Accession Site Does Not Influence the Risk of Stroke after Diagnostic Coronary Angiography or Intervention: Results from a Large Prospective Registry

INTRODUCTION: Periprocedural stroke represents a rare but serious complication of cardiac catheterization. Pooled data from randomized trials evaluating the risk of stroke following cardiac catheterization via transradial versus transfemoral access showed no difference. On the other hand, a significant difference in stroke rates favoring transradial access was found in a recent meta-analysis of observational studies. Our aim was to determine if there is a difference in stroke risk after transradial versus transfemoral catheterization within a contemporary real-world registry. METHODS: Data from 14,139 patients included in a single-center prospective registry between 2009 and 2016 were used to determine the odds of periprocedural transient ischemic attack (TIA) and stroke for radial versus femoral catheterization via multivariate logistic regression with Firth's correction. RESULTS: A total of 10,931 patients underwent transradial and 3,208 underwent transfemoral catheterization. Periprocedural TIA/stroke occurred in 41 (0.29%) patients. Age was the only significant predictor of TIA/stroke in multivariate analysis, with each additional year representing an odds ratio (OR) = 1.09 (CI 1.05-1.13, p < 0.000). The choice of accession site had no impact on the risk of periprocedural TIA/stroke (OR = 0.81; CI 0.38-1.72, p = 0.577). CONCLUSION: Observational data from a large prospective registry indicate that accession site has no influence on the risk of periprocedural TIA/stroke after cardiac catheterization

Predicting cleavability of peptide sequences by HIV protease via correlation-angle approach

In designing HIV protease inhibitors as potential drugs for AIDS therapy, knowledge about what peptide sequences in polyproteins are cleavable by HIV proteases is very useful. In this article, based on the formulation that any octapeptide can be uniquely expressed as a 160-dimensional vector and the principle that the similarity of any two such vectors is associated with their correlation angle, a new method is proposed to predict the cleavability of a peptide sequence by HIV-1 and HIV-2 proteases. The average predicted accuracy the new method for the 105 peptide sequences whose cleavability by HIV-1 protease is known is 96/105=9.14%, which is about 8% higher than that by the existing method for the same set of data. A considerably high rate of correct prediction was also obtained when the new method was used to predict the HIV-2 protease-cleaved sites in some proteins.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45081/1/10930_2005_Article_BF01028191.pd

Data Descriptor : A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins

Under ongoing climate change and increasing anthropogenic activity, which continuously challenge ecosystem resilience, an in-depth understanding of ecological processes is urgently needed. Lakes, as providers of numerous ecosystem services, face multiple stressors that threaten their functioning. Harmful cyanobacterial blooms are a persistent problem resulting from nutrient pollution and climate-change induced stressors, like poor transparency, increased water temperature and enhanced stratification. Consistency in data collection and analysis methods is necessary to achieve fully comparable datasets and for statistical validity, avoiding issues linked to disparate data sources. The European Multi Lake Survey (EMLS) in summer 2015 was an initiative among scientists from 27 countries to collect and analyse lake physical, chemical and biological variables in a fully standardized manner. This database includes in-situ lake variables along with nutrient, pigment and cyanotoxin data of 369 lakes in Europe, which were centrally analysed in dedicated laboratories. Publishing the EMLS methods and dataset might inspire similar initiatives to study across large geographic areas that will contribute to better understanding lake responses in a changing environment.Peer reviewe

Stratification strength and light climate explain variation in chlorophyll a at the continental scale in a European multilake survey in a heatwave summer

To determine the drivers of phytoplankton biomass, we collected standardized morphometric, physical, and biological data in 230 lakes across the Mediterranean, Continental, and Boreal climatic zones of the European continent. Multilinear regression models tested on this snapshot of mostly eutrophic lakes (median total phosphorus [TP] = 0.06 and total nitrogen [TN] = 0.7 mg L−1), and its subsets (2 depth types and 3 climatic zones), show that light climate and stratification strength were the most significant explanatory variables for chlorophyll a (Chl a) variance. TN was a significant predictor for phytoplankton biomass for shallow and continental lakes, while TP never appeared as an explanatory variable, suggesting that under high TP, light, which partially controls stratification strength, becomes limiting for phytoplankton development. Mediterranean lakes were the warmest yet most weakly stratified and had significantly less Chl a than Boreal lakes, where the temperature anomaly from the long-term average, during a summer heatwave was the highest (+4°C) and showed a significant, exponential relationship with stratification strength. This European survey represents a summer snapshot of phytoplankton biomass and its drivers, and lends support that light and stratification metrics, which are both affected by climate change, are better predictors for phytoplankton biomass in nutrient-rich lakes than nutrient concentrations and surface temperature

Macro-regional differentiation of the world: Authors’ concept and its application

This article is a continuation of the same authors’ study entitled ‘Concepts And Delimitation Of The World’s Macro-Regions’ prepared for the 1/2018 of this journal (Anděl et al. 2018). The main aim of the first part was an evaluation of the concepts and factors which have been used as a basis for the delimitation of the different macro-regions of the world. In this second part, the authors propose their own macro-regionalisation of the world – this is a combination of four concepts, with relatively different contents: those of De Blij and Muller (1997), Cole (1996), Huntington (1996) and Hampl (2009). This macro-regionalisation arises from sociocultural affiliation, economic interrelationships and territorial continuity. Along with the concept of the macro-regional differentiation of the world itself, we focus on evaluating the importance of the shaping of macro-regions, as well as assessing the positive and negative features of individual concepts and their influence on the macro-regional differentiation of the world

Macro-regional differentiation of the world: Authors’ concept and its application

This article is a continuation of the same authors' study entitled 'Concepts And Delimitation Of The World's Macro-Regions' prepared for the 1/2018 of this journal (Anděl et al. 2018). The main aim of the first part was an evaluation of the concepts and factors which have been used as a basis for the delimitation of the different macro-regions of the world. In this second part, the authors propose their own macro-regionalisation of the world this is a combination of four concepts, with relatively different contents: those of De Blij and Muller (1997), Cole (1996), Huntington (1996) and Hampl (2009). This macro-regionalisation arises from sociocultural affiliation, economic interrelationships and territorial continuity. Along with the concept of the macro-regional differentiation of the world itself, we focus on evaluating the importance of the shaping of macro-regions, as well as assessing the positive and negative features of individual concepts and their influence on the macro-regional differentiation of the world

Concepts and delimitation of the worldʼs macro-regions

The authors focus on the current differentiation of the world and on its cognitive, application and educational frameworks and importance for the present. Macro-regional differentiation of the world has resulted from geographic concepts and it is a foundation for understanding the global development of society. This article evaluates the specific concepts and factors that form concepts of world macro-regions prepared by famous authors. It also presents a methodological approach for macro-regional forming of the world. After a theoretical and methodological introduction there is a discussion of the differentiation of the world entitled “Macroregional differentiation of the world - formation and application.ˮ The authors also present their conception of world differentiation and evaluation of the creation macro-regions and their positive and negative influence of the macro-regional differentiation of the world

Macro-regional differentiation of the world: Authors' concept and its application

This article is a continuation of the same authors' study entitled 'Concepts And Delimitation Of The World's Macro-Regions' prepared for the 1/2018 of this journal (Anděl et al. 2018). The main aim of the first part was an evaluation of the concepts and factors which have been used as a basis for the delimitation of the different macro-regions of the world. In this second part, the authors propose their own macro-regionalisation of the world this is a combination of four concepts, with relatively different contents: those of De Blij and Muller (1997), Cole (1996), Huntington (1996) and Hampl (2009). This macro-regionalisation arises from sociocultural affiliation, economic interrelationships and territorial continuity. Along with the concept of the macro-regional differentiation of the world itself, we focus on evaluating the importance of the shaping of macro-regions, as well as assessing the positive and negative features of individual concepts and their influence on the macro-regional differentiation of the world