Evidence of the Erotic in the House of the Vettii

In this thesis I examine the erotic evidence from the House of the Vettii in Pompeii. I analyze the erotic wall-paintings in the House of the Vettii (located in rooms b, p, n, t, and x1) and the erotic graffiti found within the house (located in rooms v and a). I also consider individual and overarching themes found within the erotic wall-paintings in order to conduct a comprehensive analysis of the artwork and identify a number of themes in the decorative programme: erotic abandonment, illicit desire, and demigods that use sexual violence against mortal women. While I do not come to any unprecedented revelations in my thesis, mine is the first scholarly work to examine all the erotic evidence from one house

Grundläggande litteracitetsundervisning för ungdomar och vuxna

Lärare som arbetar med ungdomar och vuxna som ska lära sig läsa och skriva samtidigt som de ska lära sig behärska ett helt nytt språk har ingen lätt uppgift. (...

ESTUDIO COMPARATIVO DEL TRANSPORTE DE SEDIMENTOS EN FONDO EN LAS INMEDIACIONES DEL PUENTE MOTUPE

A lo largo de la cuenca del río Motupe se encuentra ubicado el Puente Motupe con una longitud de 75 m, el principal problema si se presentara un fenómeno del Niño o un nuevo Niño Costero ante los escasos estudios de transporte de sedimentos las estructuras se van a ver bastante afectadas por los sedimentos removidos y evitando el libre cauce del rio. Esta investigación tuvo como objetivo: Comparar los modelos de transporte de sedimentos en fondo en las inmediaciones del puente Motupe, empleando un diseño experimental propiamente diseño, realizando levantamiento topográfico, distribución granulométrica, estudio y análisis de los diferentes sedimentos, mediante ecuaciones de Engelund y Hanzen y Schoklistch, con las que se obtuvo el mejor ajuste para el estudio de transporte de sedimentos en fondo. Se conocieron los distintos desniveles que presenta el río Motupe a causa de los volúmenes de sedimentación que se generan, sus secciones transversales, y las distintas pendientes que se presentan a lo largo del río Motupe.Tesi

COMPARACIÓN DE LOS MODELOS DE TRANSPORTE DE SEDIMENTOS EN FONDO EN LAS INMEDIACIONES DEL PUENTE MOTUPE

A lo largo de la cuenca del río Motupe se encuentra ubicado el Puente Motupe con una longitud de 75 m, el principal problema si se presentara un fenómeno del Niño o un nuevo Niño Costero ante los escasos estudios de transporte de sedimentos las estructuras se van a ver bastante afectadas por los sedimentos removidos y evitando el libre cauce del rio. Esta investigación tiene como objetivo: Comparar los modelos de transporte de sedimentos en fondo en las inmediaciones del puente Motupe, empleando un diseño experimental propiamente diseño, realizando levantamiento topográfico, distribución granulométrica, estudio y análisis de los diferentes sedimentos, mediante ecuaciones de Engelund y Hanzen y Schoklistch, con las que se obtuvo el mejor ajuste para el estudio de transporte de sedimentos en fondo. Se conocieron los distintos desniveles que presenta el río Motupe a causa de los volúmenes de sedimentación que se generan, sus secciones transversales, y las distintas pendientes que se presentan a lo largo del río Motup

Isolation and Chemical Composition of Dinoflagellate Nuclei *

Nuclei were isolated from Peridinium cinctum. Peridinium trochoideum, Gyrodinium cohnii ( Cryptothecodinium cohnii ) and Gymnodinium nelsoni. The nuclei of G. cohnii, P. trochoideum and G. nelsoni were found to contain ∼ 6.9, 34 and 143 picograms of DNA respectively. The ratios to DNA of RNA, acid-soluble and acid-insoluble protein for G. cohnii were 0.32, 0.13 and 0.99, respectively. The corresponding values for P. trochoideum were 0.22, 0.08 and 1.22, while those for G. nelsoni were 0.21, 0.10 and 1.09. The chemical composition of dinoflagellate nuclei is compared and contrasted with that of typical eukaryotic nuclei. The culture of these difficult organisms also is discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72006/1/j.1550-7408.1973.tb03595.x.pd

Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction

Background: Assembly and disassembly of microtubules (MTs) is critical for neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating the receptor tyrosine kinase, TrkA. G protein-coupled receptors (GPCRs) as well as heterotrimeric G proteins are also involved in regulating neurite outgrowth. However, the possible connection between these pathways and how they might ultimately converge to regulate the assembly and organization of MTs during neurite outgrowth is not well understood. Results: Here, we report that Gβγ, an important component of the GPCR pathway, is critical for NGF-induced neuronal differentiation of PC12 cells. We have found that NGF promoted the interaction of Gβγ with MTs and stimulated MT assembly. While Gβγ-sequestering peptide GRK2i inhibited neurite formation, disrupted MTs, and induced neurite damage, the Gβγ activator mSIRK stimulated neurite outgrowth, which indicates the involvement of Gβγ in this process. Because we have shown earlier that prenylation and subsequent methylation/demethylation of γ subunits are required for the Gβγ-MTs interaction in vitro, small-molecule inhibitors (L-28 and L-23) targeting prenylated methylated protein methyl esterase (PMPMEase) were tested in the current study. We found that these inhibitors disrupted Gβγ and ΜΤ organization and affected cellular morphology and neurite outgrowth. In further support of a role of Gβγ-MT interaction in neuronal differentiation, it was observed that overexpression of Gβγ in PC12 cells induced neurite outgrowth in the absence of added NGF. Moreover, overexpressed Gβγ exhibited a pattern of association with MTs similar to that observed in NGF-differentiated cells. Conclusions: Altogether, our results demonstrate that βγ subunit of heterotrimeric G proteins play a critical role in neurite outgrowth and differentiation by interacting with MTs and modulating MT rearrangement. Electronic supplementary material The online version of this article (doi:10.1186/s12868-014-0132-4) contains supplementary material, which is available to authorized users

Mechanisms underlying the role of DISC1 in synaptic plasticity

Disrupted in schizophrenia 1 (DISC1) is an important hub protein, forming multimeric complexes by self‐association and interacting with a large number of synaptic and cytoskeletal molecules. The synaptic location of DISC1 in the adult brain suggests a role in synaptic plasticity, and indeed, a number of studies have discovered synaptic plasticity impairments in a variety of different DISC1 mutants. This review explores the possibility that DISC1 is an important molecule for organizing proteins involved in synaptic plasticity and examines why mutations in DISC1 impair plasticity. It concentrates on DISC1's role in interacting with synaptic proteins, controlling dendritic structure and cellular trafficking of mRNA, synaptic vesicles and mitochondria. N‐terminal directed mutations appear to impair synaptic plasticity through interactions with phosphodiesterase 4B (PDE4B) and hence protein kinase A (PKA)/GluA1 and PKA/cAMP response element‐binding protein (CREB) signalling pathways, and affect spine structure through interactions with kalirin 7 (Kal‐7) and Rac1. C‐terminal directed mutations also impair plasticity possibly through altered interactions with lissencephaly protein 1 (LIS1) and nuclear distribution protein nudE‐like 1 (NDEL1), thereby affecting developmental processes such as dendritic structure and spine maturation. Many of the same molecules involved in DISC1's cytoskeletal interactions are also involved in intracellular trafficking, raising the possibility that impairments in intracellular trafficking affect cytoskeletal development and vice versa. While the multiplicity of DISC1 protein interactions makes it difficult to pinpoint a single causal signalling pathway, we suggest that the immediate‐term effects of N‐terminal influences on GluA1, Rac1 and CREB, coupled with the developmental effects of C‐terminal influences on trafficking and the cytoskeleton make up the two main branches of DISC1's effect on synaptic plasticity and dendritic spine stability