Investigating executive functioning abilities in Tourette Syndrome (TS) and effects on adaptive functioning

This thesis focuses on Executive Functioning abilities in children and young people with Tourette Syndrome (TS). Part 1 comprises a literature review, using a systematic review method, to determine whether executive functioning impairments are present in individuals with TS. The review explores the extent to which EF impairments, if found, are exacerbated by comorbidity (e.g., with Attention-Deficit Hyperactivity Disorder, ADHD), mediated by the type of measure used, and if profiles of performance change across the developmental lifespan. The empirical research paper in Part 2 examines distinct components of executive functioning, using experimental and ecologically valid behavioural measures in a group of 47 children with diagnoses of Tourette Syndrome. Of primary interest was to explore whether executive functioning is impaired in these children, and if executive functioning abilities impact on adaptive functioning. The work described was a joint project with my colleague, Summer Fakhro. The critical appraisal (Part 3) offers some reflections about the research process, on working with young people with complex conditions in a research capacity, and outlines some recommendations for future resear

Dispersal and coastal geomorphology limit potential for mangrove range expansion under climate change

Latitudinal range limits for mangroves on high-energy, wave-dominated coasts are controlled by geomorphological features and estuarine dynamics. Mangroves reach a southern global range limit along the South African coastline, but the distribution is patchy, with stands occurring in only 16% of the estuaries in the region. Yet, the persistence of forests planted \u3e50 years ago beyond the natural distribution limit suggests that additional estuaries could support mangroves. Understanding regional drivers is necessary to inform global-scale estimates for how this important ecosystem is predicted to respond to climate change. Here, we combine species distribution modelling (MaxEnt), Lagrangian particle tracking using an eddy- and tide-resolving numerical ocean model, and connectivity matrices, to identify suitable mangrove habitats along the South African coastline at present, as well as under the IPCC RCP4.5 and RCP8.5 climate scenarios. Within the current South African distribution range (±900 km), eight more estuaries were identified to be suitable under contemporary conditions. When considering potential range extension (±110 km), an additional 14 suitable estuaries were identified. Connectivity matrices suggest limited long-distance dispersal, stranding mostly at or near the release location, and a decreased probability of connectivity towards the range limit. Under both future climate scenarios, 30% of estuaries currently supporting mangroves are predicted to become unsuitable, while an additional six estuaries beyond the current distribution are predicted to become suitable. However, there is limited connectivity between these new sites and established forests. Synthesis. This study shows that dispersal substantially limits mangrove distribution at the southern African range limit and highlights the importance of including this process in species distribution models. Ultimately, our results provide new insight into mangrove conservation and management at range limits that are not controlled predominantly by temperature, as it has been assumed that mangroves will largely expand to higher latitudes under climate change

The BCoS cognitive profile screen: Utility and predictive value for stroke

Objective: We examined the utility of the Birmingham Cognitive Screen (BCoS) in discriminating cognitive profiles and recovery of function across stroke survivors. BCoS was designed for stroke-specific problems across 5 cognitive domains: (a) controlled and spatial attention, (b) language, (c) memory, (d) number processing, and (e) praxis. Method: On the basis of specific inclusion criteria, this cross-section observational study analyzed cognitive profiles of 657 subacute stroke patients, 331 of them reassessed at 9 months. Impairments on 32 measures were evaluated by comparison with 100 matched healthy controls. Measures of affect, apathy, and activities of daily living were also taken. Between-subjects group comparisons of mean performance scores and impairment rates and within-subject examination of impairment rates over time were conducted. Logistic regressions and general linear modeling were used for multivariate analysis of domain-level effects on outcomes. Results: Individuals with repeated stroke experienced significantly less cognitive recovery at 9 months than those with a first stroke despite similar initial level of cognitive performance. Individuals with left hemisphere lesions performed more poorly than those with right hemisphere lesions, but both groups showed similar extent of recovery at 9 months. BCoS also revealed lesion-side-specific deficits and common areas of persistent problems. Functional outcome at 9 months correlated with domain-level deficits in controlled attention, spatial attention, and praxis over and above initial dependency and concurrent levels of affect and apathy. Conclusion: The study demonstrates how BCoS can identify differential cognitive profiles across patient groups. This can potentially help predict outcomes and inform rehabilitation. (PsycINFO Database Record (c) 2014 APA, all rights reserved)

Metallicity Gradients at Large Galactocentric Radii Using the Near-infrared Calcium Triplet

We describe a new spectroscopic technique for measuring radial metallicity gradients out to large galactocentric radii. We use the DEIMOS multi-object spectrograph on the Keck telescope and the galaxy spectrum extraction technique of Proctor et al. (2009). We also make use of the metallicity sensitive near-infrared (NIR) Calcium triplet (CaT) features together with single stellar population models to obtain metallicities. Our technique is applied as a pilot study to a sample of three relatively nearby (<30 Mpc) intermediate-mass to massive early-type galaxies. Results are compared with previous literature inner region values and generally show good agreement. We also include a comparison with profiles from dissipational disk-disk major merger simulations. Based on our new extended metallicity gradients combined with other observational evidence and theoretical predictions, we discuss possible formation scenarios for the galaxies in our sample. The limitations of our new technique are also discussed.Comment: 13 Pages, 9 Figures, 7 Tables, Accepted for publication in MNRA

Multifrequency Radiation of Extragalactic Large-Scale Jets

Large-scale extragalactic jets, observed to extend from a few to a few hundred kiloparsecs from active galactic nuclei, are now studied over many decades in frequency of electromagnetic spectrum, from radio until (possibly) TeV gamma rays. For hundreds of known radio jets, only about 25 are observed at optical frequencies. Most of them are relatively short and faint, with only a few exceptions, like 3C 273 or M 87, allowing for detailed spectroscopic and morphological studies. Somewhat surprisingly, the large-scale jets can be very prominent in X-rays. Up to now, about 25 jets were detected within the 1 - 10 keV energy range, although the nature of this emission is still under debate. In general, both optical and X-ray jet observations present serious problems for standard radiation models for the considered objects. Recent TeV observations of M 87 suggest the possibility of generating large photon fluxes at these high energies by its extended jet. In this paper we summarize information about multiwavelength emission of the large-scale jets, and we point out several modifications of the standard jet radiation models (connected with relativistic bulk velocities, jet radial stratification and particle energization all the way along the jet), which can possibly explain some of the mentioned puzzling observations. We also comment on gamma-ray emission of the discussed objects.Comment: 29 pages. Modified version, accepted for publication in Chinese Journal of Astronomy and Astrophysic

A Comparison of Theory-Based and Experimentally Determined Myocardial Signal Intensity Correction Methods in First-Pass Perfusion Magnetic Resonance Imaging

Objectives. To evaluate the impact of correcting myocardial signal saturation on the accuracy of absolute myocardial blood flow (MBF) measurements. Materials and Methods. We performed 15 dual bolus first-pass perfusion studies in 7 dogs during global coronary vasodilation and variable degrees of coronary artery stenosis. We compared microsphere MBF to MBF calculated from uncorrected and corrected MRI signal. Four correction methods were tested, two theoretical methods (Th1 and Th2) and two empirical methods (Em1 and Em2). Results. The correlations with microsphere MBF (n=90 segments) were: uncorrected (y=0.47x+1.1, r=0.70), Th1 (y=0.53x+1.0, r=0.71), Th2 (y=0.62x+0.86, r=0.73), Em1 (y=0.82x+0.86, r=0.77), and Em2 (y=0.72x+0.84, r=0.75). All corrected methods were not significantly different from microspheres, while uncorrected MBF values were significantly lower. For the top 50% of microsphere MBF values, flows were significantly underestimated by uncorrected SI (31%), Th1 (25%), and Th2 (19%), while Em1 (1%), and Em2 (9%) were similar to microsphere MBF. Conclusions. Myocardial signal saturation should be corrected prior to flow modeling to avoid underestimation of MBF by MR perfusion imaging

Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners.

Aims: Marathon running is a popular ambition in modern societies inclusive of non-athletes. Previous studies have highlighted concerning transient myocardial dysfunction and biomarker release immediately after the race. Whether this method of increasing physical activity is beneficial or harmful remains a matter of debate. We examine in detail the real-world cardiovascular remodeling response following competition in a first marathon. Methods: Sixty-eight novice marathon runners (36 men and 32 women) aged 30 ± 3 years were investigated 6 months before and 2 weeks after the 2016 London Marathon race in a prospective observational study. Evaluation included electrocardiography, cardiopulmonary exercise testing, echocardiography, and cardiovascular magnetic resonance imaging. Results: After 17 weeks unsupervised marathon training, runners revealed a symmetrical, eccentric remodeling response with 3-5% increases in left and right ventricular cavity sizes, respectively. Blood pressure (BP) fell by 4/2 mmHg (P < 0.01) with reduction in arterial stiffness, despite only 11% demonstrating a clinically meaningful improvement in peak oxygen consumption with an overall non-significant 0.4 ml/min/kg increase in peak oxygen consumption (P = 0.14). Conclusion: In the absence of supervised training, exercise-induced cardiovascular remodeling in real-world novice marathon runners is more modest than previously described and occurs even without improvement in cardiorespiratory fitness. The responses are similar in men and women, who experience a beneficial BP reduction and no evidence of myocardial fibrosis or persistent edema, when achieving average finishing times

Nitrifying Microorganisms Linked to Biotransformation of Perfluoroalkyl Sulfonamido Precursors from Legacy Aqueous Film-Forming Foams

Drinking water supplies across the United States have been contaminated by firefighting and fire-training activities that use aqueous film-forming foams (AFFF) containing per- and polyfluoroalkyl substances (PFAS). Much of the AFFF is manufactured using electrochemical fluorination by 3M. Precursors with six perfluorinated carbons (C6) and non-fluorinated amine substituents make up approximately one-third of the PFAS in 3M AFFF. C6 precursors can be transformed through nitrification (microbial oxidation) of amine moieties into perfluorohexane sulfonate (PFHxS), a compound of regulatory concern. Here, we report biotransformation of the most abundant C6 sulfonamido precursors in 3M AFFF with available commercial standards (FHxSA, PFHxSAm, and PFHxSAmS) in microcosms representative of the groundwater/surface water boundary. Results show rapid (\u3c1 day) biosorption to living cells by precursors but slow biotransformation into PFHxS (1–100 pM day–1). The transformation pathway includes one or two nitrification steps and is supported by the detection of key intermediates using high-resolution mass spectrometry. Increasing nitrate concentrations and total abundance of nitrifying taxa occur in parallel with precursor biotransformation. Together, these data provide multiple lines of evidence supporting microbially limited biotransformation of C6 sulfonamido precursors involving ammonia-oxidizing archaea (Nitrososphaeria) and nitrite-oxidizing bacteria (Nitrospina). Further elucidation of interrelationships between precursor biotransformation and nitrogen cycling in ecosystems would help inform site remediation efforts

A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology.

OBJECTIVES: To assess whether it is feasible to quantify acute change in temporal lobe volume and total oedema volumes in herpes simplex virus (HSV) encephalitis as a preliminary to a trial of corticosteroid therapy. METHODS: The study analysed serially acquired magnetic resonance images (MRI), of patients with acute HSV encephalitis who had neuroimaging repeated within four weeks of the first scan. We performed volumetric measurements of the left and right temporal lobes and of cerebral oedema visible on T2 weighted Fluid Attenuated Inversion Recovery (FLAIR) images using stereology in conjunction with point counting. RESULTS: Temporal lobe volumes increased on average by 1.6% (standard deviation (SD 11%) in five patients who had not received corticosteroid therapy and decreased in two patients who had received corticosteroids by 8.5%. FLAIR hyperintensity volumes increased by 9% in patients not receiving treatment with corticosteroids and decreased by 29% in the two patients that had received corticosteroids. CONCLUSIONS: This study has shown it is feasible to quantify acute change in temporal lobe and total oedema volumes in HSV encephalitis and suggests a potential resolution of swelling in response to corticosteroid therapy. These techniques could be used as part of a randomized control trial to investigate the efficacy of corticosteroids for treating HSV encephalitis in conjunction with assessing clinical outcomes and could be of potential value in helping to predict the clinical outcomes of patients with HSV encephalitis