What Electrophysiology Tells Us About Alzheimer’s Disease::A Window into the Synchronization and Connectivity of Brain Neurons

Electrophysiology provides a real-time readout of neural functions and network capability in different brain states, on temporal (fractions of milliseconds) and spatial (micro, meso, and macro) scales unmet by other methodologies. However, current international guidelines do not endorse the use of electroencephalographic (EEG)/magnetoencephalographic (MEG) biomarkers in clinical trials performed in patients with Alzheimer’s disease (AD), despite a surge in recent validated evidence. This Position Paper of the ISTAART Electrophysiology Professional Interest Area endorses consolidated and translational electrophysiological techniques applied to both experimental animal models of AD and patients, to probe the effects of AD neuropathology (i.e., brain amyloidosis, tauopathy, and neurodegeneration) on neurophysiological mechanisms underpinning neural excitation/inhibition and neurotransmission as well as brain network dynamics, synchronization, and functional connectivity reflecting thalamocortical and cortico-cortical residual capacity. Converging evidence shows relationships between abnormalities in EEG/MEG markers and cognitive deficits in groups of AD patients at different disease stages. The supporting evidence for the application of electrophysiology in AD clinical research as well as drug discovery pathways warrants an international initiative to include the use of EEG/MEG biomarkers in the main multicentric projects planned in AD patients, to produce conclusive findings challenging the present regulatory requirements and guidelines for AD studies

Pre-sleep arousal and sleep quality during the COVID-19 lockdown in Italy

Objective: The COVID-19 pandemic has strongly affected daily habits and psychological wellbeing, and many studies point to large modifications in several sleep and sleep-related domains. Nevertheless, pre-sleep arousal during the pandemic has been substantially overlooked. Since hyperarousal represents one of the main factors for the development and the perpetuation of chronic insomnia disorder, the assessment of variables associated with high levels of pre-sleep arousal during the pandemic is clinically relevant. The study aimed to assess the prevalence and predictors of perceived sleep quality and pre-sleep arousal in an Italian sample during the COVID-19 lockdown. Methods: We used an online survey to collect self-reported sociodemographic, environmental, clinical, sleep, and sleep-related data. Our final sample included 761 participants. Results: Beyond a high frequency of poor sleep quality, depressive and stress symptoms, our results show that almost half of the sample suffered from clinically relevant levels of at least one component (ie, cognitive, somatic) of pre-sleep arousal. Subjects with greater pre-sleep arousal exhibited poorer sleep quality. Also, sleep quality was strongly associated with somatic and cognitive pre-sleep arousal. Regarding the predictors of sleep and sleep-related measures, depressive and event-related stress symptoms were the main factors associated with both poor sleep quality and pre-sleep arousal components. Moreover, specific sociodemographic and environmental variables were uniquely related to sleep quality, cognitive or somatic pre-sleep arousal. Conclusions: These findings suggest that the assessment of specific sleep-related factors (ie, pre-sleep arousal), together with more global measures of sleep quality, may be crucial to depict the complex impact of the pandemic on sleep, and to help prevent and counteract the spread of insomnia symptoms

The Completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: Growth rate of structure measurement from anisotropic clustering analysis in configuration space between redshift 0.6 and 1.1 for the Emission Line Galaxy sample

A summary of all SDSS BAO and RSD measurements with accompanying legacy figures can be found here: https://www.sdss.org/science/final-bao-and-rsd-measurements/ . The full cosmological interpretation of these measurements can be found here: https://www.sdss.org/science/cosmology-results-from-eboss/;doi:10.1093/mnras/staa3050International audienceWe present the anisotropic clustering of emission line galaxies (ELGs) from the Sloan Digital Sky Survey IV (SDSS-IV) extended Baryon Oscillation Spectroscopic Survey (eBOSS) Data Release 16 (DR16). Our sample is composed of 173 736 ELGs covering an area of 1170 deg$^2$ over the redshift range $0.6 \leq z \leq 1.1$. We use the convolution Lagrangian perturbation theory in addition to the Gaussian Streaming Redshift-Space Distortions to model the Legendre multipoles of the anisotropic correlation function. We show that the eBOSS ELG correlation function measurement is affected by the contribution of a radial integral constraint that needs to be modelled to avoid biased results. To mitigate the effect from unknown angular systematics, we adopt a modified correlation function estimator that cancels out the angular modes from the clustering. At the effective redshift, $z_{\rm eff}=0.85$, including statistical and systematical uncertainties, we measure the linear growth rate of structure $f\sigma_8(z_{\rm eff}) = 0.35\pm0.10$, the Hubble distance $D_H(z_{\rm eff})/r_{\rm drag} = 19.1^{+1.9}_{-2.1}$ and the comoving angular diameter distance $D_M(z_{\rm eff})/r_{\rm drag} = 19.9\pm1.0$. These results are in agreement with the Fourier space analysis, leading to consensus values of: $f\sigma_8(z_{\rm eff}) = 0.315\pm0.095$, $D_H(z_{\rm eff})/r_{\rm drag} = 19.6^{+2.2}_{-2.1}$ and $D_M(z_{\rm eff})/r_{\rm drag} = 19.5\pm1.0$, consistent with $\Lambda$CDM model predictions with Planck parameters

The Completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: measurement of the BAO and growth rate of structure of the emission line galaxy sample from the anisotropic power spectrum between redshift 0.6 and 1.1

Abstract We analyse the large-scale clustering in Fourier space of emission line galaxies (ELG) from the Data Release 16 of the Sloan Digital Sky Survey IV extended Baryon Oscillation Spectroscopic Survey. The ELG sample contains 173,736 galaxies covering 1,170 square degrees in the redshift range 0.6 < z < 1.1. We perform a BAO measurement from the post-reconstruction power spectrum monopole, and study redshift space distortions (RSD) in the first three even multipoles. Photometric variations yield fluctuations of both the angular and radial survey selection functions. Those are directly inferred from data, imposing integral constraints which we model consistently. The full data set has only a weak preference for a BAO feature (1.4σ). At the effective redshift zeff = 0.845 we measure $D_{\rm V}(z_{\rm eff})/r_{\rm drag} = 18.33_{-0.62}^{+0.57}$, with DV the volume-averaged distance and rdrag the comoving sound horizon at the drag epoch. In combination with the RSD measurement, at zeff = 0.85 we find $f\sigma _8(z_{\rm eff}) = 0.289_{-0.096}^{+0.085}$, with f the growth rate of structure and σ8 the normalisation of the linear power spectrum, $D_{\rm H}(z_{\rm eff})/r_{\rm drag} = 20.0_{-2.2}^{+2.4}$ and DM(zeff)/rdrag = 19.17 ± 0.99 with DH and DM the Hubble and comoving angular distances, respectively. These results are in agreement with those obtained in configuration space, thus allowing a consensus measurement of fσ8(zeff) = 0.315 ± 0.095, $D_{\rm H}(z_{\rm eff})/r_{\rm drag} = 19.6_{-2.1}^{+2.2}$ and DM(zeff)/rdrag = 19.5 ± 1.0. This measurement is consistent with a flat ΛCDM model with Planck parameters

The Completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: measurement of the BAO and growth rate of structure of the emission line galaxy sample from the anisotropic power spectrum between redshift 0.6 and 1.1

International audienceWe analyse the large-scale clustering in Fourier space of emission line galaxies (ELG) from the Data Release 16 of the Sloan Digital Sky Survey IV extended Baryon Oscillation Spectroscopic Survey. The ELG sample contains 173 736 galaxies covering 1170 deg^2 in the redshift range 0.6 < z < 1.1. We perform a BAO measurement from the post-reconstruction power spectrum monopole, and study redshift space distortions (RSD) in the first three even multipoles. Photometric variations yield fluctuations of both the angular and radial survey selection functions. Those are directly inferred from data, imposing integral constraints which we model consistently. The full data set has only a weak preference for a BAO feature (1.4σ). At the effective redshift z_eff = 0.845 we measure |$D_{\rm V}(z_{\rm eff})/r_{\rm drag} = 18.33_{-0.62}^{+0.57}$|⁠, with D_V the volume-averaged distance and r_drag the comoving sound horizon at the drag epoch. In combination with the RSD measurement, at z_eff = 0.85 we find |$f\sigma _8(z_{\rm eff}) = 0.289_{-0.096}^{+0.085}$|⁠, with f the growth rate of structure and σ_8 the normalization of the linear power spectrum, |$D_{\rm H}(z_{\rm eff})/r_{\rm drag} = 20.0_{-2.2}^{+2.4}$| and D_M(z_eff)/r_drag = 19.17 ± 0.99 with D_H and D_M the Hubble and comoving angular distances, respectively. These results are in agreement with those obtained in configuration space, thus allowing a consensus measurement of fσ_8(z_eff) = 0.315 ± 0.095, |$D_{\rm H}(z_{\rm eff})/r_{\rm drag} = 19.6_{-2.1}^{+2.2}$| and D_M(z_eff)/r_drag = 19.5 ± 1.0. This measurement is consistent with a flat ΛCDM model with Planck parameters

The completed SDSS-IV extended Baryon Oscillation Spectroscopic Survey: Large-scale Structure Catalogues and Measurement of the isotropic BAO between redshift 0.6 and 1.1 for the Emission Line Galaxy Sample

International audienceWe present the Emission Line Galaxy (ELG) sample of the extended Baryon Oscillation Spectroscopic Survey from the Sloan Digital Sky Survey IV Data Release 16. We describe the observations and redshift measurement for the 269 243 observed ELG spectra, and then present the large-scale structure catalogues, used for the cosmological analysis, and made of 173 736 reliable spectroscopic redshifts between 0.6 and 1.1. We perform a spherically averaged baryon acoustic oscillations (BAO) measurement in configuration space, with density field reconstruction: the data two-point correlation function shows a feature consistent with that of the BAO, the BAO model being only weakly preferred over a model without BAO (Δχ^2 < 1). Fitting a model constrained to have a BAO feature provides a 3.2 per cent measurement of the spherically averaged BAO distance D_V(z_eff)/r_drag = 18.23 ± 0.58 at the effective redshift z_eff = 0.845

The Completed SDSS-IV Extended Baryon Oscillation Spectroscopic Survey: Growth rate of structure measurement from cosmic voids

17 pages, 8 figuresInternational audienceWe present a void clustering analysis in configuration-space using the completed Sloan Digital Sky Survey IV (SDSS-IV) extended Baryon Oscillation Spectroscopic Survey (eBOSS) DR16 samples. These samples consist of Luminous Red Galaxies (LRG) combined with the high redshift tail of the SDSS-III Baryon Oscillation Spectroscopic Survey (BOSS) DR12 CMASS galaxies (called as LRG+CMASS sample), Emission Line Galaxies (ELG) and quasars (QSO). We build void catalogues from the three eBOSS DR16 samples using a ZOBOV-based algorithm, providing 2,814 voids, 1,801 voids and 4,347 voids in the LRG+CMASS, ELG and QSO samples, respectively, spanning the redshift range $0.6<z<2.2$. We measure the redshift space distortions (RSD) around voids using the anisotropic void-galaxy cross-correlation function and we extract the distortion parameter $\beta$. We test the methodology on realistic simulations before applying it to the data, and we investigate all our systematic errors on these mocks. We find $\beta^{\rm LRG}(z=0.74)=0.415\pm0.087$, $\beta^{\rm ELG}(z=0.85)=0.665\pm0.125$ and $\beta^{\rm QSO}(z=1.48)=0.313\pm0.134$, for the LRG+CMASS, ELG and QSO sample, respectively. The quoted errors include systematic and statistical contributions. In order to convert our measurements in terms of the growth rate $f\sigma_8$, we use consensus values of linear bias from the eBOSS DR16 companion papers~\citep{eBOSScosmo}, resulting in the following constraints: $f\sigma_8(z=0.74)=0.50\pm0.11$, $f\sigma_8(z=0.85)=0.52\pm0.10$ and $f\sigma_8(z=1.48)=0.30\pm0.13$. Our measurements are consistent with other measurements from eBOSS DR16 using conventional clustering techniques

Overview of the DESI Legacy Imaging Surveys

The DESI Legacy Imaging Surveys (http://legacysurvey.org/) are a combination of three public projects (the Dark Energy Camera Legacy Survey, the Beijing–Arizona Sky Survey, and the Mayall z-band Legacy Survey) that will jointly image ≈14,000 deg2 of the extragalactic sky visible from the northern hemisphere in three optical bands (g, r, and z) using telescopes at the Kitt Peak National Observatory and the Cerro Tololo Inter-American Observatory. The combined survey footprint is split into two contiguous areas by the Galactic plane. The optical imaging is conducted using a unique strategy of dynamically adjusting the exposure times and pointing selection during observing that results in a survey of nearly uniform depth. In addition to calibrated images, the project is delivering a catalog, constructed by using a probabilistic inference-based approach to estimate source shapes and brightnesses. The catalog includes photometry from the grz optical bands and from four mid-infrared bands (at 3.4, 4.6, 12, and 22 μm) observed by the Wide-field Infrared Survey Explorer satellite during its full operational lifetime. The project plans two public data releases each year. All the software used to generate the catalogs is also released with the data. This paper provides an overview of the Legacy Surveys project