10 research outputs found
Inhibition of plastid PPase and NTT leads to major changes in starch and tuber formation in potato
- Author
- Alisdair R Fernie
- Amir
- Andersson
- Andersson
- Ann-Sofie Fält
- Arrivault
- Arrivault
- Baba
- Bahaji
- Baroja-Fernández
- Barratt
- Denyer
- Denyer
- Emes
- Farré
- Farré
- Fusari
- Geigenberger
- Geigenberger
- Geigenberger
- Geigenberger
- George
- Gill
- Gross
- Gómez-García
- Heldt
- Helle Turesson
- Hofvander
- Hofvander
- Jammer
- Jelitto
- Kammerer
- Karimi
- Keeling
- Kopka
- Kornberg
- Kuipers
- Lahti
- Lara-Nunez
- Larsson
- Lisec
- Lloyd
- Luedemann
- Lunn
- Mariette Andersson
- Möhlmann
- Müller-Röber
- Neuhaus
- Osorio
- Per Hofvander
- Perez-Castineira
- Price
- Riewe
- Romanov
- Schulze
- Schunemann
- Serrano-Bueno
- Smith
- Smith
- Sonnewald
- Sowokinos
- Stéphanie Arrivault
- Sullivan
- Tauberger
- Tjaden
- Trentmann
- Wang
- Weigelt
- Weiner
- Youjun Zhang
- Zeeman
- Zhang
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Application of Flow Diagnostics to Rapid Production Data Integration in Complex Grids and Dual-Permeability Models
- Author
- Aanonsen
- Aanonsen
- Al Harbi
- Al-Huthali
- Al-Ramadan
- Amir Salehi
- Barenblatt
- Bhark
- Chen
- Chen
- Chen
- Cheng
- Cheng
- Cheng
- Christie
- Datta-Gupta
- Datta-Gupta
- David Castineira
- Di Donato
- Emerick
- Evensen
- Farshbaf Zinati
- Fernández-Martínez
- Feyi Olalotiti-Lawal
- Foresee
- Gil Hetz
- Hajizadeh
- Harris
- He
- He
- Ibrahima
- Jenny
- Kang
- Kazemi
- Landa
- Lantz
- Li
- Li
- Lie
- Luo
- Ma
- Mallison
- Matringe
- Mirzabozorg
- Mohamed
- Møyner
- Møyner
- Møyner
- Narr
- Natvig
- Olalotiti-Lawal
- Olalotiti-Lawal
- Oliver
- Oyerinde
- Paige
- Pan
- Parker
- Peters
- Pollock
- Prevost
- Romero
- Santoshini
- Schlumberger
- Shahvali
- Spooner
- Stenerud
- Stenerud
- Tanaka
- Tarantola
- Vasco
- Vasco
- Warren
- Wender
- Willhite
- Williams
- Wu
- Yin
- Zhang
- Zuo
- Publication venue
- 'Society of Petroleum Engineers (SPE)'
- Publication date
- Field of study
Meta-analysis: implications of interleukin-28B polymorphisms in spontaneous and treatment-related clearance for patients with hepatitis C
- Author
- A Aghemo
- A Amanzada
- A Mangia
- A Mangia
- A Moghaddam
- A Tobias
- AD Oxman
- AF Stattermayer
- AJ Sutton
- AJ Thompson
- Amanda Fernández-Rodríguez
- BA Payer
- BL Pearlman
- C Hadigan
- CD Howell
- CF Huang
- CH Liu
- CM Lange
- CS Hsu
- CS Hsu
- D Ge
- D Moher
- DH Sinn
- DL Thomas
- E Aparicio
- E Ogawa
- FE Lotrich
- G Fattovich
- H Miyaaki
- H Ochi
- H Saito
- HY Rao
- I Sporea
- I Tolmane
- J Copas
- J Fischer
- J Grebely
- J Medrano
- J Nattermann
- J Nattermann
- J Schreiber
- JA Holmes
- JA Mira
- JA Sterne
- JM Darling
- JM Ladero
- JR Vidal-Castineira
- JY Chen
- K Chayama
- K Hayashi
- K Lyoo
- K Onomoto
- K Patel
- KE Sherman
- KQ Shi
- KR Smith
- L Valenti
- LB Jorde
- LN Cavalcante
- M Inokuchi
- M Karchava
- M Kobayashi
- M Kurosaki
- M Lindh
- M Lindh
- M Romero-Gomez
- M Tajir
- M Takita
- M Venegas
- MA Montes-Cano
- María A Jiménez-Sousa
- María Guzmán-Fulgencio
- MC Renda
- MG Ghany
- ML Yu
- MM Dring
- MT Dill
- Mónica García-Álvarez
- N Akuta
- N Akuta
- N Mantel
- N Sakamoto
- NH Afdhal
- NI Rallon
- P Halfon
- PB Christensen
- PJ Clark
- PM de Rueda
- R DerSimonian
- R Jackson
- RF Galbraith
- RM Harbord
- RV Rohlfs
- S Chevaliez
- S De Nicola
- S Knapp
- S Li
- S Miyase
- S Petta
- Salvador Resino
- SR Kim
- T Asselah
- T Marcello
- T Miyamura
- TR O'Brien
- V Di Marco
- V Soriano
- V Suppiah
- V Suppiah
- W Li
- X Guo
- Y Chen
- Y Tanaka
- ZM Younossi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
BACKGROUND: Since 2009, several studies have identified single-nucleotide polymorphisms (SNPs) near the gene encoding for interleukin (IL)-28 (IL28B) that are strongly associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Because this large amount of data includes some inconsistencies, we consider assessment of the global estimate for each SNP to be essential. METHODS: Relevant studies assessing IL28B polymorphisms associated with sustained virologic response (SVR) and spontaneous clearance (SC) were identified from a literature search of PubMed up to 9 July, 2012. Studies were eligible studies if they included patients infected with HCV or HCV/HIV, or assessed any SNP located within or near the IL28B gene, SVR data available under standard treatment, and/or SC data in patients with acute HCV infection. Pooled odds ratios were estimated by fixed or random effects models when appropriate. Variables such as HCV genotype, ethnicity, and type of co-infection were studied. RESULTS: Of 282 screened studies, 67 were selected for SVR and 10 for SC. In total, 20,163 patients were studied for SVR and 3,554 for SC. For SVR, we found that all SNPs showed strong associations in patients with HCV genotypes 1 and 4, whereas the pooled ORs were almost three times lower for genotypes 2 and 3 (rs12979860 and rs8099917). Regarding ethnicity, the SNP most associated with SVR was rs12979860 in white patients, whereas in East Asians it seemed to be rs8099917. The most studied SNP (rs12979860) showed similar results for patients co-infected with HCV/HIV, as for those infected with HCV only. Finally, rs12979860 and rs8099917 both appeared to be associated with SC. CONCLUSIONS: IL28B polymorphisms influence both the outcome of interferon treatment and the natural clearance of HCV. However we did not identify a universal predictor SNP, as the best genetic markers differed depending on patient ethnicity, genotype, and type of infection. Nevertheless, our results may be useful for more precise treatment decision-making
Multi-Omics Approaches in Immunological Research
- Author
- Aden
- Aguilar
- Aguirre-Gamboa
- Aguirre-Gamboa
- Akhmedov
- Al Bander
- Ananthakrishnan
- Anderson
- Astle
- Atkinson
- Baccarelli
- Bakker
- Bar
- Barba
- Barski
- Beagrie
- Bernardes
- Bonder
- Bonnardel
- Bouhaddani
- Breuer
- Browaeys
- Bulik-Sullivan
- Buniello
- Burren
- Cairns
- Carrier
- Chan
- Chen
- Chen
- Chen
- Cheung
- Chong
- Chu
- Chua
- Conesa
- Consortium
- Corridoni
- Cortes
- Cullen
- Das
- Davis
- Deelen
- Delaneau
- Delhalle
- Dettmer
- Donovan
- Dorrestein
- Eckhardt
- Efremova
- Emdin
- Eraslan
- Erhard
- Erkelens
- Ernst
- Ernst
- Fernández-Ochoa
- Ferraro
- Fitzgibbon
- Franzosa
- Frølund
- Gamazon
- Gamazon
- Giambartolomei
- Gjoneska
- Gorrochategui
- Granja
- Greer
- Haque
- Hattori
- Hellwege
- Hemani
- Hernández-de-Diego
- Herzog
- Hu
- Huan
- Jaumot
- Ji
- Jiao
- Kapourani
- Karakike
- Katzenelenbogen
- Keating
- Kempfer
- Kiyoi
- Koch
- Kolmert
- Korsunsky
- Kriete
- Kumar
- Kundaje
- La Manno
- Langfelder
- Li
- Li
- Lister
- Liu
- Loftus
- Long
- Lund
- Mallik
- Marco
- Martin
- Martin
- Masser
- Maurano
- Mazzone
- McGowan
- McRae
- Meissner
- Meyer
- Miller
- Min
- Mirza
- Morrow
- Nagano
- Nakaya
- Nath
- Netea
- Netea
- Osterholm
- Pairo-Castineira
- Pal
- Park
- Pe’er
- Picelli
- Pidsley
- Qiu
- Ramos-Rodríguez
- Reyes
- Rosa
- Savola
- Schirmer
- Scholz
- Schreiber
- Schulte-Schrepping
- Setliff
- Shen
- Shin
- Siva
- Song
- Souter
- Stakenborg
- Stoeckius
- Stoeckius
- Stuart
- Sun
- Szklarczyk
- Szymczak
- Tian
- Topol
- Trapnell
- Van Dijk
- Vangala
- Voight
- Vujkovic-Cvijin
- Wang
- Warren
- Westra
- Winters
- Wishart
- Wu
- Xiong
- Xiong
- Xu
- Zhang
- Zhang
- Zhao
- Zhou
- Zuo
- Publication venue
- 'Frontiers Media SA'
- Publication date
- Field of study
Recommended from our members
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
- Author
- Abdelrazik M
- Abedalthagafi M
- Abel L
- Abel L
- Abellan J
- Abernathy C
- Abraheem A
- Acklery A
- Acosta-Isaac R
- Adam R
- Adams C
- Adams K
- Adams N
- Adanini O
- Afolabi D
- Agasou A
- Agravante K
- Agravante K
- Agrawal S
- Aguado JM
- Aguilar C
- Aguilar PM
- Aguilera-Albesa S
- Ahmad N
- Ahmadhaider N
- Ahmed A
- Ahmed C
- Aitkin E
- Akeroyd L
- Akhtar MN
- Akinkugbe O
- Al-Moasseb H
- Alasdair F
- Alba J
- Albu S
- Alcalá-Gallardo KAM
- Alcoba-Florez J
- Aldridge J
- Alex B
- Alexander P
- Alfonso J
- Algarin-Lara HR
- Ali A
- Ali HH
- Ali IAM
- Ali S
- Allan A
- Allan E
- Allan J
- Alldis Z
- Allen L
- Allen M
- Allen S
- Allibone S
- Allison KS
- Ally SM
- Almadana V
- Almaden-Boyle C
- Almeida J
- Almoguera B
- Alonso MR
- Altabaibeh A
- Alvarez N
- Alvaro A
- Alves MDM
- Amamio M
- Amamio M
- Amin V
- Anastasescu E
- Anderson J
- Anderson M
- Anderson P
- Anderson S
- Anderson S
- Anderson T
- Andreou P
- Andreu-Bernabeu Á
- Andrew A
- Andrew B
- Andrew G
- Andrews J
- Andrikopoulos P
- Antcliffe D
- Antoine P
- Antonijoan MR
- Antony S
- Anumakonda V
- Anwer M
- Apetri E
- Aquino M
- Arana-Arri E
- Aranda C
- Arango C
- Araque C
- Araujo IMT
- Araujo NK
- Aravindan L
- Arbane G
- Arcanjo AC
- Archer K
- Arden T
- Arias SS
- Arif S
- Armistead J
- Armstrong D
- Armstrong L
- Armstrong R
- Arnaiz A
- Arnott A
- Arora M
- Arranz MJ
- Artiga M-J
- Ashby K
- Ashok SR
- Ashraf S
- Ashton L
- Aslibekyan S
- Astin-Chamberlain R
- Atayeva N
- Attwood B
- Atwal I
- Auld F
- Austin K
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- Auton A
- Avello-Malaver Y
- Ayers A
- Ayuso C
- Bach B
- Badal B
- Baddeley A
- Bafitis V
- Baikady RR
- Bailey L
- Baillie JK
- Baillie JK
- Baillie K
- Baines D
- Baines K
- Baird T
- Baird Y
- Baker M
- Bakthavatsalam D
- Baldión-Elorza AM
- Bamford A
- Bamford A
- Bamford P
- Banach D
- Bancroft H
- Bandla N
- Bano S
- Baptista D
- Baptista-Rosas RC
- Barber R
- Barberis L
- Barberis L
- Barclay C
- Barclay L
- Barclay WS
- Barker J
- Barker M
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- Barr J
- Barranco-Díaz A
- Barreda-Sánchez M
- Barrera-Penagos V
- Barrett F
- Barron A
- Barrow E
- Barry P
- Bartley S
- Barton J
- Baruah R
- Bashyal A
- Basikolo C
- Bastion V
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- Batres SA
- Battle C
- Bauchmuller K
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- Bayo L-A
- Beadle J
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- Beasley A
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- Beavis S
- Beech E
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- Beer S
- Beesley K
- Begg C
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- Beith C
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- Bezerra JF
- Bezerra MAC
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- Blanca-López N
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- Carratto TMT
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- Carvalho MCC
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- Ceballos FC
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- Chávez MEQ
- Cid-Lopez MA
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- Cinquina Z
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- de la Horra C
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- Diz-de Almeida S
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- Docherty AB
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- Yáñez Z
- Zak A
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- Zapatero-Gaviria A
- Zarate R
- Zazo S
- Zborowski AC
- Zechner M
- Zechner M
- Zhao X
- Zheng C
- Zitter L
- Zongo O
- Zorloni C
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- Íñiguez M
- Publication venue
- Springer Nature
- Publication date
- 17/05/2023
- Field of study
Data availability: Downloadable summary data are available through the GenOMICC data site (https://genomicc.org/data). Summary statistics are available, but without the 23andMe summary statistics, except for the 10,000 most significant hits, for which full summary statistics are available. The full GWAS summary statistics for the 23andMe discovery dataset will be made available through 23andMe to qualified researchers under an agreement with 23andMe that protects the privacy of the 23andMe participants. For further information and to apply for access to the data, see the 23andMe website (https://research.23andMe.com/dataset-access/). All individual-level genotype and whole-genome sequencing data (for both academic and commercial uses) can be accessed through the UKRI/HDR UK Outbreak Data Analysis Platform (https://odap.ac.uk). A restricted dataset for a subset of GenOMICC participants is also available through the Genomics England data service. Monocyte RNA-seq data are available under the title ‘Monocyte gene expression data’ within the Oxford University Research Archives (https://doi.org/10.5287/ora-ko7q2nq66). Sequencing data will be made freely available to organizations and researchers to conduct research in accordance with the UK Policy Framework for Health and Social Care Research through a data access agreement. Sequencing data have been deposited at the European Genome–Phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number EGAS00001007111.Extended data figures and tables are available online at https://www.nature.com/articles/s41586-023-06034-3#Sec21 .Supplementary information is available online at https://www.nature.com/articles/s41586-023-06034-3#Sec22 .Code availability:
Code to calculate the imputation of P values on the basis of SNPs in linkage disequilibrium is available at GitHub (https://github.com/baillielab/GenOMICC_GWAS).Acknowledgements: We thank the members of the Banco Nacional de ADN and the GRA@CE cohort group; and the research participants and employees of 23andMe for making this work possible. A full list of contributors who have provided data that were collated in the HGI project, including previous iterations, is available online (https://www.covid19hg.org/acknowledgements).Change history: 11 July 2023: A Correction to this paper has been published at: https://doi.org/10.1038/s41586-023-06383-z. -- In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.Copyright © The Author(s) 2023, Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who are critically ill with COVID-19 can identify immunomodulatory therapies with strong beneficial effects in this group3. Here we analyse 24,202 cases of COVID-19 with critical illness comprising a combination of microarray genotype and whole-genome sequencing data from cases of critical illness in the international GenOMICC (11,440 cases) study, combined with other studies recruiting hospitalized patients with a strong focus on severe and critical disease: ISARIC4C (676 cases) and the SCOURGE consortium (5,934 cases). To put these results in the context of existing work, we conduct a meta-analysis of the new GenOMICC genome-wide association study (GWAS) results with previously published data. We find 49 genome-wide significant associations, of which 16 have not been reported previously. To investigate the therapeutic implications of these findings, we infer the structural consequences of protein-coding variants, and combine our GWAS results with gene expression data using a monocyte transcriptome-wide association study (TWAS) model, as well as gene and protein expression using Mendelian randomization. We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).GenOMICC was funded by Sepsis Research (the Fiona Elizabeth Agnew Trust), the Intensive Care Society, a Wellcome Trust Senior Research Fellowship (to J.K.B., 223164/Z/21/Z), the Department of Health and Social Care (DHSC), Illumina, LifeArc, the Medical Research Council, UKRI, a BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070 and BBS/E/D/30002275) and UKRI grants MC_PC_20004, MC_PC_19025, MC_PC_1905 and MRNO2995X/1. A.D.B. acknowledges funding from the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z), the Edinburgh Clinical Academic Track (ECAT) programme. This research is supported in part by the Data and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and Innovation (grant MC_PC_20029). Laboratory work was funded by a Wellcome Intermediate Clinical Fellowship to B.F. (201488/Z/16/Z). We acknowledge the staff at NHS Digital, Public Health England and the Intensive Care National Audit and Research Centre who provided clinical data on the participants; and the National Institute for Healthcare Research Clinical Research Network (NIHR CRN) and the Chief Scientist’s Office (Scotland), who facilitate recruitment into research studies in NHS hospitals, and to the global ISARIC and InFACT consortia. GenOMICC genotype controls were obtained using UK Biobank Resource under project 788 funded by Roslin Institute Strategic Programme Grants from the BBSRC (BBS/E/D/10002070 and BBS/E/D/30002275) and Health Data Research UK (HDR-9004 and HDR-9003). UK Biobank data were used in the GSMR analyses presented here under project 66982. The UK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Assembly Government, British Heart Foundation and Diabetes UK. The work of L.K. was supported by an RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1). J.Y. is supported by the Westlake Education Foundation. SCOURGE is funded by the Instituto de Salud Carlos III (COV20_00622 to A.C., PI20/00876 to C.F.), European Union (ERDF) ‘A way of making Europe’, Fundación Amancio Ortega, Banco de Santander (to A.C.), Cabildo Insular de Tenerife (CGIEU0000219140 ‘Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19’ to C.F.) and Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC20/57 to C.F.). We also acknowledge the contribution of the Centro National de Genotipado (CEGEN) and Centro de Supercomputación de Galicia (CESGA) for funding this project by providing supercomputing infrastructures. A.D.L. is a recipient of fellowships from the National Council for Scientific and Technological Development (CNPq)-Brazil (309173/2019-1 and 201527/2020-0)
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- Abad Gurumeta Alfredo
- Abernethy Caroline
- Abigail Patrick
- Achaibar Kira
- Adam Emily
- Afshari Arash
- Agudelo Montoya María Elizabeth
- Akgün Fatma Nur
- Aletti Gabriele
- Alkış Neslihan
- Allan Ashley
- Allan Katie
- Allaouchiche Bernard
- Allcock Clare
- Almasy Emoke
- Amey Isobel
- Amigoni Maria
- Andersen Elin
- Andersson Peder
- Anipchenko Natalya
- Antunes Pedro
- Armstrong Earlene
- Aslam Tayyba
- Assunção José-Pedro
- Ausserer Julia
- Avvai Mary
- Awad Nahla
- Ayas Montero Begoña
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- Unterbuchner Christoph
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- v Tiesenhausen Anna
- Vaida Simona
- Valldeperas Ferrer Silvia
- Valldeperas Hernandez Maria Inmaculada
- Valsamidis Dimitrios
- Van Beek Rienk
- van Dasselaar Nick
- van der Beek Tim
- Van Duivenvoorde Yoni
- van Klei Wilton A.
- Van Poorten Frans
- Van Zaane Bas
- Van Zundert Tom
- van Zyl Rebekka
- Vargas Munoz Ana Milena
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- Vasconcelos Pedro
- Vassilakis George
- Vecchiatini Tommaso
- Vercauteren Marcel
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- Večeřa Lubomir
- Vicari Sottosanti Luigi Giancarlo
- Vico Manuel
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- Vissicchio Daniela
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- Vitković Bibiana
- Vizcaychipi Marcela Paola
- Voicu Alexandra
- Voje Minca
- Volfová Ivana
- Volta Carlo Alberto
- Von Lutterotti Theresia
- Vrecič-Slabe Simona
- Vukcevic Dejan
- Vukovic Rade
- Vullo P. Agostina
- Wade Andrew
- Wallberg Hanna
- Wallden Jakob
- Wallner Johann
- Walther Sturesson Louise
- Watson Davina
- Weber Stefan
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- Weller Debbie
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- Werkmann Markus
- Westberg Henrik
- Wikström Erik
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- Wirth Steffen
- Wittmann Maria
- Wood Laura
- Wright Stella
- Zachoval Christian
- Zambon Massimo
- Zampieri Silvia
- Zampone Salvatore
- Zangrillo Alberto
- Zani Gianluca
- Zavackiene Asta
- Ziegleder Raphael
- Zonneveldt Harry
- Zsisku Lajos
- Zucker Tom-Philipp
- Zuleika Mehrun
- Zupančič Darja
- Åslin Bjorn
- Şanli Karip Ceren
- Štourač Petr
- Żukowski Maciej
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background Results from retrospective studies suggest that use of neuromuscular blocking agents during general
anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use
of neuromuscular blocking agents is associated with postoperative pulmonary complications.
Methods We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in
28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital
procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge
were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination
within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative
pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were
adjusted for surgical factors and patients’ preoperative physical status, providing adjusted odds ratios (ORadj) and
adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513.
Findings Between June 16, 2014, and April 29, 2015, data from 22803 patients were collected. The use of neuromuscular
blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who
had undergone general anaesthesia (1658 [7·6%] of 21694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj –4·4%, 95% CI
–5·5 to –3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised
without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49;
ARRadj –2·6%, 95% CI –3·9 to –1·4) and the administration of reversal agents (1·23, 1·07–1·41; –1·9%, –3·2 to –0·7)
were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex
instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj –0·3%, 95% CI –2·4 to 1·5) nor extubation at
a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; –0·4%, –3·5 to 2·2) was associated with better pulmonary outcomes.
Interpretation We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an
increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of
neuromuscular blockade against the increased risk of postoperative pulmonary complications
A second update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar MS
- Abdel-Aziz M
- Abdelrazik M
- Abdullah MS
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- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- A. M. Leonardi
- A. M. Varsani
- A. W. M. M. Kopp
- A. Abernethy
- A. Allaouchiche
- A. Balescu-Arion
- A. Barsan
- A. Beretta
- A. Bilskiene
- A. Bowen
- A. Bucolo
- A. Calhau
- A. Cammu
- A. Carise
- A. Casal
- A. Chinery
- A. Chondhury
- A. Costa
- A. Cox
- A. Curley
- A. Danninger
- A. Dinic
- A. f Hollmann
- A. Ferrando
- A. Filipescu
- A. Floris
- A. Georghiou
- A. Gibson
- A. Gievski
- A. Giovannoni
- A. Granell
- A. Grassetto
- A. Greenwood
- A. Grigoras
- A. Gritsan
- A. Guadagnin
- A. Hagau
- A. Hribar
- A. Humphreys
- A. Hussein
- A. Hyams
- A. Kumar
- A. Landoni
- A. Lišková
- A. Loganathan
- A. Luippold
- A. Macas
- A. Macgregor
- A. Margalef
- A. Melia
- A. Melotti
- A. Minto
- A. Moise
- A. Mokini
- A. Moltó
- A. Moura
- A. Negri
- A. Nicholas
- A. Novillo
- A. Oliveira
- A. Ovezov
- A. Ozbilgin
- A. Papapostolou
- A. Pasin
- A. Paunescu
- A. Petta
- A. Rato
- A. Razaque
- A. Schiavone
- A. Soro
- A. Spadaro
- A. Spindler-Vesel
- A. Stamelos
- A. Standl
- A. Sultanpori
- A. Toretti
- A. Tudor
- A. Turan
- A. Vissicchio
- A. Voje
- A. Vrecic-Slabe
- A. Wallberg
- A. Weller
- A. Zani
- A. Zieglerder
- Abad Gurumeta
- Agudelo Montoya
- Ayas Montero
- B. C. Meier
- B. V. Mushambi
- B. Allcock
- B. Assunção
- B. Ayuso
- B. Charnock
- B. Debreceni
- B. Franke
- B. Gferer
- B. Harvey
- B. Hestenes
- B. Iannuccelli
- B. Jankovic
- B. Joachim
- B. Junke
- B. Kadaoui
- B. Kuzmanovska
- B. Kyttari
- B. Levstek
- B. Malewski
- B. Marcu
- B. Mccourt
- B. Stourac
- B. Tsaousi
- B. Verheyen
- B. Vizcaychipi
- B. Wilson
- Baiardo Redaelli
- Baltasar Isabel
- Becerra Cayetano
- Belmonte Cuenca
- Bermudez Lopez
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- Guerrero Diez
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- Herrera Hueso
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- I. Cascella
- I. Cinnella
- I. Dascalu
- I. Garcia-Perez
- I. Grintescu
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- Jiménez Gomez
- Jonsson Fagerlund
- K. Adam
- K. Allan
- K. b Blobner
- K. Barbera
- K. Barros
- K. Blincoe
- K. Borys
- K. Czuczwar
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- K. Hoelbling
- K. Ilyas
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- Publication venue
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Background Results from retrospective studies suggest that use of neuromuscular blocking agents during general anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use of neuromuscular blocking agents is associated with postoperative pulmonary complications.Methods We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in 28 European countries. We included patients (aged >= 18 years) who received general anaesthesia for any in-hospital procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were adjusted for surgical factors and patients' preoperative physical status, providing adjusted odds ratios (ORadj) and adjusted absolute risk reduction (ARR(adj)). This study is registered with ClinicalTrials. gov, number NCT01865513.Findings Between June 16, 2014, and April 29, 2015, data from 22 803 patients were collected. The use of neuromuscular blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who had undergone general anaesthesia (1658 [7.6%] of 21 694); ORadj 1.86, 95% CI 1.53-2.26; ARR(adj) -4.4%, 95% CI -5.5 to -3.2). Only 2.3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1.31, 95% CI 1.15-1.49; ARR(adj) -2.6%, 95% CI -3.9 to -1.4) and the administration of reversal agents (1.23, 1.07-1.41; -1.9%, -3.2 to -0.7) were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex instead of neostigmine for reversal (ORadj 1.03, 95% CI 0.85-1 center dot 25; ARR(adj) -0.3%, 95% CI -2.4 to 1.5) nor extubation at a train-of-four ratio of 0.9 or more (1.03, 0.82-1.31; -0.4%, -3.5 to 2.2) was associated with better pulmonary outcomes.Interpretation We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of neuromuscular blockade against the increased risk of postoperative pulmonary complications
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- Abad Gurumeta Alfredo
- Abernethy Caroline
- Abigail Patrick
- Achaibar Kira
- Adam Emily
- Afshari Arash
- Agudelo Montoya María Elizabeth
- Akgün Fatma Nur
- Aletti Gabriele
- Alkış Neslihan
- Allan Ashley
- Allan Katie
- Allaouchiche Bernard
- Allcock Clare
- Almasy Emoke
- Amey Isobel
- Amigoni Maria
- Andersen Elin
- Andersson Peder
- Anipchenko Natalya
- Antunes Pedro
- Armstrong Earlene
- Aslam Tayyba
- Assunção José-Pedro
- Ausserer Julia
- Avvai Mary
- Awad Nahla
- Ayas Montero Begoña
- Ayuso Mercedes
- Azevedo Patricia
- Badarau Victoria
- Badescu Roxana
- Baiardo Redaelli Martina
- Baird Colin
- Baird Yolanda
- Baker Tim
- Balaji Packianathaswamy
- Balan Cristina
- Balandin Alina
- Balescu-Arion Carmen
- Baliuliene Vilda
- Baltasar Isabel Jorge
- Baluch Saif Nasr
- Bandrabur Daniela
- Bankewitz Carla
- Barber Katrina
- Barbera Francesco
- Barcraft-Barnes Helena
- Barletti Valentina
- Barnett Gill
- Baron Kirsty
- Barros Ana
- Barsan Victoria
- Bartlett Pauline
- Batistaki Chrysanthi
- Baumgarten Georg
- Baumüller Eva
- Baytaş Volkan
- Beauchamp Nigel
- Becerra Cayetano Isabel A.
- Bell Stephanie
- Bellandi Mattia
- Belletti Alessandro
- Belmonte Cuenca Julio
- Benitez-Cano Adela
- Beretta Luigi
- Berger Marc Moritz
- Bergmann Nicole
- Bergmark Kristina
- Bermudez Lopez Maria
- Bernotaite Monika
- Beurskens Charlotte
- Bidd Heena
- Bifulco Francesca
- Bignami Elena
- Bilic Aleksandar
- Bilskiene Diana
- Bischoff Petra
- Bishop Luke
- Bjønness Therese
- Blaylock Heather
- Blethyn Kate
- Blincoe Thomas
- Blobner Manfred
- Blobner Manfred
- Blobner Manfred
- Blokhin Ivan
- Blunt Nadia
- Boer Christa
- Bois Grégory
- Bonicolini Eleonora
- Booth Joanna
- Borecka-Kedzierska Miraslawa
- Borstnar Katarina
- Borys Michal
- Boselli Emmanuel
- Bouvet Lionel
- Bouwman Arthur
- Bowen Leonora
- Bowrey Sarah
- Boxall Leigh
- Bozić Teodora
- Bradley Tom
- Branco Teresa
- Brazzi Luca
- Brazzoni Marcella
- Brear Tracy
- Brogly Nicolas
- Brohi Farooq
- Broms Jacob
- Bubliauskas Andrius
- Bucolo Gea Erika
- Buerkle Hartmut
- Buggy Donal
- Buhre Wolfgang F.
- Bukauskas Tomas
- Butturini Francesco
- Byttner Anders
- Cabrera Díaz Itahísa
- Calderon Adriana
- Calhau Ricardo
- Callejo Angel
- Cammu Guy
- Campesato Manuela
- Camsooksai Julie
- Can Özlem Selvi
- Cantor Andreea
- Carise Elsa
- Carmona Cristina
- Carreteiro Joana
- Carrieri Cosima
- Carter Anna
- Casal Manuela
- Casanova Irene
- Cascella Marco
- Casero Luis M.
- Casiraghi Giuseppina Maria
- Castelo-Branco Laila
- Castro Arranz Carlos
- Cernea Daniela
- Cervantes Oriol
- Chandler Ben
- Charnock Robert
- Chatzimicali Aikaterini
- Chervjakov Igor
- Chinery Elaine
- Chishti Ahmad
- Chondhury Priyakam
- Christie Emily
- Christodoudiles George
- Ciardo Stefano
- Cimpeanu Luminata
- Cinnella Gilda
- Cirstea Emanuel
- Clark Sebastian
- Clayton Matthew
- Cocu Simona
- Collyer Thomas
- Colvin Carrie
- Cope Sean
- Copeta Filomena
- Copotoiu Sanda
- Correia de Barros Filinto
- Corso Ruggero Massimo
- Cortegiani Andrea
- Costa Gabriela
- Cowton Amanda
- Cox Nicola
- Craig James
- Cricca Valentina
- Cronin John
- Cunha Mariana
- Cuomo Arturo
- Curley Katherine
- Czuczwar Miroslaw
- Cîndea Iulia
- Dabrowska Dominika
- Damster Sandrine
- Danguy des Déserts Marc
- Daniliuc Aura
- Danninger Thomas
- Darwish Imad
- Dascalu Corina
- Davies Kirsty
- Davies Simon
- De Boer Hans D.
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- Debaene Bertrand
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- Dimitrovski Aleksandar
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- Domingues Susana
- Doolan James
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- Droc Gabriela
- Dum Elisabeth
- Dumitrescu Alexandra
- Duncan Louise
- Dzurňáková Paula
- Dîrzu Dan-Sebastian
- Eberl Susanne
- Edwards Jayne
- Edwards Mark
- Ekelund Kim
- Ekengren Patrik
- Elghouty Eyad
- Ellerkmann Richard
- Ellis Helen
- Elme Andreas
- Eriksson Lars I
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- Ernst Thomas
- Errando Carlos Luis
- Esteves Simao
- Ewaldsson Callis
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- Featherstone James
- Febres Daniela
- Fedorov Sergey
- Feggeler Johanna
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- Fernando Aruna
- Fernández Castineira Adrian
- Fernández-Candil Juan
- Ferrando Carlos
- Ferreira Leonia
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- Feyling Anders
- Filipescu Daniela
- Fleischer Andreas
- Floris Leda
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- Fox Benjamin
- Franke Uwe
- Frasca Denis
- Frey Christian
- Frost Victoria
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- Furneval Julie
- Fusari Maurizio
- Gallacher Stuart
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- Gavrilov Roman
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- Gioia Antonio
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- Guadagnin Giovanni Maria
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- Guttenthaler Vera
- Günther Ulf
- Güçlü Çiğdem
- Hack Yvonne
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- Helliwell Laurence
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- Humphreys Sally
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- Ionităv Victor
- Irwin Foo
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- Janez Benedik
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- Jenko Matej
- Jimenez Gomez Barbara
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- Joachim Suganthi
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- Jonikaite Lina
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- Koolen Eric
- Koopman - van Gemert Anna Wilhelmina Margaretha Maria
- Kopp Kristen
- Korfiotis Dimitrios
- Korolkov Oleg
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- Kotzinger Oskar
- Kovačević Marko
- Kranke Eva
- Kranke Peter
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