366 research outputs found
Utopia e progn?stico na hist?ria do Brasil imaginada por Joaquim Fel?cio dos Santos (1860-1873).
Programa de P?s-Gradua??o em Hist?ria. Departamento de Hist?ria, Instituto de Ci?ncias Humanas e Sociais, Universidade Federal de Ouro Preto.Esta disserta??o se desenvolveu a partir da an?lise do jornal O Jequitinhonha, que circulava em Diamantina-MG entre 1860-1873, e de seu principal colaborador e dono, Joaquim Fel?cio dos Santos. Utilizamos as publica??es dos anos de 1862 e de 1868 a 1873, per?odos nos quais foram publicados os folhetins: A Hist?ria do Bra-sil, escrita pelo Dr. Jeremias no ano de 2862 (1862) e P?ginas da Hist?ria do Bra-sil, escrita no ano de 2000 (1868-1873). As obras s?o proje??es sobre o futuro do Brasil nos anos 2000 e s?o analisadas em conjunto com duas outras obras de Fel?cio dos Santos: Mem?rias do Distrito Diamantino da Comarca do Serro Frio (1861-1862) e Acayaca: romance ind?gena (1862-1863). Al?m de realizar uma cronologia da vida de Fel?cio dos Santos e d?O Jequitinhonha, utilizamos basicamente duas categorias anal?ticas. A primeira envolve a forma??o do historiador oitocentista, empregando o conceito de historiador erudito e antiqu?rio para expressar as mu-dan?as ocorridas na segunda metade do s?culo XIX. Focamos em uma hist?ria es-crita fora do IHGB e como esta influenciou a escrita de uma hist?ria nacional. Na segunda categoria, utilizamos os conceitos trabalhados por Hans Gumbrecht sobre como o cron?topo tempo hist?rico, Stimmung e efeitos de presen?a ajudam a pensar o futuro criado por Fel?cio dos Santos, juntamente com o modelo de estratifica??es temporais de Reinhart Koselleck que temporaliza o futuro; definindo o car?ter ut?-pico ou progn?stico de determinados textos. Junto a esta an?lise utilizamos a no??o de responsabilidade da escrita da Hist?ria desenvolvida por Hayden White.This dissertation was developed from the analysis of the newspaper O Jequitin-honha, that circulated in Diamantina-MG between 1860-1873, and its main collab-orator and owner, Joaquim Fel?cio dos Santos. We use as publications from the years 1862 and 1868 to 1873 the periods in which the tracts were published: The History of Brazil, written by Dr. Jeremiah in the year 2862 (1862) and Pages of the History of Brazil, written in the year of 2000 (1868-1873). The works are projec-tions about the future of Brazil in the 2000s and are analyzed together with two other works by Fel?cio dos Santos: Memories of the Diamantino District of Serro Frio (1861-1862) and Acayaca: indigenous romance (1862-1863). In addition to performing a chronology of the life of Fel?cio dos Santos and Jequitinhonha, we basically use two analytical categories. The first involves a formation of the nine-teenth-century historian, employing the concept of an erudite historian and anti-quarian to ex-press as the media in the second half of the nineteenth century. We also focused on a story written for IHGB and how it influenced a writing of a na-tional history. In the second category, we use the concepts worked by Hans Gum-brecht, on how the historical time chronotope, Stimmung and reality effects help to think the future created by Fel?cio dos Santos, together with the time stratification model of Reinhart Koselleck The future Defining the utopian character or prognosis of textual adjustment. Together with this analysis he uses a notion of responsibility for the writing of History developed by Hayden White
Liver and Muscle in Morbid Obesity: The Interplay of Fatty Liver and Insulin Resistance
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) can be seen as a manifestation of overnutrition. The muscle is a central player in the adaptation to energy overload, and there is an association between fatty-muscle and -liver. We aimed to correlate muscle morphology, mitochondrial function and insulin signaling with NAFLD severity in morbid obese patients. METHODS: Liver and deltoid muscle biopsies were collected during bariatric surgery in NAFLD patients. NAFLD Activity Score and Younossi's classification for nonalcoholic steatohepatitis (NASH) were applied to liver histology. Muscle evaluation included morphology studies, respiratory chain complex I to IV enzyme assays, and analysis of the insulin signaling cascade. A healthy lean control group was included for muscle morphology and mitochondrial function analyses. RESULTS: Fifty one NAFLD patients were included of whom 43% had NASH. Intramyocellular lipids (IMCL) were associated with the presence of NASH (OR 12.5, p<0.001), progressive hepatic inflammation (p = 0.029) and fibrosis severity (p = 0.010). There was a trend to an association between IMCL and decreased Akt phosphorylation (p = 0.059), despite no association with insulin resistance. In turn, hepatic steatosis (p = 0.015) and inflammation (p = 0.013) were associated with decreased Akt phosphoryation. Citrate synthase activity was lower in obese patients (p = 0.047) whereas complex I (p = 0.040) and III (p = 0.036) activities were higher, compared with controls. Finally, in obese patients, complex I activity increased with progressive steatosis (p = 0.049) and with a trend with fibrosis severity (p = 0.056). CONCLUSIONS: In morbid obese patients, presence of IMCL associates with NASH and advanced fibrosis. Muscle mitochondrial dysfunction does not appear to be a major driving force contributing to muscle fat accumulation, insulin resistance or liver disease. Importantly, insulin resistance in muscle might occur at a late point in the insulin signaling cascade and be associated with IMCL and NAFLD severity
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
The Lysosome and Intracellular Signalling.
In addition to being the terminal degradative compartment of the cell's endocytic and autophagic pathways, the lysosome is a multifunctional signalling hub integrating the cell's response to nutrient status and growth factor/hormone signalling. The cytosolic surface of the limiting membrane of the lysosome is the site of activation of the multiprotein complex mammalian target of rapamycin complex 1 (mTORC1), which phosphorylates numerous cell growth-related substrates, including transcription factor EB (TFEB). Under conditions in which mTORC1 is inhibited including starvation, TFEB becomes dephosphorylated and translocates to the nucleus where it functions as a master regulator of lysosome biogenesis. The signalling role of lysosomes is not limited to this pathway. They act as an intracellular Ca2+ store, which can release Ca2+ into the cytosol for both local effects on membrane fusion and pleiotropic effects within the cell. The relationship and crosstalk between the lysosomal and endoplasmic reticulum (ER) Ca2+ stores play a role in shaping intracellular Ca2+ signalling. Lysosomes also perform other signalling functions, which are discussed. Current views of the lysosomal compartment recognize its dynamic nature. It includes endolysosomes, autolysosome and storage lysosomes that are constantly engaged in fusion/fission events and lysosome regeneration. How signalling is affected by individual lysosomal organelles being at different stages of these processes and/or at different sites within the cell is poorly understood, but is discussed
Precision measurement of violation in the penguin-mediated decay
A flavor-tagged time-dependent angular analysis of the decay
is performed using collision data collected
by the LHCb experiment at % at TeV, the center-of-mass energy of
13 TeV, corresponding to an integrated luminosity of 6 fb^{-1}. The
-violating phase and direct -violation parameter are measured
to be rad and
, respectively, assuming the same values
for all polarization states of the system. In these results, the
first uncertainties are statistical and the second systematic. These parameters
are also determined separately for each polarization state, showing no evidence
for polarization dependence. The results are combined with previous LHCb
measurements using collisions at center-of-mass energies of 7 and 8 TeV,
yielding rad and . This is the most precise study of time-dependent violation
in a penguin-dominated meson decay. The results are consistent with
symmetry and with the Standard Model predictions.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2023-001.html (LHCb
public pages
Test of lepton universality in decays
The first simultaneous test of muon-electron universality using
and decays is performed, in two ranges of the dilepton
invariant-mass squared, . The analysis uses beauty mesons produced in
proton-proton collisions collected with the LHCb detector between 2011 and
2018, corresponding to an integrated luminosity of 9 . Each
of the four lepton universality measurements reported is either the first in
the given interval or supersedes previous LHCb measurements. The
results are compatible with the predictions of the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-046.html (LHCb
public pages
Observation of a resonant structure near the threshold in the decay
An amplitude analysis of the decay is carried out to
study for the first time its intermediate resonant contributions, using
proton-proton collision data collected with the LHCb detector at centre-of-mass
energies of 7, 8 and 13 TeV. A near-threshold peaking structure, referred to as
, is observed in the invariant-mass spectrum with
significance greater than 12 standard deviations. The mass, width and the
quantum numbers of the structure are measured to be MeV,
MeV and , respectively, where the first
uncertainties are statistical and the second systematic. The properties of the
new structure are consistent with recent theoretical predictions for a state
composed of quarks. Evidence for an additional structure is
found around 4140 MeV in the invariant mass, which might be
caused either by a new resonance with the assignment or by a coupled-channel effect.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-018.html (LHCb
public pages
Measurement of the differential branching fraction
The branching fraction of the rare decay is measured for the first time, in the squared dimuon mass
intervals, , excluding the and regions. The data
sample analyzed was collected by the LHCb experiment at center-of-mass energies
of 7, 8, and 13 TeV, corresponding to a total integrated luminosity of $9\
\mathrm{fb}^{-1}q^{2}q^{2} >15.0\
\mathrm{GeV}^2/c^4$, where theoretical predictions have the smallest model
dependence, agrees with the predictions.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-050.html (LHCb
public pages
- …