22 research outputs found
A Techniques for Scalable and Effective Routability Evaluation
- Publication venue
- Publication date
- Field of study
Routing congestion has become a critical layout challenge in nanoscale circuits since it is a critical factor in determining the routability of a design. An unroutable design is not useful even though it closes on all other design metrics. Fast design closure can only be achieved by accurately evaluating whether a design is routable or not early in the design cycle. Lately, it has become common to use a âlight mode â version of a global router to quickly evaluate the routability of a given placement. This approach suffers from three weaknesses: (i) it does not adequately model local routing resources, which can cause incorrect routability predictions that are only detected late, during detailed routing, (ii) the congestion maps obtained by it tend to have isolated hot spots surrounded by noncongested spots, called ânoisy hot spotsâ, which further affects the accuracy in routability evaluation, (iii) the metrics used to represent congestion may yield numbers that do not provide sufficient intuition to the designer; moreover, they may often fail to predict the routability accurately. This paper presents solutions to these issues. First, we propose three approaches to model local routing resources. Second, we propose a smoothing technique to reduce the number of noisy hot spots and obtain a more accurate routability evaluation result. Finally, we develop a new metric which represents congestion maps with higher fidelity. We apply the proposed techniques to several industrial circuits and demonstrate that one can better predict and evaluate design routability, and congestion mitigation tools can perform muc
Effect of sitagliptin on energy metabolism and brown adipose tissue in overweight individuals with prediabetes:a randomised placebo-controlled trial
- Author
- Abreu-Vieira Gustavo
- Berbee Jimmy F.P.
- Boon Mariette R.
- Botani Kani
- de Geus-Oei Lioe-Fee
- Doornink Fleur
- Friesema Edith
- Jazet Ingrid M.
- Martinez-Tellez Borja
- Nahon Kimberley J.
- Pereira Arias-Bouda Lenka M.
- Rensen P.atrick C.N
- Ruiz Jonathan R.
- Smit Frits
- Straat Maaike E.
- van Klinken Jan B.
- van Velden Floris H.P.
- Voortman Gardi
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Aims/hypothesis: The aim of this study was to evaluate the effect of sitagliptin on glucose tolerance, plasma lipids, energy expenditure and metabolism of brown adipose tissue (BAT), white adipose tissue (WAT) and skeletal muscle in overweight individuals with prediabetes (impaired glucose tolerance and/or impaired fasting glucose). Methods: We performed a randomised, double-blinded, placebo-controlled trial in 30 overweight, Europid men (age 45.9 \xc2\xb1 6.2\xc2\xa0years; BMI 28.8 \xc2\xb1 2.3\xc2\xa0kg/m2) with prediabetes in the Leiden University Medical Center and the Alrijne Hospital between March 2015 and September 2016. Participants were initially randomly allocated to receive sitagliptin (100\xc2\xa0mg/day) (n = 15) or placebo (n = 15) for 12\xc2\xa0weeks, using a randomisation list that was set up by an unblinded pharmacist. All people involved in the study as well as participants were blinded to group assignment. Two participants withdrew from the study prior to completion (both in the sitagliptin group) and were subsequently replaced with two new participants that were allocated to the same treatment. Before and after treatment, fasting venous blood samples and skeletal muscle biopsies were obtained, OGTT was performed and body composition, resting energy expenditure and [18F] fluorodeoxyglucose ([18F]FDG) uptake by metabolic tissues were assessed. The primary study endpoint was the effect of sitagliptin on BAT volume and activity. Results: One participant from the sitagliptin group was excluded from analysis, due to a distribution error, leaving 29 participants for further analysis. Sitagliptin, but not placebo, lowered glucose excursion (\xe2\x88\x9240%; p < 0.003) during OGTT, accompanied by an improved insulinogenic index (+38%; p < 0.003) and oral disposition index (+44%; p < 0.003). In addition, sitagliptin lowered serum concentrations of triacylglycerol (\xe2\x88\x9229%) and very large (\xe2\x88\x9246%), large (\xe2\x88\x9235%) and medium-sized (\xe2\x88\x9224%) VLDL particles (all p < 0.05). Body weight, body composition and energy expenditure did not change. In skeletal muscle, sitagliptin increased mRNA expression of PGC1\xce\xb2 (also known as PPARGC1B) (+117%; p < 0.05), a main controller of mitochondrial oxidative energy metabolism. Although the primary endpoint of change in BAT volume and activity was not met, sitagliptin increased [18F] FDG uptake in subcutaneous WAT (sWAT; +53%; p < 0.05). Reported side effects were mild and transient and not necessarily related to the treatment. Conclusions/interpretation: Twelve weeks of sitagliptin in overweight, Europid men with prediabetes improves glucose tolerance and lipid metabolism, as related to increased [18F] FDG uptake by sWAT, rather than BAT, and upregulation of the mitochondrial gene PGC1\xce\xb2 in skeletal muscle. Studies on the effect of sitagliptin on preventing or delaying the progression of prediabetes into type 2 diabetes are warranted. Trial registration: ClinicalTrials.gov NCT02294084. Funding: This study was funded by Merck Sharp & Dohme Corp, Dutch Heart Foundation, Dutch Diabetes Research Foundation, Ministry of Economic Affairs and the University of Granada
Global disparities in surgeonsâ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study
- Author
- Abdelkhalek Mohamed
- AbellaÌn Antonio Melero
- AbelloÌ David
- Abu-Arish Hamdoon
- Acevedo Ana Karen Radilla
- Adamina Michel
- Adamovich Dmitry Mikhailovich
- Addeo Pietro
- Adewunmi Olayinka Lukman
- Aeschbacher Pauline
- Afolabi Akinwale Ibrahim
- Agastra Ervis
- Agresta Ferdinando
- Aguilar Juan Carlos Cardozo
- Ahmed Bensaad
- Ahmed Nauman
- Aimal Aimal Khan
- Aiolfi Alberto
- Akay Omer
- al-Najami Issam
- Al-Shehari Mohammed
- Alconchel Felipe
- Alesina Pier Francesco
- Alhazmi Ahmad
- Ali Mahmoud Ibrahim
- Aliyev Vusal
- Alonso Patricia
- Aloun Ali
- Altinel Yuksel
- Altomare Michele
- Alvarez-Gallego Mario
- Ammendola Michele
- Ammerata Giorgio
- Anania Marco
- Anas Abdelhmed
- Andreuccetti Jacopo
- Andriola Valeria
- Andriola Valeria
- Anelli Ferdinando M.
- Anestiadou Elissavet
- Angrisani Marco
- Antonacci Nicola
- Antonacci Nicola
- Antonelli Amedeo
- Antropoli Carmine
- Aparicio Antonio Carlos Maya
- Apostolou Konstantinos
- Arcudi Claudio
- Aregawi Alazar Berhe
- Argenio Giulio
- Ascari Francesca
- Asfaw Fitsum Terefe
- Athar Rahmatullah
- Atici Semra Demirli
- Au Stephanie
- Augustin Goran
- Avella Pasquale
- Avellaneda Nicolas
- Awad Ahmed K.
- Awad Selmy S.
- Awad Selmy S.
- Ayalew Alem Mekete
- Aytac Erman
- Aytac Erman
- Azevedo JoseÌ
- Baba Arshad Ahmed
- Bacchiocchi Giulia
- Bagaglini Giulia
- Bagaria Dinesh
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Bala Miklosh
- Balaphas Alexandre
- Balassone Valerio
- Baldi Caterina
- Baldini Edoardo
- Balla Andrea
- Ballester Cristina
- Bandaru Kalyan Vijay Kumar
- Bandyopadhyay Samik K.
- Bannone Elisa
- Barba Leonardo A.
- Barberis Andrea
- Barone Mirko
- Barranquero Alberto G.
- Barugola Giuliano
- Barzola Ernesto J.
- Batıkan OgÌuzkagÌan
- Bavikatte Akshay Prasannakumar
- Bayileyegn Nebiyou Simegnew
- Bedros Nicole Mary
- Beisani Marc
- Bejiga Gosa Hundie
- Bekana Bekana L.
- Belay Tatek
- Belia Francesco
- Belkacem Acidi
- Bellanova Giovanni
- Bellato Vittoria
- Bellido-luque Juan
- Bellini Maria Irene
- Bellver Pedro PalazoÌn
- Benzoni Enrico
- Benzoni Ilaria
- Bergna Alessandro
- Bhat Pawan Singh
- Bhattacharya Kaushik
- Bhattacharya Neela
- Bhatti Hamza Waqar
- Bianchi Valentina
- Bianco Giuseppe
- Biloslavo Alan
- Biniam Ewnte
- Blanco-Antona Francisco
- Bocchino Antonio
- Bointas Georgios
- Bollino Ruggero
- Bonavina Luigi
- Bondurri Andrea
- Bonilla Fernando
- Bonito Alba Correa
- Bono Dario
- Borges Nuno
- Botelho Pedro
- Bottari Andrea
- Bottcher Sofia Maria Jaume
- Bourguiba Mohamed Aboulkacem
- Bourmpouteli Eirini
- Bouzid Chafik
- Braccio Bartolomeo
- Brady Richard R. W.
- Braholli Eriol
- Brasset Camille
- Brillantino Antonio
- Brillantino Antonio
- Briones Cristhian Gonzalo Aspiazu
- Brisinda Giuseppe
- Brito Ismael
- Brookes Charlotte Elisabeth
- Brucchi Francesco
- Bulte Joris P.
- Buonomo Oreste Claudio
- Butler Rebecca Jayne
- Cacciaguerra Andrea Benedetti
- Caldeira Beatriz
- Calini Giacomo
- Calu Valentin
- Calussi Marco
- Calussi Marco
- Cammarat Roberto
- Cammarata Roberto
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- Candilio Giuseppe
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- Cannistra Marco
- Cano-Valderrama Oscar
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- Carrabetta Salvatore
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- Carvas JoaÌo M. B.
- Casagranda Biagio
- Casas Maria Agustina
- Cascales-Sanchez Pedro
- Cassese Gianluca
- Castaldi Antonio
- Castaldi Antonio
- Castellano Javier Rivera
- Castro Ernest
- Castro Maria J.
- CC Tommaso
- Celentano Valerio
- Celotti Andrea
- CerdaÌn-Santacruz Carlos
- Cereda Marco Angelo
- Ceresoli Marco
- Cero Mariagiulia Dal
- Cestaro Giovanni
- Cestino Luca
- Chai Feng Yih
- Chalkoo Mushtaq A.
- Charalabopoulos Alexandros
- Charalabopoulos Alexandros
- Charitaki Evgenia
- Chessa Antonella
- Chessa Antonella
- Chevallay Mickael
- Chia Chi Fung
- Chillarge Gauri
- Chimenti Federica
- Chitul Andrei
- Chiu Jennifer H. F.
- Chooklin Serge
- Choudhry Asad
- Chouliaras Christos
- Chowdhury Ashim
- Christodoulou Prokopis
- Chrysikos Michael
- Chukwu Isaac Sunday
- Cianci Pasquale
- Ciarleglio Francesco A.
- Cicerchia Pierfranco Maria
- Ciesielski Wojciech J.
- Cigognini Maria
- Cillara Nicola
- Cioffi Stefano Piero Bernardo
- Ciro Mauricio Pedraza
- Clementi Marco
- Clocchiatti Lucrezia
- Colak Elif
- ColaÌs-Ruiz Enrique
- Coletta Diego
- Colombari Renan C.
- Colombo Francesco
- Colucci Gianluca
- Conte Luigi E.
- Conti Luigi
- Coppola Alessandro
- Corallino Diletta
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- Corrons Laia Codina
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- Costanzo Antonio
- Costea Radu V.
- Cotsoglou Christian
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- Creavin Ben
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- CricriÌ Michele
- Crosbie Gonzalo Gabriel
- Cuccomarino Salvatore
- Cuk Vladica
- Cunha Miguel
- Curcio Silvia
- Curro Giuseppe
- Dajti Irida
- Daniel Clerc
- Dardanov Dragomir
- Davey Matthew G.
- Davies Justin
- Davis Daniel G.
- De AndreÌs-Asenjo Beatriz
- De Campos Tercio
- De Carlis Riccardo
- de las Casas Sara GortaÌzar
- De Luca Alessandro
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- De Nobili Giovanni
- de Oliveira Gabriel Paiva
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- de Santos Iglesias Francisco Juan
- De Simone Belinda
- de Vries Hilbert S.
- Debela Bizuneh Sime
- Debena Dawit Gebregiorgis
- Deerenberg Eva B.
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- del Olmo Juan Carlos MartiÌn
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- Delgado Ander Timoteo
- Delis Spiros
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- Demir Anıl
- Devriendt Stefanie
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- Di Carlo Isidoro
- Di Filippo Giacomo
- Di Franco Gregorio
- Di Lascio Pierpaolo
- Di Marco Federica
- Di Marco Federica
- Di Marco Federica
- Di Martino Marcello
- Di Martino Marcello
- Di Meo Giovanna
- di Mola Fabio F.
- Di Santo Albini Andrea G.
