Emerging targets in human lymphoma: targeting the MYD88 mutation

B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link between TLR signaling and B cell neoplasm. Recurrent oncogenic mutations in MYD88 have been found in 39% of the activated B cell-like subtype of diffuse large B cell lymphoma (ABC DLBCL). Interestingly, 29% of ABC DLBCL have a single amino acid substitution of proline for the leucine at position 265 (L265P), and the exact same variant has also been identified in a number of lymphoid malignancies. The MYD88 L265P variant was recently identified in 90% of Wadenstrom's macroglobulinemia patients. These recent developments warrant the need for novel diagnostic tools as well as targeted therapeutics. In this review, we discuss the physiological functions of MYD88 and focus on its role in B cell lymphomas, evaluating the potential for targeting oncogenic MYD88 in lymphoma

New lives in the ancestral homeland: return migration from South America to mainland Japan and Okinawa

This work presents a study of identity formation in migrants of Japanese and Okinawan descent who relocate from countries of South America to mainland Japan and to the island prefecture of Okinawa, initially to seek economic advantage. The migrants, called Nikkeijin, are predominantly progeny of earlier migrants from Japan to South America. In a cross-generational sense, they are return migrants.The ethnographic study, based on field research conducted in two sites on the mainland and in Okinawa, compares Nikkeijin experience and attitudes as they interact with native Japanese. Because of their Japanese background, Nikkeijin benefit from privileged visa status; nonetheless, in Japan they are treated as foreigners, and their identity diversifies. Nikkeijin are found to construct simultaneous social fields in both the country of departure and the new environment. This situation may be recognized through the concept of transnationalism.I argue that Nikkeijin self-identity can be multiple and flexible, and does not necessarily coincide with social identity. An increasing and officially promoted diasporic consciousness among migrants of Okinawan descent would seem to produce a different ethnic response to any on the mainland and a greater potential for integration. My thesis should contribute to the understanding of identity in Nikkeijin return migration