298 research outputs found
Expression and secretion of activin A: possible physiological and clinical implications
- Publication venue
- Publication date
- 24/01/2005
- Field of study
n/
Differential expression of follistatin and FLRG in human breast proliferative disorders
- Author
- A Deli
- A Schneyer
- B Refaat
- C Courtillot
- C Di Loreto
- C Glister
- C Welt
- CA Harrison
- D Razanajaona
- DL Page
- Enrrico Bloise
- Felice Petraglia
- Fernando M Reis
- FM Reis
- FM Reis
- Geovanni D Cassali
- Giovanni Grasso
- GP Risbridger
- H Ogino
- Henrique L Couto
- J Krneta
- J Massagué
- JE Burdette
- JE Burdette
- JJ Hill
- JS Jeruss
- K Ogawa
- L Massai
- Lauretta Massai
- Lavinia E Borges
- Marzia Mencarelli
- MC Ferreira
- Michela Muscettola
- O Hashimoto
- P Ciarmela
- P Florio
- Pasquapina Ciarmela
- PB Torres
- QY Liu
- S Saito
- SC Klein
- SJ Lee
- SJ Lin
- UA Bussmann
- V Maguer-Satta
- Vania F Amaral
- Y Kang
- Y Komatsu
- YG Chen
- Publication venue
- BioMed Central
- Publication date
- 01/01/2009
- Field of study
<p>Abstract</p> <p>Background</p> <p>Activins are growth factors acting on cell growth and differentiation. Activins are expressed in high grade breast tumors and they display an antiproliferative effect inducing G0/G1 cell cycle arrest in breast cancer cell lines. Follistatin and follistatin- related gene (FLRG) bind and neutralize activins. In order to establish if these activin binding proteins are involved in breast tumor progression, the present study evaluated follistatin and FLRG pattern of mRNA and protein expression in normal human breast tissue and in different breast proliferative diseases.</p> <p>Methods</p> <p>Paraffin embedded specimens of normal breast (NB - n = 8); florid hyperplasia without atypia (FH - n = 17); fibroadenoma (FIB - n = 17); ductal carcinoma <it>in situ </it>(DCIS - n = 10) and infiltrating ductal carcinoma (IDC - n = 15) were processed for follistatin and FLRG immunohistochemistry and <it>in situ </it>hybridization. The area and intensity of chromogen epithelial and stromal staining were analyzed semi-quantitatively.</p> <p>Results</p> <p>Follistatin and FLRG were expressed both in normal tissue and in all the breast diseases investigated. Follistatin staining was detected in the epithelial cytoplasm and nucleus in normal, benign and malignant breast tissue, with a stronger staining intensity in the peri-alveolar stromal cells of FIB at both mRNA and protein levels. Conversely, FLRG area and intensity of mRNA and protein staining were higher both in the cytoplasm and in the nucleus of IDC epithelial cells when compared to NB, while no significant changes in the stromal intensity were observed in all the proliferative diseases analyzed.</p> <p>Conclusion</p> <p>The present findings suggest a role for follistatin in breast benign disease, particularly in FIB, where its expression was increased in stromal cells. The up regulation of FLRG in IDC suggests a role for this protein in the progression of breast malignancy. As activin displays an anti-proliferative effect in human mammary cells, the present findings indicate that an increased FST and FLRG expression in breast proliferative diseases might counteract the anti-proliferative effects of activin in human breast cancer.</p
Urocortin protects chondrocytes from NO-induced apoptosis: a future therapy for osteoarthritis?
- Author
- A Abuirmeileh
- AF Seasholtz
- AJ Farrell
- AR Amin
- BK Brar
- CE Combs
- DK Grammatopoulos
- DK Grammatopoulos
- E Gonzalez-Rey
- EM Fekete
- FJ Blanco
- FM Dautzenberg
- GAC Murrell
- H Hulejová
- H Muir
- HI Roach
- J Kim
- J Pelletier
- JA Buckwalter
- JA Buckwalter
- JC Fernandes
- JR Matthews
- K Kobayashi
- K Kühn
- KM Lawrence
- KM Lawrence
- M Kohno
- M Lotz
- MA Zmijewski
- MB Goldring
- MH Perrin
- MK Kaneva
- P Florio
- PA Townsend
- RF Loeser
- RT Allen
- SJ Getting
- SP Barry
- WE Horton Jr.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Osteoarthritis (OA) is characterized by a loss of joint mobility and pain resulting from progressive destruction and loss of articular cartilage secondary to chondrocyte death and/ or senescence. Certain stimuli including nitric oxide (NO) and the pro-inflammatory cytokine tumor necrosis factor α (TNF-α have been implicated in this chondrocyte death and the subsequent accelerated damage to cartilage. In this study, we demonstrate that a corticotrophin releasing factor (CRF) family peptide, urocortin (Ucn), is produced by a human chondrocyte cell line, C-20/A4, and acts both as an endogenous survival signal and as a cytoprotective agent reducing the induction of apoptosis by NO but not TNF-α when added exogenously. Furthermore, treatment with the NO donor S-nitroso-N-acetyl-D-L-penicillamine upregulates chondrocyte Ucn expression, whereas treatment with TNF-α does not. The chondroprotective effects of Ucn are abolished by both specific ligand depletion (with an anti-Ucn antibody) and by CRF receptor blockade with the pan-CRFR antagonist α-helical CRH(9-41). CRFR expression was confirmed by reverse transcription-PCR with subsequent amplicon sequence analysis and demonstrates that C-20/A4 cells express both CRFR1 and CRFR2, specifically CRFR1α and CRFR2β. Protein expression of these receptors was confirmed by western blotting. The presence of both Ucn and its receptors in these cells, coupled with the induction of Ucn by NO, suggests the existence of an endogenous autocrine/paracrine chondroprotective mechanism against stimuli inducing chondrocyte apoptosis via the intrinsic/mitochondrial pathway
Knowledge and attitude of parents or caretakers regarding transmissibility os caries disease
- Author
- Alaluusua S
- Alaluusua S
- Ana Beatriz S. Moretti
- Anusavice KJ
- Berkowitz RJ
- Berkowitz RJ
- Caufield PW
- Caufield PW
- Chan KM
- Dafna Geller-Palti
- Emanuelsson IR
- Ersin NK
- Florio FM
- Grindefjord M
- Grönroos L
- Keyes PH
- Kohler B
- Kohler B
- Li Y
- Maria Aparecida A. M. Machado
- Mattos-Graner RO
- Mattos-Graner RO
- Napimoga MH
- Newbrun E
- Roeters FJ
- Russell MW
- Slavkin HC
- Smith DJ
- Tanzer JM
- Taubman MA
- Thais M. Oliveira
- Thiago C. Silva
- Vivian A. Biella
- Vivien T. Sakai
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Managing caries:the need to close the gap between the evidence base and current practice
- Author
- A Bakhshandeh
- A Banerjee
- A Baraba
- A Baraba
- A Jablonski-Momeni
- A Lundh
- A Sbaraini
- A Schulte
- AB Tveit
- AD da Silveira
- AG Schulte
- AS Al-Hiyasat
- BC Borges
- BC Borges
- BJ McNeil
- BO Magnusson
- BY Liu
- C Brantley
- C Chaussain-Miller
- C Fornaini
- CC Parolo
- CM Weber
- CR Barthel
- D Bonetti
- D Ricketts
- D Ricketts
- D. Ricketts
- DA Shugars
- DL Bonetti
- DN Ricketts
- DN Ricketts
- DN Ricketts
- DS Brennan
- E Leksell
- EA Kidd
- EAM Kidd
- F Schwendicke
- F Schwendicke
- F Schwendicke
- F Schwendicke
- F Schwendicke
- F Schwendicke
- F. Schwendicke
- FL Mialhe
- FM Florio
- H Ghasemi
- H Splieth Ch
- I Espelid
- I Espelid
- I Rytomaa
- J Gomez
- J Kaidonis
- J Traebert
- JC Hamilton
- JD Bader
- JD Bader
- JE Clarkson
- K Ridell
- KE Heller
- KR Baumgardner
- KT Oen
- L San Martin
- L Stangvaltaite
- LA Page
- LB Messer
- M Fontana
- M Fukushima
- M. Peters
- MB Altarabulsi
- MC Peters
- MC Peters
- ME Khalaf
- MJ Dobrow
- MJ Dobrow
- MM Ammari
- MS Alhareky
- N Kakudate
- N Pitts
- NB Pitts
- NM Nuttall
- O Haugejorden
- P Aguilar
- P Williamson
- R Watt
- S Doméjean
- S Listl
- S Martignon
- S Tubert-Jeannin
- S Vidnes-Kopperud
- S. Doméjean
- SL Handelman
- SO Griffin
- SO Griffin
- T Fusayama
- TD Clark
- TJ Heaven
- V Baelum
- VV Gordan
- VV Gordan
- Y Zadik
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/11/2015
- Field of study
A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams MR
- Adams T
- Adzic P
- Adán DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmad WH
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Allen B
- Almond J
- Alonso AG
- Alvarez JDR
- Alverson G
- Alves FL
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Ambrogi F
- Amendola C
- Amin N
- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Angioni GLP
- Antchev G
- Antunovic Z
- Anuar AAB
- Apanasevich L
- Apollinari G
- Apresyan A
- Apyan A
- Araujo M
- Arbelaez NV
- Arbol PMRD
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Askew A
- Asmuss P
- Atakisi IO
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Autermann C
- Auzinger G
- Avati V
- Avery P
- Avila C
- Ayala E
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
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- Banerjee S
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- Barbagli G
- Barberis E
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- Baringer P
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- Barney D
- Barnyakov A
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- Barrera CB
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- Bartek R
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- Baskakov A
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- Da Silva De Araujo FT
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- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Özçelik Ö
- Publication venue
- Publication date
- 01/01/2020
- Field of study
We describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in proton-proton collisions at an energy of s = 13 TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb - 1 . A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ¯
Measurement of B_{s}^{0} meson production in pp and PbPb collisions at \sqrt{SNN}
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdelalim AA
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adam W
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- Wright J
- Wu Z
- Wulz C-E
- Wurthwein F
- Wyslouch B
- Xia F
- Xiao M
- Xiao R
- Xie S
- Xie W
- Xu Q
- Yagil A
- Yalvac M
- Yang UK
- Yang YC
- Yates BR
- Yazgan E
- Yetkin EA
- Yohay R
- Yoo HD
- Yoo J
- You C
- Yu D
- Yu GB
- Yu I
- Yu SS
- Yuan L
- Yumiceva F
- Yusli MN
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zghiche A
- Zhang A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang Z
- Zhao J
- Zhokin A
- Zhu DH
- Zhu RY
- Zientek M
- Zito G
- Zobec J
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Publication venue
- 'Elsevier BV'
- Publication date
- 10/09/2019
- Field of study
The production cross sections of B_{s}^{0} mesons and charge conjugates are measured in proton-proton (pp) and PbPb collisions via the exclusive decay channel B_{s}^{0}→J/ψϕ→μ^{+}μ^{−}K^{+}K^{−} at a center-of-mass energy of 5.02 TeV per nucleon pair and within the rapidity range |y|<2.4 using the CMS detector at the LHC. The pp measurement is performed as a function of transverse momentum (p_{T}) of the B_{s}^{0} mesons in the range of 7 to 50 GeV/c and is compared to the predictions of perturbative QCD calculations. The B_{s}^{0} production yield in PbPb collisions is measured in two p_{T} intervals, 7 to 15 and 15 to 50 GeV/c, and compared to the yield in pp collisions in the same kinematic region. The nuclear modification factor (R_{AA}) is found to be 1.5±0.6(stat)±0.5(syst) for 7–15 GeV/c, and 0.87±0.30(stat)±0.17(syst) for 15–50 GeV/c, respectively. Within current uncertainties, the B_{s}^{0} results are consistent with models of strangeness enhancement, and suppression by parton energy loss, as observed for the B+ mesons
Measurement of the tt¯ production cross section, the top quark mass, and the strong coupling constant using dilepton events in pp collisions at √s = 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Acharya H
- Ackert A
- Acosta D
- Acosta JG
- Adam W
- Adams MR
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- Adzic P
- Afanasiev S
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- Ahmad A
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- Civinini C
- Claes DR
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- Wurthwein F
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- Xiao M
- Xiao R
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- Yalvac M
- Yang UK
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- Yates BR
- Yazgan E
- Yetkin EA
- Yohay R
- Yoo HD
- Yoo J
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- Yuan L
- Yumiceva F
- Yusli MN
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zghiche A
- Zhang A
- Zhang F
- Zhang H
- Zhang J
- Zhang S
- Zhang Z
- Zhao J
- Zhokin A
- Zhu DH
- Zhu RY
- Zientek M
- Zobec J
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 29/04/2019
- Field of study
A measurement of the top quark–antiquark pair production cross section σtt¯ in proton–proton collisions at a centre-of-mass energy of 13TeV is presented. The data correspond to an integrated luminosity of 35.9fb−1, recorded by the CMS experiment at the CERN LHC in 2016. Dilepton events (e ± μ ∓, μ+μ−, e+e−) are selected and the cross section is measured from a likelihood fit. For a top quark mass parameter in the simulation of mMCt=172.5GeV the fit yields a measured cross section σtt¯=803±2(stat)±25(syst)±20(lumi)pb, in agreement with the expectation from the standard model calculation at next-to-next-to-leading order. A simultaneous fit of the cross section and the top quark mass parameter in the POWHEG simulation is performed. The measured value of mMCt=172.33±0.14(stat)+0.66−0.72(syst)GeV is in good agreement with previous measurements. The resulting cross section is used, together with the theoretical prediction, to determine the top quark mass and to extract a value of the strong coupling constant with different sets of parton distribution functions
Search for contact interactions and large extra dimensions in the dilepton mass spectra from proton-proton collisions at \sqrt{s} = 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adam W
- Adams MR
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- Xiao R
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- Xu Q
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- Yates BR
- Yazgan E
- Yetkin EA
- Yohay R
- Yoo HD
- Yoo J
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- Yu GB
- Yu I
- Yu SS
- Yuan L
- Yumiceva F
- Yusli MN
- Zabi A
- Zaganidis N
- Zahid S
- Zaleski S
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zarucki M
- Zeinali M
- Zenaiev O
- Zenz SC
- Zeuner WD
- Zeyrek M
- Zghiche A
- Zhang A
- Zhang F
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- Zhang Z
- Zhao J
- Zhokin A
- Zhu DH
- Zhu RY
- Zientek M
- Zito G
- Zobec J
- Zoi I
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- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuolo D
- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/01/2019
- Field of study
A search for nonresonant excesses in the invariant mass spectra of electron and muon pairs is presented. The analysis is based on data from proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the CMS experiment in 2016, corresponding to a total integrated luminosity of 36 fb^{-1}. No significant deviation from the standard model is observed. Limits are set at 95% confidence level on energy scales for two general classes of nonresonant models. For a class of fermion contact interaction models, lower limits ranging from 20 to 32 TeV are set on the characteristic compositeness scale Λ. For the Arkani-Hamed, Dimopoulos, and Dvali model of large extra dimensions, the first results in the dilepton final state at 13 TeV are reported, and values of the ultraviolet cutoff parameter Λ_{T} below 6.9 TeV are excluded. A combination with recent CMS diphoton results improves this exclusion to Λ_{T} below 7.7 TeV, providing the most sensitive limits to date in nonhadronic final states
Search for dark matter produced in association with a single top quark or a top quark pair in proton-proton collisions at s=13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WAT Wan
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adam W
- Adams MR
- Adams T
- Adzic P
- Afanasiev S
- Agapitos A
- Agaras MN
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akbiyik M
- Akchurin N
- Akgun B
- Al-Bataineh A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Alcaraz Maestre J
- Aleksandrov A
- Alexander J
- Alhusseini M
- Ali MAB Md
- Alimena J
- Allen B
- Almond J
- Alvarez Fernandez A
- Alvarez JD Ruiz
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Ambrogi F
- Amendola C
- Amin N
- Amsler C
- Anagnostou G
- Anampa K Hurtado
- Anderson D
- Andrea J
- Andreev V
- Andreev Yu
- Andrews MB
- Androsov K
- Angioni L Pinna
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Apyan A
- Araujo M
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arndt T
- Arneodo M
- Asavapibhop B
- Asawatangtrakuldee C
- Asghar MI
- Asilar E
- Askew A
- Assran Y
- Atakisi IO
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avila C
- Ayala E
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Bagliesi G
- Bahinipati S
- Baidali S
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Ball AH
- Ball F
- Ban Y
- Band R
- Banerjee S
- Banerjee S
- Bani L
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barker A
- Barnes VE
- Barney D
- Barnyakov A
- Baron O
- Barone L
- Barria P
- Barrio Luna M
- Bartek R
- Barth C
- Bartok M
- Bartosik N
- Baselga M
- Baskakov A
- Bat A
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Baur S
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Becerra DA Sanz
- Beernaert K
- Beghin D
- Behera PK
- Behnke O
- Behrens U
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- Publication venue
- Publication date
- 01/01/2019
- Field of study
A search has been performed for heavy resonances decaying to ZZ or ZW in 2l2q final states, with two charged leptons (l = e, mu) produced by the decay of a Z boson, and two quarks produced by the decay of a W or Z boson. The analysis is sensitive to resonances with masses in the range from 400 to 4500 GeV. Two categories are defined based on the merged or resolved reconstruction of the hadronically decaying vector boson, optimized for high- and low-mass resonances, respectively. The search is based on data collected during 2016 by the CMS experiment at the LHC in proton-proton collisions with a center-of-mass energy of root s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). No excess is observed in the data above the standard model background expectation. Upper limits on the production cross section of heavy, narrow spin-1 and spin-2 resonances are derived as a function of the resonance mass, and exclusion limits on the production of W' bosons and bulk graviton particles are calculated in the framework of the heavy vector triplet model and warped extra dimensions, respectively.A search has been performed for heavy resonances decaying to ZZ or ZW in 2l2q final states, with two charged leptons (l = e, mu) produced by the decay of a Z boson, and two quarks produced by the decay of a W or Z boson. The analysis is sensitive to resonances with masses in the range from 400 to 4500 GeV. Two categories are defined based on the merged or resolved reconstruction of the hadronically decaying vector boson, optimized for high- and low-mass resonances, respectively. The search is based on data collected during 2016 by the CMS experiment at the LHC in proton-proton collisions with a center-of-mass energy of root s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1). No excess is observed in the data above the standard model background expectation. Upper limits on the production cross section of heavy, narrow spin-1 and spin-2 resonances are derived as a function of the resonance mass, and exclusion limits on the production of W' bosons and bulk graviton particles are calculated in the framework of the heavy vector triplet model and warped extra dimensions, respectively.A search for dark matter produced in association with top quarks in proton-proton collisions at a center-of-mass energy of 13 TeV is presented. The data set used corresponds to an integrated luminosity of 35.9 fb(-1) recorded with the CMS detector at the LHC. Whereas previous searches for neutral scalar or pseudoscalar mediators considered dark matter production in association with a top quark pair only, this analysis also includes production modes with a single top quark. The results are derived from the combination of multiple selection categories that are defined to target either the single top quark or the top quark pair signature. No significant deviations with respect to the standard model predictions are observed. The results are interpreted in the context of a simplified model in which a scalar or pseudoscalar mediator particle couples to a top quark and subsequently decays into dark matter particles. Scalar and pseudoscalar mediator particles with masses below 290 and 300 GeV, respectively, are excluded at 95% confidence level, assuming a dark matter particle mass of 1 GeV and mediator couplings to fermions and dark matter particles equal to unity.Peer reviewe
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