31 research outputs found
Sensitivity of melting, freezing and marine ice beneath Larsen C Ice Shelf to changes in ocean forcing
Observations of surface lowering on Larsen C Ice Shelf (LCIS), Antarctica, have prompted concern about its stability. In this study, an ocean model is used to investigate the extent to which changes in ocean forcing may have influenced ice loss and the distribution of stabilising marine ice beneath LCIS. The model uses a new bathymetry, containing a southern seabed trough discovered using seismic observations. The modelled extent of marine ice, thought to stabilise LCIS, is in good agreement with observations. Experiments applying idealised ocean warming yield an increase in melting over the southern trough. This is inconsistent with lowering observed in northern LCIS, suggesting oceanic forcing is not responsible for that signal. The marine ice extent and thickness reduces significantly under ocean warming, implying a high sensitivity of LCIS stability to changes in ocean forcing. This result could have wide implications for other cold-water ice shelves around Antarctica
An updated seabed bathymetry beneath Larsen C Ice Shelf, west Antarctic
Abstract. In recent decades, rapid ice-shelf disintegration along the Antarctic Peninsula has had a global impact through enhancing outlet glacier flow, and hence sea level rise, and the freshening of Antarctic Bottom Water. Ice shelf thinning due to basal melting results from the circulation of relatively warm water in the underlying ocean cavity. However, the effect of sub-shelf circulation on future ice-shelf stability cannot be predicted accurately with computer simulations if the geometry of the ice-shelf cavity is unknown. To address this deficit for Larsen C Ice Shelf, west Antarctica, we integrate new water-column thickness measurements with existing observations. We present these new data here along with an updated bathymetry grid of the ocean cavity. Key findings include relatively deep seabed to the south-east of the Kenyon Peninsula, along the grounding line and around the key ice shelf pinning point of Bawden Ice Rise. In addition, we can confirm that the cavityâs southern trough stretches from Mobiloil Inlet to the open ocean. These areas of deep seabed will influence ocean circulation and tidal mixing, and will therefore affect the basal-melt distribution. These results will help constrain models of ice-shelf cavity circulation with the aim of improving our understanding of sub-shelf processes and their potential influence on ice shelf stability. The data set comprises all point measurements of seabed depth and a gridded data product, derived using additional measurements of both offshore seabed depth and the thickness of grounded ice. We present all new depth measurements here as well as a compilation of previously published measurements used in the gridding process. The gridded data product is included in the supplementary material. The underlying seismic data sets which were used to determine bed depth and ice thickness are available at https://doi.org/10.5285/315740B1-A7B9-4CF0-9521-86F046E33E9A (Brisbourne et al., 2019), https://doi.org/10.5285/5D63777D-B375-4791-918F-9A5527093298 (Booth, 2019), https://doi.org/10.5285/FFF8AFEE-4978-495E-9210-120872983A8D (Kulessa and Bevan, 2019) and https://doi.org/10.5285/147BAF64-B9AF-4A97-8091-26AEC0D3C0BB (Booth et al., 2019). </jats:p
An updated seabed bathymetry beneath Larsen C Ice Shelf, Antarctic Peninsula
Abstract. In recent decades, rapid ice shelf disintegration along
the Antarctic Peninsula has had a global impact through enhancing
outlet glacier flow and hence sea level rise and the freshening of
Antarctic Bottom Water. Ice shelf thinning due to basal melting results from
the circulation of relatively warm water in the underlying ocean cavity.
However, the effect of sub-shelf circulation on future ice shelf stability
cannot be predicted accurately with computer simulations if the geometry of
the ice shelf cavity is unknown. To address this deficit for Larsen C Ice
Shelf, West Antarctica, we integrate new water column thickness measurements
from recent seismic campaigns with existing observations. We present these
new data here along with an updated bathymetry grid of the ocean cavity. Key
findings include a relatively deep seabed to the southeast of the Kenyon
Peninsula, along the grounding line and around the key ice shelf
pinning-point of Bawden Ice Rise. In addition, we can confirm that the
cavity's southern trough stretches from Mobiloil Inlet to the open ocean.
These areas of deep seabed will influence ocean circulation and tidal
mixing and will therefore affect the basal-melt distribution. These results
will help constrain models of ice shelf cavity circulation with the aim of
improving our understanding of sub-shelf processes and their potential
influence on ice shelf stability. The datasets are comprised of all the new point measurements of seabed depth. We
present the new depth measurements here, as well as a compilation of
previously published measurements. To demonstrate the improvements to the
sub-shelf bathymetry map that these new data provide we include a gridded
data product in the Supplement of this paper, derived using
the additional measurements of both offshore seabed depth and the thickness
of grounded ice. The underlying seismic datasets that were used to
determine bed depth and ice thickness are available at
https://doi.org/10.5285/315740B1-A7B9-4CF0-9521-86F046E33E9A
(Brisbourne et al., 2019), https://doi.org/10.5285/5D63777D-B375-4791-918F-9A5527093298 (Booth,
2019), https://doi.org/10.5285/FFF8AFEE-4978-495E-9210-120872983A8D
(Kulessa and Bevan, 2019) and https://doi.org/10.5285/147BAF64-B9AF-4A97-8091-26AEC0D3C0BB
(Booth et al., 2019).
</jats:p
The genetic architecture of the human cerebral cortex
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder
Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3â90 years
Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through MetaâAnalysis (ENIGMA) Consortium to examine ageârelated trajectories inferred from crossâsectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3â90âyears. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with interâindividual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical ageârelated morphometric patterns
Subcortical brain volume, regional cortical thickness, and cortical surface area across disorders: findings from the ENIGMA ADHD, ASD, and OCD Working Groups
Objective Attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. We aimed to directly compare all three disorders. The ENIGMA consortium is ideally positioned to investigate structural brain alterations across these disorders.
Methods Structural T1-weighted whole-brain MRI of controls (n=5,827) and patients with ADHD (n=2,271), ASD (n=1,777), and OCD (n=2,323) from 151 cohorts worldwide were analyzed using standardized processing protocols. We examined subcortical volume, cortical thickness and surface area differences within a mega-analytical framework, pooling measures extracted from each cohort. Analyses were performed separately for children, adolescents, and adults using linear mixed-effects models adjusting for age, sex and site (and ICV for subcortical and surface area measures).
Results We found no shared alterations among all three disorders, while shared alterations between any two disorders did not survive multiple comparisons correction. Children with ADHD compared to those with OCD had smaller hippocampal volumes, possibly influenced by IQ. Children and adolescents with ADHD also had smaller ICV than controls and those with OCD or ASD. Adults with ASD showed thicker frontal cortices compared to adult controls and other clinical groups. No OCD-specific alterations across different age-groups and surface area alterations among all disorders in childhood and adulthood were observed.
Conclusion Our findings suggest robust but subtle alterations across different age-groups among ADHD, ASD, and OCD. ADHD-specific ICV and hippocampal alterations in children and adolescents, and ASD-specific cortical thickness alterations in the frontal cortex in adults support previous work emphasizing neurodevelopmental alterations in these disorders
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years
Delineating the association of age and cortical thickness in healthy individuals is critical given the association of cortical thickness with cognition and behavior. Previous research has shown that robust estimates of the association between age and brain morphometry require largeâscale studies. In response, we used crossâsectional data from 17,075 individuals aged 3â90âyears from the Enhancing Neuroimaging Genetics through MetaâAnalysis (ENIGMA) Consortium to infer ageârelated changes in cortical thickness. We used fractional polynomial (FP) regression to quantify the association between age and cortical thickness, and we computed normalized growth centiles using the parametric Lambda, Mu, and Sigma method. Interindividual variability was estimated using metaâanalysis and oneâway analysis of variance. For most regions, their highest cortical thickness value was observed in childhood. Age and cortical thickness showed a negative association; the slope was steeper up to the third decade of life and more gradual thereafter; notable exceptions to this general pattern were entorhinal, temporopolar, and anterior cingulate cortices. Interindividual variability was largest in temporal and frontal regions across the lifespan. Age and its FP combinations explained up to 59% variance in cortical thickness. These results may form the basis of further investigation on normative deviation in cortical thickness and its significance for behavioral and cognitive outcomes