Towards an Integrative Framework for Software Architecture

A new integrative framework for software architecture is proposed, based onsolid notions from traditional architecture. It combines elements taken from the Unified ProcessModel, that has been adjusted to this end, and a generic model for information management. It isargued that this framework can contribute to the development of higher quality software

Bacteriological evaluation of vaccination against Salmonella Typhimurium with an attenuated vaccine in subclinically infected pig herds

Subclinical infections with Salmonella Typhimurium occur frequently in pigs. They constitute a risk for human salmonellosis and are difficult to control with currently available control measures. Vaccination against Salmonella Typhimurium in pigs can be an effective tool to control Salmonella infections at farm level. In the present study, the efficacy of an attenuated Salmonella Typhimurium vaccine (Salmoporc®, IDT Biologika) to control Salmonella infections in pigs was evaluated in three subclinically infected pig herds. The effect on Salmonella excretion and the number of pigs positive for Salmonella Typhimurium field and vaccine strains in ileocecal lymph nodes at slaughter were evaluated using five different vaccination strategies: 1. vaccination of sows, 2. vaccination of sows and piglets, 3. vaccination of sows and fattening pigs, 4. vaccination of piglets, 5. vaccination of fattening pigs, which were all compared to a non-vaccinated control group (experimental group 6). Each vaccination strategy was implemented in each farm, during two consecutive production cycles of the same sows. The prevalence of Salmonella Typhimurium field strain excretion was low; in total, 4% of the fecal and overshoe samples collected in the non-vaccinated control group were Salmonella Typhimurium field strain positive. The excretion of Salmonella Typhimurium field strain did not significantly differ between farms, production cycles and experimental groups. Applying vaccination in either sows and piglets, sows and fattening pigs, or in piglets only, resulted in a significantly reduced number of Salmonella Typhimurium field strain positive lymph nodes of slaughter pigs in the second production cycle, but not in the first production cycle. Vaccination of sows and piglets resulted in the most consistent reduction of Salmonella Typhimurium field strain positive lymph nodes at slaughter. The vaccine strain was detected in the lymph nodes of 13 pigs at slaughter, indicating the possible persistence of the vaccine strain until slaughter. Because of limitations in the study design, and the variability between farms and production cycles, the results of the current observational study should be extrapolated with care. Nevertheless, the results provide evidence that applying vaccination against Salmonella Typhimurium in sows and piglets (preferred), sows and fattening pigs, and piglets only can support the control of Salmonella Typhimurium infections by decreasing the prevalence of Salmonella Typhimurium field strain positive lymph nodes at slaughter

Context matters: Student-perceived binge drinking norms at faculty-level relate to binge drinking behavior in higher education

Background: Binge drinking in higher education is an important problem. To target binge drinking in students it is necessary to study the social context of students. Faculties (i.e., colleges or schools in Northern American education) are social contexts in which students behave, but little is known about how the faculty structure relates to monthly binge drinking. This study investigates the relationship with student-perceived binge drinking norms at faculty-level in addition to known personal determinants. Methods: Data were collected in 7181 students within 22 faculty-level units, using an anonymous online survey. Multilevel analyses were used to investigate the relationship of both individual-level determinants (e.g., perceived norms, social drinking motives) and student-perceived binge drinking norms at faculty-level on monthly binge drinking. Results: Two-third (62.2%) of the sample were female and the mean age was 21.06 (SD = 2.85) years. In males, significant faculty-level variance in monthly binge drinking was found. At faculty-level, only same-sex student-perceived binge drinking norms showed a positive relationship (OR = 2.581; 95%CI = [1.023,6.509]). At individual level, both opposite- and same-sex perceived binge drinking norms, and social drinking motives positively related to monthly binge drinking. In females, no significant faculty-level variance was found. Only individual-level determinants positively related to monthly binge drinking. No cross-level interactions were found. Conclusion: Besides individual determinants, especially in men, faculties are relevant environmental structures and networks to take into account when targeting binge drinking in higher education

Selective Hyper-responsiveness of the Interferon System in Major Depressive Disorders and Depression Induced by Interferon Therapy

Though an important percentage of patients with chronic hepatitis C virus (HCV) undergoing interferon (IFN) therapy develop depressive symptoms, the role of the IFN system in the pathogenesis of depressive disorders is not well understood.50 patients with HCV infection were treated with standard combination therapy (pegylated IFN-α2a/ribavirin). IFN-induced gene expression was analyzed to identify genes which are differentially regulated in patients with or without IFN-induced depression. For validation, PBMC from 22 psychiatric patients with a severe depressive episode (SDE) and 11 controls were cultivated in vitro with pegylated IFN-α2a and gene expression was analyzed.IFN-induced depression in HCV patients was associated with selective upregulation of 15 genes, including 6 genes that were previously described to be relevant for major depressive disorders or neuronal development. In addition, increased endogenous IFN-production and selective hyper-responsiveness of these genes to IFN stimulation were observed in SDE patients.Our data suggest that selective hyper-responsiveness to exogenous (IFN therapy) or endogenous (depressive disorders) type I IFNs may lead to the development of depressive symptoms. These data could lead to the discovery of novel therapeutic approaches to treat IFN-induced and major depressive disorders

Measurement of the t-channel single top quark production cross section in pp collisions at √s =7 TeV

Peer reviewe