42 research outputs found
Natural history of familial cerebral cavernous malformation syndrome in children: a multicenter cohort study
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attri- bution 4.0 International License, which permits use, sharing, adapta- tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Purpose: There is limited data concerning neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors.
Methods: We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric hospitals between January 2010 and March 2022. Subjects with first available brain MRI and [Formula: see text] 3 months of clinical follow-up were included. Neuroimaging studies were reviewed, and clinical data collected. Annual symptomatic hemorrhage risk rates and cumulative risks were calculated using survival analysis and predictors of symptomatic hemorrhagic identified using regression analysis.
Results: Forty-one children (53.7% males) were included, of whom 15 (36.3%) presenting with symptomatic hemorrhage. Seven symptomatic hemorrhages occurred during 140.5 person-years of follow-up, yielding a 5-year annual hemorrhage rate of 5.0% per person-year. The 1-, 2-, and 5-year cumulative risks of symptomatic hemorrhage were 7.3%, 14.6%, and 17.1%, respectively. The latter was higher in children with prior symptomatic hemorrhage (33.3%), CCM2 genotype (33.3%), and positive family history (20.7%). Number of brainstem (adjusted hazard ratio [HR] = 1.37, P = 0.005) and posterior fossa (adjusted HR = 1.64, P = 0.004) CCM at first brain MRI were significant independent predictors of prospective symptomatic hemorrhage.
Conclusion: The 5-year annual and cumulative symptomatic hemorrhagic risk in our pediatric FCCM cohort equals the overall risk described in children and adults with all types of CCM. Imaging features at first brain MRI may help to predict potential symptomatic hemorrhage at 5-year follow-up.info:eu-repo/semantics/publishedVersio
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
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- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
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- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
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- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
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- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
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- Cambien Francois
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- Carty Cara
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- Caspersen Ida H
- Castano-Betancourt Martha
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- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
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- Chang Yen-Pei C
- Chanock Stephen J
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- Chasman Dan
- Chaturvedi Nish
- Chen Constance
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- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
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- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
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- Connell John M
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- Coresh Josef
- Cornelis Marilyn C
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- Corsi Anna Maria
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- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
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- Curhan Gary
- d'Adamo Pio
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- Dailiana Zoe
- Danesh John
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- Dastani Zari
- Davies Gail
- Daw E Warwick
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- de Boer Ian H
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- de Faire Ulf
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- Deelman Ewa
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- Demerath Ellen W
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- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
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- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
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- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
- Esko Tonu
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- Estrada Karol
- Eury Elodie
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- Eyheramendy Susana
- Eyjolfsson Gudmundur Ingi
- Fagerholm Emma
- Falhammar Henrik
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- Ferreira Teresa
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- Forrester Terrence
- Forsblom Carol
- Foster Meredith C
- Fowke Jay
- Fowkes F Gerald R
- Fowkes Gerard R
- Fox Caroline S
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- Franceschini Nora
- Franco Oscar H
- Franco-Cereceda Anders
- Franke Andre
- Franke Lude
- Franks Paul W
- Frants Rune
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- Frayling Timothy M
- Freedman Barry I
- Freimer Nelson B
- Freitag Daniel F
- Friedrich Nele
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- Garnaas Maija
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- Giedraitis Vilmantas
- Gieger Christian
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- Glenn Kim
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- Godson Catherine
- Goel Anuj
- Goessling Wolfram
- Golay Alain
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- González-Macías Jesús
- Goodall Alison H
- Goodarzi Mark O
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- Gudnason Villi
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- Hadjadj Samy
- Hadley David
- Haessler Jeff
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- Henderson Brian
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- Witteman Jacqueline C M
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- Wood Andy
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- Wu Ying
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- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat Rüdeger
- Albert Loïc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Étienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
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- Boyer Martha L.
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- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
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- Breda David
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- Brennan David
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- Bromenschenkel Asa
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- Bujanda Edwin D.
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- Cara Mihai
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- Case Michael Eli
- Cesari Thaddeus
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- Chapman George N.
- Charlot S.
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- Chen Bin
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- Chilton Zachary S.
- Chittiraibalan Dharini
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- Cooper James L.
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- Cossou Christophe
- Costanza Brian F.
- Costas Maria Begoña Vila
- Coulais Alain
- Cox Colin R.
- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
- Davidson Greg S.
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- Deschenes Jeremy
- Dethienne Nathalie
- Detre Örs Hunor
- Diaz Rosa Izela
- Dicken Daniel
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- Disharoon Maureen O.
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- Doggett Jesse B.
- Dominguez Keisha L.
- Donaldson Thomas S.
- Doria-Warner Cristina M.
- Doty Heather
- Douglas Jr. Robert E.
- Doyon René
- Dressler Alan
- Driggers Jennifer
- Driggers Phillip A.
- Dunn Jamie L.
- DuPrie Kimberly C.
- Dupuis Jean
- Durning John
- Dutta Sanghamitra B.
- Earl Nicholas M.
- Eccleston Paul
- Ecobichon Pascal
- Egami Eiichi
- Ehrenwinkler Ralf
- Eisenhamer Jonathan D.
- Eisenhower Michael
- Eisenstein Daniel J.
- Elie Michelle L.
- Elliott James
- Elliott Kyle Wesley
- Engesser Michael
- Espinoza Néstor
- Etienne Odessa
- Etxaluze Mireya
- Evans Leah
- Fabreguettes Luce
- Falcolini Massimo
- Falini Patrick R.
- Fatig Curtis
- Feeney Matthew
- Feinberg Lee D.
- Fels Raymond
- Ferdous Nazma
- Ferguson Henry C.
- Ferrarese Laura
- Ferreira Marie-Héléne
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph Charles
- Firre Daniel
- Fix Mees
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- Fleming Scott W.
- Florian Michael
- Flynn James R.
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- Fontaine Mark R.
- Fontanella Erin Marie
- Forshay Peter Randolph
- Fortner Elizabeth A.
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- Framarini Alexandro P.
- Francisco John I.
- Franck Randy
- Franx Marijn
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- Friedman Scott D.
- Friend Katheryn E.
- Frost James R.
- Fu Henry
- Fullerton Alexander W.
- Gaillard Lionel
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- Gasman Danny
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- Gkountis Konstantinos
- Glasse Alistair
- Glassmire Kirk Zachary
- Glauser Adrian Michael
- Glazer Stuart D.
- Goldberg Joshua
- Golimowski David A.
- Gonzaga Shireen P.
- Gordon Karl D.
- Gordon Shawn J.
- Goudfrooij Paul
- Gough Michael J.
- Graham Adrian J.
- Grau Christopher M.
- Green Joel David
- Greene Gretchen R.
- Greene Thomas P.
- Greenfield Perry E.
- Greenhouse Matthew A.
- Greve Thomas R.
- Greville Edgar M.
- Grimaldi Stefano
- Groe Frank E.
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- Grumm David M.
- Grundy Timothy
- Guillard Pierre
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- Gutman Irvin Meyer
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- Guyot Benjamin
- Gáspár András
- Güdel Manuel
- Hack Warren J.
- Haderlein Peter
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- Hagedorn Andria
- Hainline Kevin
- Haley Craig
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- Hami Maryam
- Hamilton Forrest Clifford
- Hammann Jeffrey
- Hammel Heidi B.
- Hanley Christopher J.
- Hansen Carl August
- Hardy Bruce
- Harnisch Bernd
- Harr Michael Hunter
- Harris Pamela
- Hart Jessica Ann
- Hartig George F.
- Hasan Hashima
- Hashim Kathleen Marie
- Hashimoto Ryan
- Haskins Sujee J.
- Hawkins Robert Edward
- Hayden Brian
- Hayden William L.
- Healy Mike
- Hecht Karen
- Heeg Vince J.
- Hejal Reem
- Helm Kristopher A.
- Hengemihle Nicholas J.
- Henning Thomas
- Henry Alaina
- Henry Ronald L.
- Henshaw Katherine
- Hernandez Scarlin
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- Heske Astrid
- Hesman Brigette Emily
- Hickey David L.
- Hilbert Bryan N.
- Hines Dean C.
- Hinz Michael R.
- Hirsch Michael
- Hitcho Robert S.
- Hodapp Klaus
- Hodge Philip E.
- Hoffman Melissa
- Holfeltz Sherie T.
- Holler Bryan Jason
- Hoppa Jennifer Rose
- Horner Scott
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- Hunkeler Joseph S.
- Hunter Alexander
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- Hurd Spencer W.
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- Hutchings John B.
- Hylan Jason E.
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra M.
- Isaacs III John C.
- Jackson Jr. Wallace C.
- Jaffe Daniel T.
- Jahic Jasmin
- Jahromi Amir
- Jakobsen Peter
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- James John C.
- James LeAndrea Rae
- Jamieson William Brian
- Jandra Raymond D.
- Jayawardhana Ray
- Jedrzejewski Robert
- Jeffers Basil S.
- Jensen Peter
- Joanne Egges
- Johns Alan T.
- Johnson Carl A.
- Johnson Eric L.
- Johnson Patricia
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- Johnson Thomas K.
- Johnson Timothy W.
- Johnstone Doug
- Jollet Delphine
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- Kalirai Jason S.
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- Kaltenegger Lisa
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- Kassin Susan A.
- Kauffman David D.
- Kavanagh Patrick
- Kelley Leigh L.
- Kelly Douglas M.
- Kendrew Sarah
- Kennedy Herbert V.
- Kenny Deborah A.
- Keski-Kuha Ritva A.
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- Khan Ali
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- Kimble Randy A.
- King James S.
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- Kirk Jeffrey R.
- Kirkpatrick Marc E.
- Klaassen Pamela
- Klingemann Lana
- Klintworth Paul U.
- Knapp Bryan Adam
- Knight Scott
- Knollenberg Perry J.
- Knutsen Daniel Mark
- Koehler Robert
- Koekemoer Anton M.
- Kofler Earl T.
- Kontson Vicki L.
- Kovacs Aiden Rose
- Kozhurina-Platais Vera
- Krause Oliver
- Kriss Gerard A.
- Krist John
- Kristoffersen Monica R.
- Krogel Claudia
- Krueger Anthony P.
- Kulp Bernard A.
- Kumari Nimisha
- Kwan Sandy W.
- Kyprianou Mark
- Labador Aurora Gadiano
- Labiano Álvaro
- Lafrenière David
- Lagage Pierre-Olivier
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- Lajoie Charles-Philippe
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- LaMassa Stephanie Marie
- Lambros Scott D.
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- Swade Daryl Allen
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- Thompson Christopher Lee
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- Tikkanen Tuomo
- Tinnin Lee
- Tippet William Thomas
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- Trauger John
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- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
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- Wehner James
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- Weilert Mark
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- Wells Martyn
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- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
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- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
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- Yeager Christopher R.
- Yerger Ethan John
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- Young Gary
- Yu Gene
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- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Álvarez-Márquez Javier
- Östlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
The value of structuring rarity: the seven types and links to reproductive ecology
- Author
- A Baudet
- A Palo
- A Valiente-Banuet
- AD Gove
- AG Young
- AG Young
- AL Edwards
- AR Kruckeberg
- B Bytebier
- BR Murray
- BR Murray
- CE Proffitt
- CJ Krebs
- D Medan
- D Montesinos
- D Rabinowitz
- D Rabinowitz
- D Rabinowitz
- D Rabinowitz
- DJ Coates
- DJ Coates
- DMC Kuehn
- DW Morris
- E Brzosko
- EA Leger
- EJ Farnsworth
- Erin K. Espeland
- G Blanca
- GG Roitman
- H Adsersen
- H Andrewartha
- HP Linder
- HP Linder
- I Lopez-Flores
- I Talalaj
- IU CN
- J Brown
- J Dekker
- J Falinski
- J Felsenstein
- J Guitian
- J Lorite
- JA Zavala-Hurtado
- JH Brown
- JH Brown
- JL Harper
- JN Klironomos
- JP Lewis
- JS Heywood
- K Taylor
- K Thompson
- K Wesche
- KW Krauss
- L Esparza-Olguin
- L Ghermandi
- L Navarro
- L Navarro
- M Melendo
- M Saetersdal
- M Suter
- ME Cosner
- MF Simon
- MW Schwartz
- OO Osunkoya
- OO Osunkoya
- P Chesson
- P Jordano
- P Jordano
- P Wilson
- PL Ortiz
- PL Valverde
- RD Holt
- S Bernardos
- S Glemin
- S Hurtrez Bousses
- S Muller
- S Sanders
- SC Gawler
- SE Lester
- SG Hegde
- SI Higgins
- SR Kephart
- T Petanidou
- Taraneh M. Emam
- TM Knight
- VE Vivian
- W Thuiller
- WE Kunin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Baier Jeremy
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- Ballardin G.
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- Basak Soummyadip
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- Betzwieser Joseph
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- Boldrini Mattia
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- Bonino A.
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- Bossilkov V.
- Boudart Vincent
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- Brandt J.
- Braun I.
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- Brockill P.
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- Brooks Aidan
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- Bustillo J. Calderón
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- Cagnoli Gianpietro
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- Carapella G.
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- Carpinelli Massimo
- Carrillo G.
- Carter Jonathan
- Carullo Gregorio
- Casentini Claudio
- Castro-Lucas S. Y.
- Caudill S.
- Cavaglia Marco
- Cavalieri Roberto
- Cella Giancarlo
- Cerdá-Durán Pablo
- Cesarini Elisabetta
- Chaibi W.
- Chakraborty Pratik
- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
- Chang R. -J.
- Chao Shiuh
- Char Prasanta
- Charlton E. L.
- Charlton Philip
- Chassande-Mottin Eric
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chattopadhyay Debatri
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
- Chen H.
- Chen Hsin-Yu
- Chen Junxin
- Chen K. H.
- Chen Y.
- Chen Yanbei
- Chen Yitian
- Cheng H. P.
- Chessa Piero
- Cheung H. T.
- Cheung S. Y.
- Chiadini Francesco
- Chiarini G.
- Chierici R.
- Chincarini Andrea
- Chiofalo Maria Luisa
- Chiummo Antonino
- Chou C.
- Choudhary Sunil
- Christensen Nelson
- Chua Sheon S. Y.
- Chugh P.
- Chun Lung Chan Juno
- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
- Cifaldi Maria
- Ciolfi Riccardo
- Clara F.
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- Clarke J.
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
- Clearwater P.
- Clesse S.
- Coccia E.
- Codazzo Elena
- Cohadon Pierre-François
- Colace Stefano
- Colleoni Marta
- Collette C. G.
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- Colloms S.
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- Colpi Monica
- Compton C. M.
- Concetta Tringali Maria
- Connolly G.
- Conti Livia
- Corbitt Thomas
- Cordero-Carrión Isabel
- Corezzi S.
- Cornish Neil
- Corsi Alessandra
- Cortese Stefano
- Costa C. A.
- Cottingham R.
- Coughlin Michael
- Couineaux A.
- Coulon J. -P.
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- Creed R.
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- Creighton T. D.
- Cremonese Paolo
- Criswell Alexander
- Crockett-Gray J. C. G.
- Crook S.
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- Cudell Jean-René
- Cullen Torrey
- Cumming Alan
- Cuoco E.
- Cusinato Marco
- Cáceres-Barbosa V.
- César Martins Julio
- D'Angelo Beatrice
- D'Antonio Sabrina
- d'Emilio V.
- D'Onofrio Luca
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- Dabadie P.
- Dal Canton Tito
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- Danilishin Stefan
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- De Bolle Jorden
- De Laurentis Martina
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- De Marco F.
- De Matteis Fabio
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
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- Deenadayalan M.
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- Del Pozzo Walter
- Dell'Aquila Daniele
- Deléglise Samuel
- Demos N.
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- Depasse Antoine
- DePergola N.
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- Dhani A.
- Di Cesare Martina
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- Di Fronzo Chiara
- Di Giovanni Matteo
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- Di Palma Irene
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- Yokoyama Jun'ichi
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
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- De Rosa Rosario
- de rossi camilla
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- Degallaix Jerome
- Del Pozzo W.
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- Dell'Aquila Daniele
- Deléglise Samuel
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- di giovanni Fabrizio
- Di Giovanni M.
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- DI. PALMA Irene
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- Dorosh O.
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- Elizabeth Ramirez Guevara Karla
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- Estevez Dimitri
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- Fabrizi Federica
- Faedi F.
- Fafone Viviana
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- Fenyvesi Edit
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- Ferreira T. A.
- Fidecaro Francesco
- Fiori Alessio
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- Fishbach Maya
- Fisher R. P.
- Fittipaldi R.
- Fiumara V.
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- Fleischer Svenja
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- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Francisco Nuño Siles José
- Franke A.
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- Fukunaga I.
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- Gabella William
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- Gaetano Fronzé Gabriele
- Gair Jonathan
- Gais J.
- Galaudage S.
- Gallardo S.
- Gamba Rossella
- Ganapathy Dhruva
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- Gaonkar S. G.
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- Garcia-Bellido Juan
- García Quirós Cecilio
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- Gardner James W.
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- Gargiulo J.
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- Gasbarra Claudio
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- Wildberger J. B.
- Wilk O. S.
- Wilken Dennis
- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williamson Andrew R.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Y. -C.
- Yang Yang
- Yang Yi
- Yap M. J.
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
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- Errico L.
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- Yu Hang
- Yuzurihara Hirotaka
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt Jürgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
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- Schlom Jeffrey
- Schlom Jeffrey
- Schlom Jeffrey
- Schlom Jeffrey
- Schlunegger Kyle
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- Schmidt Carl
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- Schmidt Manuel
- Schoenfeld Jonathan
- Schoenhals Jonathan
- Scholler Nathalie
- Scholz Alexander
- Schreiber Taylor H
- Schroeder Andreas
- Schwab Matthias
- Schwartz Anthony L
- Schwartz Anthony L
- Schwendeman Anna
- Scrivens Maria
- Sebastian Martin
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- Segal Neil H
- Seibel Tobias
- Senbabaoglu Yasin
- Senter Peter D
- Senzer Neil
- Serpa Gregory
- Setiady Yulius
- Sette Alessandro
- Sevdali Maria
- Sexton Holly
- Sexton Holly
- Seymour Len
- Sgarrella Francesco
- Shabanowitz Jeffrey
- Shabanowitz Jeffrey
- Shafren Darren
- Shafren Darren
- Shafren Darren
- Shakya Reena
- Shamalov Katerina
- Shanker Anil
- Shanker Anil
- Sharma Manish
- Sharma Meenu
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- Shayan Gulidanna
- Shea Sofia
- Shehade Hussein
- Sheikh Nadeem A
- Shekarian Tala
- Shepard Dale
- Sherry Lorcan
- Shi Feng
- Shi Jian
- Shih Vincent F
- Shimizu Atsushi
- Shrestha Yashaswi
- Shrivastav Shruti
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- Silk Ann
- Silk Ann W
- Silva John
- Simmons John
- Simoes Ines
- Sims Jennifer S
- Singh Manisha
- Singson Victoria
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- Siurala Mikko
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- Smith Ernest
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- Smith Kelly
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- Smith Leia
- Smolkin Mark E
- Smolkin Mark E
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- Snook Adam E
- Snzol Mario
- Sokolove Jeremy
- Solowiej Jim
- Somanchi Srinivas
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- Song Xiao-Tong
- Sotayo Alaba
- Sotirovska Natalija
- Spada Filomena
- Speers Ellen
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- Spektor Alexander
- Spranger Stefani
- Spurgeon Stephen
- Squalls Olivia
- Srirangam Jay
- Srivastava Raghvendra
- Staab Mary J
- Stack Edward
- Staelens Ludovicus
- Starzynska Teresa
- Steadman Lora
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- Stefano Pierini
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- Stein Paul L
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- Ståhle Magnus
- Su Yu-Lin
- Sudarshan Naremaddepalli
- Sugarbaker David
- Sukari Ammar
- Sultan Hussein
- Sun Shaoli
- Sundararaman Srividya
- Sung Leonard
- Suresh Rahul
- Surguladze David
- Suryawanshi Satyendra
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- Taylor Allison
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- ter Meulen Jan
- ter Meulen Jan
- Terabe Masaki
- Terabe Masaki
- Termini James
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- Tewary Poonam
- Thakurta Anjan
- Thayer Matt
- Theodoraki Marie-Nicole
- Thimme Robert
- Thomas Portia
- Thomas Remy
- Thomas Vincent
- Thompson John A
- Thounaojam Menaka
- Thounaojam Menaka
- Thurston Gavin
- Tighe Rober
- Tilahun Ashenafi
- Tillé Laure
- Timmerman John
- Tipton Kimberly A
- Tipton Kimberly A
- Tognon Christina E
- Tomai Mark A
- Toms Anne
- Torno Sebold
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- Tsang Kwong
- Tsang Kwong
- Tsang Kwong Y
- Tsaparikos Konstantinos
- Tsouko Efrosini
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- Tuck David
- Tumang Joseph
- Tumang Joseph
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- Tähtinen Siri
- Tähtinen Siri
- Uecker Darrin
- Uecker Darrin
- Uecker Darrin
- Ugel Stefano
- Ugel Stefano
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- Urban Julie
- Valsesia-Wittmann Sandrine
- Valsesia-Wittmann Sandrine
- Van der Meijs Pien
- van Vugt Marianne
- van Zutphen Mariëlle
- Vanamee Eva
- Vanderslice Peter
- VanderVeen Laurie
- Vanpouille-Box Claire I
- VanVlasselaer Peter
- Varhegyi Nikole
- Vasilakos John P
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- Wittig Burghardt
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
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- Wong Chihunt
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- Wu Jennifer
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- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
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- Yan Jian
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- Ye Yun-bin
- Yin Catherine
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- Ylösmäki Erkko
- Young Gregory
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- Young Kristina
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- Zalevsky Jonathan
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- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Spinal involvement in pediatric familial cavernous malformation syndrome
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022Purpose: The aim of the study was to assess the prevalence and characteristics of spinal cord cavernous malformations (SCCM) and intraosseous spinal vascular malformations (ISVM) in a pediatric familial cerebral cavernous malformation (FCCM) cohort and evaluate clinico-radiological differences between children with (SCCM +) and without (SCCM-) SCCM.
Methods: All patients with a pediatric diagnosis of FCCM evaluated at three tertiary pediatric hospitals between January 2010 and August 2021 with [Formula: see text] 1 whole spine MR available were included. Brain and spine MR studies were retrospectively evaluated, and clinical and genetic data collected. Comparisons between SCCM + and SCCM- groups were performed using student-t/Mann-Whitney or Fisher exact tests, as appropriate.
Results: Thirty-one children (55% boys) were included. Baseline spine MR was performed (mean age = 9.7 years) following clinical manifestations in one subject (3%) and as a screening strategy in the remainder. Six SCCM were detected in five patients (16%), in the cervico-medullary junction (n = 1), cervical (n = 3), and high thoracic (n = 2) regions, with one appearing during follow-up. A tendency towards an older age at first spine MR (P = 0.14) and [Formula: see text] 1 posterior fossa lesion (P = 0.13) was observed in SCCM + patients, lacking statistical significance. No subject demonstrated ISVM.
Conclusion: Although rarely symptomatic, SCCM can be detected in up to 16% of pediatric FCCM patients using diverse spine MR protocols and may appear de novo. ISVM were instead absent in our cohort. Given the relative commonality of asymptomatic SCCM, serial screening spine MR should be considered in FCCM starting in childhood.info:eu-repo/semantics/publishedVersio
Appeal of organizational values is in the eye of the beholder: The moderating role of employee identity
- Author
- Abbott
- Aguinis
- Allport
- Braddy
- Brewer
- Brickson
- Brockner
- Burke
- Cable
- Carmines
- Cattell
- Chao
- Chao
- Chatman
- Chatman
- Chatman
- Christiansen
- Cohen
- Cummins
- Dick
- Edwards
- Erin M. Jackson
- Fabrigar
- Feather
- Finegan
- Friedman
- Gabriel
- Gerstner
- Harrison
- Harrison
- Highhouse
- Hogg
- Hu
- Jackson
- Jaussi
- Jin
- Johnson
- Johnson
- Johnson
- Johnson
- Judge
- Kashima
- Kline
- Kristof-Brown
- Kühnen
- Lane
- Lievens
- Lord
- McClelland
- McCrae
- Meyer
- Mobley
- Mobley
- Mowday
- Muchinsky
- Muthén
- Naus
- Parkes
- Patterson
- Paul
- Robert
- Rohan
- Rokeach
- Ros
- Russell E. Johnson
- Sagiv
- Schneider
- Schneider
- Schwartz
- Schwartz
- Schwartz
- Schwartz
- Schwartz
- Schwartz
- Selenta
- Simon
- Turban
- Turban
- Vancouver
- Verquer
- Wayne
- Ybarra
- Publication venue
- 'Wiley'
- Publication date
- Field of study