308 research outputs found
Impact of infection on proteome-wide glycosylation revealed by distinct signatures for bacterial and viral pathogens
Mechanisms of infection and pathogenesis have predominantly been studied based on differential gene or protein expression. Less is known about posttranslational modifications, which are essential for protein functional diversity. We applied an innovative glycoproteomics method to study the systemic proteome-wide glycosylation in response to infection. The protein site-specific glycosylation was characterized in plasma derived from well-defined controls and patients. We found 3862 unique features, of which we identified 463 distinct intact glycopeptides, that could be mapped to more than 30 different proteins. Statistical analyses were used to derive a glycopeptide signature that enabled significant differentiation between patients with a bacterial or viral infection. Furthermore, supported by a machine learning algorithm, we demonstrated the ability to identify the causative pathogens based on the distinctive host blood plasma glycopeptide signatures. These results illustrate that glycoproteomics holds enormous potential as an innovative approach to improve the interpretation of relevant biological changes in response to infection
The COMPASS Experiment at CERN
The COMPASS experiment makes use of the CERN SPS high-intensitymuon and
hadron beams for the investigation of the nucleon spin structure and the
spectroscopy of hadrons. One or more outgoing particles are detected in
coincidence with the incoming muon or hadron. A large polarized target inside a
superconducting solenoid is used for the measurements with the muon beam.
Outgoing particles are detected by a two-stage, large angle and large momentum
range spectrometer. The setup is built using several types of tracking
detectors, according to the expected incident rate, required space resolution
and the solid angle to be covered. Particle identification is achieved using a
RICH counter and both hadron and electromagnetic calorimeters. The setup has
been successfully operated from 2002 onwards using a muon beam. Data with a
hadron beam were also collected in 2004. This article describes the main
features and performances of the spectrometer in 2004; a short summary of the
2006 upgrade is also given.Comment: 84 papes, 74 figure
X-shooter, the new wide band intermediate resolution spectrograph at the ESO Very Large Telescope
X-shooter is the first 2nd generation instrument of the ESO Very Large
Telescope(VLT). It is a very efficient, single-target, intermediate-resolution
spectrograph that was installed at the Cassegrain focus of UT2 in 2009. The
instrument covers, in a single exposure, the spectral range from 300 to 2500
nm. It is designed to maximize the sensitivity in this spectral range through
dichroic splitting in three arms with optimized optics, coatings, dispersive
elements and detectors. It operates at intermediate spectral resolution
(R~4,000 - 17,000, depending on wavelength and slit width) with fixed echelle
spectral format (prism cross-dispersers) in the three arms. It includes a
1.8"x4" Integral Field Unit as an alternative to the 11" long slits. A
dedicated data reduction package delivers fully calibrated two-dimensional and
extracted spectra over the full wavelength range. We describe the main
characteristics of the instrument and present its performance as measured
during commissioning, science verification and the first months of science
operations.Comment: accepted for publication in A&
Future axion searches with the International Axion Observatory (IAXO)
The International Axion Observatory (IAXO) is a new generation axion helioscope aiming at a sensitivity to the axion-photon coupling of ga\u3b3 3c few
7 10-12 GeV-1, i.e. 1-1.5 orders of magnitude beyond the one achieved by CAST, currently the most sensitive axion helioscope. The main elements of IAXO are an increased magnetic field volume together with extensive use of x-ray focusing optics and low background detectors, innovations already successfully tested in CAST. Additional physics cases of IAXO could include the detection of electron-coupled axions invoked to explain the white dwarf cooling, relic axions, and a large variety of more generic axion-like particles (ALPs) and other novel excitations at the low-energy frontier of elementary particle physics
The Next Generation of Axion Helioscopes: The International Axion Observatory (IAXO)
The International Axion Observatory (IAXO) is a proposed 4th-generation axion helioscope with the primary physics research goal to search for solar axions via their Primakoff conversion into photons of 1 \u2013 10 keV energies in a strong magnetic field. IAXO will achieve a sensitivity to the axion-photon coupling ga\u3b3 down to a few
