229 research outputs found
Evaluation of Efficacy and Safety of Fixed Dose Lovastatin and NiacinER Combination in Asian Indian Dyslipidemic Patients: A Multicentric Study
- Author
- Publication venue
- Dove Medical Press
- Publication date
- 01/03/2006
- Field of study
Asian Indian dyslipidemia is characterized by: borderline high low-density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B; high triglycerides, low high-density lipoprotein (HDL) cholesterol and apoA1; and high lipoprotein(a) (lp[a]). We performed a controlled multicentric trial in India to evaluate the efficacy and safety of a fixed dose combination of lovastatin and niacin extended release (niacinER) formulation in patients with moderate to severe dyslipidemia. Consecutive subjects that satisfied the selection criteria, agreed to an informed consent, and with no baseline presence of liver/renal disease or heart failure were enrolled in the study. After a 4-week run-in period there were 142 patients with LDL levels ≥130 mg/dL. Eleven patients were excluded because of uncontrolled hyperglycemia and 131 patients were recruited. After baseline evaluation of clinical and biochemical parameters all subjects were administered lovastatin (20 mg) and niacinER (500 mg) combination once daily. Dose escalation was done on basis of lipid parameters at 8 weeks and in 11 patients increased to lovastatin (20 mg) and niacinER (1000 mg). An intention-to-treat analysis was performed and data was analyzed using nonparametric Wilcoxon signed rank test. Thirteen patients (10%) were lost to follow-up and 4 (3%) withdrew because of dermatological adverse effects: flushing, pruritus, and rash. The mean values of various lipid parameters (mg/dL) at baseline, and at weeks 4, 12, and 24 respectively were: total cholesterol 233.9 ± 27, 206.3 ± 27, 189.8 ± 31, and 174.9 ± 27 mg/dL; LDL cholesterol 153.4 ± 22, 127.3 ± 21, 109.2 ± 27, and 95.1 ± 23 mg/dL; triglycerides 171.1 ± 72, 159.5 ± 75, 149.2 ± 45, and 135.2 ± 40 mg/dL; HDL cholesterol 45.6 ± 7, 48.9 ± 7, 51.6 ± 9, and 53.9 ± 10 mg/dL; lp(a) 48.5 ± 26, 40.1 ± 21, 35.4 ± 21, and 26.9 ± 19 mg/dL; and apoA1/apoB ratio 0.96 ± 0.7, 1.04 ± 0.4, 1.17 ± 0.5, and 1.45 ± 0.5 (p < 0.01). The percentage of decline in various lipids at 4, 12, and 24 weeks was: total cholesterol 11.8%, 18.8%, and 25.2%; LDL cholesterol 17.0%, 28.8%, and 38.0%; triglyceride 6.8%, 12.8%, and 21.0%; lp(a) 17.5%, 26.9%, and 44.5% respectively (p < 0.01). HDL cholesterol and apoA1/apoB increased by 7.2%, 13.1%, and 18.2%; and 7.9%, 21.9%, and 51.6% respectively (p < 0.01). Target LDL levels (<100 mg/dL in subjects with manifest coronary heart disease or diabetes; <130 mg/dL in subjects with >2 risk factors) were achieved in 92 (80.7%) patients. No significant changes were observed in systolic or diastolic blood pressure, blood creatinine, transaminases, or creatine kinase. A fixed dose combination of lovastatin and niacinER significantly improved cholesterol lipoprotein lipids as well as lp(a) and apoA1/apoB levels in Asian Indian dyslipidemic patients. Satisfactory safety and tolerability profile in this population was also demonstrated
Allele-specific miRNA-binding analysis identifies candidate target genes for breast cancer risk
- Author
- A Gilam
- A Kozomara
- A Maia
- A-r Lee
- A-T Maia
- AC Antoniou
- AD Johnson
- AJ Enright
- AM Burger
- B John
- B Li
- B Panwar
- BL Brewster
- BP Lewis
- CC Lord
- D Betel
- D Welter
- DM Glubb
- DP Bartel
- DR Zerbino
- ER Gamazon
- F Kassie
- FJ Couch
- G Fehringer
- G Sun
- G Wang
- GP Wagner
- HS Lo
- J Gong
- J Lonsdale
- J MacArthur
- J Wynendaele
- J Xavier
- J Zhu
- JD French
- K Lawrenson
- K Michailidou
- K Michailidou
- K Michailidou
- KB Meyer
- LJ Chin
- LW Wattenberg
- M Ghoussaini
- M Mele
- M Morley
- M Wang
- MJ Li
- ML Freedman
- MS Nicoloso
- MT Maurano
- P Flicek
- Q Li
- R Liu
- S Durinck
- S-l Hu
- SL Edwards
- T Koguchi
- T Pastinen
- T Pastinen
- TG Consortium
- TGP Consortium
- V Agarwal
- W McLaren
- Y Chen
- Y Hamdi
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Most breast cancer (BC) risk-associated single-nucleotide polymorphisms (raSNPs) identified in genome-wide association studies (GWAS) are believed to cis-regulate the expression of genes. We hypothesise that cis-regulatory variants contributing to disease risk may be affecting microRNA (miRNA) genes and/or miRNA binding. To test this, we adapted two miRNA-binding prediction algorithms-TargetScan and miRanda-to perform allele-specific queries, and integrated differential allelic expression (DAE) and expression quantitative trait loci (eQTL) data, to query 150 genome-wide significant ( P≤5×10-8 ) raSNPs, plus proxies. We found that no raSNP mapped to a miRNA gene, suggesting that altered miRNA targeting is an unlikely mechanism involved in BC risk. Also, 11.5% (6 out of 52) raSNPs located in 3'-untranslated regions of putative miRNA target genes were predicted to alter miRNA::mRNA (messenger RNA) pair binding stability in five candidate target genes. Of these, we propose RNF115, at locus 1q21.1, as a strong novel target gene associated with BC risk, and reinforce the role of miRNA-mediated cis-regulation at locus 19p13.11. We believe that integrating allele-specific querying in miRNA-binding prediction, and data supporting cis-regulation of expression, improves the identification of candidate target genes in BC risk, as well as in other common cancers and complex diseases.Funding Agency
Portuguese Foundation for Science and Technology
CRESC ALGARVE 2020
European Union (EU)
303745
Maratona da Saude Award
DL 57/2016/CP1361/CT0042
SFRH/BPD/99502/2014
CBMR-UID/BIM/04773/2013
POCI-01-0145-FEDER-022184info:eu-repo/semantics/publishedVersio
SPARC 2016 Salford postgraduate annual research conference book of abstracts
- Author
- Abdalla KSA
- Abdullah M
- Abubaker MSS
- Adebayo O
- Adunola T
- Adwik S
- Aiyenitaju OT
- Akinsola OO
- Al-Abboodi HMA
- Al-Ani A
- Al-Bayati Zaid Jafer
- Al-Falahy NFA
- Al-Isawi Rawaa Hussein
- Al-Mukaram NAR
- Al-ossmi Laith Hady
- Al-Turki RA
- Alabdalkarim SI
- Albelazi MS
- Alexander D
- Alkayed H
- Almadani N
- Almfleah AMA
- Alquwez N
- Alshaheen H
- Amadi AI
- Ashtiani F
- Atallah HM
- Avgoustaki F
- Bakare WA
- Barnes N
- Barratt AE
- Barton J
- Brettell L
- Brissenden PG
- Butler DE
- Byrne HM
- Campbell J
- Carter M
- Chadwell AEA
- Chandler JDB
- Costamagna E
- Cunningham EA
- Danaan GN
- Davis D
- Dinu ILI
- Dodd J
- Doroh RM
- Dron RM
- Ebnmhana JA
- Edge CE
- Egena O
- Ekuma CV
- Elhoush R
- Elmuntser A
- Enyita C
- Evangelopoulou E
- Fakhrudeen A
- Fawkes R
- Fenton A
- Forde J
- Frigenti PP
- Ghanbour HA
- Ghulam HS
- Gill N
- Goyol S
- Greuel H
- Hadgraft N
- Hall J
- Hart AM
- Hasan A
- Haynes E
- Heale R
- Heaney N
- Heaton C
- Hussein A
- Iheme JO
- Iliyasu U
- Iredale S
- JERVIS BK
- Jones C
- Kassim ME
- Kerr G
- Keshwan AJ
- Kevill J
- Khan IM
- Lomas M
- Maghrabi A
- Mahmood A
- Mardan A
- Martin P
- Mashiter C
- McCarthy R
- McGown AT
- Meikle GT
- Menelec V
- Moezoddin A
- Mohammed R
- Mohammed WA
- Moraitis E
- Morlan-Mairal M
- Mosa H
- Muhammad M
- Munro NM
- Nassrullah ZFA
- Nyam C
- Odufuwa K
- Osman H
- Panwar P
- Peets AG
- Phakphum A
- Price A
- Rajab M
- Rodrigues Nogueira Forti I
- Salamati Nia Seyed Payam
- Sani Pour F
- Sasse F
- Schork IG
- Scott R
- Silva HCE
- Stan DM
- Sudarsono AS
- Swamy AM
- Szeto SS
- Temile SO
- van der Veen S
- WILLETT J
- Williams AE
- Yadav R
- Yangomodou OD
- Yousef R
- Publication venue
- University of Salford
- Publication date
- 14/06/2016
- Field of study
Preliminary safety and efficacy of first-line pertuzumab combined with trastuzumab and taxane therapy for HER2-positive locally recurrent or metastatic breast cancer (PERUSE).
- Author
- Abdel Azeem H
- Abulkhair O
- Achille M
- Aksoy S
- Alabiso O
- Alarc\uf3n J
- Aleknavicius E
- Alexandre J
- Allen M
- Alonso I.
- Alonso JL
- Altwegeiri T
- Amorim G
- Andel J
- Andrade J
- Andreetta C
- Andres Conejero R
- Angel Garcia J
- Ant\uf3n Torres A
- Arance A
- Arcediano A
- Artignan X
- Augereau P
- Aziz Z
- Azribi F
- Bachelot T
- Bachmeier K
- Baird R
- Barletta H
- Barnadas Molins A
- Barraclough L
- Barrett S
- Barrios C
- Baruch NB
- Beato C
- Beith J
- Berdah JF
- Beresford M
- Bernstein V
- Bj\uf6meklett HG
- Bodoky G
- Boer K
- Bondarenko I
- Bonetti A
- Bourgeois H
- Brain E
- Butt M
- Califaretti N
- Campone M
- Cariello A
- Cascinu S
- Castillo C
- Catala S
- Cavero M
- Cede\uf1o M
- Chakraborti P
- Christensen B
- Cicin I
- Ciruelos E
- Cocquyt V
- Cort\ue9s J
- Coskun HS
- Costa L
- Coudert B
- Cruz M
- Curigliano G
- Dalenc F
- Dalmau E
- Damasceno M
- De Boer R
- de Gr\ue8ve J
- de Jongh F
- de la Cruz LR
- de Prado DS
- Del Mar Gordon M
- Del Val O
- Di Costanzo F
- Dohollou N
- Dominguez A
- du Toit Y
- Easton V
- Echarri MJ
- Efremidou A
- El-Saghir N
- Errihani H
- Ettl J
- Evron E
- Facchini T
- Fein LE
- Feng J
- Ferra\uf9 F
- Ferreira A
- Fountzilas G
- Fox S
- Frassoldati A
- Fried G
- Gaafar R
- Gal\ue1n A
- Garate CO
- Garc\ueda M
- Garcia Mata J
- Garcia A
- Garcia L
- Garre EG
- Geffen D
- Genet D
- Gennari A
- Ghosn M
- Giacobino A
- Gianni L
- Goldberg H
- Goncalves A
- Gonzalez A
- Gozy M
- Grasso D
- Greil R
- Gridelli C
- Grischke EM
- Grosjean J
- Guerra YC
- Hegg R
- Hernandez C
- Hesse T
- Hicks J
- Hicks J
- Hoffmann O
- Hu X
- Huizing M
- Humphreys A
- Illarramendi JJ
- Inbar M
- Jafri M
- Jerusalem G
- Jes\ufas Flori\ue1n Jerico MS
- Jiang J
- Jiveliouk I
- Joffe J
- Joy A
- Juarez A
- Juhasz B
- Juhasz-Boess I
- Juozaityte E
- K\ufchn T
- K\ufctner R
- Kaen LA
- Kahan Z
- Kalofonos H
- Karminsky N
- Khandan F
- Klint L
- Kovalyov O
- Kukulska M
- L\uf3pez L\uf3pez R
- Laing R
- Lang I
- Laplaige P
- Largillier R
- Latini L
- Lazaro J
- Levitt N
- Li H
- Li N
- Li N
- Lindegger N
- Llombart A
- Llorca C
- Llorente R
- Loman N
- Lopez Ceballos MH
- Lueck HJ
- Luigi C
- Lux M
- Mano M
- Mart\uednez Ja\uf1ez N
- Martin P
- Martinez E
- Martinez MP
- Matos E
- Mattson J
- Matus J
- Mavroudis D
- McAdam K
- McCarthy N
- Mele M
- Menj\uf3n Beltr\ue1n S
- Merot JL
- Miles D
- Montemurro F
- Mueller V
- Murias A
- Narbe U
- Newby J
- Ngan R
- Nowecki Z
- Ober A
- Oltra A
- Oosterkamp R
- Orfeuvre H
- Ozyilkan O
- Padrik P
- Paluch-Shimon S
- Panasci L
- Panwar U
- Papazisis K
- Passos Coelho JL
- Pectasides D
- Pelaez I
- Peretz-Yablonski T
- Perez M
- Peron YI
- Perren T
- Perrin C
- PERUSE investigators: Bouzid K
- Petzer A
- Poole C
- Pottier V
- Puglisi F
- Rafael Rodriguez Cid J
- Rashid K
- Rayson D
- Redondo A
- Repp R
- Revesz J
- Ribelles N
- Ricci F
- Rigg A
- Robidoux A
- Rodr\uedguez R
- Rodriguez C
- Roerdink H
- Rosengarten O
- Ruggeri EM
- Ruohola J
- Saad Eldin I
- Saarni O
- Salas F
- Sanchez R
- Saura S
- Schmid P
- Schneeweiss A
- Schroeder W
- Sehdev S
- Shparyk Y
- Siddiqi N
- Simon E
- Singer C
- Smiljanic S
- Smok-Kalwat J
- Soria T
- Sousa G
- Steger G
- Stemmer S
- Stoeger H
- Streb J
- Stuart-Harris R
- Susnjar S
- Tanner M
- Taylor W
- Teixeira L
- Tondini C
- Tong Z
- Torrego JC
- Trifunovic J
- Turner N
- Uslu R
- V\ue1squez FM
- Van de Wouw Y
- Van den Bosch J
- Van der Velden A
- Van Warmerdam L
- Varughese M
- Vasilopoulos G
- Vera R
- Verma S
- Verrill M
- Vi\uf1as Villaro G
- Voitko N
- von Schumann R
- Vrijaldenhoven S
- Wagner S
- Wang S
- Wardley A
- Waters S
- Westwell S
- Wheatley D
- Wildiers H
- Wojtukiewicz M
- Woodward N
- Wronski A
- Yeo B
- Yordi G
- Zahm DM
- Zhang Q
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND:
Pertuzumab combined with trastuzumab and docetaxel is the standard first-line therapy for HER2-positive metastatic breast cancer, based on results from the phase III CLEOPATRA trial. PERUSE was designed to assess the safety and efficacy of investigator-selected taxane with pertuzumab and trastuzumab in this setting.
PATIENTS AND METHODS:
In the ongoing multicentre single-arm phase IIIb PERUSE study, patients with inoperable HER2-positive advanced breast cancer (locally recurrent/metastatic) (LR/MBC) and no prior systemic therapy for LR/MBC (except endocrine therapy) received docetaxel, paclitaxel or nab-paclitaxel with trastuzumab [8\u2009mg/kg loading dose, then 6\u2009mg/kg every 3\u2009weeks (q3w)] and pertuzumab (840\u2009mg loading dose, then 420\u2009mg q3w) until disease progression or unacceptable toxicity. The primary end point was safety. Secondary end points included overall response rate (ORR) and progression-free survival (PFS).
RESULTS:
Overall, 1436 patients received at least one treatment dose (initially docetaxel in 775 patients, paclitaxel in 589, nab-paclitaxel in 65; 7 discontinued before starting taxane). Median age was 54\u2009years; 29% had received prior trastuzumab. Median treatment duration was 16\u2009months for pertuzumab and trastuzumab and 4\u2009months for taxane. Compared with docetaxel-containing therapy, paclitaxel-containing therapy was associated with more neuropathy (all-grade peripheral neuropathy 31% versus 16%) but less febrile neutropenia (1% versus 11%) and mucositis (14% versus 25%). At this preliminary analysis (52 months' median follow-up), median PFS was 20.6 [95% confidence interval (CI) 18.9-22.7] months overall (19.6, 23.0 and 18.1\u2009months with docetaxel, paclitaxel and nab-paclitaxel, respectively). ORR was 80% (95% CI 78%-82%) overall (docetaxel 79%, paclitaxel 83%, nab-paclitaxel 77%).
CONCLUSIONS:
Preliminary findings from PERUSE suggest that the safety and efficacy of first-line pertuzumab, trastuzumab and taxane for HER2-positive LR/MBC are consistent with results from CLEOPATRA. Paclitaxel appears to be a valid alternative taxane backbone to docetaxel, offering similar PFS and ORR with a predictable safety profile.
CLINICALTRIALS.GOV:
NCT01572038
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmed A
- Ahuja S
- Aime C
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alvarez Gonzalez B
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Antchev G
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Aspell P
- Atakisi IO
- Atanassov I
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydogmus Sen F
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Baginyan A
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Bakirci MN
- Baldenegro Barrera C
- Ball AH
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrio Luna M
- Bartek R
- Bartosik N
- Bartók M
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baxter S
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerril Gonzalez H
- Bechtel J
- Bedoya CF
- Beghin D
- Behera PK
- Behera SC
- Behnke O
- Bein S
- Belchior Batista Das Chagas E
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belyaev A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Beni N
- Benitez JF
- Benussi L
- Berardi V
- Berenguer Antequera J
- Beretvas A
- Bergauer T
- Berger P
- Berger T
- Beri SB
- Bermúdez Martínez A
- Bernardes CA
- Bernet C
- Berretti M
- Berry D
- Berryhill J
- Bertacchi V
- Besancon M
- Beschi A
- Bhal E
- Bhardwaj A
- Bharti M
- Bhat MA
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
- Bhattacharya S
- Bheesette S
- Bhowmik D
- Bhowmik S
- Bhyun JH
- Bi R
- Bialkowska H
- Bianchini L
- Bianco M
- Bianco S
- Biasini M
- Biino C
- Bilei GM
- Bilin B
- Bin Anuar AA
- Bisello D
- Black K
- Blekman F
- Blinov V
- Bloch D
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boletti A
- Bologna S
- Bols ES
- Bonacorsi D
- Bonanomi M
- Bonham B
- Bonomally S
- Boos E
- Boran F
- Borchsh V
- Borg J
- Borgonovi L
- Bornheim A
- Borras K
- Bortignon P
- Bose T
- Bossini E
- Botta C
- Botta V
- Bottigli U
- Boudoul G
- Bouhali O
- Bourgatte G
- Bourilkov D
- Bozzo M
- Bragagnolo A
- Braghieri A
- Braibant-Giacomelli S
- Brainerd C
- Brandao Malbouisson H
- Brandt S
- Branson JG
- Breedon R
- Breeze S
- Brew C
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brochero Cifuentes JA
- Brom J-M
- Brondolin E
- Brooke JJ
- Brown RM
- Brunner D
- Bruno G
- Brzhechko D
- Brücken E
- Bucci R
- Buccilli A
- Buchanan J
- Buchmuller O
- Buchot Perraguin A
- Bueghly J
- Bundock A
- Bunkowski K
- Buontempo S
- Burkett K
- Burkhardt H
- Burkle B
- Burt K
- Bury F
- Busson P
- Busza W
- Butalla S
- Butler JN
- Butler PH
- Butz E
- Bylinkin A
- Bylsma B
- Cabrera A
- Cabrillo IJ
- Cadamuro L
- Cafagna FS
- Caillol C
- Cakir A
- Calandri A
- Calderon De La Barca Sanchez M
- Calderon A
- Cali IA
- Call K
- Calligaris L
- Calzaferri S
- Camen C
- Caminada L
- Campagnari C
- Campanini R
- Campbell A
- Camporesi T
- Candelise V
- Canelli MF
- Canepa A
- Cankocak K
- Capeans Garrido M
- Capiluppi P
- Cappati A
- Caputo C
- Caraway B
- Cardini A
- Cardwell B
- Carle A
- Carlin R
- Carrera Jarrin E
- Carrillo Montoya CA
- Carrillo Moreno S
- Cartiglia N
- Carvalho Antunes De Oliveira A
- Carvalho W
- Casarsa M
- Caspart R
- Cassese A
- Castaldi R
- Castaneda Hernandez A
- Castilla-Valdez H
- Castro A
- Catanesi MG
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Ceard L
- Ceccarelli R
- Cepaitis V
- Cepeda M
- Cerati GB
- Cerci S
- Cerminara G
- Cerrada M
- Cerri O
- Cetorelli F
- Chabert EC
- Chahal GS
- Chang P
- Chang P
- Chanon N
- Chao Y
- Chapon E
- Charaf O
- Charlot C
- Chatterjee RM
- Chatterjee S
- Chaudhary G
- Chauhan S
- Chauhan S
- Chawla R
- Chazin Quero B
- Checchia P
- Chekhovsky V
- Chen C
- Chen GM
- Chen HS
- Chen KF
- Chen M
- Chen PH
- Chen X
- Chen Y
- Chen Y
- Chen Z
- Chenarani S
- Cheng T
- Cheng Y
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung HWK
- Chhibra SS
- Chiarito B
- Chinellato J
- Chistov R
- Chlebana F
- Cho S
- Choi J
- Choi S
- Choi Y
- Chou JP
- Choudhary BC
- Choudhury S
- Chu J
- Chudasama R
- Chwalek T
- Ciangottini D
- Ciocca C
- Ciocci MA
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- Özçelik Ö
- Široký J
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
- Author
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- Abbiendi G
- Abbrescia M
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- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
Evidence for Top Quark Production in Nucleus-Nucleus Collisions
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- Zuolo D
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- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Peer reviewe
