Discovery of a New Quadruple Lens HST 1411+5211

Gravitational lensing is an important tool for probing the mass distribution of galaxies. In this letter we report the discovery of a new quadruple lens HST 1411+5211 found in archived WFPC2 images of the galaxy cluster CL140933+5226. If the galaxy is a cluster member then its redshift is $z=0.46$. The images of the source appear unresolved in the WFC implying that the source is a quasar. We have modeled the lens as both a single galaxy and a galaxy plus a cluster. The latter model yields excellent fits to the image positions along with reasonable parameters for the galaxy and cluster making HST 1411+5211 a likely gravitational lens. Determination of the source redshift and confirmation of the lens redshift would allow us to put strong constraints on the mass distribution of the lensing galaxy.Comment: 11 pages including 1 postscript figure, aastex. Accepted to the ApJL. Also available from: http://www.astro.lsa.umich.edu:80/users/philf/www/papers/list.htm

Unusual Behavior of Antiferromagnetic Superconductors in Low Magnetic Fields

In this article, we examine the superconducting properties of low- and high-$T_c$ magnetic superconductors in magnetic fields close to the first penetration field. Attention is paid to the properties that relate to the interactions between antiferromagnetism and superconductivity. It is suggested that several features characterizing the interplay between magnetic and superconducting subsystems in low-$T_c$ superconductors can also be present in high-$T_c$ materials, however, they have not been observed for any non-substituted antiferromagnetic superconductors of the Y123 type. For the Gd$_{1+x}$Ba$_{2-x}$Cu$_3$O$_{7-\delta}$ compound, a peak in the temperature dependence of the ac susceptibility has been found for $x = 0.2$ near the N\'{e}el temperature of the Gd sublattice. This peak is attributed to the suppression of superconducting persistent currents due to the pair breaking effect that results from the enhanced magnetic fluctuations in the vicinity of the phase transition temperature. This observation indicates that the interaction between magnetic and conducting electrons is present for the composition with $x = 0.2$, where magnetism is enhanced and superconductivity diminished.Comment: To be published in Physica C; 14 pages, 7 figure

Computationally motivated synthesis and enzyme kinetic evaluation of N-(β-d-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors

Following our recent study of N-(β-D-glucopyranosyl)-oxadiazole-carboxamides (Polyák et al., Biorg. Med. Chem. 2013, 21, 5738) revealed as moderate inhibitors of glycogen phosphorylase (GP), in silico docking calculations using Glide have been performed on N-(β-D-glucopyranosyl)-1,2,4-triazolecarboxamides with different aryl substituents predicting more favorable binding at GP. The ligands were subsequently synthesized in moderate yields using N-(2,3,4,6-terta-O-acetyl-β-D-glucopyranosyl)-tetrazole-5-carboxamide as starting material. Kinetics experiments against rabbit muscle glycogen phosphorylase b (RMGPb) revealed the ligands to be low µM GP inhibitors; the phenyl analogue (Ki = 1 µM) is one of the most potent N-(β-D-glucopyranosyl)-heteroaryl-carboxamide-type inhibitors of the GP catalytic site discovered to date. Based on QM and QM/MM calculations, the potency of the ligands is predicted to arise from favorable intra- and intermolecular hydrogen bonds formed by the most stable solution phase tautomeric (t2) state of the 1,2,4-triazole in a conformationally dynamic system. ADMET property predictions revealed the compounds to have promising pharmacokinetic properties without any toxicity. This study highlights the benefits of a computationally lead approach to GP inhibitor design

Constraining the Chemical Signatures and the Outburst Mechanism of the Class 0 Protostar HOPS 383

We present observations toward HOPS 383, the first known outbursting Class 0 protostar located within the Orion molecular cloud using ALMA, VLA, and SMA. The SMA observations reveal envelope scale continuum and molecular line emission surrounding HOPS 383 at 0.85 mm, 1.1 mm, and 1.3 mm. The images show that HCO$^+$ and H$^{13}$CO$^+$ peaks on or near the continuum, while N$_2$H$^+$ is reduced at the same position. This reflects the underlying chemistry where CO evaporating close to the protostar destroys N$_2$H$^+$ while forming HCO$^+$. We also observe the molecular outflow traced by $^{12}$CO ($J = 2 \rightarrow 1$) and ($J = 3 \rightarrow 2$). A disk is resolved in the ALMA 0.87 mm dust continuum, orthogonal to the outflow direction, with an apparent radius of $\sim$62 AU. Radiative transfer modeling of the continuum gives disk masses of 0.02 M$_{\odot}$ when fit to the ALMA visibilities. The models including VLA 8 mm data indicate that the disk mass could be up to a factor of 10 larger due to lower dust opacity at longer wavelengths. The disk temperature and surface density profiles from the modeling, and an assumed protostar mass of 0.5 M$_{\odot}$ suggest that the Toomre $Q$ parameter $< 1$ before the outburst, making gravitational instability a viable mechanism to explain outbursts at an early age if the disk is sufficiently massive.Comment: Accepted by Ap

Learning object relationships which determine the outcome of actions

Peer reviewedPublisher PD

AEGIS at CERN: Measuring Antihydrogen Fall

The main goal of the AEGIS experiment at the CERN Antiproton Decelerator is the test of fundamental laws such as the Weak Equivalence Principle (WEP) and CPT symmetry. In the first phase of AEGIS, a beam of antihydrogen will be formed whose fall in the gravitational field is measured in a Moire' deflectometer; this will constitute the first test of the WEP with antimatter.Comment: Presented at the Fifth Meeting on CPT and Lorentz Symmetry, Bloomington, Indiana, June 28-July 2, 201

iGentifier: indexing and large-scale profiling of unknown transcriptomes

Development and refinement of methods to analyse differential gene expression has been essential in the progress of molecular biology. A novel approach called iGentifier is presented for profiling known and unknown transcriptomes, thus bypassing a major limitation in microarray analysis. The iGentifier technology combines elements of fragment display (e.g. Differential Display or RMDD) and tag sequencing (e.g. SAGE, MPSS) and allows for analysis of samples in high throughput using current capillary electrophoresis equipment. Application to epidermal tissue of wild-type and mlo5 barley (Hordeum vulgare) plants, infected with powdery mildew [Blumeria graminis (DC.) E.O. Speer f.sp.hordei], led to the identification of several 100 genes induced or repressed upon infection with many well known for their response to fungal pathogens or other stressors. Ten of these genes are suggested to be classified as marker genes for durable resistance mediated by the mlo5 resistance gene

Shear-Induced Unfolding Activates von Willebrand Factor A2 Domain for Proteolysis

To avoid pathological platelet aggregation by von Willebrand factor (VWF), VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13-mediated proteolysis in a shear flow dependent manner. We examined if tensile stress in VWF under shear flow activates the VWF A2 domain for cleavage by ADAMTS13 using molecular dynamics simulations. We indeed observed stepwise unfolding of A2 and exposure of its deeply buried ADAMTS13 cleavage site. Interestingly, disulfide bonds in the adjacent and highly homologous VWF A1 and A3 domains obstruct their mechanical unfolding. We generated a full length mutant VWF featuring a homologous disulfide bond in A2 (N1493C and C1670S), in an attempt to lock A2 against unfolding. We find this mutant to feature ADAMTS13-resistant behavior in vitro. Our results yield molecular-detail evidence for the force-sensoring function of VWF A2, by revealing how tension in VWF due to shear flow selectively exposes the A2 proteolysis site to ADAMTS13 for cleavage while keeping the folded remainder of A2 intact and functional. We find the unconventional knotted Rossman fold of A2 to be the key to this mechanical response, tailored for regulating VWF size and activity. Based on our model we can explain the pathomechanism of some natural mutations in the VWF A2 domain that significantly increase the cleavage by ADAMTS13 without shearing or chemical denaturation, and provide with the cleavage-activated A2 conformation a structural basis for the design of inhibitors for VWF type 2 diseases