2,687 research outputs found
Craniofacial morphology does not support a pre-contact Carib “invasion” of the northern Caribbean
The short-duration GRB 050724 host galaxy in the context of the long-duration GRB hosts
We report optical and near-infrared broad band observations of the
short-duration GRB 050724 host galaxy, used to construct its spectral energy
distribution (SED). Unlike the hosts of long-duration gamma-ray bursts (GRBs),
which show younger stellar populations, the SED of the GRB 050724 host galaxy
is optimally fitted with a synthetic elliptical galaxy template based on an
evolved stellar population (age ~2.6 Gyr). The SED of the host is difficult to
reproduce with non-evolving metallicity templates. In contrast, if the short
GRB host galaxy metallicity enrichment is considered, the synthetic templates
fit the observed SED satisfactorily. The internal host extinction is low (A_v
\~< 0.4 mag) so it cannot explain the faintness of the afterglow. This short
GRB host galaxy is more massive (~5x10^10 Mo) and luminous (~1.1 L*) than most
of the long-duration GRB hosts. A statistical comparison based on the ages of
short- and long-duration GRB host galaxies strongly suggests that
short-duration GRB hosts contain, on average, older progenitors. These findings
support a different origin for short- and long-duration GRBs.Comment: A&A in pres
e-MIR2: a public online inventory of medical informatics resources
Background. Over the last years, the number of available informatics resources in medicine has grown exponentially. While specific inventories of such resources have already begun to be developed for Bioinformatics (BI), comparable inventories are as yet not available for Medical Informatics (MI) field, so that locating and accessing them currently remains a hard and time-consuming task. Description. We have created a repository of MI resources from the scientific literature, providing free access to its contents through a web-based service. Relevant information describing the resources is automatically extracted from manuscripts published in top-ranked MI journals. We used a pattern matching approach to detect the resources? names and their main features. Detected resources are classified according to three different criteria: functionality, resource type and domain. To facilitate these tasks, we have built three different taxonomies by following a novel approach based on folksonomies and social tagging. We adopted the terminology most frequently used by MI researchers in their publications to create the concepts and hierarchical relationships belonging to the taxonomies. The classification algorithm identifies the categories associated to resources and annotates them accordingly. The database is then populated with this data after manual curation and validation. Conclusions. We have created an online repository of MI resources to assist researchers in locating and accessing the most suitable resources to perform specific tasks. The database contained 282 resources at the time of writing. We are continuing to expand the number of available resources by taking into account further publications as well as suggestions from users and resource developers
Broad-line Balmer Decrements in Blue Active Galactic Nuclei
We have investigated the broad-line Balmer decrements (Halpha/Hbeta) for a
large, homogeneous sample of Seyfert 1 galaxies and QSOs using spectroscopic
data obtained in the Sloan Digital Sky Survey. The sample, drawn from the
Fourth Data Release, comprises 446 low redshift (z < 0.35) active galactic
nuclei (AGN) that have blue optical continua as indicated by the spectral
slopes in order to minimize the effect of dust extinction. We find that (i) the
distribution of the intrinsic broad-line Halpha/Hbeta ratio can be well
described by log-Gaussian, with a peak at Halpha/Hbeta=3.06 and a standard
deviation of about 0.03 dex only; (ii) the Balmer decrement does not correlate
with AGN properties such as luminosity, accretion rate, and continuum slope,
etc.; (iii) on average, the Balmer decrements are found to be only slightly
larger in radio-loud sources (3.37) and sources having double-peaked
emission-line profiles (3.27) compared to the rest of the sample. We therefore
suggest that the broad-line Halpha/Hbeta ratio can be used as a good indicator
for dust extinction in the AGN broad-line region; this is especially true for
radio-quiet AGN with regular emission-line profiles, which constitute the vast
majority of the AGN population.Comment: To appear in MNRAS. The data and the fitted parameters for the
decomposed spectral components (continuum, FeII and other emission lines) of
the 446 blue AGNs are available at
http://staff.ustc.edu.cn/~xbdong/Data_Release/blueAGN_DR4
Breath Formate Is a Marker of Airway S-Nitrosothiol Depletion in Severe Asthma
-nitrosothiols (SNOs), a class of endogenous airway smooth muscle relaxants. This deficiency results from increased activity of an enzyme that both reduces SNOs to ammonia and oxidizes formaldehyde to formic acid, a volatile carboxylic acid that is more easily detected in exhaled breath condensate (EBC) than SNOs. We therefore hypothesize that depletion of airway SNOs is related to asthma pathology, and breath formate concentration may be a proxy measure of SNO catabolism. (r = −0.39, p = 0.002, asthmatics only), and positively correlated with the NO-derived ion nitrite (r = 0.46, p<0.0001) as well as with total serum IgE (r = 0.28, p = 0.016, asthmatics only). Furthermore, formate was not significantly correlated with other volatile organic acids nor with inhaled corticosteroid dose.-nitrosothiols
The starburst-AGN connection in the merger galaxy Mrk 938: an infrared and X-ray view
Mrk938 is a luminous infrared galaxy in the local Universe believed to be the
remnant of a galaxy merger. It shows a Seyfert 2 nucleus and intense star
formation according to optical spectroscopic observations. We have studied this
galaxy using new Herschel far-IR imaging data in addition to archival X-ray,
UV, optical, near-IR and mid-IR data. Mid- and far-IR data are crucial to
characterise the starburst contribution, allowing us to shed new light on its
nature and to study the coexistence of AGN and starburst activity in the local
Universe. The decomposition of the mid-IR Spitzer spectrum shows that the AGN
bolometric contribution to the mid-IR and total infrared luminosity is small
(Lbol(AGN)/LIR~0.02), which agrees with previous estimations. We have
characterised the physical nature of its strong infrared emission and
constrained it to a relatively compact emitting region of <2kpc. It is in this
obscured region where most of the current star formation activity is taking
place as expected for LIRGs. We have used Herschel imaging data for the first
time to constrain the cold dust emission with unprecedented accuracy. We have
fitted the integrated far-IR spectral energy distribution and derived the
properties of the dust, obtaining a dust mass of 3x10^7Msun. The far-IR is
dominated by emission at 35K, consistent with dust heated by the on-going star
formation activity.Comment: 12 pages, 6 figures, 4 tables, accepted for publication in MNRA
A Variable-Density Absorption Event in NGC 3227 mapped with Suzaku and Swift
The morphology of the circumnuclear gas accreting onto supermassive black
holes in Seyfert galaxies remains a topic of much debate. As the innermost
regions of Active Galactic Nuclei (AGN) are spatially unresolved, X-ray
spectroscopy, and in particular line-of-sight absorption variability, is a key
diagnostic to map out the distribution of gas. Observations of variable X-ray
absorption in multiple Seyferts and over a wide range of timescales indicate
the presence of clumps/clouds of gas within the circumnuclear material. Eclipse
events by clumps transiting the line of sight allow us to explore the
properties of the clumps over a wide range of radial distances from the
optical/UV Broad Line Region (BLR) to beyond the dust sublimation radius.
Time-resolved absorption events have been extremely rare so far, but suggest a
range of density profiles across Seyferts. We resolve a weeks-long absorption
event in the Seyfert NGC 3227. We examine six Suzaku and twelve Swift
observations from a 2008 campaign spanning 5 weeks. We use a model accounting
for the complex spectral interplay of three differently-ionized absorbers. We
perform time-resolved spectroscopy to discern the absorption variability
behavior. We also examine the IR-to-X-ray spectral energy distribution (SED) to
test for reddening by dust. The 2008 absorption event is due to
moderately-ionized () gas covering 90% of the line of
sight. We resolve the density profile to be highly irregular, in contrast to a
previous symmetric and centrally-peaked event mapped with RXTE in the same
object. The UV data do not show significant reddening, suggesting that the
cloud is dust-free. The 2008 campaign has revealed a transit by a filamentary,
moderately-ionized cloud of variable density that is likely located in the BLR,
and possibly part of a disk wind.Comment: Accepted for publication by A&
Intermittent control models of human standing: similarities and differences
Two architectures of intermittent control are compared and contrasted in the context of the single inverted pendulum model often used for describing standing in humans. The architectures are similar insofar as they use periods of open-loop control punctuated by switching events when crossing a switching surface to keep the system state trajectories close to trajectories leading to equilibrium. The architectures differ in two significant ways. Firstly, in one case, the open-loop control trajectory is generated by a system-matched hold, and in the other case, the open-loop control signal is zero. Secondly, prediction is used in one case but not the other. The former difference is examined in this paper. The zero control alternative leads to periodic oscillations associated with limit cycles; whereas the system-matched control alternative gives trajectories (including homoclinic orbits) which contain the equilibrium point and do not have oscillatory behaviour. Despite this difference in behaviour, it is further shown that behaviour can appear similar when either the system is perturbed by additive noise or the system-matched trajectory generation is perturbed. The purpose of the research is to come to a common approach for understanding the theoretical properties of the two alternatives with the twin aims of choosing which provides the best explanation of current experimental data (which may not, by itself, distinguish beween the two alternatives) and suggesting future experiments to distinguish between the two alternatives
Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease
Background
Systematic evaluations of the quality of research on a single prognostic biomarker are rare. We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events among patients with stable coronary disease.
Methods and Findings
We searched MEDLINE (1966 to 2009) and EMBASE (1980 to 2009) and selected prospective studies of patients with stable coronary disease, reporting a relative risk for the association of CRP with death and nonfatal cardiovascular events. We included 83 studies, reporting 61,684 patients and 6,485 outcome events. No study reported a prespecified statistical analysis protocol; only two studies reported the time elapsed (in months or years) between initial presentation of symptomatic coronary disease and inclusion in the study. Studies reported a median of seven items (of 17) from the REMARK reporting guidelines, with no evidence of change over time.
The pooled relative risk for the top versus bottom third of CRP distribution was 1.97 (95% confidence interval [CI] 1.78–2.17), with substantial heterogeneity (I2 = 79.5). Only 13 studies adjusted for conventional risk factors (age, sex, smoking, obesity, diabetes, and low-density lipoprotein [LDL] cholesterol) and these had a relative risk of 1.65 (95% CI 1.39–1.96), I2 = 33.7. Studies reported ten different ways of comparing CRP values, with weaker relative risks for those based on continuous measures. Adjusting for publication bias (for which there was strong evidence, Egger's p<0.001) using a validated method reduced the relative risk to 1.19 (95% CI 1.13–1.25). Only two studies reported a measure of discrimination (c-statistic). In 20 studies the detection rate for subsequent events could be calculated and was 31% for a 10% false positive rate, and the calculated pooled c-statistic was 0.61 (0.57–0.66).
Conclusion
Multiple types of reporting bias, and publication bias, make the magnitude of any independent association between CRP and prognosis among patients with stable coronary disease sufficiently uncertain that no clinical practice recommendations can be made. Publication of prespecified statistical analytic protocols and prospective registration of studies, among other measures, might help improve the quality of prognostic biomarker research
FRA2A is a CGG repeat expansion associated with silencing of AFF3
Folate-sensitive fragile sites (FSFS) are a rare cytogenetically visible subset of dynamic mutations. Of the eight molecularly characterized FSFS, four are associated with intellectual disability (ID). Cytogenetic expression results from CGG tri-nucleotide-repeat expansion mutation associated with local CpG hypermethylation and transcriptional silencing. The best studied is the FRAXA site in the FMR1 gene, where large expansions cause fragile X syndrome, the most common inherited ID syndrome. Here we studied three families with FRA2A expression at 2q11 associated with a wide spectrum of neurodevelopmental phenotypes. We identified a polymorphic CGG repeat in a conserved, brain-active alternative promoter of the AFF3 gene, an autosomal homolog of the X-linked AFF2/FMR2 gene: Expansion of the AFF2 CGG repeat causes FRAXE ID. We found that FRA2A-expressing individuals have mosaic expansions of the AFF3 CGG repeat in the range of several hundred repeat units. Moreover, bisulfite sequencing and pyrosequencing both suggest AFF3 promoter hypermethylation. cSNP-analysis demonstrates monoallelic expression of the AFF3 gene in FRA2A carriers thus predicting that FRA2A expression results in functional haploinsufficiency for AFF3 at least in a subset of tissues. By whole-mount in situ hybridization the mouse AFF3 ortholog shows strong regional expression in the developing brain, somites and limb buds in 9.5-12.5dpc mouse embryos. Our data suggest that there may be an association between FRA2A and a delay in the acquisition of motor and language skills in the families studied here. However, additional cases are required to firmly establish a causal relationship
- …