Epidemics In The North Bulgarian Black Sea Region In XIX Century. 1. Contributions of assoc. Prof. Vladimir vassilev, MD, PHD, DMS For Their Study

Епидемиите от заразни болести възникват много често изненадващо и много бързо засягат населението на обширни територии, прераствайки в пандемии. През XIX век областта на северното Българско Черноморие е арена на няколко военни конфликта, всеки един от които се придружава от различни епидемии. В настоящата статия се дискутират приносите на моя колега, забележителния български учен в областта на историята на медицината, ст.н.с. д-р Владимир Добринов Василев, д.м.н., за детайлните и много компетентни изследвания на споменатите по-горе епидемии, на базата на неговия много богат личен архив, както и на базата на моите лични контакти с него по проблема „История на медицината”.The epidemics of contagious diseases arise very often surprisingly, and very quickly affect the people from large territories, increasing in pandemics. During the XIX century, the North Bulgaria Black Sea region was arena of several military conflicts, every one of which was accompanied from various epidemics. In this paper are discussed the contributions of my college, famous Bulgarian scientist in the field of History of Medicine, Assoc. Prof. Vladimir Dobrinov Vassilev, MD, PhD, DMS, for detailed and very competent studies of the epidemics mentioned above, on the basis of her very rich personal archive, as well as on the basis of my personal communications with him on the topics „History of Medicine”

Generalized Euler Angle Paramterization for SU(N)

In a previous paper (math-ph/0202002) an Euler angle parameterization for SU(4) was given. Here we present the derivation of a generalized Euler angle parameterization for SU(N). The formula for the calculation of the Haar measure for SU(N) as well as its relation to Marinov's volume formula for SU(N) will also be derived. As an example of this parameterization's usefulness, the density matrix parameterization and invariant volume element for a qubit/qutrit, three qubit and two three-state systems, also known as two qutrit systems, will also be given.Comment: 36 pages, no figures; added qubit/qutrit work, corrected minor definition problems and clarified Haar measure derivation. To be published in J. Phys. A: Math. and Ge

A Parametrization of Bipartite Systems Based on SU(4) Euler Angles

In this paper we give an explicit parametrization for all two qubit density matrices. This is important for calculations involving entanglement and many other types of quantum information processing. To accomplish this we present a generalized Euler angle parametrization for SU(4) and all possible two qubit density matrices. The important group-theoretical properties of such a description are then manifest. We thus obtain the correct Haar (Hurwitz) measure and volume element for SU(4) which follows from this parametrization. In addition, we study the role of this parametrization in the Peres-Horodecki criteria for separability and its corresponding usefulness in calculating entangled two qubit states as represented through the parametrization.Comment: 23 pages, no figures; changed title and abstract and rewrote certain areas in line with referee comments. To be published in J. Phys. A: Math. and Ge

CXCR4 Mediated Chemotaxis Is Regulated by 5T4 Oncofetal Glycoprotein in Mouse Embryonic Cells

5T4 oncofetal molecules are highly expressed during development and upregulated in cancer while showing only low levels in some adult tissues. Upregulation of 5T4 expression is a marker of loss of pluripotency in the early differentiation of embryonic stem (ES) cells and forms an integrated component of an epithelial-mesenchymal transition, a process important during embryonic development and metastatic spread of epithelial tumors. Investigation of the transcriptional changes in early ES differentiation showed upregulation of CXCL12 and down-regulation of a cell surface protease, CD26, which cleaves this chemokine. CXCL12 binds to the widely expressed CXCR4 and regulates key aspects of development, stem cell motility and tumour metastasis to tissues with high levels of CXCL12. We show that the 5T4 glycoprotein is required for optimal functional cell surface expression of the chemokine receptor CXCR4 and CXCL12 mediated chemotaxis in differentiating murine embryonic stem cells and embryo fibroblasts (MEF). Cell surface expression of 5T4 and CXCR4 molecules is co-localized in differentiating ES cells and MEF. By contrast, differentiating ES and MEF derived from 5T4 knockout (KO) mice show only intracellular CXCR4 expression but infection with adenovirus encoding mouse 5T4 restores CXCL12 chemotaxis and surface co-localization with 5T4 molecules. A series of chimeric constructs with interchanged domains of 5T4 and the glycoprotein CD44 were used to map the 5T4 sequences relevant for CXCR4 membrane expression and function in 5T4KO MEF. These data identified the 5T4 transmembrane domain as sufficient and necessary to enable CXCR4 cell surface expression and chemotaxis. Furthermore, some monoclonal antibodies against m5T4 can inhibit CXCL12 chemotaxis of differentiating ES cells and MEF which is not mediated by simple antigenic modulation. Collectively, these data support a molecular interaction of 5T4 and CXCR4 occurring at the cell surface which directly facilitates the biological response to CXCL12. The regulation of CXCR4 surface expression by 5T4 molecules is a novel means to control responses to the chemokine CXCL12 for example during embryogenesis but can also be selected to advantage the spread of a 5T4 positive tumor from its primary site

Search for microscopic black holes in pp collisions at √s=8 TeV

This is the pre-print version of the final published paper that is available from the link below.A search for microscopic black holes and string balls is presented, based on a data sample of pp collisions at √s = 8TeV recorded by the CMS experiment at the Large Hadron Collider and corresponding to an integrated luminosity of 12 fb-1. No excess of events with energetic multiparticle _nal states, typical of black hole production or of similar new physics processes, is observed. Given the agreement of the observations with the expected standard model background, which is dominated by QCD multijet production, 95% con_dence level limits are set on the production of semiclassical or quantum black holes, or of string balls, corresponding to the exclusions of masses below 4.3 to 6.2TeV, depending on model assumptions. In addition, model-independent limits are set on new physics processes resulting in energetic multiparticle _nal states

Search for the standard model Higgs boson produced in association with a top-quark pair in pp collisions at the LHC

This is the pre-print version of the final published paper that is available from the link below.A search for the standard model Higgs boson produced in association with a top-quark pair is presented using data samples corresponding to an integrated luminosity of 5.0 fb-1 (5.1 fb-1) collected in pp collisions at the center-of-mass energy of 7TeV (8TeV). Events are considered where the top-quark pair decays to either one lepton+jets (tt→lvqq’bb) or dileptons [tt→l(+)vl(-)vbb], l being an electron or a muon. The search is optimized for the decay mode H → bb. The largest background to the ttH signal is top-quark pair production with additional jets. Artificial neural networks are used to discriminate between signal and background events. Combining the results from the 7TeV and 8TeV samples, the observed (expected) limit on the cross section for Higgs boson production in association with top quark pairs for a Higgs boson mass of 125 GeV is 5.8 (5.2) times the standard model expectatio

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Penilaian Kinerja Keuangan Koperasi di Kabupaten Pelalawan

This paper describe development and financial performance of cooperative in District Pelalawan among 2007 - 2008. Studies on primary and secondary cooperative in 12 sub-districts. Method in this stady use performance measuring of productivity, efficiency, growth, liquidity, and solvability of cooperative. Productivity of cooperative in Pelalawan was highly but efficiency still low. Profit and income were highly, even liquidity of cooperative very high, and solvability was good

Juxtaposing BTE and ATE – on the role of the European insurance industry in funding civil litigation

One of the ways in which legal services are financed, and indeed shaped, is through private insurance arrangement. Two contrasting types of legal expenses insurance contracts (LEI) seem to dominate in Europe: before the event (BTE) and after the event (ATE) legal expenses insurance. Notwithstanding institutional differences between different legal systems, BTE and ATE insurance arrangements may be instrumental if government policy is geared towards strengthening a market-oriented system of financing access to justice for individuals and business. At the same time, emphasizing the role of a private industry as a keeper of the gates to justice raises issues of accountability and transparency, not readily reconcilable with demands of competition. Moreover, multiple actors (clients, lawyers, courts, insurers) are involved, causing behavioural dynamics which are not easily predicted or influenced. Against this background, this paper looks into BTE and ATE arrangements by analysing the particularities of BTE and ATE arrangements currently available in some European jurisdictions and by painting a picture of their respective markets and legal contexts. This allows for some reflection on the performance of BTE and ATE providers as both financiers and keepers. Two issues emerge from the analysis that are worthy of some further reflection. Firstly, there is the problematic long-term sustainability of some ATE products. Secondly, the challenges faced by policymakers that would like to nudge consumers into voluntarily taking out BTE LEI