Observation of the B-s(0) -> X(3872)phi Decay
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
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- Capiluppi P
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- Cockerill DJA
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
Using a data sample of proton-proton collisions at root s = 13 TeV, corresponding to an integrated luminosity of 140 fb(-1) collected by the CMS experiment in 2016-2018, the B-s(0) -> X(3872)phi decay is observed. Decays into J/psi pi(+)pi(-) and K+K- are used to reconstruct, respectively, the X(3872) and phi. The ratio of the product of branching fractions B[B-s(0) -> X(3872)phi]B[X(3872) -> J/psi pi(+)pi(-)] to the product B[B-s(0) ->psi(2S)phi]B[psi(2S) -> J/psi pi(+)pi(-)] is measured to be [2.21 +/- 0.29(stat) +/- 0.17(syst)]%. The ratio B[B-s(0) -> X(3872)phi]/B[B-0 -> X(3872)K-0] is found to be consistent with one, while the ratio B[B-s(0) -> X(3872)phi]/B[B+-> X(3872)K+] is two times smaller. This suggests a difference in the production dynamics of the X(3872) in B-0 and B(0)s meson decays compared to B+. The reported observation may shed new light on the nature of the X(3872) particle.Peer reviewe
Observation of a New Excited Beauty Strange Baryon Decaying to Ξb- π+π-
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- Yu PR
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- Yumiceva F
- Yusli MN
- Zabi A
- Zacharopoulou A
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti M
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- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
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- Zhizhin I
- Zhokin A
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- Zorbilmez C
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- Zuolo D
- Zygala L
- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- American Physical Society
- Publication date
- 01/01/2021
- Field of study
The Ξb-π+π- invariant mass spectrum is investigated with an event sample of proton-proton collisions at s=13 TeV, collected by the CMS experiment at the LHC in 2016-2018 and corresponding to an integrated luminosity of 140 fb-1. The ground state Ξb- is reconstructed via its decays to J/ψΞ- and J/ψΛK-. A narrow resonance, labeled Ξb(6100)-, is observed at a Ξb-π+π- invariant mass of 6100.3±0.2(stat)±0.1(syst)±0.6(Ξb-) MeV, where the last uncertainty reflects the precision of the Ξb- baryon mass. The upper limit on the Ξb(6100)- natural width is determined to be 1.9 MeV at 95% confidence level. The low Ξb(6100)- signal yield observed in data does not allow a measurement of the quantum numbers of the new state. However, following analogies with the established excited Ξc baryon states, the new Ξb(6100)- resonance and its decay sequence are consistent with the orbitally excited Ξb- baryon, with spin and parity quantum numbers JP=3/2-
Measurement of the inclusive and differential Higgs boson production cross sections in the decay mode to a pair of τ Leptons in pp collisions at sqrt[s]=13 TeV
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- Zahid S
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- Zalewski P
- Zanetti M
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- Zecchinelli AG
- Zeinali M
- Zeuner WD
- Zghiche A
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- Zhizhin I
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- Ziemons T
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- Zorbilmez C
- Zotto P
- Zotz A
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- Álvarez Fernández A
- Özçelik Ö
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2022
- Field of study
Measurements of the inclusive and differential fiducial cross sections of the Higgs boson are presented, using the τ lepton decay channel. The differential cross sections are measured as functions of the Higgs boson transverse momentum, jet multiplicity, and transverse momentum of the leading jet in the event, if any. The analysis is performed using proton-proton collision data collected with the CMS detector at the LHC at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 138 fb^{-1}. These are the first differential measurements of the Higgs boson cross section in the final state of two τ leptons. In final states with a large jet multiplicity or with a Lorentz-boosted Higgs boson, these measurements constitute a significant improvement over measurements performed in other final states
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