Automated Generation of an Energy Simulation Model for an Existing Building from UAV Imagery

An approach to automatically generate a dynamic energy simulation model in Modelica for a single existing building is presented. It aims at collecting data about the status quo in the preparation of energy retrofits with low effort and costs. The proposed method starts from a polygon model of the outer building envelope obtained from photogrammetrically generated point clouds. The open-source tools TEASER and AixLib are used for data enrichment and model generation. A case study was conducted on a single-family house. The resulting model can accurately reproduce the internal air temperatures during synthetical heating up and cooling down. Modelled and measured whole building heat transfer coefficients (HTC) agree within a 12% range. A sensitivity analysis emphasises the importance of accurate window characterisations and justifies the use of a very simplified interior geometry. Uncertainties arising from the use of archetype U-values are estimated by comparing different typologies, with best- and worst-case estimates showing differences in pre-retrofit heat demand of about ±20% to the average; however, as the assumptions made are permitted by some national standards, the method is already close to practical applicability and opens up a path to quickly estimate possible financial and energy savings after refurbishment

Material investigations to facilitate the applicability of microwave radar to energy-related wall structure analysis

Existing buildings often have low energy efficiency standards. For the preparation of retrofits, reliable high-quality data about built-in materials is required. Contactless measuring technologies, especially microwave radar, have the potential to enable an easy-to-apply and automatable way to analyse the structures and thermal properties of existing building walls, but the relationship between materials, their thermal properties, and their electromagnetic properties, such as the permittivity, is needed for its application. This article presents an analysis of the relationship between electromagnetic and thermal properties for a variety of building materials. Systematic measurements were performed for samples (burnt clay bricks, calcium silicate bricks, autoclaved aerated concrete and lightweight concrete) mainly originating from demolished buildings. The thermal conductivity, thermal capacitance, and dielectric permittivity were measured and the hypothesis of a correlation between permittivity and thermal parameters was partly confirmed. This information is a prerequisite for using microwave radar sensing technology to determine heat transfer coefficients of existing building walls. The next research step is the development of a corresponding measurement and evaluation method

Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors

Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence. Conversely, THC also has potentially therapeutic effects, including analgesia, muscle relaxation, and neuroprotection. However, the mechanisms that dissociate these responses are still not known. Using mice lacking the serotonin receptor 5-HT2A, we revealed that the analgesic and amnesic effects of THC are independent of each other: while amnesia induced by THC disappears in the mutant mice, THC can still promote analgesia in these animals. In subsequent molecular studies, we showed that in specific brain regions involved in memory formation, the receptors for THC and the 5-HT2A receptors work together by physically interacting with each other. Experimentally interfering with this interaction prevented the memory deficits induced by THC, but not its analgesic properties. Our results highlight a novel mechanism by which the beneficial analgesic properties of THC can be dissociated from its cognitive side effects

Building Tomograph – From Remote Sensing Data of Existing Buildings to Building Energy Simulation Input

Existing buildings often have low energy efficiency standards. For the preparation of retrofits, reliable high-quality data about the status quo is required. However, state-of-the-art analysis methods mainly rely on on-site inspections by experts and hence tend to be cost-intensive. In addition, some of the necessary devices need to be installed inside the buildings. As a consequence, owners hesitate to obtain sufficient information about potential refurbishment measures for their houses and underestimate possible savings. Remote sensing measurement technologies have the potential to provide an easy-to-use and automatable way to energetically analyze existing buildings objectively. To prepare an energetic simulation of the status quo and of possible retrofit scenarios, remote sensing data from different data sources have to be merged and combined with additional knowledge about the building. This contribution presents the current state of a project on the development of new and the optimization of conventional data acquisition methods for the energetic analysis of existing buildings solely based on contactless measurements, general information about the building, and data that residents can obtain with little effort. For the example of a single-family house in Morschenich, Germany, geometrical, semantical, and physical information are derived from photogrammetry and quantitative infrared measurements. Both are performed with the help of unmanned aerial vehicles (UAVs) and are compared to conventional methods for energy efficiency analysis regarding accuracy of and necessary effort for input data for building energy simulation. The concept of an object-oriented building model for measurement data processing is presented. Furthermore, an outlook is given on the project involving advanced remote sensing techniques such as ultrasound and microwave radar application for the measurement of additional energetic building parameters

[3H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions

[3H]Adenine has previously been used to label the newly discovered G protein-coupled murine adenine receptors. Recent reports have questioned the suitability of [3H]adenine for adenine receptor binding studies because of curious results, e.g. high specific binding even in the absence of mammalian protein. In this study, we showed that specific [3H]adenine binding to various mammalian membrane preparations increased linearly with protein concentration. Furthermore, we found that Tris-buffer solutions typically used for radioligand binding studies (50 mM, pH 7.4) that have not been freshly prepared but stored at 4°C for some time may contain bacterial contaminations that exhibit high affinity binding for [3H]adenine. Specific binding is abolished by heating the contaminated buffer or filtering it through 0.2-μm filters. Three different, aerobic, gram-negative bacteria were isolated from a contaminated buffer solution and identified as Achromobacter xylosoxidans, A. denitrificans, and Acinetobacter lwoffii. A. xylosoxidans, a common bacterium that can cause nosocomial infections, showed a particularly high affinity for [3H]adenine in the low nanomolar range. Structure–activity relationships revealed that hypoxanthine also bound with high affinity to A. xylosoxidans, whereas other nucleobases (uracil, xanthine) and nucleosides (adenosine, uridine) did not. The nature of the labeled site in bacteria is not known, but preliminary results indicate that it may be a high-affinity purine transporter. We conclude that [3H]adenine is a well-suitable radioligand for adenine receptor binding studies but that bacterial contamination of the employed buffer solutions must be avoided

Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity

K2 products are synthetic cannabinoid-laced, marijuana-like drugs of abuse, use of which is often associated with clinical symptoms atypical of marijuana use, including hypertension, agitation, hallucinations, psychosis, seizures and panic attacks. JWH-018, a prevalent K2 synthetic cannabinoid, is structurally distinct from Δ(9)-THC, the main psychoactive ingredient in marijuana. Since even subtle structural differences can lead to differential metabolism, formation of novel, biologically active metabolites may be responsible for the distinct effects associated with K2 use. The present study proposes that K2's high adverse effect occurrence is due, at least in part, to distinct JWH-018 metabolite activity at the cannabinoid 1 receptor (CB1R).JWH-018, five potential monohydroxylated metabolites (M1-M5), and one carboxy metabolite (M6) were examined in mouse brain homogenates containing CB1Rs, first for CB1R affinity using a competition binding assay employing the cannabinoid receptor radioligand [(3)H]CP-55,940, and then for CB1R intrinsic efficacy using an [(35)S]GTPγS binding assay. JWH-018 and M1-M5 bound CB1Rs with high affinity, exhibiting K(i) values that were lower than or equivalent to Δ(9)-THC. These molecules also stimulated G-proteins with equal or greater efficacy relative to Δ(9)-THC, a CB1R partial agonist. Most importantly, JWH-018, M2, M3, and M5 produced full CB1R agonist levels of activation. CB1R-mediated activation was demonstrated by blockade with O-2050, a CB1R-selective neutral antagonist. Similar to Δ(9)-THC, JWH-018 and M1 produced a marked depression of locomotor activity and core body temperature in mice that were both blocked by the CB1R-preferring antagonist/inverse agonist AM251.Unlike metabolites of most drugs, the studied JWH-018 monohydroxylated compounds, but not the carboxy metabolite, retain in vitro and in vivo activity at CB1Rs. These observations, combined with higher CB1R affinity and activity relative to Δ(9)-THC, may contribute to the greater prevalence of adverse effects observed with JWH-018-containing products relative to cannabis

Endocannabinoid-Mediated Plasticity in Nucleus Accumbens Controls Vulnerability to Anxiety after Social Defeat Stress

Chronic social defeat stress (CSDS) is a clinically relevant model of mood disorders. The relationship between the CSDS model and a physiologically pertinent paradigm of synaptic plasticity is not known. Here, we found that cluster analysis of the emotional behavior states of mice exposed to CSDS allowed their segregation into anxious and non-anxious groups. Endocannabinoid-mediated spike-timing dependent plasticity (STDP) in the nucleus accumbens was attenuated in non-anxious mice and abolished in anxious mice. Anxiety-like behavior in stressed animals was specifically correlated with their ability to produce STDP. Pharmacological enhancement of 2-arachidonoyl glycerol (2-AG) signaling in the nucleus accumbens normalized the anxious phenotype and STDP in anxious mice. These data reveal that endocannabinoid modulation of synaptic efficacy in response to a naturalistic activity pattern is both a molecular correlate of behavioral adaptability and a crucial factor in the adaptive response to chronic stress.Dépression et NutritionFP7-267196-MSCA-COFUND-AgreenSkill

The endocannabinoid system in mental disorders: Evidence from human brain studies

Mental disorders have a high prevalence compared with many other health conditions and are the leading cause of disability worldwide. Several studies performed in the last years support the involvement of the endocannabinoid system in the etiopathogenesis of different mental disorders. The present review will summarize the latest information on the role of the endocannabinoid system in psychiatric disorders, specifically depression, anxiety, and schizophrenia. We will focus on the findings from human brain studies regarding alterations in endocannabinoid levels, cannabinoid receptors and endocannabinoid metabolizing enzymes in patients suffering mental disorders. Studies carried out in humans have consistently demonstrated that the endocannabinoid system is fundamental for emotional homeostasis and cognitive function. Thus, deregulation of the different elements that are part of the endocannabinoid system may contribute to the pathophysiology of several mental disorders. However, the results reported are controversial. In this sense, different alterations in gene and/or protein expression of CB1 receptors have been shown depending on the technical approach used or the brain region studied. Despite the current discrepancies regarding cannabinoid receptors changes in depression and schizophrenia, present findings point to the endocannabinoid system as a pivotal neuromodulatory pathway relevant in the pathophysiology of mental disorders.This study was supported by the Spanish Ministry of Economy and Competitiveness (SAF2015-67457-R, MINECO/FEDER), the Plan Estatal de I+D+i 2013-2016, the Instituto de Salud Carlos III-Subdirección General de Evaluación y Fomento de la Investigación, Spanish Ministry of Economy, FEDER (PI13/01529) and the Basque Government (IT616/13). I I-L is a recipient of a Predoctoral Fellowship from the Basque Government. E F-Z is a recipient of a Predoctoral Fellowship from the University of Cantabria. CM is a recipient of a Postdoctoral Marie Skłodowska-Curie Individual Fellowship (H2020-MSCA-IF-2016, ID 747487)

Messung der Reflexionseigenschaften von Absorbern für die Strahlungsflussdichtemessung an Solarturmreceivern

Um die Flussdichtemessung an Solarturmreceivern zu verbessern, ist die Nutzung der am Absorber reflektierten Strahlung vielversprechend [1]. Zu diesem Zweck wurde im Rahmen dieser Arbeit ein Messverfahren weiterentwickelt, erprobt und bewertet, mit dem die orts- und richtungsabhängigen Reflexionseigenschaften von Solarturmabsorbern ermittelt werden können. Dabei wird der Absorber durch Überstreichen mit den Brennflecken einzelner Heliostaten „gescannt“. Am Solarturm Jülich wurde das Verfahren erstmalig vollständig angewendet und die BRDF aller Absorberteilbereiche für alle relevanten Einstrahlungsrichtungen ermittelt. Das Phänomen der Retroreflexion sowie Unterschiede in der Richtungsabhängigkeit der BRDF verschiedener Absorbercups wurden als relevant erkannt. Bei Testmessungen der Flussdichteverteilung zeigten sich deutliche Verbesserungen der Gleichmäßigkeit gegenüber einem bestehenden Verfahren, was zu einer positiven Beurteilung des Scan-Verfahrens führt