A KBE System for the design of wind tunnel models using reusable knowledge components

Ponencia presentada en el VI Congreso Internacional de Ingeniería de Proyectos celebrada en Barcelona en el año 2002Knowledge-Based Engineering (KBE) has gradually gained prominence as a major tool to speed up product development, especially in large scale projects such the ones that take place in aerospace and automotive industry. The encoding of design knowledge from domain experts into computer codes that can generate complex geometric data has demonstrated significant savings in manpower and time resources for routine design problems. This paper is the experience of the development of a KBE application for the design and manufacture of a wind tunnel testing model of an aircraft nacelle. The industrial project is aimed to investigate the feasibility of KBE introduction in the company. This causes the researcher to achieve effective design task automation and at the same time consider how the KBE codes could be extended to other products in the company. The adoption of reusable knowledge components is then introduced as the response to the knowledge modelling issues in current KBE systems.Las tecnologías de ingeniería basada en el conocimiento (KBE, Knowledge-Based Engineering), han adquirido prominencia gradualmente como la principal herramienta orientada a acelerar el desarrollo de productos, especialmente en proyectos de gran tamaño como los que se llevan a cabo en la industria aerospacial y del automóvil. De este modo, la codificación del conocimiento de los expertos en diseño de un cierto dominio en forma de programas informáticos capaces de generar datos sobre la geometría de un producto, ha demostrado un significante ahorro en recursos humanos y tiempo en problemas de diseño rutinario. Este artículo reporta algunas experiencias en el desarrollo de una aplicación KBE destinada al diseño y fabricación de modelos de componentes de aeronaves de los que se utilizan en los ensayos aerodinámicos en túnel de viento. El proyecto industrial en el que se basa el trabajo aquí presentado es la investigación acerca de la idoneidad de introducir tecnologías de ingeniería basada en el conocimiento en la compañía colaboradora. Esta premisa dirige la motivación del trabajo desarrollado no sólo a cubrir la necesidad de una efectiva automatización de tareas de diseño en el caso de estudio escogido sino que además considera la extensión de los códigos KBE a otros productos de la compañía colaboradora. La respuesta a este problema se da en forma de la introducción de componentes reusables de conocimiento, (RKC, Reusable Knowledge Components), los cuales se muestran como una alternativa para acometer los problemas de modelado de conocimiento en los actuales sistemas KBE

FORMA and BEFORE: Expanding applications of optical tweezers

We introduce two methods based on statistical inference to calibrate optical tweezers. Both outperform well-established methods and cover a broader application field, including non-conservative force fields and out of equilibrium systems

Validation of the Women’s Views of Birth Labor Satisfaction Questionnaire (WOMBLSQ4) in the Spanish Population

The satisfaction of women with the birth experience has implications for the health and wellness of the women themselves and also of their newborn baby. The objectives of this study were to determine the factor structure of the Women’s Views of Birth Labor Satisfaction Questionnaire (WOMBLSQ4) questionnaire on satisfaction with the attention received during birth delivery in Spanish women and to compare the level of satisfaction of pregnant women during the birth process with that in other studies that validated this instrument. A cross-sectional study using a self-completed questionnaire of 385 Spanish-speaking puerperal women who gave birth in the Public University Hospitals of Granada (Spain) was conducted. An exploratory factor analysis of the WOMBLSQ4 questionnaire was performed to identify the best fit model. Those items that showed commonalities higher than 0.50 were kept in the questionnaire. Using the principal components method, nine factors with eigenvalues greater than one were extracted after merging pain-related factors into a single item. These factors explain 90% of the global variance, indicating the high internal consistency of the full scale. In the model resulting from the WOMBLSQ4 questionnaire, its nine dimensions measure the levels of satisfaction of puerperal women with childbirth care. Average scores somewhat higher than those of the original questionnaire and close to those achieved in the study carried out in Madrid (Spain) were obtained. In clinical practice, this scale may be relevant for measuring the levels of satisfaction during childbirth of Spanish-speaking women

Coupling of individual quantum emitters to channel plasmons.

Efficient light-matter interaction lies at the heart of many emerging technologies that seek on-chip integration of solid-state photonic systems. Plasmonic waveguides, which guide the radiation in the form of strongly confined surface plasmon-polariton modes, represent a promising solution to manipulate single photons in coplanar architectures with unprecedented small footprints. Here we demonstrate coupling of the emission from a single quantum emitter to the channel plasmon polaritons supported by a V-groove plasmonic waveguide. Extensive theoretical simulations enable us to determine the position and orientation of the quantum emitter for optimum coupling. Concomitantly with these predictions, we demonstrate experimentally that 42% of a single nitrogen-vacancy centre emission efficiently couples into the supported modes of the V-groove. This work paves the way towards practical realization of efficient and long distance transfer of energy for integrated solid-state quantum systems.E.B.-U., R.M., M.G. and R.Q. acknowledge the European Community’s Seventh Framework Programme (grant ERC- Plasmolight; no. 259196) and Fundació privada CELLEX. E.B.-U. acknowledges support of the FPI fellowship from the Spanish MICINN. R.M. acknowledges support of Marie Curie and NEST fellowships. C.G.-B. and F.J.G.-V. acknowledge the European Research Council (ERC-2011-AdG, Proposal No. 290981). C.G.-B., E.M., and F.J.G.-V. acknowledge the Spanish MINECO (Contract No. MAT2011-28581-C02-01). C.G.-B. acknowledges support of the FPU fellowship from the Spanish MECD. I.P.R., T.H. and S.I.B. acknowledge financial support for this work from the Danish Council for Independent Research (the FTP project ANAP, Contract No. 09-072949) and from the European Research Council, Grant No. 341054 (PLAQNAP). Y.A. acknowledges the support of RYC-2011-08471 fellowship from MICINN. We thank Luis Martin-Moreno and Cesar E. García for fruitful discussions, Jana M. Say and Louise J. Brown for providing the ND solution, and Ioannis Tsioutsios for support with the AFM manipulation technique.This is the final published version. It first appeared at http://www.nature.com/ncomms/2015/150807/ncomms8883/full/ncomms8883.html

Plasma coenzyme Q10 status is impaired in selected genetic conditions.

Identifying diseases displaying chronic low plasma Coenzyme Q10 (CoQ) values may be important to prevent possible cardiovascular dysfunction. The aim of this study was to retrospectively evaluate plasma CoQ concentrations in a large cohort of pediatric and young adult patients. We evaluated plasma CoQ values in 597 individuals (age range 1 month to 43 years, average 11 years), studied during the period 2005-2016. Patients were classified into 6 different groups: control group of healthy participants, phenylketonuric patients (PKU), patients with mucopolysaccharidoses (MPS), patients with other inborn errors of metabolism (IEM), patients with neurogenetic diseases, and individuals with neurological diseases with no genetic diagnosis. Plasma total CoQ was measured by reverse-phase high-performance liquid chromatography with electrochemical detection and ultraviolet detection at 275 nm. ANOVA with Bonferroni correction showed that plasma CoQ values were significantly lower in the PKU and MPS groups than in controls and neurological patients. The IEM group showed intermediate values that were not significantly different from those of the controls. In PKU patients, the Chi-Square test showed a significant association between having low plasma CoQ values and being classic PKU patients. The percentage of neurogenetic and other neurological patients with low CoQ values was low (below 8%). In conclusión, plasma CoQ monitoring in selected groups of patients with different IEM (especially in PKU and MPS patients, but also in IEM under protein-restricted diets) seems advisable to prevent the possibility of a chronic blood CoQ suboptimal status in such groups of patients

Production and evolution of Li, Be and B isotopes in the Galaxy

We reassess the problem of the production and evolution of the light elements Li, Be and B and of their isotopes in the Milky Way, in the light of new observational and theoretical developments. The main novelty is the introduction of a new scheme for the origin of Galactic cosmic rays (GCR), which for the first time enables a self-consistent calculation of their composition during galactic evolution. The scheme accounts for key features of the present-day GCR source composition, it is based on the wind yields of the Geneva models of rotating, mass losing stars and it is fully coupled to a detailed galactic chemical evolution code. We find that the adopted GCR source composition accounts naturally for the observations of primary Be and helps understanding why Be follows closer Fe than O. We find that GCR produce ~70% of the solar B11/B10 isotopic ratio; the remaining 30% of B11 presumably result from neutrino-nucleosynthesis in massive star explosions. We find that GCR and primordial nucleosynthesis can make at most 30% of solar Li. At least half of solar Li has to originate in low-mass stellar sources (red giants, asymptotic giant branch stars or novae), but the required average yields of those sources are found to be much larger than obtained in current models of stellar nucleosynthesis. We also present radial profiles of LiBeB elemental and isotopic abundances in the Milky Way disc. We argue that the shape of those profiles - and the late evolution of LiBeB in general - reveals important features of the production of those light elements through primary and secondary processes.Comment: Final version, matches the one to appear in Astronomy and Astrophysics, typos corrected, references adde

Gain control network conditions in early sensory coding

Gain control is essential for the proper function of any sensory system. However, the precise mechanisms for achieving effective gain control in the brain are unknown. Based on our understanding of the existence and strength of connections in the insect olfactory system, we analyze the conditions that lead to controlled gain in a randomly connected network of excitatory and inhibitory neurons. We consider two scenarios for the variation of input into the system. In the first case, the intensity of the sensory input controls the input currents to a fixed proportion of neurons of the excitatory and inhibitory populations. In the second case, increasing intensity of the sensory stimulus will both, recruit an increasing number of neurons that receive input and change the input current that they receive. Using a mean field approximation for the network activity we derive relationships between the parameters of the network that ensure that the overall level of activity of the excitatory population remains unchanged for increasing intensity of the external stimulation. We find that, first, the main parameters that regulate network gain are the probabilities of connections from the inhibitory population to the excitatory population and of the connections within the inhibitory population. Second, we show that strict gain control is not achievable in a random network in the second case, when the input recruits an increasing number of neurons. Finally, we confirm that the gain control conditions derived from the mean field approximation are valid in simulations of firing rate models and Hodgkin-Huxley conductance based models

Prostaglandin F 2α-induced prostate transmembrane protein, androgen induced 1 mediates ovarian cancer progression increasing epithelial plasticity

The role of prostaglandin (PG) F2a has been scarcely studied in cancer. We have identified a new function for PGF2a in ovarian cancer, stimulating the production of Prostate Transmembrane Protein, Androgen Induced 1 (PMEPA1). We show that this induction increases cell plasticity and proliferation, enhancing tumor growth through PMEPA1. Thus, PMEPA1 overexpression in ovarian carcinoma cells, significantly increased cell proliferation rates, whereas PMEPA1 silencing decreased proliferation. In addition, PMEPA1 overexpression buffered TGF signaling, via reduction of SMADdependent signaling. PMEPA1 overexpressing cells acquired an epithelial morphology, associated with higher Ecadherin expression levels while catenin nuclear translocation was inhibited. Notwithstanding, high PMEPA1 levels also correlated with epithelial to mesenchymal transition markers, such as vimentin and ZEB1, allowing the cells to take advantage of both epithelial and mesenchymal characteristics, gaining in cell plasticity and adaptability. Interestingly, in mouse xenografts, PMEPA1 overexpressing ovarian cells had a clear survival and proliferative advantage, resulting in higher metastatic capacity, while PMEPA1 silencing had the opposite effect. Furthermore, high PMEPA1 expression in a cohort of advanced ovarian cancer patients was observed, correlating with Ecadherin expression. Most importantly, high PMEPA1 mRNA levels were associated with lower patient survivalThis work was supported by grants from Ministerio de Ciencia e Innovación (SAF201342850R and SAF201675988R) Comunidad de Madrid (S2017/BMD3671. INFLAMUNECM), Fondo de Investigaciones Sanitarias (BIOIMID) to M.F. and grants from the AECC (Grupos Estables de Investigacion 2011AECC GCB 110333 REVE) and the Instituto de Salud Carlos III (ISCIII: PI16/00134 and CIBEONC: CB16/12/00295) to G.M.B. K.S. was recipient of a Spanish Association Against Cancer oncology investigator grant (AECC AIO). A.J.S. and AM were recipients of FPU predoctoral fellowships from the Spanish Ministry of Education, Culture and Sports (FPU20122084 and 5338, respectively)

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target

Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years. However, tumor cells are not alone. A series of extracellular components and stromal cells, such as endothelial cells, cancer-associated fibroblasts, tumor-associated macrophages and tumor-infiltrating T cells, surround tumor cells in the so-called tumor microenvironment. Metabolic features of these cells are being studied in deep in order to find relationships between metabolism within the tumor microenvironment and tumor progression. Moreover, it cannot be forgotten that tumor growth is able to modulate host metabolism and homeostasis, so that tumor microenvironment is not the whole story. Importantly, the metabolic switch in cancer is just a consequence of the flexibility and adaptability of metabolism and should not be surprising. Treatments of cancer patients with combined therapies including anti-tumor agents with those targeting stromal cell metabolism, anti-angiogenic drugs and/or immunotherapy are being developed as promising therapeutics.Mª Carmen Ocaña is recipient of a predoctoral FPU grant from the Spanish Ministry of Education, Culture and Sport. Supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript