Ectoparasites of Coragyps atratus (Bechstein, 1793) (Accipitriformes: Cathartidae) on Bucaramanga, Santander, Colombia

Identificar y conformar una lista de especies de ectoparásitos en el gallinazo negro en dos localidades de la ciudad de Bucaramanga, Colombia. Alcance. Realizar un aporte al conocimiento sobre las especies de ectoparásitos encontrados en piel y plumaje del gallinazo negro en el área metropolitana de Bucaramanga, en el nororiente de los Andes. Metodología. Las aves fueron capturadas en la Plaza de Mercado Guarín y en el Centro de Disposición de Residuos Sólidos “El Carrasco”, ambos en el área metropolitana de Bucaramanga, Colombia. Para obtener los ectoparásitos, los gallinazos se introdujeron uno por uno, en una cámara de fumigación previamente modificada para preservar la vida del ave durante el procedimiento. Adicionalmente, se tomaron algunas plumas y se preservaron en etanol 70%. Principales resultados. Se colectaron 1.696 ectoparásitos sobre 18 gallinazos negros (Coragyps atratus) en dos sitios de Bucaramanga (Colombia). Los parásitos fueron identificados como Cathartacarus coragyps (Gabuciniidae), Dermanysus gallinae (Dermanyssidae), Cuculiphilus alternatus (Menoponidae), Falcolipeurus marginalis (Philopteridae), Laemobothrion glutinans (Laemobothriidae) y Olfesia bisulcata (Hippoboscidae). Las especies más abundantes fueron Cuculiphilus alternatus con 1.217 individuos y Cathartacarus coragyps con 295. Conclusiones. La mayor parte de estos registros son nuevos para la región y amplían el conocimiento con respecto a la distribución de estos ectoparásitos. Tanto las pruebas de Mann-Whitney como los índices parasitológicos calculados permiten observar diferencias entre los dos sitios de muestreo.To identify and to list ectoparasite species of black vulture in two locations in Bucaramanga, Colombia. Scope. To contribute to the knowledge of ectoparasites species found in black vultures in the metropolitan area of Bucaramanga, at the northeastern Andes. Methodology. The birds were captured in Guarin Marketplace and "El Carrasco" Solid Waste Disposal Center, both in the metropolitan area of Bucaramanga, Colombia. To obtain the ectoparasites, each black vulture were introduced into a fumigation chamber previously modified to preserve the life of the bird during the procedure. Moreover, some feathers were taken and preserved in ethanol 70%. Main results. In total, 1,696 ectoparasites were collected from 18 black vultures (Coragyps atratus) in two localities of Bucaramanga (Colombia). The parasites were identified as Cathartacarus coragyps (Gabuciniidae), Dermanysus gallinae (Dermanyssidae), Cuculiphilus alternatus (Menoponidae), Falcolipeurus marginalis (Philopteridae), Laemobothrion glutinans (Laemobothriidae) and Olfesia bisulcata (Hippoboscidae). The most abundant species were Cuculiphilus alternatus with 1,217 specimens and Cathartacarus coragyps with 295. Conclusions. Most of these records are new to the region and contribute to improving the knowledge concerning the ectoparasites distribution in the study area. Mann-Whitney tests and the calculated parasitological indexes show differences between the two sampling places

The merger that led to the formation of the Milky Way's inner stellar halo and thick disk

The assembly process of our Galaxy can be retrieved using the motions and chemistry of individual stars. Chemo-dynamical studies of the nearby halo have long hinted at the presence of multiple components such as streams, clumps, duality and correlations between the stars' chemical abundances and orbital parameters. More recently, the analysis of two large stellar surveys have revealed the presence of a well-populated chemical elemental abundance sequence, of two distinct sequences in the colour-magnitude diagram, and of a prominent slightly retrograde kinematic structure all in the nearby halo, which may trace an important accretion event experienced by the Galaxy. Here report an analysis of the kinematics, chemistry, age and spatial distribution of stars in a relatively large volume around the Sun that are mainly linked to two major Galactic components, the thick disk and the stellar halo. We demonstrate that the inner halo is dominated by debris from an object which at infall was slightly more massive than the Small Magellanic Cloud, and which we refer to as Gaia-Enceladus. The stars originating in Gaia-Enceladus cover nearly the full sky, their motions reveal the presence of streams and slightly retrograde and elongated trajectories. Hundreds of RR Lyrae stars and thirteen globular clusters following a consistent age-metallicity relation can be associated to Gaia-Enceladus on the basis of their orbits. With an estimated 4:1 mass-ratio, the merger with Gaia-Enceladus must have led to the dynamical heating of the precursor of the Galactic thick disk and therefore contributed to the formation of this component approximately 10 Gyr ago. These findings are in line with simulations of galaxy formation, which predict that the inner stellar halo should be dominated by debris from just a few massive progenitors.Comment: 19 pages, 8 figures. Published in Nature in the issue of Nov. 1st, 2018. This is the authors' version before final edit

The alpha-galactosidase A p.Arg118Cys variant does not cause a Fabry disease phenotype: data from individual patients and family studies

Acessível em: www.ncbi.nlm.nih.gov/pmc/articles/PMC4423738/Lysosomal α-galactosidase A (α-Gal) is the enzyme deficient in Fabry disease (FD), an X-linked glycosphingolipidosis caused by pathogenic mutations affecting the GLA gene. The early-onset, multi-systemic FD classical phenotype is associated with absent or severe enzyme deficiency, as measured by in vitro assays, but patients with higher levels of residual α-Gal activity may have later-onset, more organ-restricted clinical presentations. A change in the codon 118 of the wild-type α-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue - GLA p.(Arg118Cys) -, has been recurrently described in large FD screening studies of high-risk patients. Although the Cys118 allele is associated with high residual α-Gal activity in vitro, it has been classified as a pathogenic mutation, mainly on the basis of theoretical arguments about the chemistry of the cysteine residue. However its pathogenicity has never been convincingly demonstrated by pathology criteria. We reviewed the clinical, biochemical and histopathology data obtained from 22 individuals of Portuguese and Spanish ancestry carrying the Cys118 allele, including 3 homozygous females. Cases were identified either on the differential diagnosis of possible FD manifestations and on case-finding studies (n=11; 4 males), or on unbiased cascade screening of probands' close relatives (n=11; 3 males). Overall, those data strongly suggest that the GLA p.(Arg118Cys) variant does not segregate with FD clinical phenotypes in a Mendelian fashion, but might be a modulator of the multifactorial risk of cerebrovascular disease. The Cys118 allelic frequency in healthy Portuguese adults (n=696) has been estimated as 0.001, therefore not qualifying for "rare" condition

Mindfulness in primary care healthcare and teaching professionals and its relationship with stress at work: a multicentric cross-sectional study

Background: Work stress is a common problem among the health personnel of the Spanish National Health System. The objective of this paper is to assess the state of mindfulness among Spanish primary care providers and to evaluate its potential relationship with work stress and basic labor and sociodemographic characteristics. Methods: Cross-sectional, multi-centric study. Primary care nurses, teachers, teaching collaborators and residents assigned to six Spanish Family Medicine/Family and Community Care Departments were invited to participate (n = 475). A template was designed in Google Forms, including sociodemographic and work-related variables. The state of mindfulness was measured with the Five Facet Mindfulness Questionnaire (FFMQ), while work-related stress was measured using an ordinal scale ranging from 0 to 10 points. Descriptive and inferential statistical analyses were carried out, as well as bivariate and multivariate statistics. Results: The mean age of participants was 40, 14 ± 13.12 (range:23–65 years); 66.9% were women, 42.5% internal medicine residents, 29.3% family physicians, and 20.2% nurses. More than half (54.5%) knew about mindfulness, with 24.0% have received training on it, and 22.5% were usual practitioners. The average level of mindfulness was 127.18 ± 15.45 (range: 89–177). The average score of stress at work was 6.00 ± 2.44; 49.9% (range: 0–10). 49.9% of participants scored 7 or more on the stress at work scale. There was an inverse correlation between the levels of mindfulness (FFMQ total score) and work-related stress (Spearman’s r = - 0.155, p = 0.003). Significant relationships between the mindfulness practice and the level of mindfulness (F = 29.80, p < 0.001), as well as between the mindfulness practice and the level of work-related stress (F = 9.68, p = 0.042), were also found. Conclusions: Levels of mindfulness in primary care health providers were in line with those levels observed in other groups of health professionals. Half of all of the primary care providers suffered from a high degree of stress. Although weak, inverse relationships were observed between levels of mindfulness and stress at work, with lower values of stress at work among those who practiced mindfulness. Trial registration: NCT03629457

Controlled clinical trial comparing the effectiveness of a mindfulness and self-compassion 4-session programme versus an 8-session programme to reduce work stress and burnout in family and community medicine physicians and nurses: MINDUUDD study protocol

Background: Health personnel are susceptible to high levels of work stress and burnout due to the psychological and emotional demands of their work, as well as to other aspects related to the organisation of that work. This paper describes the rationale and design of the MINDUUDD study, the aim of which is to evaluate the effectiveness of a mindfulness and self-compassion 4-session programme versus the standard 8-session programme to reduce work stress and burnout in Family and Community Medicine and Nursing tutors and residents. Methods: The MINDUDD study is a multicentre cluster randomised controlled trial with three parallel arms. Six Teaching Units will be randomised to one of the three study groups: 1) Experimental Group-8 (EG8); 2) Experimental Group-4 (EG4) Control group (CG). At least 132 subjects will participate (66 tutors/66 residents), 44 in the EG8, 44 in the EG4, and 44 in the CG. Interventions will be based on the Mindfulness-Based Stress Reduction (MBSR) program, including some self-compassion practices of the Mindful Self-Compassion (MSC) programme. The EG8 intervention will be implemented during 8 weekly face-to-face sessions of 2.5 h each, while the EG4 intervention will consist of 4 sessions of 2.5 h each. The participants will have to practice at home for 30 min/day in the EG8 and 15 min/day in the EG4. The Five Facet Mindfulness Questionnaire (FFMQ), Self-Compassion Scale (SCS), Perceived Stress Questionnaire (PSQ), Maslach Burnout Inventory (MBI), Jefferson Scale of Physician Empathy (JSPE), and Goldberg Anxiety-Depression Scale (GADS) will be administered. Measurements will be taken at baseline, at the end of the programs, and at three months after completion. The effect of the interventions will be evaluated by bivariate and multivariate analyses (Multiple Linear Regression). Discussion: If the abbreviated mindfulness programme is at least as effective as the standard program, its incorporation into the curriculum and training plans will be easier and more appropriate. It will also be more easily applied and accepted by primary care professionals because of the reduced resources and means required for its implementation, and it may also extend beyond care settings to academic and teaching environments as well

A mid-third millennium BC collective burial cave in central iberia: El Rebollosillo (Torrelaguna, Madrid)

[EN] El Rebollosillo is a small karstic cave located in the center of Iberia used for the disposition of secondary burials during the mid third millennium BC. We present bioanthropological, isotopic (87Sr/86Sr, δ 13C y δ 18O) analyses and 16 radiocarbon dates on human remains, as well as mineralogical characterization of 6 beads (4 of them variscite from Palazuelo de las Cuevas, Zamora), and a quantitative analysis of 43 pottery fragments recovered during the 1989 excavations. A minimum of 21 individuals have been identified, covering all age ranges and sex. Low percentages of pathologies have been detected, mainly dental calculus and caries, with specific cases of cribra orbitalia, periostosis and arthritis. Only adults received a clearly individualized treatment, suggestive of achieved status. We interpret the evidence as a multi-staged mortuary program, the last phase of which is documented at the site, with previous stages perhaps carried out elsewhere, and we evaluate these results in the context of the regional funerary record.[ES] El Rebollosillo es una pequeña cueva kárstica situada en el centro de la Península Ibérica utilizada para la disposición de enterramientos secundarios en la mitad del III milenio AC. Presentamos resultados bioantropológicos, isotópicos (87Sr/86Sr, δ13C y δ18O) y 16 dataciones radiocarbónicas de los restos humanos, una descripción cuantificada de los 43 fragmentos cerámicos y de caracterización mineralógica de 6 cuentas recuperadas durante la excavación de 1989, cuatro de las cuales probablemente proceden de Palazuelo de las Cuevas (Zamora). El análisis bioantropológico indica un mínimo de 21 individuos con todos los rangos de edad y sexo. Se han detectado bajos porcentajes de patologías, mayoritariamente cálculo dental y caries, con casos puntuales de cribra orbitalia, periostosis y artrosis. La disposición de los restos sugiere que sólo los adultos recibieron un tratamiento claramente individualizado, quizás acorde con un estatus adquirido con la edad. Proponemos que el registro representa la última fase de un programa mortuorio cuyas etapas previas debieron desarrollarse en otros lugares y valoramos estos resultados en el contexto del registro funerario regional.Peer Reviewe

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286