Nonoperative Management Of Splenic Injury Grade Iv Is Safe Using Rigid Protocol [tratamento Não Operatório De Lesão Esplênica Grau Iv é Seguro Usando-se Rígido Protocolo]

Objective: To demonstrate the protocol and experience of our service in the nonoperative management (NOM) of grade IV blunt splenic injuries. Methods: This is a retrospective study based on trauma registry of a university hospital between 1990-2010. Charts of all patients with splenic injury were reviewed and patients with grade IV lesions treated nonoperatively were included in the study. Results: ninety-four patients with grade IV blunt splenic injury were admitted during this period. Twenty-six (27.6%) met the inclusion criteria for NOM. The average systolic blood pressure on admission was 113.07 ± 22.22 mmHg, RTS 7.66 ± 0.49 and ISS 18.34 ± 3.90. Ten patients (38.5%) required blood transfusion, with a mean of 1.92 ± 1.77 packed red cells per patient. Associated abdominal injuries were present in two patients (7.7%). NOM failed in two patients (7.7%), operated on due to worsening of abdominal pain and hypovolemic shock. No patient developed complications related to the spleen and there were no deaths in this series. Average length of hospital stay was 7.12 ± 1.98 days. Conclusion: Nonoperative treatment of grade IV splenic injuries in blunt abdominal trauma is safe when a rigid protocol is followed.404323328Raza, M., Abbas, Y., Devi, V., Prasad, K.V., Rizk, K.N., Nair, P.P., Non operative management of abdominal trauma-a 10 years review (2013) World J Emerg Surg., 8 (1), p. 14. , [online] Acessado em 05/04/2013Moore, E.E., Cogbill, T.H., Jurkovich, G.J., Shackford, S.R., Malangoni, M.A., Champion, H.R., Organ injury scaling: Spleen and liver (1994 revision) (1995) J Trauma, 38, p. 323Jeremitsky, E., Smith, R.S., Ong, A.W., Starting the clock: Defining nonoperative management of blunt splenic injury by time (2013) Am J Surg., 205 (3), pp. 298-301Lippert, S.J., Hartin Jr., C.W., Ozgediz, P.L., Glick, P.L., Caty, M.G., Flynn, W.J., Splenic conservation: Variation between pediatric and adut trauma centers (2013) J Surg Res., 182 (1), pp. 17-20Stassen, N.A., Bhullar, I., Cheng, J.D., Crandall, M.L., Friese, R.S., Guillamondegui, O.D., Selective nonoperative management of blunt splenic injury: An Eastern Association for the Surgery of Trauma practice management guideline (2012) J Trauma Acute Care Surg., 73 (5 SUPPL. 4), pp. S294-S300Starling, S.V., Rodrigues, J.M.S., Reis, M.C.W., Trauma contuso do baço: Quando operar? (2011) Atualidades em Clínica Cirúrgica-Intergastro e Trauma, pp. 29-51. , In: Fraga GP, Sevá-Pereira G, Lopes LR, Editora Atheneu, São Paulo, 2011Carvalho, F.H., Romeiro, P.C., Collaço, I.A., Baretta, G.A., Freitas, A.C., Matias, J.E., Prognostics factors related to non surgical treatment failure of splenic injuries in the abdominal blunt trauma (2009) Rev Col Bras Cir., 36 (2), pp. 123-130Olthof, D.C., Joosse, P., Van Der Vlies, C.H., De Haan, R.J., Goslings, J.C., Prognostic factors for failure of nonoperative management in adults with blunt splenic injury: A systematic review (2013) J Trauma Acute Care Surg., 74 (2), pp. 546-557Bhullar, I.S., Frykberg, E.R., Siragusa, D., Chesire, D., Paul, J., Tepas III, J.J., Age does not affect outcomes of nonperative management of blunt splenic trauma (2012) J Am Coll Surg., 214 (6), pp. 958-964Galvan, D.A., Peitzman, A.B., Failure of nonoperative management of abdominal solid organ injuries (2006) Curr Opin Crit Care., 12 (6), pp. 590-594Mantovani, M., Mauro, J.F., Fraga, G.P., Meirelles, G.V., Trauma abdominal fechado: Tratamento não-operatório das lesões esplênicas (2002) Rev Para Med., 16 (2), pp. 46-51Zarzaur, B.L., Kozar, R.A., Fabian, T.C., Coimbra, R., A survey of American Association for the Surgery of Trauma member practices in the management of blunt splenic injury (2011) J Trauma., 70 (5), pp. 1026-1031Bhullar, I.S., Frykberg, E.R., Tepas III, J.J., Siragusa, D., Loper, T., Kerwin, A.J., At first blush: Absence of computed tomography contrast extravasation in grade IV or V adult blunt splenic trauma should not preclude angioembolization (2013) J Trauma Acute Care Surg., 74 (1), pp. 105-111Meguid, A.A., Bair, H.A., Howells, G.A., Bendick, P.J., Kerr, H.H., Villalba, M.R., Prospective evaluation of criteria for the nonoperative management of blunt splenic trauma (2003) Am Surg., 69, pp. 238-243Peitzman, A.B., Heil, B., Rivera, L., Federle, M.B., Harbrecht, B.G., Clancy, K.D., Blunt splenic injury in adults: Multi-institutional study of the Eastern Association for the surgery of trauma (2000) J Trauma., 49, pp. 177-189Pearl, R.H., Wesson, D.E., Spence, L.J., Filler, R.M., Ein, S.H., Shandling, B., Splenic injury: A 5-year update with improved results and changing criteria for conservative management (1989) J Pediatr Surg., 24, pp. 428-431Albrecht, R.M., Schermer, C.R., Morris, A., Nonoperative management of blunt splenic injuries: Factors influencing success in age > 55 years (2002) Am Surg., 68, pp. 227-231Cocanour, C.S., Moore, F.A., Ware, D.N., Marvin, R.G., Duke, J.H., Age should not be a consideration for nonoperative management of blunt splenic injury (2000) J Trauma., 48, pp. 606-612Tsugawa, K., Koyanagi, N., Hashizume, M., Ayukawa, K., Wada, H., Tomikawai, M., New insight for management of blunt splenic trauma: Significant differences between young and elderly (2002) Hepato-gastroenterology., 49, pp. 1144-1149Krause, K.R., Howells, G.A., Bair, H.A., Glover, J.L., Madrazo, B.L., Wasvary, H.J., Nonoperative management of blunt splenic injury in adults 55 years and older: A twenty-year experience (2000) Am Surg., 66, pp. 636-640Harbrecht, B.G., Peitzman, A.B., Rivera, L., Heil, B., Croce, M., Morris Jr., J.A., Contribution of age and gender to outcome of blunt splenic injury in adults: Multicenter study of the eastern association for the surgery of trauma (2001) J Trauma., 51, pp. 887-895Willmann, J.K., Roos, J.E., Platz, A., Pfammatter, T., Hilfiker, P.R., Marincek, B., Multidetector CT: Detection of active hemorrhage in patients with blunt abdominal trauma (2002) AJR., 179 (2), pp. 437-444Malangoni, M.A., Cué, J.I., Fallat, M.E., Willing, S.J., Richardson, J.D., Evaluation of splenic injury by computed tomography and its impact on treatment (1990) Ann Surg., 211, pp. 592-599Mirvis, S.E., Whitley, N.O., Gens, D.R., Blunt splenic trauma in adults: CTbased classification and correlation with prognosis and treatment (1989) Radiology., 171, pp. 33-39Skattum, J., Titze, T.L., Dormagen, J.B., Aaberge, I.S., Bechensteen, A.G., Gaarder, P.I., Preserved splenic function after angioembolisation of high grade injury (2012) Injury., 43, pp. 62-66Pachter, H.L., Guth, A.A., Hofstetter, S.R., Spencer, F.C., Changing patterns in the management of splenic trauma: The impact of nonoperative management (1998) Ann Surg., 227, pp. 708-719Powell, M., Courcoulas, A., Gardner, M., Lynch, J., Harbrecht, B.G., Udekwu, A.O., Management of blunt splenic trauma: Significant differences between adults and children (1997) Surgery, 122, pp. 654-660Hunt, J.P., Lentz, C.W., Cairns, B.A., Ramadan, F.M., Smith, D.L., Rutledge, R., Management and outcome of splenic injury: The results of a five-year statewide population-based study (1996) Am. Surg., 62, pp. 911-917Velmahos, G.C., Zacharias, N., Emhoff, T.A., Feeney, J.M., Hurst, J.M., Crookes, B.A., Management of the most severely injured spleen: A multicenter study of the Research Consortium of New England Centers for Trauma (ReCONECT) (2010) Arch Surg., 145 (5), pp. 456-460Branco, B.C., Tang, A.L., Rhee, P., Fraga, G.P., Nascimento, B., Rizoli, S., O'Keeffe, T., Selective Nonoperative Management of High Grade Splenic Trauma (2013) Rev Col Bras Cir, 40 (3), pp. 246-25

The Starburst-AGN connection: The role of stellar clusters in AGNs

Nuclear stellar clusters are a common phenomenon in spirals and in starbursts galaxies, and they may be a natural consequence of the star formation processes in the central regions of galaxies. HST UV imaging of a few Seyfert 2 galaxies have resolved nuclear starbursts in Seyfert 2 revealing stellar clusters as the main building blocks of the extended emission. However, we do not know whether stellar clusters are always associated with all types of nuclear activity. We present NUV and optical images provided by HST to find out the role that stellar clusters play in different types of AGNs (Seyferts and LLAGNs). Also with these images, we study the circumnuclear dust morphology as a probe of the circumnuclear environment of AGNs. Here we present a summary of the the first results obtained for the sample of Seyferts and LLAGN galaxies.Comment: Contribution to the conference proceedings "Space Astronomy: The UV window to the Universe", El Escorial (Spain), May 28-June 1 2007, submitted to Ap&SS, invited ed. Gomes de Castro, A.I. Further explanations are in Mu\~noz Marin, et al (2007) and Gonzalez Delgado et al (2007); and the full collection of figures are at the ULR: http://www.iaa.es/~rosa/research/LLAGNs2007/LLAGNs-HSTIma1.html http://www.iaa.es/~manuel/publications/paper01.htm

Development and evaluation of a de-identification procedure for a case register sourced from mental health electronic records

Background: Electronic health records (EHRs) provide enormous potential for health research but also present data governance challenges. Ensuring de-identification is a pre-requisite for use of EHR data without prior consent. The South London and Maudsley NHS Trust (SLaM), one of the largest secondary mental healthcare providers in Europe, has developed, from its EHRs, a de-identified psychiatric case register, the Clinical Record Interactive Search (CRIS), for secondary research. Methods: We describe development, implementation and evaluation of a bespoke de-identification algorithm used to create the register. It is designed to create dictionaries using patient identifiers (PIs) entered into dedicated source fields and then identify, match and mask them (with ZZZZZ) when they appear in medical texts. We deemed this approach would be effective, given high coverage of PI in the dedicated fields and the effectiveness of the masking combined with elements of a security model. We conducted two separate performance tests i) to test performance of the algorithm in masking individual true PIs entered in dedicated fields and then found in text (using 500 patient notes) and ii) to compare the performance of the CRIS pattern matching algorithm with a machine learning algorithm, called the MITRE Identification Scrubber Toolkit – MIST (using 70 patient notes – 50 notes to train, 20 notes to test on). We also report any incidences of potential breaches, defined by occurrences of 3 or more true or apparent PIs in the same patient’s notes (and in an additional set of longitudinal notes for 50 patients); and we consider the possibility of inferring information despite de-identification. Results: True PIs were masked with 98.8% precision and 97.6% recall. As anticipated, potential PIs did appear, owing to misspellings entered within the EHRs. We found one potential breach. In a separate performance test, with a different set of notes, CRIS yielded 100% precision and 88.5% recall, while MIST yielded a 95.1% and 78.1%, respectively. We discuss how we overcome the realistic possibility – albeit of low probability – of potential breaches through implementation of the security model. Conclusion: CRIS is a de-identified psychiatric database sourced from EHRs, which protects patient anonymity and maximises data available for research. CRIS demonstrates the advantage of combining an effective de-identification algorithm with a carefully designed security model. The paper advances much needed discussion of EHR de-identification – particularly in relation to criteria to assess de-identification, and considering the contexts of de-identified research databases when assessing the risk of breaches of confidential patient information

Possible Unconventional Superconductivity In Substituted Bafe 2 As 2 Revealed By Magnetic Pair-breaking Studies

The possible existence of a sign-changing gap symmetry in BaFe 2 As 2 -derived superconductors (SC) has been an exciting topic of research in the last few years. To further investigate this subject we combine Electron Spin Resonance (ESR) and pressure-dependent transport measurements to investigate magnetic pair-breaking effects on BaFe 1.9 M 0.1 As 2 (M = Mn, Co, Cu, and Ni) single crystals. An ESR signal, indicative of the presence of localized magnetic moments, is observed only for M = Cu and Mn compounds, which display very low SC transition temperature (T c) and no SC, respectively. From the ESR analysis assuming the absence of bottleneck effects, the microscopic parameters are extracted to show that this reduction of T c cannot be accounted by the Abrikosov-Gorkov pair-breaking expression for a sign-preserving gap function. Our results reveal an unconventional spin- and pressure-dependent pair-breaking effect and impose strong constraints on the pairing symmetry of these materials.4Kamihara, Y., Watanabe, T., Hirano, M., Hosono, H., Iron-based layered superconductor La[O12xFx]FeAs (x 5 0. 05-0. 12) with Tc 5 26 K (2008) J. Am. Chem. Soc., 130, p. 3296Rotter, M., Spin density wave anomaly at 140 K in the ternary iron arsenide BaFe2As2 (2008) Phys. Rev. B, 78, pp. 020503RIshida, K., Nakai, Y., Hosono, H., To what extent iron-pnictide new superconductors have been clarified: A progress report (2009) J. Phys. Soc. Japan, 78, p. 062001Hirschfeld, P.J., Korshunov, M.M., Mazin, I.I., Gap symmetry and structure of Fe-based superconductors (2011) Rep. Prog. Phys., 74, p. 124508Chubukov, A.V., Pairing mechanism in fe-based superconductors (2012) Annu. Rev. Cond. Mat. Phys., 3, p. 57Bittar, E.M., Co-substitution effects on the fe valence in the BaFe2As2 superconducting compound: A study of hard x-ray absorption spectroscopy (2011) Phys. Rev. Lett., 107, p. 267402Granado, E., Pressure and chemical substitution effects in the local atomic structure of BaFe2As2 (2011) Phys. Rev. B, 83, p. 184508Wadati, H., Elfimov, I., Sawatzky, G.A., Where are the extra d electrons in transition-metal-substituted iron pnictides? (2010) Phys. Rev. Lett., 105, p. 157004Ideta, S., Dependence of carrier doping on the impurity potential in transition-metal-substituted feas-based superconductors (2013) Phys. Rev. Lett., 110, p. 107007Berlijn, T., Lin, C.-H., Garber, W., Ku, W., Do transition-metal substitutions dope carriers in iron-based superconductors? (2012) Phys. Rev. Lett., 108, p. 207003Hin, Z.P., Haule, K., Kotliar, G., Kinetic frustration and the nature of the magnetic and paramagnetic states in iron pnictides and iron chalcogenides (2011) Nature Materials, 10, pp. 932a-935aRosa, P.F.S., Evolution of Eu21 spin dynamics in Ba12xEuxFe2As2 (2012) Phys. Rev. B, 86, p. 165131Rosa, P.F.S., (2014) Site Specific Spin Dynamics in BaFe2As2: Tuning the Ground State by Orbital Differentiation, , arxiv:1402. 2001v01Garitezi, T.M., Transport critical current measurements on a Cu-substituted BaFe2As2 superconductor (2014) J. Appl. Phys., 115, pp. 17D704Rosa, P.F.S., Pressure effects on magnetic pair-breaking in Mn- and Eusubstituted BaFe2As2 (2014) J. Appl. Phys., 115, pp. 17D702Thaler, A., Physical and magnetic properties of Ba(Fe12xMnx) 2As2 single crystals (2011) Phys. Rev. B, 84, p. 144528Et Al., A., Pressure effects on the electron-doped high Tc superconductor BaFe22xCoxAs2 (2008) J Phys. Cond. Mat., 20, p. 472201Et Al., D., Pressure versus concentration tuning of the superconductivity in Ba(Fe12xCox) 2As2 (2010) J. Phys. Soc. Japan, 79, p. 124705Yamaichi, S., Katagiri, T., Sasagawa, T., Uniaxial pressure effects on the transport properties in Ba(Fe12xCox) 2As2 single crystals (2013) Physica C, 494, pp. 62-64Canfield, P.C., Budko, S.L., Ni, N., Yan, J.Q., Kracher, A., Decoupling of the superconducting and magnetic/structural phase transitions in electron-doped BaFe2As2 (2009) Phys. Rev. B, 80, pp. 060501RKirshenbaum, K., Saha, S.R., Ziemak, S., Drye, T., Paglione, J., Universal pairbreaking in transition metal-substituted iron-pnictide superconductors (2012) Phys. Rev. B, 86, pp. 140505ROnari, S., Kontani, H., Violation of Andersonaŝ Theorem for the Sign-Reversing s-Wave State of Iron-Pnictide Superconductors (2009) Phys. Rev. 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Surtos de enfermidades transmitidas por alimentos causados por Salmonella Enteritidis

OBJETIVO: São descritos surtos de salmonelose notificados no período de julho de 1993 a junho de 1997 na região Noroeste do Estado de São Paulo, Brasil, tendo em vista os vários surtos de veiculação alimentar ocasionados por Salmonella nessa região. MÉTODO: Foram obtidos 19 inquéritos epidemiológicos para análise de dados, 87 amostras de fezes e 38 amostras de alimentos, incluindo 12 de ovos para análise microbiológica. Cepas de Salmonella foram submetidas a sorotipagem, fagotipagem e teste de sensibilidade a 13 agentes antimicrobianos. RESULTADOS: Foram acometidas 906 pessoas com 295 hospitalizações. Cepas de Salmonella Enteritidis Fagotipo 4 foram isoladas de 80,5% das coproculturas, de todas amostras de alimentose de 41,7% dos ovos. Em 22 (95,7%) surtos os a salmonela foi veiculada por alimentos contendo ovos crus ou semicrus. Os testes de sensibilidade a antimicrobianos revelaram sensibilidade à maioria das cepas. CONCLUSÕES: Considerando os resultados obtidos, torna-se necessária a implantação e intensificação de medidas de controle na produção e armazenamento dos ovos, além da orientação à população quanto aos riscos no consumo inadequado desse alimento.OBJECTIVE: It is to describe outbreaks of salmonellosis reported from July 1993 through June 1997 in the Northwest region of S. Paulo State, Brazil, one of the areas where several foodborne outbreaks of salmonellosis have been recently detected. METHOD: Data of 19 epidemiological investigations were analysed; 87 stool specimens and 38 food samples (including 12 of shell eggs) were processed for microbiological analysis. Salmonella strains were identified by serotyping, phagetyping and antimicrobial susceptibility testing. RESULTS: There were 906 ill persons including 295 hospitalized patients. Phage type 4 (PT 4) Salmonella Enteritidis strains were isolated from 80.5% of stool samples, from all food samples and from 41.7% of eggs. Of the outbreaks, 95.7% were associated with the consumption of food containing raw or undercooked eggs. All strains were susceptible to the 13 antimicrobials, except the strains from the nosocomial outbreak. CONCLUSIONS: The results obtained show the need for the implementation of control measures regarding egg procdution and storage, as well as for guidance to the public as to the risks involved in the consumption of inadequately prepared eggs

The Fueling and Evolution of AGN: Internal and External Triggers

In this chapter, I review the fueling and evolution of active galactic nuclei (AGN) under the influence of internal and external triggers, namely intrinsic properties of host galaxies (morphological or Hubble type, color, presence of bars and other non-axisymmetric features, etc) and external factors such as environment and interactions. The most daunting challenge in fueling AGN is arguably the angular momentum problem as even matter located at a radius of a few hundred pc must lose more than 99.99 % of its specific angular momentum before it is fit for consumption by a BH. I review mass accretion rates, angular momentum requirements, the effectiveness of different fueling mechanisms, and the growth and mass density of black BHs at different epochs. I discuss connections between the nuclear and larger-scale properties of AGN, both locally and at intermediate redshifts, outlining some recent results from the GEMS and GOODS HST surveys.Comment: Invited Review Chapter to appear in LNP Volume on "AGN Physics on All Scales", Chapter 6, in press. 40 pages, 12 figures. Typo in Eq 5 correcte

Cardiovascular safety of celecoxib in acute myocardial infarction patients: a nested case-control study

The objective was to measure the impact of exposure to coxibs and non-steroidal antiinflammatory drugs (NSAID) on morbidity and mortality in older patients with acute myocardial infarction (AMI). A nested case-control study was carried out using an exhaustive population-based cohort of patients aged 66 years and older living in Quebec (Canada) who survived a hospitalization for AMI (ICD-9 410) between 1999 and 2002. The main variables were all-cause and cardiovascular (CV) death, subsequent hospital admission for AMI, and a composite end-point including recurrent AMI or CV death. Conditional logistic regressions were used to estimate the risk of mortality and morbidity. A total of 19,823 patients aged 66 years and older survived hospitalization for AMI in the province of Quebec between 1999 and 2002. After controlling for covariables, the risk of subsequent AMI and the risk of composite end-point were increased by the use of rofecoxib. The risk of subsequent AMI was particularly high for new rofecoxib users (HR 2.47, 95% CI 1.57–3.89). No increased risk was observed for celecoxib users. No increased risk of CV death was observed for patients exposed to coxibs or NSAIDs. Patients newly exposed to NSAIDs were at an increased risk of death (HR 2.22, 95% CI 1.30–3.77) and of composite end-point (HR 2.28, 95% CI 1.35–3.84). Users of rofecoxib and NSAIDs, but not celecoxib, were at an increased risk of recurrent AMI and of composite end-point. Surprisingly, no increased risk of CV death was observed. Further studies are needed to better understand these apparently contradictory results

Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}=2.76 TeV

The elliptic, $v_2$, triangular, $v_3$, and quadrangular, $v_4$, azimuthal anisotropic flow coefficients are measured for unidentified charged particles, pions and (anti-)protons in Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV with the ALICE detector at the Large Hadron Collider. Results obtained with the event plane and four-particle cumulant methods are reported for the pseudo-rapidity range $|\eta|<0.8$ at different collision centralities and as a function of transverse momentum, $p_{\rm T}$, out to $p_{\rm T}=20$ GeV/$c$. The observed non-zero elliptic and triangular flow depends only weakly on transverse momentum for $p_{\rm T}>8$ GeV/$c$. The small $p_{\rm T}$ dependence of the difference between elliptic flow results obtained from the event plane and four-particle cumulant methods suggests a common origin of flow fluctuations up to $p_{\rm T}=8$ GeV/$c$. The magnitude of the (anti-)proton elliptic and triangular flow is larger than that of pions out to at least $p_{\rm T}=8$ GeV/$c$ indicating that the particle type dependence persists out to high $p_{\rm T}$.Comment: 16 pages, 5 captioned figures, authors from page 11, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186

Centrality dependence of charged particle production at large transverse momentum in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm{NN}}} = 2.76 TeV

The inclusive transverse momentum ($p_{\rm T}$) distributions of primary charged particles are measured in the pseudo-rapidity range $|\eta|<0.8$ as a function of event centrality in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}=2.76$ TeV with ALICE at the LHC. The data are presented in the $p_{\rm T}$ range $0.15<p_{\rm T}<50$ GeV/$c$ for nine centrality intervals from 70-80% to 0-5%. The Pb-Pb spectra are presented in terms of the nuclear modification factor $R_{\rm{AA}}$ using a pp reference spectrum measured at the same collision energy. We observe that the suppression of high-$p_{\rm T}$ particles strongly depends on event centrality. In central collisions (0-5%) the yield is most suppressed with $R_{\rm{AA}}\approx0.13$ at $p_{\rm T}=6$-7 GeV/$c$. Above $p_{\rm T}=7$ GeV/$c$, there is a significant rise in the nuclear modification factor, which reaches $R_{\rm{AA}} \approx0.4$ for $p_{\rm T}>30$ GeV/$c$. In peripheral collisions (70-80%), the suppression is weaker with $R_{\rm{AA}} \approx 0.7$ almost independently of $p_{\rm T}$. The measured nuclear modification factors are compared to other measurements and model calculations.Comment: 17 pages, 4 captioned figures, 2 tables, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/284