Experience Dependent Cross-modal Regulation of Cortical Circuitry

Sensory experience is essential not only for the formation and maintenance of cortical circuits during development but also throughout life. Neural networks within the brain regulate activity based on experience, using both synapse specific (Hebbian) and global (homeostatic) mechanisms to achieve optimal signal processing without compromising their overall excitability. The loss of one sense can trigger compensation of spared sensory modalities, which is called cross-modal plasticity. These behavioral enhancements are realized through both Hebbian and homeostatic mechanisms to compensate for the loss of one sense, processing spared senses with heightened sensitivity via alterations in cortical circuit strengths. Specifically, spared cortex enhances the feed-forward signal arriving from the thalamus while deprived cortex remains unchanged, regardless of sensory modality. Loss of vision induces enhanced feed-forward signal propagation throughout layer 4 of auditory cortex and up to layer 2/3. In layer 2/3, Hebbian strengthening of feed-forward signals combine with homeostatic scaling down of spontaneous events and weakened lateral inputs to enhance the signal to noise ratio in auditory cortex after loss of sight. These changes in excitation are complemented by alterations in inhibitory transmission, with an increase in spontaneous event frequency in superficial layers, and an increase in parvalbumin mediated evoked inhibition in layer 4. An increase in spontaneous inhibitory synaptic transmission in layer 2/3 may dampen excitable inputs, allowing only the strong and salient signals to impact the network, while stronger evoked inhibition in layer 4 may serve to sharpen tuning as the signal arrives to auditory cortex. Both cross-modal and uni-modal (within the modality) plasticity require similar molecular mechanisms, as the scaling down of spontaneous events in superficial auditory cortex is abolished without the presence of Arc, an activity regulated protein which is known to regulate synaptic AMPA receptor localization. Arc’s involvement with activity regulated production of amyloid beta (Aβ) indicates that Aβ may play a role in normal physiological maintenance of homeostasis in the network. Here we observed an inability of visual cortex layer 2/3 neurons to homeostatically adapt to loss of vision in mice lacking the main enzyme necessary to produce Aβ. Together these results indicate that cross-modal and uni-modal plasticity may use similar molecular mechanisms to homeostatically adapt to changes in sensory environment. The brain’s ability to undergo cross-modal regulation of synaptic strength in response to loss of a sensory modality extends well beyond the classical critical period, and in some cases may be more readily recruited after uni-modal sensory perturbations. The critical period may reflect an optimal balance of excitation and inhibition, which may be reopened throughout life to enable an organism to adapt to their surroundings

Control Force Compensation in Ground-Based Flight Simulators

This paper presents the results of a study that investigated if controller force compensations accounting for the inertial force and moment due to the aircraft motion during flight have a significant effect on pilot control behavior and performance. Seven rotorcraft pilots performed a side-step and precision hovering task in light turbulence in the Vertical Motion Simulator. The effects of force compensation were examined for two different simulated rotorcraft: linear and UH-60 dynamics with two different force gradient of the lateral stick control. Four motion configurations were used: large motion, hexapod motion, fixed-base motion, and fixed-base motion with compensation. Control-input variables and task performance such as the time to translate to the designated hover position, station-keeping position errors, and handling qualities ratings were used as measures. Control force compensation enabled pilot control behavior and performance more similar to that under high- or medium-fidelity motion to some extent only. Control force compensation did not improve overall task performance considering both rotorcraft models at the same time. The control force compensation had effects on the linear model with lighter force gradient, but only a minimal effect on pilots? control behavior and task performance for the UH-60 model, which had a higher force gradient. This suggests that the control force compensation has limited benefits for controllers that have higher stiffness

The JWST Early-Release Science Program for Direct Observations of Exoplanetary Systems Ii: A 1 To 20 Μm Spectrum of the Planetary-Mass Companion Vhs 1256-1257 B

We present the highest fidelity spectrum to date of a planetary-mass object. VHS 1256 b is a (∼8″, a = 150 au), young, planetary-mass companion that shares photometric colors and spectroscopic features with the directly imaged exoplanets HR 8799c, d, and e. As an L-to-T transition object, VHS 1256 b exists along the region of the color-magnitude diagram where substellar atmospheres transition from cloudy to clear. We observed VHS 1256 b with JWST\u27s NIRSpec IFU and MIRI MRS modes for coverage from 1 to 20 μm at resolutions of ∼1000-3700. Water, methane, carbon monoxide, carbon dioxide, sodium, and potassium are observed in several portions of the JWST spectrum based on comparisons from template brown dwarf spectra, molecular opacities, and atmospheric models. The spectral shape of VHS 1256 b is influenced by disequilibrium chemistry and clouds. We directly detect silicate clouds, the first such detection reported for a planetary-mass companion

The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems II: A 1 to 20 Micron Spectrum of the Planetary-Mass Companion VHS 1256-1257 b

We present the highest fidelity spectrum to date of a planetary-mass object. VHS 1256 b is a $<$20 M$_\mathrm{Jup}$ widely separated ($\sim$8\arcsec, a = 150 au), young, planetary-mass companion that shares photometric colors and spectroscopic features with the directly imaged exoplanets HR 8799 c, d, and e. As an L-to-T transition object, VHS 1256 b exists along the region of the color-magnitude diagram where substellar atmospheres transition from cloudy to clear. We observed VHS 1256~b with \textit{JWST}'s NIRSpec IFU and MIRI MRS modes for coverage from 1 $\mu$m to 20 $\mu$m at resolutions of $\sim$1,000 - 3,700. Water, methane, carbon monoxide, carbon dioxide, sodium, and potassium are observed in several portions of the \textit{JWST} spectrum based on comparisons from template brown dwarf spectra, molecular opacities, and atmospheric models. The spectral shape of VHS 1256 b is influenced by disequilibrium chemistry and clouds. We directly detect silicate clouds, the first such detection reported for a planetary-mass companion.Comment: Accepted ApJL Iterations of spectra reduced by the ERS team are hosted at this link: https://github.com/bemiles/JWST_VHS1256b_Reduction/tree/main/reduced_spectr

The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems IV: NIRISS Aperture Masking Interferometry Performance and Lessons Learned

We present a performance analysis for the aperture masking interferometry (AMI) mode on board the James Webb Space Telescope Near Infrared Imager and Slitless Spectrograph (JWST/NIRISS). Thanks to self-calibrating observables, AMI accesses inner working angles down to and even within the classical diffraction limit. The scientific potential of this mode has recently been demonstrated by the Early Release Science (ERS) 1386 program with a deep search for close-in companions in the HIP 65426 exoplanetary system. As part of ERS 1386, we use the same dataset to explore the random, static, and calibration errors of NIRISS AMI observables. We compare the observed noise properties and achievable contrast to theoretical predictions. We explore possible sources of calibration errors, and show that differences in charge migration between the observations of HIP 65426 and point-spread function calibration stars can account for the achieved contrast curves. Lastly, we use self-calibration tests to demonstrate that with adequate calibration, NIRISS AMI can reach contrast levels of $\sim9-10$ mag. These tests lead us to observation planning recommendations and strongly motivate future studies aimed at producing sophisticated calibration strategies taking these systematic effects into account. This will unlock the unprecedented capabilities of JWST/NIRISS AMI, with sensitivity to significantly colder, lower mass exoplanets than ground-based setups at orbital separations inaccessible to JWST coronagraphy.Comment: 20 pages, 12 figures, submitted to AAS Journal

The JWST Early Release Science Program for Direct Observations of Exoplanetary Systems V: Do Self-Consistent Atmospheric Models Represent JWST Spectra? A Showcase With VHS 1256 b

The unprecedented medium-resolution (R~1500-3500) near- and mid-infrared (1-18um) spectrum provided by JWST for the young (140+/-20Myr) low-mass (12-20MJup) L-T transition (L7) companion VHS1256b gives access to a catalogue of molecular absorptions. In this study, we present a comprehensive analysis of this dataset utilizing a forward modelling approach, applying our Bayesian framework, ForMoSA. We explore five distinct atmospheric models to assess their performance in estimating key atmospheric parameters: Teff, log(g), [M/H], C/O, gamma, fsed, and R. Our findings reveal that each parameter's estimate is significantly influenced by factors such as the wavelength range considered and the model chosen for the fit. This is attributed to systematic errors in the models and their challenges in accurately replicating the complex atmospheric structure of VHS1256b, notably the complexity of its clouds and dust distribution. To propagate the impact of these systematic uncertainties on our atmospheric property estimates, we introduce innovative fitting methodologies based on independent fits performed on different spectral windows. We finally derived a Teff consistent with the spectral type of the target, considering its young age, which is confirmed by our estimate of log(g). Despite the exceptional data quality, attaining robust estimates for chemical abundances [M/H] and C/O, often employed as indicators of formation history, remains challenging. Nevertheless, the pioneering case of JWST's data for VHS1256b has paved the way for future acquisitions of substellar spectra that will be systematically analyzed to directly compare the properties of these objects and correct the systematics in the models.Comment: 32 pages, 16 figures, 6 tables, 2 appendice

The \textit{JWST} Early Release Science Program for Direct Observations of Exoplanetary Systems III: Aperture Masking Interferometric Observations of the star HIP\,65426 at 3.8 μm\boldsymbol{3.8\,\rm{\mu m}}

We present aperture masking interferometry (AMI) observations of the star HIP 65426 at $3.8\,\rm{\mu m}$ as a part of the \textit{JWST} Direct Imaging Early Release Science (ERS) program obtained using the Near Infrared Imager and Slitless Spectrograph (NIRISS) instrument. This mode provides access to very small inner working angles (even separations slightly below the Michelson limit of ${}0.5\lambda/D$ for an interferometer), which are inaccessible with the classical inner working angles of the \textit{JWST} coronagraphs. When combined with \textit{JWST}'s unprecedented infrared sensitivity, this mode has the potential to probe a new portion of parameter space across a wide array of astronomical observations. Using this mode, we are able to achieve a contrast of $\Delta m_{F380M}{\sim }7.8$\,mag relative to the host star at a separation of {\sim}0.07\arcsec but detect no additional companions interior to the known companion HIP\,65426\,b. Our observations thus rule out companions more massive than 10{-}12\,\rm{M\textsubscript{Jup}} at separations ${\sim}10{-}20\,\rm{au}$ from HIP\,65426, a region out of reach of ground or space-based coronagraphic imaging. These observations confirm that the AMI mode on \textit{JWST} is sensitive to planetary mass companions orbiting at the water frost line, even for more distant stars at $\sim$100\,pc. This result will allow the planning and successful execution of future observations to probe the inner regions of nearby stellar systems, opening essentially unexplored parameter space.Comment: 15 pages, 9 figures, submitted to ApJ Letter

Direct imaging and spectroscopy of exoplanetary systems with the JWST early release science program

The direct characterization of exoplanetary systems with high contrast imaging is among the highest priorities for the broader exoplanet community. As large space missions will be necessary for detecting and characterizing exo-Earth twins, developing the techniques and technology for direct imaging of exoplanets is a driving focus for the community. For the first time, JWST will directly observe extrasolar planets at mid-infrared wavelengths beyond 5 μm, deliver detailed spectroscopy revealing much more precise chemical abundances and atmospheric conditions, and provide sensitivity to analogs of our solar system ice-giant planets at wide orbital separations, an entirely new class of exoplanet. However, in order to maximise the scientific output over the lifetime of the mission, an exquisite understanding of the instrumental performance of JWST is needed as early in the mission as possible. In this paper, we describe our 55-hour Early Release Science Program that will utilize all four JWST instruments to extend the characterisation of planetary mass companions to ∼15-20 μm as well as image a circumstellar disk in the mid-infrared with unprecedented sensitivity. Our program will also assess the performance of the observatory in the key modes expected to be commonly used for exoplanet direct imaging and spectroscopy, optimize data calibration and processing, and generate representative datasets that will enable a broad user base to effectively plan for general observing programs in future cycles

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

The JWST Early Release Science Program for the Direct Imaging and Spectroscopy of Exoplanetary Systems

The direct characterization of exoplanetary systems with high-contrast imaging is among the highest priorities for the broader exoplanet community. As large space missions will be necessary for detecting and characterizing exo-Earth twins, developing the techniques and technology for direct imaging of exoplanets is a driving focus for the community. For the first time, JWST will directly observe extrasolar planets at mid-infrared wavelengths beyond 5 μm, deliver detailed spectroscopy revealing much more precise chemical abundances and atmospheric conditions, and provide sensitivity to analogs of our solar system ice-giant planets at wide orbital separations, an entirely new class of exoplanet. However, in order to maximize the scientific output over the lifetime of the mission, an exquisite understanding of the instrumental performance of JWST is needed as early in the mission as possible. In this paper, we describe our 55 hr Early Release Science Program that will utilize all four JWST instruments to extend the characterization of planetary-mass companions to ∼15 μm as well as image a circumstellar disk in the mid-infrared with unprecedented sensitivity. Our program will also assess the performance of the observatory in the key modes expected to be commonly used for exoplanet direct imaging and spectroscopy, optimize data calibration and processing, and generate representative data sets that will enable a broad user base to effectively plan for general observing programs in future Cycles