710 1212 GeV 121 for a wide range of axion masses up to 3c 0.25 eV. This is an improvement over the currently best (3rd generation) axion helioscope, the CERN Axion Solar Telescope (CAST), of about 5 orders of magnitude in signal strength, corresponding to a factor 3c 20 in the axion photon coupling. IAXO's sensitivity relies on the construction of a large superconducting 8-coil toroidal magnet of 20 m length optimized for axion research. Each of the eight 60 cm diameter magnet bores is equipped with x-ray optics focusing the signal photons into 3c 0.2 cm2 spots that are imaged by very low background x-ray detectors. The magnet will be built into a structure with elevation and azimuth drives that will allow solar tracking for 12 hours each day. This contribution is a summary of our papers [1], [2] and [3] and we refer to these for further details
Conceptual design of the International Axion Observatory (IAXO)
The International Axion Observatory (IAXO) will be a forth generation axion
helioscope. As its primary physics goal, IAXO will look for axions or
axion-like particles (ALPs) originating in the Sun via the Primakoff conversion
of the solar plasma photons. In terms of signal-to-noise ratio, IAXO will be
about 4-5 orders of magnitude more sensitive than CAST, currently the most
powerful axion helioscope, reaching sensitivity to axion-photon couplings down
to a few GeV and thus probing a large fraction of the
currently unexplored axion and ALP parameter space. IAXO will also be sensitive
to solar axions produced by mechanisms mediated by the axion-electron coupling
with sensitivity for the first time to values of not
previously excluded by astrophysics. With several other possible physics cases,
IAXO has the potential to serve as a multi-purpose facility for generic axion
and ALP research in the next decade. In this paper we present the conceptual
design of IAXO, which follows the layout of an enhanced axion helioscope, based
on a purpose-built 20m-long 8-coils toroidal superconducting magnet. All the
eight 60cm-diameter magnet bores are equipped with focusing x-ray optics, able
to focus the signal photons into cm spots that are imaged by
ultra-low-background Micromegas x-ray detectors. The magnet is built into a
structure with elevation and azimuth drives that will allow for solar tracking
for 12 h each day.Comment: 47 pages, submitted to JINS
The IAXO Helioscope
The IAXO (International Axion Experiment) is a fourth generation helioscope with a sensitivity, in terms of detectable signal counts, at least 104 better than CAST phase-I, resulting in sensitivity on ga¿ one order of magnitude better. To achieve this performance IAXO will count on a 8-coil toroidal magnet with 60 cm diameter bores and equipped with X-ray focusing optics into 0.20 cm2 spots coupled to ultra-low background Micromegas X-ray detectors. The magnet will be on a platform that will allow solar tracking for 12 hours per day. The next short term objectives are to prepare a Technical Design Report and to construct the first prototypes of the hardware main ingredients: demonstration coil, X-ray optics and low background detector while refining the physics case and studying the feasibility studies for Dark Matter axions
Emotional design and human-robot interaction
Recent years have shown an increase in the importance of emotions applied to the Design field - Emotional Design. In this sense, the emotional design aims to elicit (e.g., pleasure) or prevent (e.g., displeasure) determined emotions, during human product interaction. That is, the emotional design regulates the emotional interaction between the individual and the product (e.g., robot). Robot design has been a growing area whereby robots are interacting directly with humans in which emotions are essential in the interaction. Therefore, this paper aims, through a non-systematic literature review, to explore the application of emotional design, particularly on Human-Robot Interaction. Robot design features (e.g., appearance, expressing emotions and spatial distance) that affect emotional design are introduced. The chapter ends with a discussion and a conclusion.info:eu-repo/semantics/acceptedVersio
Advanced Virgo Plus: Future Perspectives
While completing the commissioning phase to prepare the Virgo interferometer for the next joint Observation Run (O4), the Virgo collaboration is also finalizing the design of the next upgrades to the detector to be employed in the following Observation Run (O5). The major upgrade will concern decreasing the thermal noise limit, which will imply using very large test masses and increased laser beam size. But this will not be the only upgrade to be implemented in the break between the O4 and O5 observation runs to increase the Virgo detector strain sensitivity. The paper will cover the challenges linked to this upgrade and implications on the detector's reach and observational potential, reflecting the talk given at 12th Cosmic Ray International Seminar - CRIS 2022 held in September 2022 in Napoli
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