The electrochemical behaviour of cobalt in alkaline solutions Part I. The potentiodynamic response in the potential region of the Co/CoO couple

The potentiodynamic response of cobalt in KOH solutions (10−2 M⩽c⩽2.5 M) in the potential range of the thermodynamic stability of the Co(II) species reveals two limiting electrochemical behavirours. One of them corresponds to the first potentiodynamic scan and the other is associated with the stabilized E/I profile resulting after a prolonged potential scanning. The former is related to the large contribution of the metal electrodissolution process. The second is explained in terms of reactions taking place at the sandwich-type structured interface. Ageing effects of Co(II) surface species are also considered in the interpretation of results.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA)Facultad de Ciencias Exacta

Walking vector soliton caging and releasing

We address the formation and propagation of vector solitons in optical lattices in the presence of anisotropy-induced walk-off between ordinary and extraordinary polarized field components. Stable vector solitons trapped by the lattice form above a threshold power, while decreasing the lattice depth below a critical value results in the abrupt release of the caged solitons, that then move across the lattice and may get trapped in a desired lattice channel.Comment: 13 pages, 4 figures, to appear in Optics Letter

Multistable Solitons in Higher-Dimensional Cubic-Quintic Nonlinear Schroedinger Lattices

We study the existence, stability, and mobility of fundamental discrete solitons in two- and three-dimensional nonlinear Schroedinger lattices with a combination of cubic self-focusing and quintic self-defocusing onsite nonlinearities. Several species of stationary solutions are constructed, and bifurcations linking their families are investigated using parameter continuation starting from the anti-continuum limit, and also with the help of a variational approximation. In particular, a species of hybrid solitons, intermediate between the site- and bond-centered types of the localized states (with no counterpart in the 1D model), is analyzed in 2D and 3D lattices. We also discuss the mobility of multi-dimensional discrete solitons that can be set in motion by lending them kinetic energy exceeding the appropriately crafted Peierls-Nabarro barrier; however, they eventually come to a halt, due to radiation loss.Comment: 12 pages, 17 figure

The electrochemical behaviour of cobalt in alkaline solutions Part I. The potentiodynamic response in the potential region of the Co/CoO couple

The potentiodynamic response of cobalt in KOH solutions (10−2 M⩽c⩽2.5 M) in the potential range of the thermodynamic stability of the Co(II) species reveals two limiting electrochemical behavirours. One of them corresponds to the first potentiodynamic scan and the other is associated with the stabilized E/I profile resulting after a prolonged potential scanning. The former is related to the large contribution of the metal electrodissolution process. The second is explained in terms of reactions taking place at the sandwich-type structured interface. Ageing effects of Co(II) surface species are also considered in the interpretation of results.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA)Facultad de Ciencias Exacta

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth

The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is unknown. We show that pericyte FAK regulates tumour growth and angiogenesis in multiple mouse models of melanoma, lung carcinoma and pancreatic B-cell insulinoma and provide evidence that loss of pericyte FAK enhances Gas6-stimulated phosphorylation of the receptor tyrosine kinase, Axl with an upregulation of Cyr61, driving enhanced tumour growth. We further show that pericyte derived Cyr61 instructs tumour cells to elevate expression of the proangiogenic/protumourigenic transmembrane receptor Tissue Factor. Finally, in human melanoma we show that when 50% or more tumour blood vessels are pericyte-FAK negative, melanoma patients are stratified into those with increased tumour size, enhanced blood vessel density and metastasis. Overall our data uncover a previously unknown mechanism of tumour growth by pericytes that is controlled by pericyte FAK

Testing and Modeling of the Mars Atmospheric Processing Module

Here we report further progress in the development of the MARCO POLO-Mars Pathfinder Atmospheric Processing Module (APM). The APM is designed to demonstrate in situ resource utilization (ISRU) of the Martian atmosphere, which primarily consists of carbon dioxide (CO2). The APM is part of a larger project with the overall goal of collecting and utilizing CO2 found in the atmosphere and water in the regolith of Mars to produce methane and oxygen to be used as rocket propellant, eliminating the need to import those to Mars for human missions, thus significantly reducing costs. The initial focus of NASA's new ISRU Project is modeling of key ISRU components, such as the CO2 Freezers and the Sabatier reactor of the APM. We have designed models of those components and verified the models with the APM by gathering additional data for the Sabatier reactor. Future efforts will be focused on simultaneous operations of the APM and other MARCO POLO-Mars Pathfinder modules

Anticancer Gene Transfer for Cancer Gene Therapy

Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have been developed that target cancer cells leaving normal cells unharmed. Here we review such cancer specific gene therapy systems currently used in the treatment of cancer and discuss the major challenges and future directions in this field

Neutron structure function and inclusive DIS from H-3 and He-3 at large Bjorken-x

A detailed study of inclusive deep inelastic scattering (DIS) from mirror A = 3 nuclei at large values of the Bjorken variable x is presented. The main purpose is to estimate the theoretical uncertainties on the extraction of the neutron DIS structure function from such nuclear measurements. On one hand, within models in which no modification of the bound nucleon structure functions is taken into account, we have investigated the possible uncertainties arising from: i) charge symmetry breaking terms in the nucleon-nucleon interaction, ii) finite Q**2 effects neglected in the Bjorken limit, iii) the role of different prescriptions for the nucleon Spectral Function normalization providing baryon number conservation, and iv) the differences between the virtual nucleon and light cone formalisms. Although these effects have been not yet considered in existing analyses, our conclusion is that all these effects cancel at the level of ~ 1% for x < 0.75 in overall agreement with previous findings. On the other hand we have considered several models in which the modification of the bound nucleon structure functions is accounted for to describe the EMC effect in DIS scattering from nuclei. It turns out that within these models the cancellation of nuclear effects is expected to occur only at a level of ~ 3%, leading to an accuracy of ~ 12 % in the extraction of the neutron to proton structure function ratio at x ~ 0.7 -0.8$. Another consequence of considering a broad range of models of the EMC effect is that the previously suggested iteration procedure does not improve the accuracy of the extraction of the neutron to proton structure function ratio.Comment: revised version to appear in Phys. Rev. C; main modifications in Section 4; no change in the conclusion

An image-based visual strategy for working with color contrasts during design

acceptedVersio

Differential branching fraction and angular analysis of the decay B0→K∗0μ+μ−

The angular distribution and differential branching fraction of the decay B 0→ K ∗0 μ + μ − are studied using a data sample, collected by the LHCb experiment in pp collisions at s√=7 TeV, corresponding to an integrated luminosity of 1.0 fb−1. Several angular observables are measured in bins of the dimuon invariant mass squared, q 2. A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be q20=4.9±0.9GeV2/c4 , where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions