USOS DE LAS ESPECIES DEL GÉNERO ASCLEPIAS L. (APOCYNACEAE, ASCLEPIADOIDEAE), INFORMACIÓN DEL HERBARIO NACIONAL DE MÉXICO, MEXU

Asclepias is an American genus of widegeographical distribution. Of the 68 species of Asclepias occurring in Mexico, 17have reported uses. This article focuseson 14 species used as medicinal plants bymany social groups, including indigenouscultures that possess a vast knowledge oftraditional medicine. The medicinal species contain alkaloids, flavonoids, tannins,and cardiac glycosides and have analgesic,dermatological, laxative, and respiratoryproperties. Some are also considered toxic.Besides their medicinal uses, Asclepiasspecies provide food, fodder, ornament,and fiber for textile production. The uses ofthese plants are summarized, emphasizingtheir medicinal properties as well as someof their pharmacological aspects. Most of the information was extracted from theMexican National Herbarium (MEXU),Mexican Ethnobotanical Plants Database(BADEPLAM), and thorough bibliographical research covering traditional medicine,phytochemistry, and pharmacology of themedicinal species of Asclepias.El género Asclepias es un género americanode amplia distribución en México con 68especies a lo largo del país, 17 de las cualestienen algún uso. De estas especies, 14 sonutilizadas como plantas medicinales porvarios grupos humanos, entre éstos, algunasetnias que poseen un vasto conocimientode medicina tradicional. Algunas de las especies usadas como medicinales contienenalcaloides, flavonoides, taninos y glicósidoscardiacos (cardenólidos). Las principalespropiedades medicinales que se atribuyenal género son analgésicas, dermatológicas,purgantes y contra infecciones respiratorias, aunque también hay algunas que sonconsideradas tóxicas. Además de sus usosmedicinales, las Asclepias se emplean enusos alimentarios, forrajeros, ornamentalesy textiles. Se hizo la revisión de los usos,dando énfasis a las especies con propiedadesmedicinales y se revisaron algunos de losaspectos farmacológicos de las mismas.La mayoría de la información procede delHerbario Nacional (MEXU), de la Base deDatos Etnobotánicos de Plantas Mexicanas(BADEPLAM) y de una amplia revisión bibliográfica sobre medicina tradicional,fitoquímica y farmacología de las especiesmedicinales de este géner

Intención de compra a granel de los Millennials en la ciudad de Córdoba

Trabajo final (Licenciatura en Administración con orientación en Comercialización) -- Universidad Nacional de Córdoba. Facultad de Ciencias Económicas, 2022.Fil: Buffa, Julieta. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Fernández, Camila Aylén. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Romero Brewer, María Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Vocos Mansilla, Clara. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Propósito: En el último tiempo el cuidado del medioambiente, sobre todo a la hora de consumir, ha cobrado gran importancia, y en este entorno se destaca la Generación Millennial, por lo que el propósito de esta investigación profesional es conocer cómo afectan diversas variables como “atributos ecológicos”, “valor de marca”, “calidad percibida” y sociodemográficas en su intención de realizar compras a granel. Metodología: Se llevó adelante una investigación cuantitativa. El universo estudiado se compone por jóvenes de entre 17 y 42 años de edad que están a cargo de las decisiones de compra del hogar y residen en la ciudad de Córdoba. Para la recolección de los datos se realizó un cuestionario administrado mediante Google Forms. A su vez se aplicó un muestreo no probabilístico por cuotas de edad, sexo y nivel socioeconómico. El análisis de los datos recolectados se realizó a través del software estadístico SPSS, utilizando regresiones lineales, tablas cruzadas y clústers. Conclusiones: Las variables “valor de marca” y “atributos ecológicos” afectan e influyen de manera positiva y directa en la “intención de compra”. El “valor de marca” es la variable de mayor influencia, mientras que las demás presentan un menor valor. Sin embargo, esta relación es débil entendiendo que no son las únicas que determinan su poder de influencia en la “intención de compra” a granel. Por otro lado, según estas variables juntas con el sexo y nivel socioeconómico, la muestra seleccionada se encuentra conformada por tres perfiles de consumidores: Involucrados, Indiferentes e Interesados. Limitaciones: La principal limitación que se encontró a la hora de realizar esta investigación fue el no estudiar las posibles correlaciones entre las variables, por lo que se podría perder información relevante en cuanto a la conformación de la “intención de compra”. Es por ello que se recomienda completar el modelo propuesto con nuevas variables. Originalidad-valor: El presente trabajo sirve como punto de partida para nuevas y más amplias investigaciones. También como base para emprendedores a granel y para aquellos que buscan instaurar Supermercados a granel dentro de la ciudad de Córdoba, ayudándolos a definir su mercado objetivo.Fil: Buffa, Julieta. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Fernández, Camila Aylén. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Romero Brewer, María Constanza. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina.Fil: Vocos Mansilla, Clara. Universidad Nacional de Córdoba. Facultad de Ciencias Económicas; Argentina

Lack of astrocytic glycogen alters synaptic plasticity but not seizure susceptibility

Brain glycogen is mainly stored in astrocytes. However, recent studies both in vitro and in vivo indicate that glycogen also plays important roles in neurons. By conditional deletion of glycogen synthase (GYS1), we previously developed a mouse model entirely devoid of glycogen in the central nervous system (GYS1Nestin-KO). These mice displayed altered electrophysiological properties in the hippocampus and increased susceptibility to kainate-induced seizures. To understand which of these functions are related to astrocytic glycogen, in the present study, we generated a mouse model in which glycogen synthesis is eliminated specifically in astrocytes (GYS1Gfap-KO). Electrophysiological recordings of awake behaving mice revealed alterations in input/output curves and impaired long-term potentiation, similar, but to a lesser extent, to those obtained with GYS1Nestin-KO mice. Surprisingly, GYS1Gfap-KO mice displayed no change in susceptibility to kainate-induced seizures as determined by fEPSP recordings and video monitoring. These results confirm the importance of astrocytic glycogen in synaptic plasticity

Lack of p62 Impairs Glycogen Aggregation and Exacerbates Pathology in a Mouse Model of Myoclonic Epilepsy of Lafora

Lafora disease (LD) is a fatal childhood-onset dementia characterized by the extensive accumulation of glycogen aggregates-the so-called Lafora Bodies (LBs)-in several organs. The accumulation of LBs in the brain underlies the neurological phenotype of the disease. LBs are composed of abnormal glycogen and various associated proteins, including p62, an autophagy adaptor that participates in the aggregation and clearance of misfolded proteins. To study the role of p62 in the formation of LBs and its participation in the pathology of LD, we generated a mouse model of the disease (malinKO) lacking p62. Deletion of p62 prevented LB accumulation in skeletal muscle and cardiac tissue. In the brain, the absence of p62 altered LB morphology and increased susceptibility to epilepsy. These results demonstrate that p62 participates in the formation of LBs and suggest that the sequestration of abnormal glycogen into LBs is a protective mechanism through which it reduces the deleterious consequences of its accumulation in the brain

Phylogenomics illuminates the backbone of the Myriapoda Tree of Life and reconciles morphological and molecular phylogenies

© The Author(s) 2017 This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The attached file is the published version of the article

Cosmological distance indicators

We review three distance measurement techniques beyond the local universe: (1) gravitational lens time delays, (2) baryon acoustic oscillation (BAO), and (3) HI intensity mapping. We describe the principles and theory behind each method, the ingredients needed for measuring such distances, the current observational results, and future prospects. Time delays from strongly lensed quasars currently provide constraints on $H_0$ with < 4% uncertainty, and with 1% within reach from ongoing surveys and efforts. Recent exciting discoveries of strongly lensed supernovae hold great promise for time-delay cosmography. BAO features have been detected in redshift surveys up to z <~ 0.8 with galaxies and z ~ 2 with Ly-$\alpha$ forest, providing precise distance measurements and $H_0$ with < 2% uncertainty in flat $\Lambda$CDM. Future BAO surveys will probe the distance scale with percent-level precision. HI intensity mapping has great potential to map BAO distances at z ~ 0.8 and beyond with precisions of a few percent. The next years ahead will be exciting as various cosmological probes reach 1% uncertainty in determining $H_0$, to assess the current tension in $H_0$ measurements that could indicate new physics.Comment: Review article accepted for publication in Space Science Reviews (Springer), 45 pages, 10 figures. Chapter of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Ag

The role of representatives of dominant shareholders with the sustainable development through corporate social responsibility matters

In this paper, we analyse the effect that directors representing controlling shareholders have on corporate social responsibility (CSR) matters since these investors are the core shareholders in civil law countries, given their high presence on boards. Thus, we analyse the effect of institutional directors on CSR disclosure, but also the impact of the classification of these directors between pressure-sensitive and pressure-resistant institutional directors, depending on if they maintain only an investment relationship with the firm or both an investment and commercial link, respectively. We hypothesise a quadratic relationship between institutional directors and CSR disclosure. We show a curvilinear relationship between institutional directors/pressure-resistant directors and CSR reporting, suggesting that these directors may play two opposite roles (monitoring or entrenchment with managers). However, pressure-sensitive directors do not affect CSR disclosure. These findings indicate that there is an association between board members and strategic decisions. Moreover, our evidence shows that institutional directors do not act in an identical way. Finally, the enhancement of corporate governance depends on the proportion of institutional and pressureresistant directors on boards

Microsimulation and Policy Analysis

We provide an overview of microsimulation approaches for assessing the effects of policy on income distribution. We focus on the role of tax-benefit policies and review the concept of microsimulation and how it contributes to the analysis of income distribution in general and policy evaluation in particular. We consider the main challenges and limitations of this approach and discuss directions for future developments