An mri-based radiomic prognostic index predicts poor outcome and specific genetic alterations in endometrial cancer

Integrative tumor characterization linking radiomic profiles to corresponding gene expression profiles has the potential to identify specific genetic alterations based on non-invasive radiomic profiling in cancer. The aim of this study was to develop and validate a radiomic prognostic index (RPI) based on preoperative magnetic resonance imaging (MRI) and assess possible associations between the RPI and gene expression profiles in endometrial cancer patients. Tumor texture features were extracted from preoperative 2D MRI in 177 endometrial cancer patients. The RPI was developed using least absolute shrinkage and selection operator (LASSO) Cox regression in a study cohort (n = 95) and validated in an MRI validation cohort (n = 82). Transcriptional alterations associated with the RPI were investigated in the study cohort. Potential prognostic markers were further explored for validation in an mRNA validation cohort (n = 161). The RPI included four tumor texture features, and a high RPI was significantly associated with poor disease-specific survival in both the study cohort (p < 0.001) and the MRI validation cohort (p = 0.030). The association between RPI and gene expression profiles revealed 46 significantly differentially expressed genes in patients with a high RPI versus a low RPI (p < 0.001). The most differentially expressed genes, COMP and DMBT1, were significantly associated with disease-specific survival in both the study cohort and the mRNA validation cohort. In conclusion, a high RPI score predicts poor outcome and is associated with specific gene expression profiles in endometrial cancer patients. The promising link between radiomic tumor profiles and molecular alterations may aid in developing refined prognostication and targeted treatment strategies in endometrial cancer.publishedVersio

EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), 2013. Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals).

A risk ranking process identified Salmonella spp. and pathogenic verocytotoxin-producing Escherichia coli (VTEC) as current high-priority biological hazards for meat inspection of bovine animals. As these hazards are not detected by traditional meat inspection, a meat safety assurance system for the farm-to-chilled carcass continuum using a risk-based approach was proposed. Key elements of the system are risk-categorisation of slaughter animals for high-priority biological hazards based on improved food chain information, as well as risk-categorisation of slaughterhouses according to their capability to control those hazards. Omission of palpation and incision during post-mortem inspection for animals subjected to routine slaughter may decrease spreading and cross-contamination with the high-priority biological hazards. For chemical hazards, dioxins and dioxin-like polychlorinated biphenyls were ranked as being of high potential concern; all other substances were ranked as of medium or lower concern. Monitoring programmes for chemical hazards should be more flexible and based on the risk of occurrence, taking into account the completeness and quality of the food chain information supplied and the ranking of chemical substances, which should be regularly updated to include new hazards. Control programmes across the food chain, national residue control programmes, feed control and monitoring of environmental contaminants should be better integrated. Meat inspection is a valuable tool for surveillance and monitoring of animal health and welfare conditions. Omission of palpation and incision would reduce detection effectiveness for bovine tuberculosis and would have a negative impact on the overall surveillance system especially in officially tuberculosis free countries. The detection effectiveness for bovine cysticercosis, already low with the current meat inspection system, would result in a further decrease, if palpation and incision are removed. Extended use of food chain information could compensate for some, but not all, the information on animal health and welfare lost if only visual post-mortem inspection is applied

Oscillating foil propulsion

Unsteady foil theory is discussed and applied on several cases of an oscillating foil. The oscillating foil is meant as a propulsion system for a platform supply vessel.Four case studies of foil oscillation have been performed. A thrust coefficient of 0.1 was achieved at an efficiency of 0.75. A thrust coefficient of minimum 0.184 is necessary to overcome the calm water resistance of the foil.Issues connected to coupled vessel-foil models are discussed

Talentudvikling: Erfaringer fra et talentudviklingsmiljø med fokus på skolegang og sportslig udvikling

50 timers ugentligt skolearbejde, er hvad gymnasierne forventer af deres elever, når både den skemalagte undervisning og hjemmearbejdet regnes med. For mange unge elite-atleter kan denne arbejdsbelastning være svær at få til at gå op med en træningsuge, der ofte beslaglægger mere end 20 timer, når alle typer af træning tælles med. At mange af talenterne tilmed må transportere sig langt mellem hjem, skole og træning gør bare ondt værre, og de unge eliteudøvere stilles derfor ofte overfor valget: Skal jeg passe min skole eller min træning?For at imødegå denne problematik etableredes for mere end tyve år siden Team Danmark-ordningen, der på udvalgte gymnasier, giver idrætstalentfulde gymnasielever mulighed for at strække uddannelsen over fire år i stedet for tre. Men er det ekstra år nødvendigt, eller kan det have utilsigtede konsekvenser for eleverne at forlænge skoletiden? Er der alternativer til den fireårige TD-ordning? Denne artikel beskriver oprettelsen og udviklingen af talentudviklingsmiljøet på Stenhus Gymnasium i Holbæk og belyser, hvordan spillerne på Stenhus Basketball College udvikler deres talent uden at gå på kompromis i deres valg af ungdomsuddannelse