Cuando el cáncer de seno no significa insatisfacción sexual. Un estudio comparativo

CUANDO EL CÁNCER DE SENO NO SIGNIFICA INSATISFACCIÓN SEXUAL. UN ESTUDIO COMPARATIVO ENTRE PACIENTES Y UN GRUPO DE MUJERES SANAS EN COLOMBI

Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart

In the diabetic heart, chronic activation of the PPARα pathway drives excessive fatty acid (FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy. The related nuclear receptor, PPARβ/δ, is also highly expressed in the heart, yet its function has not been fully delineated. To address its role in myocardial metabolism, we generated transgenic mice with cardiac-specific expression of PPARβ/δ, driven by the myosin heavy chain (MHC-PPARβ/δ mice). In striking contrast to MHC-PPARα mice, MHC-PPARβ/δ mice had increased myocardial glucose utilization, did not accumulate myocardial lipid, and had normal cardiac function. Consistent with these observed metabolic phenotypes, we found that expression of genes involved in cellular FA transport were activated by PPARα but not by PPARβ/δ. Conversely, cardiac glucose transport and glycolytic genes were activated in MHC-PPARβ/δ mice, but repressed in MHC-PPARα mice. In reporter assays, we showed that PPARβ/δ and PPARα exerted differential transcriptional control of the GLUT4 promoter, which may explain the observed isotype-specific effects on glucose uptake. Furthermore, myocardial injury due to ischemia/reperfusion injury was significantly reduced in the MHC-PPARβ/δ mice compared with control or MHC-PPARα mice, consistent with an increased capacity for myocardial glucose utilization. These results demonstrate that PPARα and PPARβ/δ drive distinct cardiac metabolic regulatory programs and identify PPARβ/δ as a potential target for metabolic modulation therapy aimed at cardiac dysfunction caused by diabetes and ischemia

Many Labs 2: Investigating Variation in Replicability Across Samples and Settings

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP

Más allá del comportamiento religioso: escala de las creencias post-críticas en mujeres con cáncer de seno en Colombia

El objetivo de la presente investigación fue establecer si la Escala de las Creencias Post-Críticas (PCBS), desarrollada por Hutsebaut et al (1996,1997), es un instrumento válido en el estudio de la religiosidad y espiritualidad de las pacientes con cáncer de seno en Colombia. En segundo lugar, se quiso comprobar la estructura bi-factorial de la escala. Se encontró validez convergente entre los constructos evaluados tanto del SBI-15R (System of Belief Inventory) como del BMMRS (Multidimensional Measure of Religiosity and Spirituality) con el primer factor de la PCBS (Inclusión vs. Exclusión), y por otro lado, las correlaciones entre el segundo factor de la PCBS (Literal vs. Simbólico) y los dos instrumentos mencionados anteriormente, evidenciando validez divergente. Finalmente, los datos de las pacientes no se ajustaron al modelo bi-factorial de la PCBS.The aim of this research was to evaluate if the Post Critical Belief Scale (PCBS), developed by Hutsbaut et al (1996, 1997) is a valid instrument in the study of religiosity and spirituality in breast cancer patients in Colombia. The results showed an adequate convergent and diverget validity, when compared with the other two instruments used (SBI-15 TR, System of Belief Inventory and some items of the BMMRS, Brief Multidimensional Measurement of Religiousness/Spirituality). On the other hand the scores obtained in the CFA were not the expected, and three factors were extracted instead of two

Legislative Documents

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