Experimental cross-correlation Nitrogen Q-branch CARS Thermometry in a Spark Ignition Engine

A purely experimental technique was employed to derive temperatures from nitrogen Q-branch Coherent Anti-Stokes Raman Scattering (CARS) spectra, obtained in a high pressure, high temperature environment (spark ignition Otto engine). This was in order to obviate any errors arising from deficiencies in the spectral scaling laws which are commonly used to represent nitrogen Q-branch CARS spectra at high pressure. The spectra obtained in the engine were compared with spectra obtained in a calibrated high pressure, high temperature cell, using direct cross-correlation in place of the minimisation of sums of squares of residuals. The technique is demonstrated through the measurement of air temperature as a function of crankshaft angle inside the cylinder of a motored single-cylinder Ricardo E6 research engine, followed by the measurement of fuel-air mixture temperatures obtained during the compression stroke in a knocking Ricardo E6 engine. A standard CARS program (SANDIA’s CARSFIT) was employed to calibrate the altered non-resonant background contribution to the CARS spectra that was caused by the alteration to the mole fraction of nitrogen in the unburned fuel-air mixture. The compression temperature profiles were extrapolated in order to predict the auto-ignition temperatures

Exploring the relation between flapping behaviour and accelerometer signal during ascending flight, and a new approach to calibration

We understand little about the energetic costs of flight in free-ranging birds; in part since current techniques for estimating flight energetics in the wild are limited. Accelerometry is known to estimate energy expenditure through body movement in terrestrial animals, once calibrated using a treadmill with chamber respirometry. The flight equivalent, a wind tunnel with mask respirometry, is particularly difficult to instigate, and has not been applied to calibrate accelerometry. We take the first steps in exploring a novel method for calibrating accelerometers with flight energy expenditure. We collected accelerometry data for Harris’s Hawks Parabuteo unicinctus flying to varying heights up to 4.1 m over a small horizontal distance; the mechanical energy expended to gain height can be estimated from physical first principles. The relationship between accelerometry and mechanical energy expenditure was strong, and while a simple wing flapping model confirmed that accelerometry is sensitive to both changes in wing beat amplitude and frequency, the relationship was explained predominately by changes in wing beat frequency, and less so by changes in amplitude. Our study provides initial, positive evidence that accelerometry can be calibrated with body power using climbing flights, potentially providing a basis for estimating flapping flight metabolic rate at least in situations of altitude gain

Constraining the primordial spectrum of metric perturbations from gravitino and moduli production

We consider the production of gravitinos and moduli fields from quantum vacuum fluctuations induced by the presence of scalar metric perturbations at the end of inflation. We obtain the corresponding occupation numbers, up to first order in perturbation theory, in terms of the power spectrum of the metric perturbations. We compute the limits imposed by nucleosynthesis on the spectral index $n_s$ for different models with constant $n_s$. The results show that, in certain cases, such limits can be as strong as $n_s<1.12$, which is more stringent than those coming from primordial black hole production.Comment: 16 pages, LaTeX, 5 figures. Corrected figures, new references included. Final version to appear in Phys. Rev.

Reduced Incidence of Hepatic Encephalopathy and Higher Odds of Resolution Associated With Eradication of HCV Infection

Background & Aims: It is unclear whether a sustained virologic response (SVR) to direct-acting antiviral (DAA) therapy reduces the risk of incident hepatic encephalopathy (HE) in patients with hepatitis C virus (HCV) infection or whether it leads to resolution of pre-existent HE. Methods: We identified 71,457 patients who initiated antiviral treatments in the Veterans Affairs Healthcare System from January 1, 1999 through December 31, 2015; 35,871 patients (58%) received only interferon, 4535 patients (7.2%) received DAAs plus interferon, and 21,948 patients (35%) received DAA-only regimens. We collected data from patients through October 31, 2018, for an average of 6.6 years. We evaluated the association between SVR and the development of incident HE or the resolution of pre-existent HE (defined by cessation of pharmacotherapy) as well as the risk of hospitalization with HE after adjusting for potential confounders. Results: Compared to no SVR, SVR after DAA therapy was associated with a significantly lower risk of developing HE (0.28 vs 1.39 per 100 person-years; adjusted hazard ratio [AHR] 0.41; 95% CI, 0.32–0.51). This association persisted among patients with co-morbid alcohol use disorder and diabetes as well as patients with cirrhosis (AHR, 0.36; 95% CI, 0.31–0.43) and model for end-stage liver disease (MELD) scores of 9 or more (AHR, 0.36; 95% CI, 0.30–0.44). SVR was also associated with reduced risk of hospitalization with HE (AHR, 0.59; 95% CI, 0.43–0.81). Among 2396 patients who were receiving pharmacotherapy for HE at the time of antiviral treatment, SVR was associated with a significantly increased likelihood of HE resolution for those with MELD scores below 9 (AHR, 2.26; 95% CI, 1.74–2.93) but not those with MELD scores of 9 or more. Conclusions: In a retrospective study of veterans, we found DAA eradication of HCV infection to be associated with a 59% reduction in risk of development of HE and a > 2-fold increased likelihood of resolution of pre-existing HE in all subgroups except patients with MELD scores of 9 or more

The trans-activation domain of the sporulation response regulator Spo0A revealed by X-ray crystallography

Sporulation in Bacillus involves the induction of scores of genes in a temporally and spatially co-ordinated programme of cell development. Its initiation is under the control of an expanded two-component signal transduction system termed a phosphorelay. The master control element in the decision to sporulate is the response regulator, Spo0A, which comprises a receiver or phosphoacceptor domain and an effector or transcription activation domain. The receiver domain of Spo0A shares sequence similarity with numerous response regulators, and its structure has been determined in phosphorylated and unphosphorylated forms. However, the effector domain (C-Spo0A) has no detectable sequence similarity to any other protein, and this lack of structural information is an obstacle to understanding how DNA binding and transcription activation are controlled by phosphorylation in Spo0A. Here, we report the crystal structure of C-Spo0A from Bacillus stearothermophilus revealing a single alpha -helical domain comprising six alpha -helices in an unprecedented fold. The structure contains a helix-turn-helix as part of a three alpha -helical bundle reminiscent of the catabolite gene activator protein (CAP), suggesting a mechanism for DNA binding. The residues implicated in forming the sigma (A)-activating region clearly cluster in a flexible segment of the polypeptide on the opposite side of the structure from that predicted to interact with DNA. The structural results are discussed in the context of the rich array of existing mutational data

Tomography of Galactic star-forming regions and spiral arms with the Square Kilometre Array

Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike LicenceVery Long Baseline Interferometry (VLBI) at radio wavelengths can provide astrometry accurate to 10 micro-arcseconds or better (i.e. better than the target GAIA accuracy) without being limited by dust obscuration. This means that unlike GAIA, VLBI can be applied to star-forming regions independently of their internal and line-of-sight extinction. Low-mass young stellar objects (particularly T Tauri stars) are often non-thermal compact radio emitters, ideal for astrometric VLBI radio continuum experiments. Existing observations for nearby regions (e.g. Taurus, Ophiuchus, or Orion) demonstrate that VLBI astrometry of such active T Tauri stars enables the reconstruction of both the regions' 3D structure (through parallax measurements) and their internal kinematics (through proper motions, combined with radial velocities). The extraordinary sensitivity of the SKA telescope will enable similar "tomographic mappings" to be extended to regions located several kpc from Earth, in particular to nearby spiral arm segments. This will have important implications for Galactic science, galactic dynamics and spiral structure theories.Final Published versio

A Generalized Fluctuation-Dissipation Theorem for Nonlinear Response Functions

A nonlinear generalization of the Fluctuation-Dissipation Theorem (FDT) for the n-point Green functions and the amputated 1PI vertex functions at finite temperature is derived in the framework of the Closed Time Path formalism. We verify that this generalized FDT coincides with known results for n=2 and 3. New explicit relations among the 4-point nonlinear response and correlation (fluctuation) functions are presented.Comment: 34 pages, Revte

S-matrix elements and off-shell tachyon action with non-abelian gauge symmetry

We propose that there is a unique expansion for the string theory S-matrix elements of tachyons that corresponds to non-abelian tachyon action. For those S-matrix elements which, in their expansion, there are the Feynman amplitudes resulting from the non-abelian kinetic term, we give a prescription on how to find the expansion. The gauge invariant action is an $\alpha'$ expanded action, and the tachyon mass $m$ which appears as coefficient of many different couplings, is arbitrary. We then analyze in details the S-matrix element of four tachyons and the S-matrix element of two tachyons and two gauge fields, in both bosonic and superstring theories, in favor of this proposal. In the superstring theory, the leading terms of the non-abelian gauge invariant couplings are in agreement with the symmetrised trace of the direct non-abelian generalization of the tachyonic Born-Infeld action in which the tachyon potential is consistent with $V(T)=e^{\pi\alpha' m^2T^2}$. In the bosonic theory, on the other hand, the leading terms are those appear in superstring case as well as some other gauge invariant couplings which spoils the symmetrised trace prescription. These latter terms are zero in the abelian case.Comment: Latex, 27 pages, no figures,v4:change the introduction section, add some notes to clarify the idea, add reference

Cosmology from Rolling Massive Scalar Field on the anti-D3 Brane of de Sitter Vacua

We investigate a string-inspired scenario associated with a rolling massive scalar field on D-branes and discuss its cosmological implications. In particular, we discuss cosmological evolution of the massive scalar field on the ant-D3 brane of KKLT vacua. Unlike the case of tachyon field, because of the warp factor of the anti-D3 brane, it is possible to obtain the required level of amplitude of density perturbations. We study the spectra of scalar and tensor perturbations generated during the rolling scalar inflation and show that our scenario satisfies the observational constraint coming from the Cosmic Microwave Background anisotropies and other observational data. We also implement the negative cosmological constant arising from the stabilization of the modulus fields in the KKLT vacua and find that this leads to a successful reheating in which the energy density of the scalar field effectively scales as a pressureless dust. The present dark energy can be also explained in our scenario provided that the potential energy of the massive rolling scalar does not exactly cancel with the amplitude of the negative cosmological constant at the potential minimum.Comment: RevTex4, 15 pages, 5 eps figures, minor clarifications and few references added, final version to appear in PR

Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV

Results are presented from a search for a W' boson using a dataset corresponding to 5.0 inverse femtobarns of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W' to t b, leading to a final state signature with a single lepton (e, mu), missing transverse energy, and jets, at least one of which is tagged as a b-jet. A W' boson that couples to fermions with the same coupling constant as the W, but to the right-handed rather than left-handed chiral projections, is excluded for masses below 1.85 TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge coupling for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe