El juego motor como mediador en el aprendizaje de las matemáticas en Educación Infantil.

Este proyecto de innovación pretende ofrecer una alternativa metodológica en la que se utilice el juego motor como recurso pedagógico para promover el aprendizaje de las matemáticas en Educación Infantil. Para argumentar esta propuesta, se ha partido de las evidencias presentadas por distintos autores a partir de una búsqueda bibliográfica en distintas bases de datos. A partir de la literatura y el principio de globalidad, justificamos la incorporación del juego motor como mediador en el aprendizaje globalizado en esta etapa educativa. Los resultados de este Trabajo de Fin de Grado (TFG) apuntan hacia la mejora del proceso de enseñanza-aprendizaje con el uso del juego motor como recurso pedagógico, favoreciéndose, además, una mejora de la motivación del alumnado para enfrentarse con estos procesos.This innovation project pretends offer a methodologic alternative in which is used motor game as pedagogic resource to promote the mathematical learning in Preschool. To argue this proposal, was based on the evidences presented by different authors from a bibliographic search in different databases. From literature and globality principle, we justify incorporation of motor game as mediator of global learning in this education stage. The results of this Bachelor's Degree Final Project point to the improve of teaching-learning process with the use of motor game as pedagogical resource, favouring, also, a improve of the student’s motivation to face these processes

Caracterización morfológica y bioquímica de frutos de tejocote (Crataegus mexicana DC.) de Lerma y Ocoyoacac, México

Se caracterizó morfológica y bioquímicamente a frutos de 49 tejocoteros (Crataegus mexicana DC.) de Santa María Tlalmimilolpan, Lerma y Ocoyoacac, México, encontrando diferencias estadísticas (P < 0.05) para peso, longitud (L) y diámetro de fruto (D); relación L/D, porcentaje de pulpa; peso, longitud del eje mayor y longitud del eje menor del endocarpio; pH, acidez titulable, compuestos fenólicos y azúcares totales. Al formarse cuatro grupos, los grupos ii y iii, sobresalieron para peso de fruto con 17.4 y 13.6 g, respectivamente. El grupo i presentó un mayor contenido de compuestos fenólicos (16.5 mg g-1 PF), mientras que en el grupo iv se presentó el más alto contenido de azúcares totales (102.9 mg g-1 PF).Se caracterizó morfológica y bioquímicamente a frutos de 49 tejocoteros (Crataegus mexicana DC.) de Santa María Tlalmimilolpan, Lerma y Ocoyoacac, México, encontrando diferencias estadísticas (P ≤ 0.05) para peso, longitud (L) y diámetro de fruto (D); relación L/D, porcentaje de pulpa; peso, longitud del eje mayor y longitud del eje menor del endocarpio; pH, acidez titulable, compuestos fenólicos y azúcares totales. Al formarse cuatro grupos, los grupos ii y iii, sobresalieron para peso de fruto con 17.4 y 13.6 g, respectivamente. El grupo i presentó un mayor contenido de compuestos fenólicos (16.5 mg g-1 PF), mientras que en el grupo iv se presentó el más alto contenido de azúcares totales (102.9 mg g-1 PF)

Relevance of Qualitative Research Approach in Evaluating Mental Health Interventions among Victims of Violence

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Death receptor 5 expression is inversely correlated with prostate cancer progression.

Prostate carcinoma (PCa) is one of the most common cancers in men. Prostate-specific antigen (PSA) has been widely used to predict the outcome of PCa and screening with PSA has resulted in a decline in mortality. However, PSA is not an optimal prognostic tool as its sensitivity may be too low to reduce morbidity and mortality. Consequently, there is a demand for additional robust biomarkers for prostate cancer. Death receptor 5 (DR5) has been implicated in the prognosis of several cancers and it has been previously shown that it is negatively regulated by Yin Yang 1 (YY1) in prostate cancer cell lines. The present study investigated the clinical significance of DR5 expression in a prostate cancer patient cohort and its correlation with YY1 expression. Immunohistochemical analysis of protein expression distribution was performed using tissue microarray constructs from 54 primary PCa and 39 prostatic intraepithelial neoplasia (PIN) specimens. DR5 expression was dramatically reduced as a function of higher tumor grade. By contrast, YY1 expression was elevated in PCa tumors as compared with that in PIN, and was increased with higher tumor grade. DR5 had an inverse correlation with YY1 expression. Bioinformatic analyses corroborated these data. The present findings suggested that DR5 and YY1 expression levels may serve as progression biomarkers for prostate cancer

The antiviral and virucidal activities of voacangine and structural analogs extracted from Tabernaemontana cymosa depend on the Dengue virus strain

Currently, no specific licensed antiviral exists for treating the illness caused by dengue virus (DENV). Therefore, the search for compounds of natural origin with antiviral activity is an important area of research. In the present study, three compounds were isolated and identified from seeds of Tabernaemontana cymosa plants. The in vitro antiviral effect of those compounds and voacangine against different DENV strains was assessed using different experimental approaches: compounds added before the infection (Pre), at the same time with the virus (Trans), after the infection (Post) or compounds present in all moments of the experiment (Pre-Trans-Post, Combined treatment). In silico studies (docking and molecular dynamics) were also performed to explain the possible antiviral mechanisms. The identified compounds were three structural analogs of voacangine (voacangine-7-hydroxyindolenine, rupicoline and 3-oxo-voacangine). In the Pre-treatment, only voacangine-7-hydroxyindolenine and rupicoline inhibited the infection caused by the DENV-2/NG strain (16.4% and 29.6% infection, respectively). In the Trans-treatment approach, voacangine, voacangine-7-hydroxyindolenine and rupicoline inhibited the infection in both DENV-2/NG (11.2%, 80.4% and 75.7% infection, respectively) and DENV-2/16681 infection models (73.7%, 74.0% and 75.3% infection, respectively). The latter strain was also inhibited by 3-oxo-voacangine (82.8% infection). Moreover, voacangine (most effective virucidal agent) was also effective against one strain of DENV-1 (DENV-1/WestPac/74) and against the third strain of DENV-2 (DENV-2/S16803) (48.5% and 32.4% infection, respectively). Conversely, no inhibition was observed in the post-treatment approach. The last approach (combined) showed that voacangine, voacangine-7-hydroxyindolenine and rupicoline inhibited over 90% of infections (3.5%, 6.9% and 3.5% infection, respectively) of both strains (DENV-2/NG and DENV-2/16681). The free energy of binding obtained with an in silico approach was favorable for the E protein and compounds, which ranged between −5.1 and −6.3 kcal/mol. Finally, the complex formed between DENV-2 E protein and the best virucidal compound was stable for 50 ns. Our results show that the antiviral effect of indole alkaloids derived from T. cymose depends on the serotype and the virus strain.https://scienti.colciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000213748https://scholar.google.es/citations?user=flSrsSIAAAAJ&hl=eshttps://scienti.minciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000000695https://orcid.org/0000-0002-9429-005

Lower urinary tract symptoms secondary to a vaginal leiomioma the female prostate: case report

This is a case report of lower urinary tract symptoms secondary to a vaginal leiomioma “the female prostate”. A 45-year-old female patient with no significant personal history, sensation of a vaginal foreign body accompanied by lower urinary tract symptoms, on vaginal physical examination with a 7×7 cm deep tumor, increased consistency, not painful, without hemorrhage. Magnetic resonance imaging with hypointense T1 and T2 images, few linear hyperintense areas in T2, homogeneous postgadolinium enhancement 69×66×53 mm, solid tumor dependent on the vaginal vault. Tumor markers CA 19-9: 5.98 U/ml, CEA: 1.09 ng/ml and CA 125: 11.73 U/ml. Open surgery was performed in which a 8×6 cm tumor was found in the vaginal vault dependent on the posterior wall of the vagina. Histopathological report: conventional leiomyoma measuring 9×7.5 cm in long axes, without nuclear atypia. With resolution of symptoms in the lower urinary tract, with normal urinary frequency, without presence of urgency, without urinary incontinence or voiding symptoms. It is important to identify and diagnose lower urinary tract symptoms always, since they could be an initial manifestation of pelvic tumors in which the treatment approach should not be delayed.

NutriSalud

El proyecto Nutrisalud S.A.C consiste en la venta de menús saludables a través de un web app, la cual incluye el delivery gratis en los distritos de Miraflores, Barranco, Surquillo, Surco, San Isidro y Jesús Maria, el segmento del cliente al que apunta el proyecto empresarial, son hombres y mujeres entre 21 y 40 años que deseen cuidar su nutrición y tener una vida más saludable. El presente proyecto nace debido al exceso del consumo de comida rápida, grasa saturada, grasa trans, azúcar, sodio, entre otros. Según Instituto Nacional de Salud (INS) el 70 % de la población entre hombres y mujeres padecen de obesidad y sobrepeso perjudicando su salud a largo plazo. Para realizar este proyecto empresarial se necesita una inversión total de S/.47,489.00 la cual incluye inversión tangible, intangible, capital de trabajo y gastos pre operativos, dinero que se necesitara para comenzar las operaciones del proyecto, los accionistas realizarán un aporte propio del 60% del dinero que se necesita para ser realidad el proyecto, pero además, se requiere de inversores externos para completar el resto de la inversión, solo para fines del curso se considera financiamiento tradicional (bancos).The Nutrisalud SAC project consists of the sale of healthy menus through an web app, which includes free delivery in the districts of Miraflores, Barranco, Surquillo, Surco, San Isidro and Jesús Maria, the customer segment targeted by the project business, are men and women between 21 and 40 years of age who want to take care of their nutrition and have a healthier life. This project was born due to the excess consumption of fast food, saturated fat, trans fat, sugar, sodium, among others. According to the National Institute of Health (INS), 70% of the population between men and women suffer from obesity and overweight, harming their long-term health. To carry out this business project, a total investment of S / 47,489.00 is needed, which includes tangible and intangible investment, working capital and pre-operative expenses, money that will be needed to start the operations of the project. The shareholders will make their own contribution of 60%. of the money that is needed to make the project a reality, but in addition external investors are required to complete the rest of the investment, only for the purposes of the course it is considered traditional financing (banks).Trabajo de investigació

A predominant involvement of the triple seropositive patients and others with rheumatoid factor in the association of smoking with rheumatoid arthritis

The major environmental risk factor for rheumatoid arthritis (RA) is smoking, which according to a widely accepted model induces protein citrullination in the lungs, triggering the production of anticitrullinated protein antibodies (ACPA) and RA development. Nevertheless, some research findings do not fit this model. Therefore, we obtained six independent cohorts with 2253 RA patients for a detailed analysis of the association between smoking and RA autoantibodies. Our results showed a predominant association of smoking with the concurrent presence of the three antibodies: rheumatoid factor (RF), ACPA and anti-carbamylated protein antibodies (ACarPA) (3 Ab vs. 0 Ab: OR = 1.99, p = 2.5 × 10?8). Meta-analysis with previous data (4491 patients) confirmed the predominant association with the concurrent presence of the three antibodies (3 Ab vs. 0 Ab: OR = 2.00, p = 4.4 ×10?16) and revealed that smoking was exclusively associated with the presence of RF in patients with one or two antibodies (RF+ 1+2 vs. RF? 0+1+2: OR = 1.32, p = 0.0002). In contrast, no specific association with ACPA or ACarPA was found. Therefore, these results showed the need to understand how smoking favors the concordance of RA specific antibodies and RF triggering, perhaps involving smoking-induced epitope spreading and other hypothesized mechanisms

La vid silvestre en México. Actualidades y potencial

En ocho capítulos se aborda el estado del arte de la vid silvestre en MéxicoEl estudio de las especies vegetales nativas de México representa un reto que cada día más investigadores mexicanos asumen. Durante muchos años, el apoyo a la investigación pública ha sido mínimo; desde el punto de vista agronómico es insuficiente para avanzar a la velocidad que requiere nuestro país para afrontar problemas de producción y distribución de alimentos. Por esa razón, entre otras, me es grato presentar esta obra que compila parte de los trabajos de la Red de Vid Silvestre patrocinada por el Sistema Nacional de Recursos Fitogenéticos (sinarefi) dependiente de la sagarpa; trabajos apuntalados por investigadores que sin pertenecer a la red han colaborado en el estudio de las plantas del género Vitis. En este libro se muestra el potencial del país para aprovechar el recurso vid, empleado desde antes de la conquista española por nativos mexicanos que conocían sus bondades. Es necesario continuar el avance en el conocimiento de este recurso, por ello el presente libro pretende invitar a toda persona interesada en contribuir con el rescate y conservación de las vides mexicanas. Los autores y editores, así como las instituciones en donde laboramos y aquellas que patrocinan estas investigaciones, esperamos se cumpla este objetivo y que el lector, alumno, profesor, investigador, público en general, disfrute esta lectura y, sobre todo, se interese en el recurso VitisSEP, SINAREFI, UAEME

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson