Exploring the association of the National Benchmark Test results with the academic performance of medical students who completed the degree in minimum time

The National Benchmark Tests (NBT) have been used for selection and placement of students in South Africa since 2005. The NBT assess students’ cognitive knowledge in three domains: academic literacy; quantitative literacy; and mathematics. In this study we aimed to explore the NBT entry-level abilities in relation to school quintiles of the 2011 class of medical students at the University of the Witwatersrand who graduated in minimum time and to explore the link between the NBT domains and academic performance in the first, third, and sixth year of study. The results of students who attended Quintile 5 schools (n = 93) show that 31% obtained proficiency in NBT mathematics, 65% in NBT academic literacy, and 79% in NBT quantitative literacy. The academic literacy domain was a consistently significant predictor in all three years of study. The results show that proficiency and intermediate upper levels of all NBT domains are associated with minimum time completion

A critical evaluation of the anaesthetic services in the province of Gauteng outside the greater Johannesburg area

M.Med. (Anaesthesia), Faculty of Health Sciences, University of the Witwatersrand, 2011The purpose of this study was to evaluate the anaesthetic services in the province of Gauteng outside of the greater Johannesburg area in two parts: Part 1: assessing the level of training in anaesthesia of those doctors who deliver the anaesthetic service in the area described and Part 2: reviewing the records of anaesthetics delivered in a two week period. Part 1 of the study was conducted using a questionnaire at three academic and five non academic hospitals. The questionnaire was administered to all doctors delivering anaesthesia at these hospitals and achieved a response rate of 50% and 69,2% at the academic and non academic hospitals respectively. Part 2 of the study reviewed the records of anaesthetic procedures performed over a two week period using the theatre registers as a primary data source and then a formal record retrieval for additional data. The findings of part one showed that the majority (n=15, 83.33%) of practitioners at the non academic hospitals did not have a postgraduate qualification in anaesthesia while this applied to a smaller (n=22, 39.29%) proportion at the academic hospitals. There are significantly fewer doctors with postgraduate qualifications in anaesthesia at the non academic hospitals studied. Similarly 45% of the doctors at the non academic hospitals felt that their training was inadequate for the anaesthetics they were expected to perform. The findings of part two showed that a wide range of procedures were performed for patients of all ages. There were significant differences in the distribution of major and minor cases between the regional and district hospitals. While the selection of anaesthetic was appropriate in all cases, there was a higher than accepted rate of general anaesthesia for caesarean sections. However, there was no significant difference in the length of hospital stay following either a spinal or a general anaesthetic for Caesarean Sections. Most of the cases reviewed took shorter than an hour to be completed and most patients were discharged within a week of surgery. In only 27 (5%) of the procedures reviewed could a complete anaesthetic record be retrieved

The nature of social accountability in South African medical practice and education: a qualitative reflection

Social accountability describes the extent to which a medical education institution’s research, service and education make a difference to the health status of the community in which they work. An individual practitioner is expected to attain a range of graduate attributes and competencies many of which enable a responsive approach to practice in society

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Artropolis 90 : Lineages & Linkages

Varney documents the processes of organizing and mounting an exhibition of over 200 contemporary British Columbia artists. Includes artist's statements

Functional impact of global rare copy number variation in autism spectrum disorders.

International audienceThe autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and repetitive behaviours. Individuals with an ASD vary greatly in cognitive development, which can range from above average to intellectual disability. Although ASDs are known to be highly heritable ( approximately 90%), the underlying genetic determinants are still largely unknown. Here we analysed the genome-wide characteristics of rare (<1% frequency) copy number variation in ASD using dense genotyping arrays. When comparing 996 ASD individuals of European ancestry to 1,287 matched controls, cases were found to carry a higher global burden of rare, genic copy number variants (CNVs) (1.19 fold, P = 0.012), especially so for loci previously implicated in either ASD and/or intellectual disability (1.69 fold, P = 3.4 x 10(-4)). Among the CNVs there were numerous de novo and inherited events, sometimes in combination in a given family, implicating many novel ASD genes such as SHANK2, SYNGAP1, DLGAP2 and the X-linked DDX53-PTCHD1 locus. We also discovered an enrichment of CNVs disrupting functional gene sets involved in cellular proliferation, projection and motility, and GTPase/Ras signalling. Our results reveal many new genetic and functional targets in ASD that may lead to final connected pathways

Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo

Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software

Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19

Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes