Comfort and perceived air quality in refurbished social houses with mechanical ventialtion system: The impact of occupants behaviour

Abstract The ever-growing demand for a better indoor air quality in residential buildings is increasing the number of whole-house ventilation system installations in new constructions and renovation. In Italy, for residential sector, the national code does not prescribe the use of mechanical ventilation (MV) systems, so their installation is left to the choice of house owners. Two three-storey social housing apartment blocks in Northern Italy were studied. To reduce energy consumption, building envelopes as well as heating systems were refurbished. The thermal insulation was increased and the existing gas heater units were replaced with more efficient radiant ceiling systems. The refurbishment measures were the same for both constructions beside the MV system, which was installed in only one building. Indoor temperature and relative humidity were monitored for several apartments during the heating season. The occupants were surveyed to investigate their thermal comfort and perceived air quality. The occupants were interviewed to better understand their responses, and to know how they operate the heating system and the mechanical ventilation system (when present). Survey results show that there are no differences in terms of thermal comfort and perceived air quality between the occupants of the buildings with and without MV systems. The findings may be related to occupants' behaviour

Comfort and perceived air quality in refurbished social houses with mechanical ventilation system: The impact of occupants behaviour

The ever-growing demand for a better indoor air quality in residential buildings is increasing the number of whole-house ventilation system installations in new constructions and renovation. In Italy, for residential sector, the national code does not prescribe the use of mechanical ventilation (MV) systems, so their installation is left to the choice of house owners. Two three-storey social housing apartment blocks in Northern Italy were studied. To reduce energy consumption, building envelopes as well as heating systems were refurbished. The thermal insulation was increased and the existing gas heater units were replaced with more efficient radiant ceiling systems. The refurbishment measures were the same for both constructions beside the MV system, which was installed in only one building. Indoor temperature and relative humidity were monitored for several apartments during the heating season. The occupants were surveyed to investigate their thermal comfort and perceived air quality. The occupants were interviewed to better understand their responses, and to know how they operate the heating system and the mechanical ventilation system (when present). Survey results show that there are no differences in terms of thermal comfort and perceived air quality between the occupants of the buildings with and without MV systems. The findings may be related to occupants' behaviour. © 2015 The Authors

Results and complications of bilateral limb lengthening in achondroplasia: a retrospective analysis

BackgroundAchondroplasia is one of the main causes of disharmonic dwarfism. Patients with achondroplasia might have physical and psychological limitations due to their disproportionate stature. Surgical limb lengthening is the only practical option available to achieve a stature comparable to normal population range. The purpose of this study is to analyze results and complications of our lengthening protocol.MethodsA retrospective analysis was performed on 33 patients with achondroplasia (21 females and 12 males) undergoing simultaneous bilateral tibia or femur lengthening in four surgical stages from 2017 to 2021 (46 lengthening procedures, with a total of 56 tibias and 36 femurs). For each patient, patients’ characteristics and antero-posterior and lateral radiographs were obtained. The following parameters were analyzed: duration of lengthening with external fixator, amount of lengthening, complications or events that influenced outcomes and the healing index (HI).ResultsThe average tibial and femoral gain was 7.9 cm and 6.9 cm, respectively. The tibiae achieved better results than the femurs (p = 0.005). Nineteen complications were reported for 92 segments (20.7%), and the variables influencing complications were: step (p = 0.002) and fixation duration (p = 0.061).ConclusionsBilateral parallel lower limb lengthening in four surgical steps may be a viable technique in patients with achondroplasia

Meniscal femoral and tibial surfaces characterization in the swine model.

Menisci are wedge-like structures interposed, in the knee joint, between the femoral and the tibial articular heads (Kohn et al. 1995; Greis et al. 2002). Improving the articular surface, the cellular nutrition and the articular lubrication, they are essential structures for the prevention of gonarthrosis (Proctor et al.1989; Makris et al. 2011). This study is focused upon the relationship between the contact forces at the femoral and tibial surfaces and the corresponding structure of these meniscal surfaces. For this purpose, 20 adult (~9 months old) female pigs (Landrace x Large white, average weight 75–90 kg; n=80 meniscal samples) were obtained from a local slaughterhouse and dissected to isolate the menisci. Swine meniscal samples were evaluated from morphological (Safranin-O, Sirius Red and collagen type I and II) (Di Giancamillo et al. 2014), biochemical (DNA and glycosaminoglycans, or GAGs, contents) and biomechanical (compression and traction tests) points of view at the level of femoral and tibial meniscal surfaces. Results revealed a characterization of the meniscus which is biomechanical-dependent.  The femoral surface, morphologically characterized by the interposition of radial and oblique fibers and biomechanically by the femoral condyles compression, sliding and rolling forces, shows a higher compressive modulus (p<0.05) and a greater amount of cells and GAGs deposition (p<0.01 for each analysis). On the other hand, results from traction test revealed a higher tensile modulus (p<0.05) in the tibial surface, characterized by a circumferential arrangement of the fibers and a poorer GAGs deposition and cellular distribution (p<0.01). Results (summarized in the figure 1) from this work suggest that a biphasic “femoral-to-tibial” scaffold that mimic the different behavior and composition of the two meniscal surfaces could be useful in the light of meniscal replacement.

Coding with me: exploring the effect of coding intervention on preschoolers’ cognitive skills

In the last ten years, the topic of Computational Thinking (CT) has been gaining increasing attention from researchers in the education field. Starting from kindergarten, increasingly programming activities such as coding and educational robotics are proposed to enhance CT and some cognitive skills, such as problem- solving, spatial and reasoning skills. The most commonly used tools are the so- called tangible interfaces, such as floor-robots (e.g. Cubetto, Bee and Blue-Bot and others), through which children can interact with the object and learn playfully. Investigating the effects of CT activities on children's cognitive abilities is important to understand the impact in kindergarten and to comprehend in which developmental periods these activities might be most successful. The aim of the present study is that of evaluating the effect of a coding intervention, based on CT, through the use of the Cubetto robot, on the cognitive skills of 4-years-old children. The coding intervention included three sessions and required the manipulation of physical objects to plan and conduct a Cubetto journey. Results showed that children of the experimental group performed better than those of the control group in programming the Cubetto path after the intervention

Molecular determinants of ER-Golgi contacts identified through a new FRET-FLIM system

ER-TGN contact sites (ERTGoCS) have been visualized by electron microscopy, but their location in the crowded perinuclear area has hampered their analysis via optical microscopy as well as their mechanistic study. To overcome these limits we developed a FRET-based approach and screened several candidates to search for molecular determinants of the ERTGoCS. These included the ER membrane proteins VAPA and VAPB and lipid transfer proteins possessing dual (ER and TGN) targeting motifs that have been hypothesized to contribute to the maintenance of ERTGoCS, such as the ceramide transfer protein CERT and several members of the oxysterol binding proteins. We found that VAP proteins, OSBP1, ORP9, and ORP10 are required, with OSBP1 playing a redundant role with ORP9, which does not involve its lipid transfer activity, and ORP10 being required due to its ability to transfer phosphatidylserine to the TGN. Our results indicate that both structural tethers and a proper lipid composition are needed for ERTGoCS integrity.Peer reviewe

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective

Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injurie

Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective

Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injurie