocity dispersions with unprecedented accuracy, precision, and spatial resolution. The maps show the complexity and richness of the velocity field of the galactic disc. We observe streaming motions in all the components of the velocities as well as patterns in the velocity dispersions. For example, we confirm the previously reported negative and positive galactocentric radial velocity gradients in the inner and outer disc, respectively. Here, we see them as part of a non-axisymmetric kinematic oscillation, and we map its azimuthal and vertical behaviour. We also witness a new global arrangement of stars in the velocity plane of the solar neighbourhood and in distant regions in which stars are organised in thin substructures with the shape of circular arches that are oriented approximately along the horizontal direction in the U - V plane. Moreover, in distant regions, we see variations in the velocity substructures more clearly than ever before, in particular, variations in the velocity of the Hercules stream. Conclusions. Gaia DR2 provides the largest existing full 6D phase-space coordinates catalogue. It also vastly increases the number of available distances and transverse velocities with respect to Gaia DR1. Gaia DR2 offers a great wealth of information on the Milky Way and reveals clear non-axisymmetric kinematic signatures within the Galactic disc, for instance. It is now up to the astronomical community to explore its full potential.Peer reviewe

Influence of the natural oxidation of the leachate organic fraction from a landfill on groundwater quality, Belo Horizonte: Minas Gerais, south-eastern Brazil.

The objective of this work was to evaluate the influence of the natural degradation of the leachate organic fraction from the Belo Horizonte landfill on groundwater chemical evolution. The work focused on the modifications introduced by redox reactions in the presence of terminal electron acceptors. Twenty-one sampling points distributed along 13 monitoring wells were selected for the analysis of the chemical indicators of interest (TDS, SO4 -2, Fe?2, Ba, pH and Eh). The behaviour of the variables involved in the alteration of the water quality was assessed by the spatial distribution of target parameters, elaboration of redox diagrams and chemical modelling that focused on the determination of mineral saturation indexes. The study showed a trend toward pyrite precipitation, which leads to the removal of chemical species such as divalent iron and sulphur as sulphide from the system. This removal disturbs the chemical equilibrium, typically by moving the reactions to replenish the sulphate concentration present in the groundwater. This process occurs primarily through the dissolution of compounds that have sulphate in their chemical composition, such as barite, suggesting that part of the barium concentration in the subsurface can be of geogenic origin. This study demonstrated the importance of knowing the nature of the geochemical processes in groundwater contaminated by urban solid waste

Compensating deforestation with forest surplus : key regulatory issues within Brazil's atlantic forest.

Brazil has created a market mechanism for compensating past deforestation based on the acquisition of forest surplus from different properties. This mechanism, known in Brazil as the ?CRA market?, could become the world's largest forest compensation program. The success of this market depends on the specifics of regulations that are yet to come. The objective of this article was to explore three relevant issues to the regulation of a future CRA market within the Atlantic Forest of Minas Gerais state: the balance between supply and demand; incentives for trade in priority areas; and potential policy overlaps between different compensation programs. Based on geospatial evaluations and content analysis of government documents, the study revealed a potential oversupply of CRAs in the Minas Gerais Atlantic Forest, as surplus areas were found to be 2.76 greater than deficit areas. Eventual incentives for trade in priority areas could lessen oversupply, but unfold into sensitive territorial tradeoffs. The potential overlap between the CRA market and the existing compensation program of the Atlantic Forest Act, while still unclear, is unlikely to be a very relevant one. Future avenues of research are suggeste

Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection

In schistosomiasis mansoni, parasite eggs precipitate an intrahepatic granulomatous and fibrosing inflammatory process, which is mediated by, and dependent on, MHC class II-restricted CD4 T helper (Th) lymphocytes specific for schistosome egg antigens (SEA). In the mouse model of the disease, CBA mice develop large granulomas, whereas in C57BL/6 (BL/6) mice these granulomas are significantly smaller. To further investigate how the prevailing cytokine environment influences the development of the egg-induced immunopathology, we immunized the low-pathology BL/6 mice with SEA in complete Freund's adjuvant (CFA) once before, and once again during, the course of a 7-week infection. This immunization caused a pronounced Th1 shift in the SEA-specific CD4 T cell response, which was detected in the mesenteric lymph nodes (MLNs) and spleens, as well as in the granulomatous lesions themselves. The immunized mice displayed a dramatic enhancement of hepatic egg-induced immunopathology manifested by a marked increase in granuloma size and parenchymal inflammation, leading to early death. Control mice immunized with equivalent amounts of SEA or CFA alone displayed the smaller hepatic lesions in a Th2-dominant environment typically seen in the unimmunized BL/6 mice. Analysis of granuloma and MLN lymphocytes from the SEA/CFA-immunized mice revealed that the proportion of CD4 T cells was unchanged in comparison with the control BL/6 groups and remained significantly lower than that seen in the normally high-pathology CBA strain. These results suggest that the shift toward Th1-type cytokine production by a numerically stable population of CD4 T cells correlates with severe exacerbation of immunopathology in schistosomiasis