- Di Saverio Salomone
- Di Saverio Salomone
- Di Venere Beatrice
- Diaz-Elizondo Jose Antonio
- Diaz-Elizondo Jose Antonio
- Digne-Malcolm Holly Jane
- Dimitrov Evgeni
- Dinagde Tesfaye Aga
- DiÌaz Carlos JGoÌmez
- Don Cristine Brooke Pathirannehalage
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- Douka Eleftheria
- Drogouti Maria
- Dudi-Venkata Nagendra N.
- Dulskas Audrius
- Dulskas Audrius
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- DâAcapito Fabrizio
- DâAmbrosio Marco
- DâAmbrosio Marco
- DâUgo Stefano
- Efetov Sergey
- Efetov Sergey
- Elfeki Hossam
- Elghadban Hosam Mohamed
- Emile Sameh
- Ercolani Giorgio
- ErdogÌan Emre
- Ermias Nebiyou
- Escalante Karol S.
- Espino Eduardo Morales
- Esposito Francesco
- Esposito Giuseppe
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- Faro Carmelo Lo
- Faro Carmelo Lo
- Farolfi Tommaso
- Farooqui Marryam Riaz
- Farrarons Sara SentiÌ
- FarreÌ Silvia PeÌrez
- Farrukh Maira
- Fazio Federico
- Feituri Nura
- Feleke Tsega Terefe
- Felsenreich Daniel M.
- Fernandez Carmen Cagigas
- FernaÌndez FernaÌndez June
- Fernicola Agostino
- Ferrara Francesco
- Ferrari Davide
- Ferrario Luca
- Ferreira Rodrigo Vaz
- Ferretti Carlotta
- Ferronetti Antonio
- Festa Federico
- Fichera Alessandro
- Fiore Felicia
- Fleming Andrew Martin
- Fleres Francesco
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- Folliero Cristina
- Fonseca Vinicius Cordeiro
- ForcignanoÌ Edoardo
- Foreman Michaael L.
- Formisano Giampaolo
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- Francone Elisa
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- Freixa Celia Caula
- Frontali Alice
- Frountzas Maximos
- Funk Geoffrey A.
- Fuschillo Giacomo
- Gachabayov Mahir
- Galeev Shamil I.
- Galiffa Giampaolo
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- Garoufalia Zoe
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- Giuffrida Maria Carmela
- Giuffrida Mario
- Giuliani Antonio
- Giuliani Giuseppe
- Glasbey James
- Gomes Carlos Augusto
- Gonfa Kebebe Bekele
- Gonsaga Ricardo Alessandro Teixeira
- Gonzalez Ana
- GonzaÌlez Lluis GarciÌa
- GonzaÌlez Tomas Elosua
- Gourgiotis Stavros
- GoÌmez Marta JimeÌnez
- GoÌmez Marta JimeÌnez
- GoÌktepe Berk
- Grama Florin A.
- Granata Roberta
- Gravante Gianpiero
- Greco Antonio
- Grimaldi Luciano
- Grossi Ugo
- Guerci Claudio
- Guerrero MariÌa Alejandra
- Guevara Jenny
- Guitart Marc PeÌrez
- Gulcu Baris
- Guler Mert
- Gulmez Mehmet
- Gunay Emre
- Gupta Amit
- Gupta Ashish
- Gussago Stefano
- GuÌlcuÌ Barış
- GuÌngoÌr Mert
- Hailemariam Dagnachew H.
- Halder Subhadip
- Hale Lyman Lansing
- Harvitkar Rafique Umer
- Hassen Khalid Arebo
- Hernandez-Garcia Miguel
- HernaÌndez Edgard EfreÌn Lozada
- Horesh Nir
- Iacobone Maurizio
- Iannone Immacolata
- IbaÌnÌez Noelia
- Ibrahim Aini Fahriza
- Idiz Ufuk Oguz
- Ielpo Benedetto
- Ielpo Benedetto
- Imana Ruhama Yoseph
- Inama Marco
- Ingallinella Sara
- Ingallinella Sara
- Ioannidis Argyrios
- Ioannidis Orestis
- Iodice Alessandra
- Ioia Giovanna
- Iordache-Petrescu Madalina Ionela
- Iossa Angelo
- Iqbal Muhammad Rafaih
- Iranzo Marina AlarcoÌn
- Isik Arda
- Izzo Giuliano
- Jamiri Al-Radjid
- Jansson Hannes
- Johnson Benjamin E.
- JordaÌo Daniel Filipe Martins
- Juloski Jovan
- Junior Marcelo A. F. Ribeiro
- Kampouroglou Georgios
- Kapsampelis Panagiotis
- Kara Yasin
- Karamarkovic Aleksandar
- Karamarkovic Aleksandar
- Karamarkovic Aleksandar
- Kaur Mandeep
- Kchaou Ali
- Kebede Kirubel Abebe
- Keci Laura
- Keller Deborah S.
- Kelly Michael E.
- Khan Huma Ahmed
- Khan Jan Sher
- Khan Mansoor
- Khobragade Krunal H.
- Kiros Samuel
- Klib Mohamad
- Klimczak Tomasz Jerzy
- Knickerbocker Chase Barrett
- Kobe Yoshiro
- KoeÌter Tijmen
- Koh Peng Soon
- Komaei Iman
- Koneti Akshadhar J.
- Konstantoudakis Georgios
- Koppel Darren
- Korkoman Mohammed J.
- Kosir Jurij A.
- Kovacevic Bojan
- Krsicka Petr
- Kucuk Gultekin Ozan
- Kucukarslan Rabia
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- La Vaccara Vincenzo
- Labat Miriam Cazador
- Lafranceschina Stefano
- Lancellotti Francesco
- Landaluce-Olavarria Aitor
- Lapolla Pierfrancesco
- Laracca Giovanni Guglielmo
- Lasarte Mateusz PJeÌšckowski Aingeru Sarriuga
- Lasithiotakis Konstantinos
- Lauricella Sara
- Lee Lee Yeong Sing
- Lenz Jorge Godoy
- Leo Cosimo Alex
- Lesko Dusan
- Leventoglu Sezai
- Levi Sandri Giovanni Battista
- Lianos Georgios D.
- Licardie Eugenio
- Lichliter Warren E.
- Linares Neiling Massiel Oviedo
- Lisi Giorgio
- Lisi Giorgio
- Litta Francesco
- Litvin Andrey
- Locci Eleonora
- Lolis Evangelos
- Lopez Maria Martinez
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- Lorenzo Irving
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- Low Juin
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- LoÌpez-LoÌpez Victor
- LoÌpez-Soler Guillermo
- Luberto Antonio
- Luglio Gaetano
- Lukmonov Saidrakhim
- Luque Eduardo J.
- Luzzi Andrea Pierre
- Machairas Nikolaos
- Madrid Fausto A.
- Maggi Giulia
- Major Piotr
- Malerba Michele
- Malerba Michele
- Mambrilla Sara
- Mambrilla Sara
- Manatakis Dimitrios K.
- Manfredelli Simone
- Manfredelli Simone
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- Manigrasso Michele
- Manrique Mario Montes
- Manrique Mario Montes
- Mansour Ahmed Mohammed Farid Mahmoud
- Manto Ottavia
- Manzo Carlo Alberto
- Marafante Chiara
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- Marano Luigi
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- Marino Marco V.
- Maroni Norvana
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- Marra Ester
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- Marsanic Patrizia
- Marsella Valentina Enrica
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- Martini Francesco
- MartiÌn-PeÌrez Beatriz
- MartiÌnez Isidro
- Maruccia Michele
- Marwat Muhammad Ibrahim
- Marziali Irene
- Mascherini Matteo
- MascianaÌ Gianluca
- Masetti Michele
- Masior Ćukasz
- Massaro Daniele
- Massey Lisa H.
- Mastella Federica
- Mastronardi Manuela
- Materazzo Marco
- Materazzo Marco
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- Mc Farlane Sebastian Jeri
- Mccawley Niamh
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- Mendes Beatriz ISilva
- Meneghini Simona
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- Menna Maria Paola
- Menna Maria Paola
- Mercado Octavio Avila
- Merlini David
- Merlini David A.
- Merlini Ilenia
- Merlo Ignacio Guillermo
- Meyer Jeremy
- Michael Michael
- Mifsut Patricia
- Miggino Marco
- Miguel Gustavo Machain
- MiguelaÌnÌez Isabel Pascual
- Mihailescu Andrei
- Mihailescu Andrei
- Milana Flavio
- Milana Flavio
- Milanesi Maria
- Milito Pamela
- Milne David M.
- Mineccia Michela
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- Moeckli Beat
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- Mohammed Abdullahi Ibrahim
- Mohammed Mohammed Mustafa
- Moletta Lucia
- Moncada-Ortega Augusto
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- Montiel Carmen Galiana
- Montuori Mauro
- Morales Emilio J.
- Morales Emilio J.
- Morales-Conde Salvador
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- Mukherjee Indraneil
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- Muriel Maria Emilia
- Murillo Gabriela Aracelly Arroyo
- Murzi Valentina
- Mutlu Arda Ulaş
- Muttillo Edoardo Maria
- Nacion Aeris Jane D.
- Naeem Awais
- Nagarajan Prasanth
- Naik Prashant
- Napetti Sara
- Nardo Bruno
- Nari Gustavo Adrian
- Natalia Savvala N.
- Nava Andrea Kazemi
- Navarro-SaÌnchez Antonio
- Nazir Fozia
- Nazir Fozia
- Neary Peter M.
- Negasa Tolera A.
- Negoi Ionut
- Neri Ignacio
- Neves Fernanda V. S.
- Newton Carla Joyce
- Nicolaescu Diana C.
- Nicolazzi Marco
- Nidaw Melkamu Kibret
- Nigri Giuseppe
- Nigri Giuseppe
- NL Harish
- Ntomi Vasileia
- null null
- Nunziante Marco
- Obiagwu Ndubuisi K.
- Oddis Lidia
- Oddis Lidia
- Oliva Alba
- Olivier James B.
- Olivieri Laura
- Olmi Stefano
- Ortega Irene
- Ortega Nuria
- Ortenzi Monica
- Ossola Paolo
- Pach Radoslaw
- Pachajoa Diana Alejandra Pantoja
- Pacilli Mario
- Palmisano Silvia
- Palomba Giuseppe
- Panaccio Paolo
- Pandanaboyana Sanjay
- Pangeni Anang
- Paniagua-Garcia-SenÌorans Marta
- Panyko ArpaÌd
- PanÌella Clara
- Papadopoulos Aristeidis
- Papatheodorou Panayiotis
- Paradiso Giulia
- Paramasvaran Ganendra
- Paranyak Mykola
- ParrenÌo-Manchado Felipe Carlos
- Pascale Marco Maria
- Pascual Franco
- Pasculli Alessandro
- Paspala Anna
- Pata Francesco
- Pata Francesco
- Pattacini Gianmaria Casoni
- Pavlovic Mladen
- Pavone Giovanna
- Pazos Natalia SuaÌrez
- Pecorelli NicoloÌ
- Pedrazzani Corrado
- Pelegrina Amalia
- Pellicciaro Marco
- Pellino Gianluca
- Pellino Gianluca
- Peloso Andrea
- Pennisi Damiano
- Perez Guillermo
- Perez-Sanchez Luis E.
- Perfecto Arkaitz
- Perotti Bruno
- Perra Teresa
- Perrone Gennaro
- Pesce Antonio
- Petagna Lorenzo
- Peters Paul Adewunmi
- Petrakis Georgios
- Petropoulou Thalia
- Petrucciani Niccolo
- PeÌrez Raquel Escalera
- PeÌrez-BertoÌlez Sonia
- Pham Thuy Vy
- Picardi Biagio
- Picchetto Andrea
- Piccoli Micaela
- Piccolo Gaetano
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- Pilia Tiziana
- Pinotti Enrico
- Pio Luca
- Piozzi Guglielmo N.
- Piras Carla
- Pisaniello Donatella
- Pisano Marcello
- Pisano Michele
- Pisanu Adolfo
- Podda Mauro
- Podda Mauro
- Poillucci Gaetano
- Police Andrea
- Porcellini Iride
- Porcu Alberto
- Potkonjak Dario
- Poto Gianmario Edoardo
- Pouwels Sjaak
- Pozza Gioia
- Pradelle Irene
- Prieto Mikel
- Puccioni Caterina
- Puglisi Silvana Bernadetta
- Queffurus Michael
- Quiroga-Garza Alejandro
- Qureshi Ahmad Uzair
- Rachadell Juan JoseÌ
- Ramos-De la Medina Antonio
- Rasheed Faaiz
- Rashid Arshad
- Reccia Isabella
- Reid Rebecca
- Reitano Elisa
- Reiti Andrian
- Richards Chris B.
- Rico Douglas
- Rida Khaled
- Ridolfi Cristina
- Rizzuto Antonia
- Roat Rajesh
- Rocca Aldo
- Rodas Edgar B.
- Rodriguez Agustin E.
- Rodriguez-Lopez Mario
- Roesel Raffaello
- Roesel Raffaello
- Rojas-Bonet Noel
- Romano Angela
- Romano Fabrizio
- Romano Francesco Maria
- Romanzi Andrea
- Rompianesi Gianluca
- Ros Emilio PenÌa
- Rosa Fausto
- Rosa Fausto
- Roscio Francesco
- RoseÌs Helena Salvador
- Rossi Stefano
- Rosso Edoardo
- Rottoli Matteo
- Rubio Ainhoa Valle
- Rueda Erick
- Rusli Siti Mayuha
- Russo Alfio Alessandro
- Russo Iris Shari
- RutegaÌrd Martin
- Sabbatini Sonia
- Sabia Domenico
- Saeidi Sara
- Sahid Saidah
- Sahnan Kapil
- Sahnan Kapil
- Saladino Edoardo
- Salamea Juan C.
- Salido Andrea JimeÌnez
- Salimian Nick
- Salinas Roberto PauÌl Andrade
- Saliu Fatmir
- Salvador Alan Francisco Alfaro
- Salvans Silvia
- Salvetti Francesco
- Samadov Elgun
- Sammartano Fabrizio
- Santocchi Pietro
- Santoliquido Matteo
- Santos BaÌrbara Ribeiro
- Saracoglu Can
- Saraiya Swapnil Mukesh
- Sarmiento Ray Inocencio
- Saroglu Azize
- Sartori Alberto
- Sasia Diego
- Saumtally Mohammad Saad
- SaÌnchez Tatiana GoÌmez
- SaÌnchez-CabuÌs Santiago
- SaÌnchez-GuilleÌn Luis
- Sbacco Valentina
- Scabini Stefano
- Scaringi Stefano
- Scaringi Stefano
- Schena Carlo Alberto
- Schiavo Ciro
- Schiltz Boris
- Schizas Dimitrios
- Schlottmann Francisco
- Sciaudone Guido
- Scopelliti Michele
- Scotti Mauro Alessandro
- Scotti Mauro Alessandro
- Scotto Bruno
- Segura-Sampedro Juan J.
- Selvaggi Francesco
- Selvaggi Lucio
- Sensi Bruno
- Serena De Fatico Gilda
- Seretis Charalampos
- Sergeant Gregory
- Serrablo Alejandro
- Serradilla-MartiÌn Mario
- Serrano-Navidad Monica
- Sevik Husnu
- Seyfried Steffen
- Shalaby Mostafa
- Shiferaw Desta
- Siagian Dumaria Ketty
- Sibaja-Matamoros Dauber A.
- Sica Giuseppe S.
- Sidiropoulou Zacharoula
- Silvestro Roberto
- Singares Eduardo Smith
- Singh-Ranger Gurpreet
- Siragusa Leandro
- Slesser Alistair A. P.
- Sliwinski Svenja Christin
- Smerieri Elia
- Smerieri Nazareno
- Soares Antonio S.
- Soldini Gabriele
- Sotiropoulou Maria
- Sotiropoulu Maria
- Souadka Amine
- Sousa Xavier
- Souza Hamilton Petry
- Spampinato Marcello Giuseppe
- Sparavigna Marco
- Spartalis Eleftherios
- Spartalis Michael
- Sperotto Beatrice
- Spiezio Giovanni
- Spoletini Gabriele
- Stecca Tommaso
- Stijns Jasper
- Stocco Alberto
- Stringfield Sarah Beth
- Stubbs Benjamin M.
- Subramaniam Ravichandran
- Supit Tommy
- Syed Syed Muhammad Ali
- Syn Nicholas L.
- Synekidou Eirini
- Tadesse Robel
- Taeme Mulugeta
- Taffese Abebe
- Takkenberg Marijn
- Tallon-Aguilar Luis
- Tamini NicoloÌ
- Tampaki Ekaterini Christina
- Tampakis Athanasios
- Tan Jessica J.
- Tan Jih Huei
- Tandoi Francesco
- Tantravahi Umasankar
- Tarallo Mariarita
- Tartaglia Nicola
- Tasselli Francesco Menegon
- Tasselli Francesco Menegon
- Tatar Cihad
- Tayeh Salim
- Taylor John Vincent
- Ted Tedla Gebretsadik
- Teddy Tewodros Abule Bilata
- Tegegn Ayenachew Getachew
- Tejedor Patricia
- Tekin Oguzhan
- Tellez Clara
- Tenconi Silvia Maria
- Tense Tadesse H.
- Tepelenis Kostas
- Teran Alfonso Ivan Sanchez
- TereÌs Lara Blanco
- Terwes Natasha Loria
- Tesfay Goytom Knfe
- Thambi Prem
- Tita AgustiÌn
- Tolla Ashenafi Negash
- Tolonen Matti
- Tomada Elisa Paoluzzi
- Tomasicchio Giovanni
- Toscano Marta JimeÌnez
- Toti Johannes M. A.
- Travers Lawrence Albert Salter
- Tropeano Francesca Paola
- Tryliskyy Yegor
- Tsouknidas Ioannis
- Tufo Andrea
- Tur-Martinez Jaume
- Tur-Martinez Jaume
- Tura Marina Vila
- Turrado-Rodriguez Victor
- Turri Giulia
- Tutino Roberta
- Uccelli Matteo
- Uggeri Fabio
- Uzunoglu Mustafa Yener
- Uzzau Alessandro
- Uzzau Alessandro
- Vailas Michail
- Vailas Michail
- Valadez Michel Hernandez
- Valdivieso Xavier HGarciÌa
- Valinoti AgustiÌn
- Van Doorn Berend
- van Ramshorst Gabrielle
- Vanerio Patricio
- Vannelli Alberto
- Vanni Gianluca
- Vanni Gianluca
- Varela Cristopher
- Varela Cristopher L.
- Vargas Luis Felipe Cabrera
- Vellei Samantha
- Verdi Daunia
- Veroux Massimiliano
- Veroux Massimiliano
- Vescio Francesca
- Vigorita Vincenzo
- Vilallonga Ramon
- Vincenzi Paolo
- Vinci Danilo
- Vinci Danilo
- Violante Tommaso
- Visag-Castillo Victor
- Voon Kelvin
- WaleÌšdziak Maciej
- Wani Ajaz
- Wani Ishfaq Ahmad
- Wani Rauf
- Wassie Chekol
- Wilkins Alex
- Wyroslak-Najs Justyna
- Yallew Gebeyaw Mengist
- Yang Wah
- Yildirim Ali Cihat
- Yildiz Ishak
- Yiu Andrew
- Yiu Andrew
- Younis Muhammad Umar
- Yusoff Ahmad Ramzi
- Zacharis Georgios
- Zafra David Ambrona
- Zaghloul Tarek M.
- Zambon Martina
- Zanus Giacomo
- Zarnescu Narcis Octavian
- Zeb Muhammad
- Zena Alemayehu Shanko
- Zerbo Domenico
- Zuchini AndreÌs Mendoza
- Zullo Alessia
- Publication venue
- Publication date
- 29/04/2024
- Field of study
: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSSŸ v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI
Memory Partitioning and Other Applications
- Publication venue
- Publication date
- Field of study
Sleep mode operation and exploiting it to minimize the average power consumption are of great importance in modern VLSI circuits. In general, sleep mode refers to the mode in which part(s) of the system are idle. In this paper, we study the problem of partitioning a circuit according to the activity patterns of its elements such that circuit elements with similar activity patterns are packed into the same partition. Then a partition can be placed in sleep mode during the time intervals all elements contained in that partition are idle. We formulate the partitioning problem to exploit sleep mode operation and show that the problem is NP-complete. Wepresent polynomial time algorithms for practical classes of the problem. Applications of the problem to memory and module partitioning and clock gating are discussed. The experimental data con rm that a careful partitioning allows upto 40 % more sleep time which could be exploited to minimize the average power consumption
Techniques for scalable and effective routability evaluation
- Author
- Publication venue
- 'Association for Computing Machinery (ACM)'
- Publication date
- Field of study
Development of Chitosan and Alginate Nanocapsules to Increase the Solubility, Permeability and Stability of Curcumin
- Author
- A Prokop
- AS Pasternak
- Bruno Solis-Cruz
- C Prego
- C-C Lin
- CR Maruyama
- D Fischer
- D MarkoviÄ
- D Natrajan
- Daniel Hernandez-Patlan
- E Fröhlich
- E SzymaĆska
- Eric Beyssac
- F Danhier
- G Began
- Ghislain Garrait
- Guillermo Tellez
- Gustavo R. Rivera-Rodriguez
- IK Priyadarsini
- IM Lubben Van der
- KM VĂ„rum
- L Mazzarino
- L Zhao
- M Amidi
- M Fresta
- M Huang
- M Tuorkey
- Mario Alberto Cano-Vega
- MM-Y Chan
- MR Maradana
- N Khayata
- N Nafee
- N Rokhati
- NG Schipper
- P Anand
- P Lertsutthiwong
- Q Li
- Raquel Lopez-Arellano
- RB Mythri
- S Rodrigues
- S Salatin
- SA Agnihotri
- SH Suhaimi
- T Ak
- T Hamaguchi
- VP Menon
- W Wongcharoen
- Xochitl Hernandez-Velasco
- Y Xiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Carbon Sequestration of Caesalpinia platyloba S. Watt (Leguminosae) (Lott 1985) in the Tropical Deciduous Forest
- Author
- A Blanco-GarcĂa
- A BĂșrquez
- Antonio Luna-GonzĂĄlez
- AR Stage
- BB Zepeda
- D Lin
- D Piotto
- D Piotto
- D PĂ©rez
- D Torres
- DE Orihuela-Belmonte
- DM Nanang
- E RincĂłn
- E Tellez-MejĂa
- F Wang
- FX Schumacher
- G Cruz de LeĂłn
- GB Williamson
- GB Witt
- GJC GonzĂĄlez
- H Gang
- H RendĂłn-Carmona
- HĂ©ctor Abelardo GonzĂĄlez-Ocampo
- I Arroyo-Quiroz
- I Gelfand
- I MĂ©ndez-Larios
- I Newton
- J Ardo
- J Bohn
- J Chave
- J Chave
- J Chave
- J Navar-Chaidez
- JC Stegen
- JF Noronha
- JF Perez-Quezada
- JI Yerena-Yamallel
- JK Vanclay
- JL Clutter
- JM GrĂŒnzweig
- JM Maass
- JM Torres-Rojo
- JosĂ© LuĂs GarcĂa-HernĂĄndez
- JP Gittinger
- K Jeddi
- K Jeddi
- K Mokany
- K Rennolls
- KI Paul
- LL Douglass
- M Datta
- M Iftekhar
- M Jeréz-Rico
- M Kraenzel
- Mariano Norzagaray-Campos
- MartĂn MartĂnez-Salvador
- MD Nosetto
- N Torelli
- Norma Diaz-Gustavo
- O Bastian
- O Mares-Arreola
- O Vallejos
- P ChacĂłn
- P Huante
- P Meunpong
- PC Van Deusen
- Quazi K. Hassan
- R DĂĄvalos-Sotelo
- R Foroughbakhch
- R Forster
- R Lal
- R RodrĂguez-Laguna
- R Salcido
- R-G Sandra
- RK Chaturvedi
- RM Scheller
- RS Felger
- RS Felger
- S Brown
- S Engel
- S Mansourian
- T Escalante
- TW Daniel
- VJ Jaramillo
- WL Megginson
- WL Pritchett
- X Liu
- Y Liu
- YL Hu
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Outcomes from elective colorectal cancer surgery during the SARSâCoVâ2 pandemic
- Author
- 6\u11f\ufcc\ufc H
- 6fner D
- 6hlberger L
- \u106oza I
- \uc2ngelo M
- \uc4lg\ue5 A
- \uc7elebi F
- \uc7olak E
- Aawsaj Y
- Abad Gurumeta A
- Abad\u2010Motos A
- Abate E
- Abbott D
- Abdalla M
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarim M
- Abdur\u2010Rahman L
- Abel MK
- Aboelkassem Ibrahim A
- Abou Chaar MK
- Abou Chaar Mohamad K.
- Abreu da Silva A
- Abubakar A
- Acebes Garc\ueda F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Afonso J
- Agapov M
- Agarwal Arnav
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agresta F
- Aguado H
- Aguilar Gonzalez M
- Aguilera Lorena Maria
- Ahmed Z
- Ahmeidat A
- Ahn JH
- Aiken T
- Aim\ue9 A
- Akalin M
- Akaydin E
- Akhtar MA
- Akhter Rahman MM
- Akin E
- Al Abdallah M
- Al Awwad S
- Al Habes H
- Al Maadany FS
- AL Sayed M
- Al\u2010Habsi R
- Al\u2010Khayal K
- Al\u2010Masri M
- Al\u2010Mohammad A
- Al\u2010Najjar H
- Alaa S
- AlAamer O
- Aladeojebi A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alawneh F
- Albertsmeier M
- Albertsmeiers Markus
- Alcaide Matas F
- Alderson Derek
- Aldokali N
- Aleksi\u107 L
- Alemanno G
- Alfieri S
- Alghamdi M
- Alhamed A
- Alharthi M
- Alhassan N
- Ali Adil AK
- Ali M
- Ali S
- Aliyeva Z
- Aljiffry M
- Alkadeeki G
- Almeida AC
- Almeida JI
- Almeida\u2010Reis R
- Almgla N
- Alnumani T
- Alobeed O
- Alonso de la Fuente N
- Alonso Poza A
- Alonso\u2010Lamberti L
- Alqannas M
- Alselaim N
- Alser Osaid
- Alshaar Muhammad
- Alshahrani M
- Alshammari S
- Alsharif F
- Alshryda Sattar
- Altintoprak F
- Alurralde C
- Alvarez E
- Alyami M
- Alzamanan M
- Amaral MJ
- Amin Sahid N
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade R
- Angelou D
- Annamalai S
- Annessi V
- Antic A
- Antonakis P
- Antonopoulou MI
- Anula R
- Aprile A
- Aremu M
- Arican C
- Arigoni M
- Arikan AE
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arrowsmith L
- Arulanantham A
- Asaad P
- Ashcroft J
- Ashmore C
- Ashoush F
- Askari A
- Asqalan A
- Athanasakis E
- Athanasiou A
- Atherton R
- Attia D
- Avci EK
- Aversano A
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Aydin C
- Ayorinde J
- Aytac E
- Ayub B
- Ayubi A
- Ayyaz M
- Azam M
- Azamat \u130F
- Azevedo C
- Azevedo Jos\ue9
- Azevedo P
- Ba\u10di\u107 G
- Ba\ueda C
- Babar MS
- Baca B
- Badra R
- Baena Sanfeliu E
- Bagraith K
- Baiao JM
- Baig M
- Bail\uf3n M
- Baili E
- Bajomo O
- Baker A
- Baker O
- Bakmaz B
- Balabel M
- Balasubramaniam D
- Baldari L
- Baldi C
- Baldini E
- Bali R
- Balik E
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandara GBKD
- Bandovas JP
- Bankhead\u2010Kendall Brittany K
- Banky B
- Baptista VH
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- Barker D
- Barlow Emma
- Baron RD
- Barrat B
- Barrett J
- Barrios O
- Barry C
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- Bartolini I
- Bartolome MA Hernandez
- Basendowah M
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- Becker R
- Beech N
- Bekheit M
- Belia F
- Bellacci A
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- Bello J
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- Belluco C
- Beltr\ue1n de Heredia J
- Belvedere A
- Benavides Buleje JA
- Benkabbou A
- Benson Ruth A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Bernasconi M
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- Bertolani E
- Beyer K
- Beyrne C
- Bezede C
- Bhalla A
- Bhangu A
- Bhangu Aneel
- Bhangu Aneel
- Bhangu Aneel
- Bhangu Aneel
- Bhasin S
- Bhat GA
- Bhat MA
- Bhatti MI
- Bianchini M
- Bianco F
- Bianco F
- Bigelow B
- Bilgin IA
- Bin Nasser A
- Bin Traiki T
- Biondi A
- Bisagni P
- Bisset C
- Blackwell L
- Blanco\u2010Colino R
- Blanco\u2010Colino Ruth
- Blas Laina JL
- Blazquez Martin A
- Bodla AS
- Boeck M
- Boeker C
- Bonci E
- Bond\u2010Smith G
- Bondurri A
- Bong C
- Boni L
- Bonnet S
- Borges F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boulton AJ
- Boutall A
- Boutros M
- Boutros M
- Bowman S
- Boyce R
- Boyd\u2010Carson H
- Bozkurt E
- Bozkurt MA
- Brachini G
- Bradulskis S
- Brar Amanpreet
- Bravo Infante R
- Breen Kerry A
- Bretherton Chris
- Brewer H
- Brito da Silva F
- Brixton G
- Brocklehurst M
- Brown B
- Brown S
- Brunt A
- Bruscino A
- Bu\u11fra D
- Bueno Ca\uf1ones AD
- Buerba GA
- Burahee A
- Burgan D
- Burke J
- Burke Joshua
- Buta M
- Butt UI
- Bywater Edward
- Cagigal Ortega EP
- Cagigas Fernandez C
- Cai\uf1a Ruiz R
- Caiado A
- Cakmak G
- Calabr\uf2 M
- Calvo Espino P
- Camacho C
- Caminsky NG
- Campagnaro T
- Campbell W
- Canas\u2010Martinez A
- Cano A
- Cano\u2010Valderrama O
- Canonico G
- Canotilho R
- Cantalejo diaz M
- Capelli P
- Capezzuoli L
- Capitan\u2010Morales L
- Capolupo GT
- Caram EL
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carrano FM
- Carrasco Prats M
- Caruana Edward J
- Carvello MM
- Casati M
- Casiraghi T
- Cassinotti E
- Castro Ruiz C
- Cato LD
- Cayetano Paniagua L
- cberr\ufcck L
- Cecire J
- Ceranic M
- Cervellera M
- Cervera I
- Chakrabortee Sohini
- Chan E
- Chan E
- Chand M
- Chand Manish
- Charalabopoulos A
- Chase T
- Chatzikomnitsa P
- Chaudhry Daoud
- Chavarrias N
- Chebaro A
- Chen S
- Chern H
- Chessa A
- Cheung LK
- Chevallay M
- Chia Z
- Chiappini A
- Chiarugi M
- Chiozza M
- Chitul A
- Cholewa H
- Choolani Bhojwani E
- Choudhry A
- Chowdhury A
- Chowdri NA
- Choynowski M
- Christensen Peter
- Christidis P
- Christoforidis D
- Chrysos E
- Chumbinho B
- Chung E
- Cianflocca D
- Cicerchia PM
- Cintas Catena J
- Ciofic E
- Cirillo B
- Cirocchi N
- Claro M
- Clifford R
- Coccolini F
- Cocozza E
- Coffey JC
- Colao Garc\ueda L
- Collera P
- Colletti G
- Colombari RC
- Colombo F
- Confalonieri M
- Connelly TM
- Conti L
- Conti L
- Contis I
- Corbellini C
- Corless K
- Correa Bonito A
- Correia de S\ue1 T
- Correia AM
- Corrigan M
- Cort\ue9s Guiral D
- Corte Real J
- Cosimelli M
- Costa Santos D
- Costa M
- Costa MJMA
- Costanzi A
- Costeira B
- Costigan F
- Cotoia A
- Cotte E
- Coughlin P
- Cox Daniel
- Cozza V
- Creavin B
- Crichton A
- Cristian D
- Cros B
- Crugnale AS
- Cuadrado\u2010Garc\ueda A
- Cukier Moises
- Cullivan O
- Cuming T
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- Curl\u2010Roper T
- Cvetkovic A
- D\u2019Aloisio G
- D\u2019Ugo D
- D\u2019Ugo S
- D\u2019Urso A
- D\uedaz P\ue9rez D
- D\uedaz Pe\uf1a P
- D\uedez\u2010Valladares L
- da N\uf3voa Gomes Miguel Sampaio
- Dainius E
- Daliya P
- Daly A
- Danias N
- Daniels IR
- Davidson Giana H
- Davies E
- Davies RJ
- Dawson Brett E
- Day A
- De Andr\ue9s Asenjo B
- De Andres Olabarria U
- De Lacy FB
- De Manzoni Garberini A
- De Miguel Ardevines MDC
- De Nardi P
- De Palma G.D.
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Del Campo Mart\uedn M
- Del valle E
- Delgado B\ufardalo L
- Delimpalta C
- Dellaportas D
- Delrio P
- Demir H
- Demirli At\u131c\u131 S
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Deus AC
- Devezas V
- Devine M
- Di Bella A
- Di Candido F
- Di Franco G
- Di Giuseppe M
- Di Lauro K
- Di Maria Grimaldi S
- Di Martino C
- Di Martino M
- Di Marzo F
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
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- Diamantis A
- Diaz Del Gobbo R
- Diez Alonso M
- Dijan E
- Dikicier E
- Dincer HA
- Dione Parreno\u2010Sacdalanm Marie
- Divya GS
- Dixon J
- Dom\uednguez I
- Domingos JC
- Donati D
- Doyle A
- Drake Thomas M
- Duchalais E
- Dudi\u2010Venkata NN
- Duff S
- Dunne N
- Duque\u2010Mall\ue9n V
- Dur\ue1n Ballesteros M
- Dwidar O
- Dziakova J
- Eardley N
- Earley H
- Eastmond A
- Ebbeh\uf8j AL
- Economopoulou P
- Edward Fitzgerald J
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Aim
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic.
Method
This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data.
Results
From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58â14.06), postoperative SARS-CoV-2 (16.90, 7.86â36.38), male sex (2.46, 1.01â5.93), age >70 years (2.87, 1.32â6.20) and advanced cancer stage (3.43, 1.16â10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%).
Conclusion
Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks
Delaying surgery for patients with a previous SARS-CoV-2 infection
- Author
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- Wong Mpk
- X De Sousa
- X Morales
- X S Tan
- Y Aawsaj
- Y Al-Tamimi
- Y Arkha
- Y Ayasra
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- Y Fayed
- Y H Lam
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- Z Inic
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- Z M Barrett-Brown
- Z Mahasin
- Z Seymour
- Z Vilendecic
- Z Zakaria
- Ă De la Hoz RodrĂguez
- à Fernåndez Camuñas
- Ă Ryan
- Ćœ GrubaÄ
- Đ ĐĐ°ĐŒĐ°Đ»ĐŸĐČ
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Not availabl
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acosta MĂ©rida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
- Adi H
- Adiamah A
- Adisa Adewale
- Afzal MF
- Agapov M
- Agarwal Arnav
- Aggarwal M
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguado LĂłpez H
- Aguiar JĂșnior S
- Aguilar Gonzalez M
- Ahmed A
- Ahmed A
- Ahmed K
- Ahmed ME
- Ahmed Z
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Akalin M
- Akaydin E
- Akbas A
- Akhtar MA
- Akhtar N
- Akhter Rahman MM
- Akin E
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al ahmad F
- Al Asadi T
- Al Awwad S
- Al Ayed A
- Al Habes H
- Al Riyami S
- AL Sayed M
- Alaa S
- AlAamer O
- Aladeojebi A
- Alagoa Joao A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alamri Alex
- Alanazi F
- Alawneh F
- Albaqami F
- Albertsmeier M
- Albertsmeier Markus
- Alcaide Matas F
- Alconchel F
- AlcĂĄzar JA
- Alderson Derek
- Aldokali N
- AleksiÄ L
- Alemanno G
- Alfaifi J
- Alfieri S
- Alfonso Garcia M
- Algallai M
- Alghamdi M
- Alghuliga A
- Alhamed A
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- Alhassan N
- Ali karar AA
- Ali Sani S
- Ali AA
- Ali M
- Ali S
- Alishi Y
- Aliyeva Z
- Aljiffry M
- Alkadiki Ghadah Z
- Alkhateb S
- Allue M
- Almaadany Faraj S
- Almassaudi A
- Almeida AC
- Almeida JI
- AlmeidaâReis R
- Almezghwi H
- Almgla N
- Almond Max
- Alnumani T
- Alobaysi S
- Alobeed O
- Alonso de la Fuente N
- Alonso Poza A
- AlonsoâLamberti L
- Alqahtani D
- Alqannas M
- Alrahawy M
- Alsayadi M
- Alsayadi R
- Alselaim N
- Alser Osaid
- Alshaar Muhammad
- Alshahrani A
- Alshahrani M
- Alshammari S
- Alshareea E
- Alshareef K
- Alsharif F
- Alshryda Sattar
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- Alvarez MR
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- Alzaede S
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- Alzeerelhouseini H I. A.
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- AlâMohammad A
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- AlâNajjar H
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- AlâSlaibi I
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
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- Angelou D
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- Arulanantham A
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- Augestad Knut Magne
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- Cano A
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- Cantalejo diaz M
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- Capezzuoli L
- CapitanâMorales L
- Capkinoglu E
- Capolupo GT
- Capunge I
- CarabiasâOrgaz A
- Caram EL
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- Charre L
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- Chaturvedi A
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- Chatzikomnitsa P
- Chaudhry Daoud
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- Che jusoh A
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- Chebaro A
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- Chessa A
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- Cheung LK
- Chevallay M
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- Christoforidis D
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- Chumbinho B
- Chung E
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- Cianflocca D
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- Cintas Catena J
- Ciofic E
- Cirillo B
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- Clarizia G
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- Cocozza E
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- Cohen Paul
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- Colombari RC
- Colombo F
- Colquhoun Alexandra
- Colsa P
- Colvin HV
- Conesa A
- Confalonieri M
- Connelly T
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- Correia AM
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- CrausâMiguel A
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- Y J
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- Yetkin G
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- YeĆilyurt D
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- Yigitbas H
- Yildirim A
- Yildiz A
- Yildiz A
- Young R
- Yousof EA
- Youssef M
- Yurttas C
- YĂĄnez C
- YĂŒksel E
- Zafar SN
- Zakaria AD
- Zakaria Z
- Zakharenko A
- Zambon M
- ZamfirâChiruâAnton M
- Zanus G
- Zegarac M
- ZeliÄ M
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zizzo M
- Zmora O
- Zografos C
- Zonta S
- Zorrilla OrtĂșzar J
- Zourntou S
- Zubaidi A
- Ăngelo M
- ĂlgĂ„ A
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- Ăzant A
- Ăzçay N
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ćawnicka A
- ĆœateckĂœ J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease